한림대학교 HALLYM UNIVERSITY

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독 
- piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels vea activation of alpha-secretase and matrix metalloproteinase=9 [Journal of Functional Foods, SCI급, 공동(교신), 2016]
- Inhibition of mitochondrial clearance and Cu/Zn-SOD activity enhance 6-hydroxydopamine-induced neuronal apoptosis [Molecular Neurobiology, SCI급 공동(교신), 2016]
- Beta-amyloid oligomers induce early loss of presynaptic proteins in primary neurons by caspase-dependent and proteasome-dependent mechanisms[Neuroreport, SCI급, 공동(교신), 2014]
- Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secreta expression and activity [Neurotoxicology, 공동(교신), 2013] 

공동저자 : 공동저자(참여) 
- Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of nuetrophils toward an antitumor phenotype [Onciommunology, SCI급, 공동(참여), 2016]
- LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission[CELL DEATH AND DIFFERENTIATION, SCI급, 공동(참여), 2014]
- Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus[Neuroscience Research, SCI급, 공동(참여), 2014]
- Impairment fo autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation [Plos One, 공동(참여), 2013]
- S1 pocket of glutamate carboxypeptidase II: a new binding site for amyloid-β degradation [Biochemical and Biophysical Research Communications, 공동(참여), 2013]
- The effect of P2X7 receptor activation on nuclear factor-kappa B phosphorylation induced by status epilepticus in the rat hippocampus [Hippocampus, 공동(참여), 2013]
- Endothelial transient receptor potential conical channel (TRPC)-3 activation induces vasogenic edema formation in the rat piriform cortex following status epilepticus [Cellular and molecular Neurobiology, 공동(참여), 2013] 

■ 주요연구주제
- 알츠하이머 치매의 신약 후보 물질 발굴
- 알츠하이머 치매의 바이오마커 발굴
- 퇴행성신경질환 유래 세포사멸 기전 분석

■ 학회활동
- 대한 해부학회
- 대한 뇌신경과학회
- 미국 신경과학회

주저자 : 제1저자, 공동저자(교신), 단독

Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity.[Mol Brain, SCI급, 공동(교신), 2015]

P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus. [Front Cell Neurosci, SCI급, 공동(교신), 2015]

Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats. [Neuroscience, SCI급, 공동(교신), 2015]

Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus. [Brain Res, SCI급, 공동(교신), 2015]

LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission. [Cell Death Differ, SCI급, 공동(제1), 2014]

PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner. [Cell Death Dis, SCI급, 공동(제1), 2014]

공동저자 : 공동저자(참여)

Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress. [J Neurosci, SCI급, 공동(참여), 2015]

Cellular and regional specific changes in multidrug efflux transporter expression during recovery of vasogenic edema in the rat hippocampus and piriform cortex. [BMB Rep, SCI급, 공동(참여), 2015]

Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus. [Neurosci Res, SCI급, 공동(참여), 2014]

주요연구주제

ER stress, Mitochondrial mitopathy, Neurological disease

학회활동

대한 해부학회

미국 신경과학회

주저자 : 제1저자, 공동저자(교신), 단독

Down-regulation of Tet2 prevents TSDR demethylation in IL2 deficient regulatory T cells[Biochemical and Biophysical Research Communications, SCI급, 공동(교신), 2014]

주요연구주제

T 세포 분화

자가면역질환

면역조절

학회활동

대한 면역학회

미국 면역학회

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독
- Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death [Biochem. Biophys. Res. Comm, SCI급, 공동(교신), 2015]
- The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells[Korean J Physiol. Pharmacol., SCI급, 공동(교신), 2014]

공동저자 : 공동저자(참여)
- Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease. [BMB Reports, SCI급, 공동(참여), 2015]
- The effects of PEP-1-FK506BP on dry eye disease in a rat model. [BMB Reports, SCI급, 공동(참여), 2015]
- Down-regulation of MAPK/NF-κB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model.[International Immunopharmacology, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 인슐린분비세포의 세포사를 억제하는 PEP-1-HO-1 융합단백질의 영향 및 기전연구
- 세포침투성 PEP-1-PON1의 항당뇨병 효능 및 기전연구
- 근세포의 포도당흡수에 대한 자색옥수수추출액의 영향 및 기전연구

■ 학회활동
- 대한 생리학회
- 한국 생화학 분자생물학회
- 미국 췌장학회
- 한국 노화학회

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독
- Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials [Scientific Reports, SCI급, 공동(교신), 2017]

- Decoding intravesical pressure from local field potentials in rat lumbosacral spinal cord [Journal of neural engineering, SCI급, 공동(교신), 2016]

- Development of wireless neural interface system [Biomedical Engineering Letters, KCI, 공동(교신), 2016]

- Increased immunoreactivity of c-Fos in the spinal cord of the aged mouse and dog[Molecular Medicine Reports, SCI급, 공동(교신), 2015]

- Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord[Journal of Veterinary Science, SCI급, 공동(교신), 2014]

공동저자 : 공동저자(참여)

- Rostral agranular insular cortex lesion with motor cortex stimulation enhances pain modulation effect on neuropathic pain model [Neural plasticity, SCI급, 공동(참여), 2016]

- Neuromodulation methods for animal locomotion control [Biomedical Engineering Letters, KCI, 공동(참여), 2016]

- Neuroprotection of posttreatment with risperidone, an atypical antipsychotic drug, in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke[JOURNAL OF NEUROSCIENCE RESEARCH, SCI급, 공동(참여), 2014]

- A hybrid NIRS-EEG system for self-paced brain computer interface with online motor imagery[Journal of Neuroscience Methods, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 뇌-기계 접속

■ 학회활동
- 한국뇌신경과학회
- 대한의용생체공학회
- 대한생리학회
- BRC Int’l conference

주저자 : 제1저자, 공동저자(교신), 단독

Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats [Neuroendocrinology, SCI급, 공동(교신), 2015]

A water-ethanol extract from the mushroom Phellinus igniarius (Piwep) reduces transient cerebral ischemia-induced neuronal death [International Journal of Medicinal Mushrooms, SCI급, 공동(교신), 2015]

Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice [Journal of Neuroinflammation, SCI급, 공동(교신), 2015]

Adipose-Derived Mesenchymal Stem Cells Reduce Neuronal Death After Transient Global Cerebral Ischemia Through Prevention of Blood-Brain Barrier Disruption and Endothelial Damage[Stem Cells Translational Medicine, SCI급, 공동(교신), 2015]

Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death [Brain Research, SCI급, 공동(교신), 2015]

"A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord[BioMed Research International, SCI급, 공동(교신), 2014]"

Colchicine induced intraneuronal free zinc accumulation and dentate granule cell degeneration[Metallomics, SCI급, 공동(교신), 2014]

Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus[J Trace Elem Med Biol, SCI급, 공동(교신), 2014]

EAAC1 Gene Deletion Increases Neuronal Death and Blood Brain Barrier Disruption after Transient Cerebral Ischemia in Female Mice[IJMS, SCI급, 공동(교신), 2014] 

1. 주요연구주제
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경손상의 기전 연구
- 중추신경계 내에서 아연 (Zinc)의 생리, 해부, 병리적 역할
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경재생의 기전 연구 
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경손상에 줄기세포의 투여가 미치는 영향
- 다발성 경화증의 발병기전 및 치료
2. 학회활동
- 대한 생리학회 이사
- 세계 신경과학회 정 회원 

■ 논문
주저자: 제1저자, 공동저자(교신), 단독 
- Effect of Wnt3a on keratinocytes utilizing in vitro and bioinformatics analysis[Int J Mol Sci, SCI급, 공동교신, 2014] 
- Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer’s disease[Nutrition Research & Practice, SCIE급, 교신, 2014]
- Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1(Extracellular NAD cleaving activity, fMLP, FPRL1, Human neutrophils)[Korean J Physiol Pharmacol, SCIE급, 교신, 2014] 

공동저자: 공동저자(참여) 
- Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death [BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급, 공동(참여), 2015] 
- Methoxy Poly(ethylene glycol)-Poly(lactide) Nanoparticles Encapsulating Quercetin Act as an Effective Anticancer Agent by Inducing Apoptosis in Breast Cancer [PHARMACEUTICAL RESEARCH, SCI급, 공동(참여), 2015] 
- Flow cytometric measurement of respiratory burst activity and surface expression of neutrophils for septic patient prognosis [Cytometry. Part B, Clinical cytometry, SCI급, 공동(참여), 2015] 
- Impact of serial measurements of lysophosphatidylcholine on 28-day mortality prediction in patients admitted to the intensive care unit with severe sepsis or septic shock[Journal of Critical Care, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 패혈증의 치료제에 대한 연구와 그 기전에 대한 연구 

■ 학회활동
- 대한 약리학회
- 미국 약리학회

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model [ANIMAL CELLS AND SYSTEMS, SCI급, 공동(교신), 2015] 
- Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model [The Korean Journal of Physiology & Pharmacology, SCI급, 공동(교신), 2015] 
- Involvement of alpha(2)-adrenergic receptor in the regulation of the blood glucose level induced by immobilization stress [ARCHIVES OF PHARMACAL RESEARCH, SCI급, 공동(교신), 2015] 
- Temporal expression of hippocampal lysophosphatidic acid receptors and their roles in kainic acid-induced neurotoxicity[Genes Genom, SCI급, 공동(교신), 2014]
- Ghrelin administered spinally increases the blood glucose level in mice[Peptides, SCI급, 공동(교신), 2014] 
- The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice[The Korean Journal of Physiology & Pharmacology, SCI급, 단독, 2014]
- Effects of nateglinide and repaglinide administered intracerebroventricularly on the CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice[Brain Research Bulletin, SCI급, 공동(교신), 2014] 
- Effect of tolbutamide, glyburide and glipizide administered supraspinally on CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice[Brain Research, SCI급, 공동(교신), 2014] 
- The modulatory role of alpha-melanocyte stimulating hormone administered spinally in the regulation of blood glucose level in D-glucose-fed and restraint stress mouse models[Neuropeptides, SCI급, 공동(교신), 2014] 
- Pertussis Toxin Administered Spinally Induces a Hypoglycemic Effect on Normal and Diabetic Mice[Pharmacology, SCI급, 공동(교신), 2014] 
- Involvement of a2-adrenergic receptor in the regulationof the blood glucose level induced by immobilization stress[Arch. Pharm. Res., SCI급, 공동(교신), 2014] 
- Role of corticotropin-releasing hormone receptor 1 in the regulation of nociception in mice[Animal Cells and Systems, SCI급, 공동(교신), 2014]
- Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice[Neuroscience Research, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Activation of spinal α2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow[European Journal of Pharmacology, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 통증과 오피오이드 시스템에 관련한 신호전달 메커니즘 규명
- 카이닉 산에 의산 신경세포 손상 모델에서의 신경세포 사멸 및 보호효과 관련 메커니즘 규명
- 통증과 당대사 관련 메커니즘 규명
- 중추신경계와 당대사의 상호 관련 메커니즘 규명

2. 학회활동
- 대한 약리학회 이사
- 대한 뇌신경학회 정회원
- 스트레스학회 정회원
- 대한 당뇨학회 정회원

■ 논문
주저자: 제1저자, 공동저자(교신), 단독 
- Morus alba Accumulates Reactive Oxygen Species to Initiate Apoptosis via FOXO-Caspase 3-Dependent Pathway in Neuroblastoma Cells. [Molecules and Cells, SCI급, 공동(교신), 2015] 
- PLGA-Loaded Gold-Nanoparticles Precipitated with Quercetin Downregulate HDAC-Akt Activities Controlling Proliferation and Activate p53-ROS Crosstalk to Induce Apoptosis in Hepatocarcinoma Cells. [Molecules and Cells, SCI급, 공동(교신), 2015] 
- Induction of apoptosis by Dioscorea nipponica Makino extracts in human SH-SY5Y neuroblastoma cells via mitochondria-mediated pathway[Animal Cells and Systems, SCI급, 공동(교신), 2014] 
- Application of in Utero Electroporation of G-Protein Coupled Receptor (GPCR) Genes, for Subcellular Localization of Hardly Identifiable GPCR in Mouse Cerebral Cortex[Molecues and Cells, SCI급, 공동(교신), 2014] 
 

공동저자: 공동저자(참여) 
- Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder. [Endocrinol Metab, KCI등재, 공동(참여), 2015]
- MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling.[Cell Death and Diseases, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 신경발달에 관여하는 뇌 유전자의 기능 연구
- GPCR 수용체의 분자약리학적 작용기전연구
- 뇌신경 발달장애 연구 동물모델 개발

■ 학회활동
- 미국 신경과학회 정회원
- 한국 뇌신경과학회 이사
- 한국 분자세포생물학회 이사
- 대한 약리학회 정회원
- 한국 통합생물학회 이사

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Lysophosphatidic acid activates β-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells. [Mol Med Rep, SCI급, 공동(교신), 2013] 
- Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillin dependent pathway. [Int J Mol Med, SCI급, 공동(교신), 2013]
 
2. 공동저자: 공동저자(참여) 
- The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells[KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, SCI급, 공동(참여), 2014] 
- Lys1110 of TRPM2 is critical for channel activation. [Biochem J, SCI급, 공동(참여), 2013]
- Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice [Peptides, SCI급, 공동(참여), 2013]

1. 주요연구주제
- 사람 호중구에서 라이소지질의 작용기전 
- 사람 호중구에서 CGRP의 작용기전 

2. 학회활동
- 대한 약리학회
- 미국 중환자학회

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(교신), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Purple perilla extracts with alpha-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages [INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SCI급, 공동(참여), 2015] 
- Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice [NUTRITION RESEARCH AND PRACTICE, SCI급, 공동(참여), 2015] 
- A functional egg yolk powder containing an antibody against Niemann-Pick C1-like1 (NPC1L1) lowers cholesterol levels in high cholesterol diet induced hypercholesterolemic SD rats [FOOD SCIENCE AND BIOTECHNOLOGY, SCI급, 공동(참여), 2015] 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Purple Perilla Extracts Allay ER Stress in Lipid-Laden Macrophages[PLOS ONE, SCI급, 공동(참여), 2014] 
- Rubus coreanus Miquel ameliorates scopolamine-induced memory impairments in ICR mice. [J Med Food, SCI급, 공동(참여),2014] 

1. 주요연구주제
- Molecular mechanism of cellular and organismal Aging (세포 및 조직 노화의 분자기전 연구) 
- Molecular mechanism for regulation of ROS, DNA damage, and DNA repair during aging (노화과정에서 활성산소, 유전자손상 및 복구 조절기전 연구)
- Mechanism for regulation of aging by FOXO (전사인자 FOXO에 의한 노화조절기전 연구)
- Development of anti-aging materials and medicine (항노화물질 및 의약개발)

2. 학회활동
- 한국 노화학회 
- 한국 생화학-분자생물학회 
- International Association of Gerontology and Geriatrics (세계노인과학회)

1. 주저자: 제1저자, 공동저자(교신), 단독 
- IkappaB kinase r/nuclear Factor-kappaB-essential modulator (IKKgamma/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated kinase (ROCK) to phosphorylate IKKbeta in response to transforming growth factor (TGF)-beta1[J. Biol. Chem., SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [Tumor Biology, SCI급, 공동(참여), 2015] 
- PV.1 suppresses the expression of FoxD5b during neural induction in Xenopus embryos[Mol Cells, SCI급, 공동(참여), 2014] 
- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Report, SCI급, 공동(참여), 2014] 
- Rab3a promotes brain tumor initiation and progression[Mol Biol Rep, SCI급, 공동(참여), 2014] 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1[Tumour Biol, SCI급, 공동(참여), 2014] 
- Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[Mol Biol Rep, SCI급, 공동(참여), 2014] 

1. 주요연구주제
- Rho GTPases에 의한 신호전달 
- RhoA-mediated regulation of inflammatory signal transduction by TGF-β, ROS, insulin, and amyloid-β.
- Tumorigenesis by ROS mediated by RhoA GTPase
- RhoA-mediated phagocytosis and ROS production mechanisms in macrophages
- Neurite outgrowth of PC12 cells mediated by RhoA activity.
- Change of endothelial cells regulated by Rho GTPases depending on ageing
2. 학회활동
- 생화학분자생물학회 대의원 
- 한국 분자세포생물학회 정회원 
- 한국 노화학회 정회원 
- 세포생물학회 정회원

1. 주저자: 제1저자, 공동저자(교신), 단독 
- PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis [BIOMED RESEARCH INTERNATIONAL, SCI급, 공동(교신), 2015] 
- PV.1 Suppresses the Expression of FoxD5b during Neural Induction in Xenopus Embryos[Molecules and Cells, SCI급, 공동(교신), 2014] 
- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Reports, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype. [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Rab3a promotes brain tumor initiation and progression[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(참여), 2014] 

1. 주요연구주제
- 척추동물 모델을 이용한 배의 초기발생과에서의 신호전달과 전사조절 기전연구 
- 척추동물 원시배발생과 신경발생에 관여하는 유전자의 탐색과 기능분석

 
2. 학회활동
- 한국 분자세포생물학회 정회원/제노프스분과 분과장 
- 생화학분자생물학회 정회원 
- 한국생명과학회 정회원/강원지부장 

■ 논문

주저자: 제1저자, 공동저자(교신), 단독 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(교신), 2015] 
- Rab3a promotes brain tumor initiation and progression[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(교신), 2014] 

공동저자: 공동저자(참여) 
- IRF7 promotes glioma cell invasion by inhibiting AGO2 expression [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- PV.1 Suppresses the Expression of FoxD5b during Neural Induction in Xenopus Embryos[MOLECULES AND CELLS, SCI급, 공동(참여), 2014] 
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Reports, SCI급, 공동(참여), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(참여), 2014] 

■ 주요연구주제
- 다양한 세포에서 단백질체학을 이용한 특정 수식화된 단백질의 (post-translational modification)의 대량분리와 기능분석(Lysine methylation methylation, sumolyation, Acetylation, Phosphorylation, O-GlcNAc modification...) 
- 새로운 단백질수식 확인 및 수식화된 단백질분리를 위한 단백질체학 기술개발 (Development of new technology to isolate and identify novel post-translational modifications)
- 인체질병 또는 중요한 세포내 핵심단백질의 새로운수식의 발굴 및 수식과 기능을 종합한 단백질기능 지도작성 (construction of multisite modification map) 
- 세포내 특정 핵심단백질과의 상호작용 단백질분리 및 기능분석
- 단백질체학을 이용한 질병의 조기진단을위한 인체질환 특이적 단백질 바이오마커 (biomarker) 발굴
- 특정 단백질의수식이 뇌종양세포 및 뇌종양줄기세포 발생에 미치는 영향분석

■ 학회활동
- 생화학분자생물학회 정회원 
- 한국 분자세포생물학회 정회원 

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Phosphatidylinositol-Glycan-Phospholipase D is Involved in Neurodegeneration in Prion Disease [PLOS One, SCI급, 공동(교신), 2015] 
- Nε-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms [Molecular Neurobiology, SCI급, 공동(교신), 2015] 
- RARB and STMN2 polymorphisms are not associated with sporadic Creutzfeldt-Jakob disease (CJD) in the Korean population[Molecular Biology Reports, SCI급, 공동(교신), 2014] 
- Genetic studies in human prion diseases[Journal of Korean Medical Science, SCI급, 공동(교신), 2014]
- Dysfunction of mitochondrial dynamics in the brains of scrapie-infected mice[Biochemical and Biophysical Research Communications, SCI급, 공동(교신), 2014] 
- Deficiency of prion protein induces impaired autophagic flux in neurons[Froitier in Aging Neuroscience, SCI급, 공동(교신), 2014]
 
2. 공동저자: 공동저자(참여) 
- Mass Spectrometric Identification of Citrullination Sites and Immunohistochemical Detection of Citrullinated Glial Fibrillary Acidic Protein in Alzheimer’s Disease Brains[Journal of Neuroscience Research, SCI급, 공동(참여), 2015] 
- Upregulation of Connexin 43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease [Journal of Alzheimer's Disease, SCI급, 공동(참여), 2015]
- Lysosomal Trafficking of TGFBIp via Caveolae-Mediated Endocytosis [PLOS One, SCI급, 공동(참여), 2015] 
- Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease [Molecular Neurobiology, SCI급, 공동(참여), 2015] 
- Auraptene Increases the Production of Amyloid-β via c-Jun N-Terminal Kinases-Dependent Activation of γ-Secretase [Journal of Alzheimer's Disease, SCI급, 공동(참여), 2015] 
- ATBF1 is a Novel Amyloid-β Protein Precursor (AβPP) Binding Protein that Affects AβPP Expression.[Jornal of Alzheimer's disease, SCI급, 공동(참여), 2015] 
- Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies[Neuropathology and Applied Neurobiology, SCI급, 공동(참여), 2014] 
- Tunicamycin induces paraptosis potentiated by inhibition of BRAFV600E in FRO anaplastic thyroid carcinoma cells[Anticancer Research, SCI급, 공동(참여), 2014]
- Stearoyl coenzyme a desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replication[Journal of Virology, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 프리온 질환에서 퇴행성 신경변화에 대한 병리기전 
- 프리온 질환의 조기 진단 기법 및 치료제 개발
- 노화에 따른 퇴행성 신경변화에서 내인성 레트로바이러스의 역할 구명 

2. 학회활동
- 대한 바이러스학회
- 미국 바이러스학회
- 미국 신경과학회
- 유럽연합 프리온학회
- 아시아-태평양 프리온학회
- 대한민국 의학한림원

■ 논문

주저자: 제1저자, 공동저자(교신), 단독 

- Detection of organophosphate bound butyrylcholinesterase using a monoclonal antibody[Applied Biological Chemistry, SCIE급, 공동(교신), 2017

- Generation of a monoclonal antibody that has reduced binding activity to VX-inactivated butyrylcholinesterase (BuChE) compared to BuChE by phage display. [Biotechnology and Bioprocess Engineering, SCI급, 공동(교신), 2017]

- Evaluation of ImmuneMed scrub typhus rapid test kit, for diagnosis of scrub typhus [JOURNAL OF VECTOR BORNE DISEASES, SCI급, 공동(교신), 2016]

- Clinical Evaluation of Rapid Diagnostic Test Kit for Scrub Typhus with Improved Performance[Journal of Korean Medical Science, SCI급, 공동(교신), 2016]

- Clinical Evaluation of Rapid Diagnostic Test Kit Using the Polysaccharide as a Genus-Specific Diagnostic Antigen for Leptospirosis in Korea, Bulgaria, and Argentina[Journal of Korean Medical Science, SCI급, 공동(교신), 2016]

공동저자: 공동저자(참여) 
- Identification of Leptospira species of Korean Isolates using Phylogenetic Analysis of Polymerase Chain Reaction-amplified 16S rDNA and LipL32 Genes[Journal of Bacteriology and Virology, KCI등재, 공동(참여), 2014] 

■ 주요연구주제
- 항바이러스물질 연구 및 개발 
- 급성열성질환 진단키트개발, 제조 및 마케팅 
- 60Hz 자기장 노출에 대한 동물 생체 영향 분석 

■ 학회활동
- 대한미생물학회 평의원, 이사, 회장, 이사장 
- 한국미생물학회연합 회장
- 대한면역학회 이사
- 대한바이러스학회 평의원
- 미국미생물학회 회원
- 한국전자파학회 전자장과 생체관계연구회 위원
- 생체전자파학회 회원
- 중앙약사심의위원회 위원
- 한국전력공사 전자계 자문위원
- KISTI 강원 과학기술정보 클러스터협의회 자문위원
- 강원 바이오산업 인력양성사업단 산학협력위원회 위원
- 새누리당 정책자문위원회 위원(교육과학기술)

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines [BMB Reports, SCI급, 공동(교신), 2015] 
- Monoclonal Antibodies Against the Human Respiratory Syncytial Virus Obtained by Immunization with Epitope Peptides and CpG-DNA-liposome Complex [Monoclonal antibodies in immunodiagnosis and immunotherapy, SCI급, 공동(교신), 2015] 
- Perspective of peptide vaccine composed of epitope peptide, CpG-DNA, and liposome complex without carriers. [Advances in Protein Chemistry and Structural Biology, SCI급, 공동(교신), 2015] 
- Production of epitope-specific antibodies by immunization with synthetic epitope peptide formulated with CpG-DNA-liposome complex without carriers [Methods in Molecular Biology, SCOPUS, 공동(교신), 2015] 
- Therapeutic effect of a TM4SF5-specific peptide vaccine against colon cancer in a mouse model[BMB reports, SCI급, 공동(교신), 2014] 
- Expression of UNC93A induced by CpG-DNA-liposome complex in mice[Journal of the Korean Society for Applied Biological Chemistry, SCI급, 공동(교신), 2014] 
- Monoclonal antibody targeting of the cell surface molecule TM4SF5 inhibits the growth of hepatocellular carcinoma[Cancer Research, SCI급, 공동(교신), 2014] 
- Effect of epitope-CpG-DNA-liposome complex without carriers on vaccination of respiratory syncytial virus infection[Journal of the Korean Society for Applied Biological Chemistry, SCI급, 공동(교신), 2014] 
- Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model[Oncotarget, SCI급, 공동(교신), 2014]
 
2. 공동저자: 공동저자(참여) 
- Middle Ear Response of Muc5ac and Muc5b Mucins to Nontypeable Haemophilus influenzae[JAMA Otolaryngology-Head & Neck Surgery, SCI급, 공동(참여), 2015] 
- Efficient doxorubicin delivery using deaggregated and carboxylated nanodiamonds for cancer cell therapy [Nanoscience and Nanotechnology Letters, SCI급, 공동(참여), 2015] 
- NADPH oxidase activation contributes to native low-density lipoprotein-induced proliferation of human aortic smooth muscle cells [EXPERIMENTAL AND MOLECULAR MEDICINE, SCI급, 공동(참여), 2015] 
- Liposome-Encapsulated CpG Enhances Antitumor Activity Accompanying the Changing of Lymphocyte Populations in Tumor via Intratumoral Administration [NUCLEIC ACID THERAPEUTICS, SCI급, 공동(참여)] 
- Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells [CELL STRESS CHAPERONES, SCI급, 공동(참여), 2015] 
- The LRP1-independent mechanism of PAI-1-inudced migration in CpG-ODN activated macrophages[INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, SCI급, 공동(참여), 2014] 
- The PDZ-binding motif of the avian NS1 protein affects transmission of the 2009 influenza A(H1N1) virus[Biochemical and Biophysical Research Communications, SCI급, 공동(참여), 2014]
- Plasminogen activator inhibitor-1 regulates infiltration of macrophages into melanoma via phosphorylation of FAK-Tyr(925)[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급, 공동(참여), 2014] 
- Inhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4[BMC Microbiology, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 선천면역
- 백신개발
- 항체개발

2. 학회활동
- 대한 바이러스학회 평의원
- 대한 미생물학회 평의원
- 생화학분자생물학회 운영위원, 강원분회장, BMB reports 편집위원
- 대한 면역학회 평의원
- World Journal of Immunology, Editorial Board

1. 주저자: 제1저자, 공동저자(교신), 단독 
- The Elevation of Annals of Rehabilitation Medicine to the Status of an International Journal After Adopting an English-Only Policy. [Annals of Rehabilitation Medicine, SCOPUS, 단독, 2015] 
- Evidence of the Internationalization of Clinical Endoscopy Based on Journal Metrics. [Clinical Endoscopy, SCOPUS, 단독, 2015]
- How much progress has been made in journal metrics two years after the citation analysis of the Korean Journal of Urology? [Korean Journal of Urology, SCOPUS, 단독, 2015] 
- Using Journal Article Tag Suite extensible markup language for scholarly journal articles written in Korean[Science Editing, 국내일반, 공동(교신), 2014] 
- Ethical Issue in Preparing Manuscript on Esthetic Patients[Archives of Aesthetic Plastic Surgery, KCI등재, 단독, 2014] 
- 의학교육에서 컴퓨터바탕검사와 문항은행 데이터베이스 구축[Korean Medical Education Review, KCI후보, 단독, 2014]
- Correlation among the citation indices of Korean scientific journals listed in international databases[Science Editing, 국내일반, 공동(교신), 2014] 
- Increase in frequency of citation by SCIE journals of non-Medline journals after listing in an open access full-text database[Science Editing, 국내일반, 공동(교신), 2014] 
- How Far Has the International Neurourology Journal Progressed Since Its Transformation Into an English Language Journal?[International Neuroruology Journal, SCI급, 단독, 2014] 
- 학술지에 적용하는 새 정보기술: ORCID, CrossMark, and FundRef[Journal of the Korean Medical Association, SCI급, 단독, 2014]
- Journal Metrics-Based Position of Diabetes & Metabolism Journal after the Change of Its Text Language to English[Diabetes and Metabolism Journal, SCI급, 단독, 2014] 
- Parasitic Diseases as the Cause of Death of Prisoners of War during the Korean War (1950-1953)[Korean Journal of Parasitology, SCI급, 단독, 2014]
- What Happened When CrossCheck Was Not Used for a Month in Journal of Neurogastroenterology and Motility?[Journal of Neurogastroenterology and Motility, SCI급, 단독, 2014] 
- How Journal Metrics Illustrate the Transformation of Archives of Plastic Surgery into an International Journal.[Archives of Plastic Surgery, SCI급, 단독, 2014]
- Journal Article Tag Suite 1.0: National Information Standards Organization standard of journal extensible markup language[Science Editing, 국내일반, 단독, 2014] 
- Uploading garbage files to the DOI system of a journal: a new type of misconduct[Learned Publishing, SCI급, 공동(교신), 2014]
- 국제 수준 학술지로 도약과 의사소통술[Korean Journal of Medical Education, KCI등재, 단독, 2014]
- Coding practice of the Journal Article Tag Suite extensible markup language[Science Editing, 국내일반, 단독, 2014] 
- "What is the position of Clinical and Experimental Reproductive Medicine in its scholarly journal network based on journal metrics?[Clinical and Experimental Reproductive Medicine, SCI급, 단독, 2014]"
- Asian Science Editors’ Conference and Workshop 2014[European Science Editing, SCI급, 단독, 2014]
 
2. 공동저자: 공동저자(참여) 
- Human Infections with Spirometra decipiens Plerocercoids Identified by Morphologic and Genetic Analyses in Korea [Korean Journal of Parasitology, SCI급, 공동(참여), 2015]
- Cross-reactivity of Toxocariasis with Crude Antigen of Toxascaris leonina Larvae by ELISA [Journal of Korean Medical Science, SCI급, 공동(참여), 2015] 
- 개 회충 게놈 응용 사례에서 공개용 분석 툴을 사용한 드래프트 게놈 어셈블리 생성[TIISE Transactions on Computing Practices, KCI등재, 공동(참여), 2014] 

1. 주요연구주제
- Epidemiology and genetic biology of toxocariasis
- Computerized adaptive testing in evaluation of medical education
- Consultation for the globalization of the medical journal from Korea

2. 학회활동
- Korean Society for Parasitology (Korea)
- The Korean Society of Medical Education (Korea)
- Korean Council of Science Editors (Korea)

[논문]

1. Structural factors of the Middle East respiratory syndrome Coronavirus outbreak as a public health crisis in Korea and future response strategies. (J Prev Med Public Health, 2015)

2. Relationship between Metabolic Syndrome and Lower Urinary Tract Symptoms: Hallym Aging Study (BIOMED RESEARCH INTERNATIONAL, 2015)

3. Trend of suicide rates according to urbanity among adolescents by gender and suicide method in Korea, 1997-2012 International (Journal of Environmental Research and Public Health, 2015)

4. Gender differences in adiponectin levels and body composition in older adults: (Hallym aging studyBMC Geriatrics, 2014)

5. Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: (The Hallym Aging StudyGenes and Genomics, 2014)

6. Cohort Profile: Community-based prospective cohort from the National Cancer Center, Korea Int (J Epidemiol, 2015)

7. Vegetable intake, but not fruit intake, was associated with a reduction in the risk of cancer incidence and mortality in middle-aged Koran men (J Nutrition, 2015)

8. A genome-wide association study of copy-number variation identifies putative loci associated with osteoarthritis in Koreans. (BMC Musculoskeletal Disorders. 2015)

9. Household and area income levels are associated with smoking status in the Korean adult population (BMC Public Health, 2015)

10. Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk (NATURE GENETICS, 2014)

11. Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian (populationsHypertension Research, 2014)

12. Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East (AsiansInternational Journal of Cancer, 2014)

13. Population-Attributable Causes of Cancer in Korea: Obesity and Physical (InactivityPLOS ONE, 2014)

14. Association between BMI, Smoking, and Alcohol with Prostate Cancer Mortality in the Asia Cohort ConsortiumAmerican (J Epidemiology, 2014)

[주요연구주제]

1. 자살예방을 위한 코호트 구축 연구

2. 지역사회 건강수준 평가연구

3. 지역사회기반 노인연구: 한림노년연

4. 유전체 코호트 구축사업: 검진자코호트 구축

5. 시료은행 구축

[학회활동]

1. 한국 역학회

2. 대한 예방의학회

3. Society for Epidemiology Research

4. Gerontological Society of America 

■ 논문

주저자: 제1저자, 공동저자(교신), 단독 
- Effects of an empowerment program for self-management among rural older adults with hypertension in South Korea [Australian Journal of Rural Health, SCI급, 공동(교신), 2015] 
- 만성 질환 관리 평가 도구를 이용한 보건소 만성 질환 관리 수준 평가 [보건행정학회지, KCI 등재, 공동(제일), 2014] 
 
공동저자: 공동저자(참여) 
- Older adults’ perception of chronic illness management in South Korea [Journal of Preventive Medicine and Public Health, SCOPUS 및 KCI 등재, 공동(참여), 2014]
- Do Not Resuscitate (DNR)와 Advance Directives (AD)에 대한 환자 보호자와 의료인의 인식 [한국호스피스완화의료학회지, KCI 등재, 공동(참여), 2014] 
- 델파이 법을 이용한 일차의료 개념 정의: 이차 출판 [보건행정학회지, KCI 등재, 공동(참여), 2014] 

■ 주요 연구 주제
- 일차의료
- 만성 질환 관리 평가 
- 보건의료 관리 연구 일반

■ 학회 활동
- 대한예방의학회
- 한국보건행정학회
- 한국건강형평성학회
- 한국농촌의학지역보건학회

- 주저자: 제1저자, 공동저자(교신), 단독 Anti-adipogenic Effects in 3T3-L1 Cells of Acetone Extracts and Fractions from Styrax japonica Fruit. [Food Sci Biotechnology, SCI급, 공동(교신), 2015]

Anti-apoptotic effects of silk fibroin hydrolysate in RIN5F cell on high glucose condition. [Animal Cells and System, SCI급, 공동(교신), 2015]

Anti-obesity Effects of the Stem Bark of Japanese Horse Chestnut (Aesulus turbinate) in 3T3-L1 Preadipocytes. [Food Sci Biotechnology, SCI급, 공동(교신), 2014]

- 공동저자: 공동저자(참여) Helicobacter apodemus sp. nov., a new Helicobacter species identified from the gastrointestinal tract of striped field mice in Korea. [Journal of Veterinary Science, SCI급, 공동(참여), 2015]

Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride. [Genes & Genomics, SCI급, 공동(참여), 2015]

Comparison of N-methyl-D-aspartate receptor subunit 1 and 4-hydroxynonenal in the hippocampus of natural and chemical-induced aging accelerated mice. [Neurochem Res, SCI급, 공동(참여), 2014]

Genetic risk assessment for cardiobascular disease wuth seven genes associated with plasma C-reactive protein concentrations in Asian populations. [Hypertension Research, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 신경질환관련 모델동물의 개발
- 난청 마우스 모델동물에서 transmenbrane inner ear 유전자의 기능에 관한 연구
- 당뇨병 치료를 위한 치료제 및 기능성 식품 개발

2. 학회활동
- 질환모델동물연구회 회장 
- Lab. Anim. Res. 편집위원장 
- 한국유전체학회 회원 
- 한국분자세포생물학회 회원

1. 주저자: 제1저자, 공동저자(교신), 단독 

- Identification of pleiotropic genetic variants affecting osteoporosis risk in a Korean elderly cohort [Journal of Bone and Mineral Metabolism, SCI급, 공동(교신), 2019] 

- Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia [BMC Medical Genetics, SCI급, 공동(교신), 2017]

- Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population [PLoS One, SCI급, 공동(교신), 2017]

- Genetic Effect of Transforming growth factor alpha Gene Variants to the Risk of Nonsyndromic Cleft Lip with or without Palate in Korean Populations [The Cleft Palate-Craniofacial Journal, SCI급, 공동(교신), 2015]

- Interactions of Genetic and Non-genetic Factors on Plasma hs-CRP Concentration in a Korean Community-based Cohort Study [Genes & Genomics, SCI급, 공동(교신), 2015] 

- Male-specific genetic effect on hypertension and metabolic disorders[HUMAN GENETICS, SCI급, 공동(교신), 2014] 

- Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian populations[HYPERTENSION RESEARCH, SCI급, 공동(교신), 2014] 

 
2. 공동저자: 공동저자(참여) 

- Pan-cancer analysis of whole genomes [Nature, SCI급, 공동(참여), 2020]

- Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: The Hallym Aging Study [Genes & Genomics, SCI급, 공동(참여), 2015] 

- Investigation of Parental Transmission of RUNX2 Single Nucleotide Polymorphism and Its Association With Nonsyndromic Cleft Lip With or Without Palate[CLEFT PALATE-CRANIOFACIAL JOURNAL, SCI급, 공동(참여), 2014] 

1. 주요연구주제
- 유전역학 
- 유전체 연관성 연구
- 질병위험예측 

2. 학회활동
- American Society of Human Genetics
- International Human Genome Organization
- European Society of Human Genetics
- 한국 유전체학회

[논문]

1. The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression. (Biomolecules and Therapeutics, 2016)

2. Laparoscopic treatment for post-cholecystectomy Mirizzi syndrome. (Korean J Hepatobiliary Pancreat Surg, 2013)

3. Comparison of endoscopic submucosal dissection and surgical resection for treating gastric subepithelial tumours. (Scand J Gastroenterol, 2016)

4. Phase II study of docetaxel, oxaliplatin, and S-1 therapy in patients with metastatic gastric cancer. (Gastric Cancer, 2016)

5. One-year experience with single incision laparoscopic cholecystectomy in a single center: without the use of inverse triangulation. (Ann Surg Treat Res, 2016)

6. Second-Line Irinotecan, Leucovorin, and 5-Fluorouracil for Gastric Cancer Patients after Failed Docetaxel and S-1. (Gastroenterol Res Pract , 2016)

7. HIPK2 expression in progression of cutaneous epithelial neoplasm. (International Journal of Dermatology, SCI급, 공동(참여), 2015)

8. 3,4,5-Trihydroxycinnamic acid increases heme-oxygenase-1 (HO-1) and decreases macrophage infiltration in LPS-induced septic kidney. (Molecular And Cellular Biology, 2014)

9. Geldanamycin attenuates 3‑nitropropionic acid‑induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells. (International Journal of Molecular Medicine, 2014)

10. Factors that affect surgery after endoscopic resection of early gastric cancer patients. (Korean Journal of Clinical Oncology, 2013)

11. Outcome of transilluminated powered phlebectomy for varicose vein: review of 299 patients (447 limbs). (Surgery Today, 2013)

[주요연구주제]

의학교육-역량개발

평가도구 개발

교수법

[학회활동]

대한 의학교육학회 회원

대한 의사협회 평생회원

대한 외과학회 평생회원

대한 위암학회 평생회원

대한 종양외과학회 평생회원

1) Geum-Young Lee*, Won-Keun Kim*, Kyungmin Park*, Seung-Ho Lee, Jusun Hwang, Jin Sun No, Seungchan Cho, Daesang Lee, Dong-Hyun Song, Se Hun Gu, Man-Seong Park, Seung Tae Jung, Young-Su Kim, and Jin-Won Song, Phylogeographic Diversity and Hybrid Zone of Hantaan orthohantavirus Collected in Gangwon Province, Republic of Korea, PLoS Neglected Tropical Diseases, 14(10): e0008714 (2020) *Equal contribution 

2) Seung-Ho Lee*, Jin Sun No*, Won-Keun Kim*, Ewa Gajda, Agnieszka Perec-Matysiak, Jeong-Ah Kim, Joanna Hildebrand, Richard Yanagihara, and Jin-Won Song, Molecular epidemiology and genetic diversity of orthohantaviruses in small mammals in western Poland, American Journal of Tropical Medicine and Hygiene, 103(1): 193-199 (2020) *Equal contribution

3) Seung-Ho Lee*, Won-Keun Kim*, Kyungmin Park, Jin Sun No, Geum Young Lee, Heung-Chul Kim, Terry A. Klein, Mi-Sook Min, Seo-Jin Lee, Jusun Hwang,  Man-Seong Park, and Jin-Won Song, Genetic Diversity and Phylogeography of Jeju Orthohantavirus (Hantaviridae) in the Republic of Korea, Virology, 543:13-19 (2020) *Equal contribution

4) Won-Keun Kim, Jin Sun No, Daesang Lee, Jaehun Jung, Hayne Park, Yongjin Yi, Jeong-Ah Kim, Seung-Ho Lee, Yujin Kim, Sunhye Park, Seungchan Cho, Geum-Young Lee, Dong Hyun Song, Se Hun Gu, Kkothanahreum Park, Heung-Chul Kim, Michael R. Wiley, Patrick S. G. Chain, Seong Tae Jeong, Terry A. Klein, Gustavo Palacios, and Jin-Won Song, Active Targeted Surveillance to Identify Sites of Emergence of Hantavirus, Clinical Infectious Diseases, Mar. 20th, 70(3) 464-473 (2020)

5) Jin Sun No*, Won-Keun Kim*, Seungchan Cho*, Seung-Ho Lee, Jeong-Ah Kim, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Michael R. Wiley, Gustavo Palacios, and Jin-Won Song, “Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues, Scientific Reports, 9: 16631 (2019) *Equal contribution

6) Heung-Chul Kim*, Won-Keun Kim*, Jin Sun No, Seung-Ho Lee, Se Hun Gu, Sung-Tae Chong, Terry A. Klein, and Jin-Won Song, Urban Rodent Surveillance, Climatic Association and Genomic Analysis of Seoul Virus Collected at U.S. Army Garrison, Seoul, Republic of Korea, 2006-2010, American Journal of Tropical Medicine and Hygiene, 99(2): 470-476 (2018) *Equal contribution

7) Won-Keun Kim*, Jin Sun No*, Seung-Ho Lee, Dong Hyun Song, Daesang Lee, Jeong-Ah Kim, Se Hun Gu, Sunhye Park, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, Michael R. Wiley, Gustavo Palacios, Jin-Won Song, Multiplex PCR-based next-generation sequencing and global diversity of Seoul virus in humans and rats, Emerging Infectious Diseases, 24(2): 249-257 (2018) *Equal contribution
[http://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=52844&idauthorid=24053&ttype=2]

8) Heung-Chul Kim*, Won-Keun Kim*, Terry A. Klein, Sung-Tae Chong, Peter V. Nunn, Jeong-Ah Kim, Seung-Ho Lee, Jin Sun No and Jin-Won Song, Hantavirus Surveillance and Genetic Diversity Targeting Small Mammals at Camp Humphreys, a US Military Installation and new expansion site, Republic of Korea, PLoS One, 12(4): e0176514 (2017) *Equal contribution

9) Seung-Ho Lee*, Won-Keun Kim*, Jin Sun No, Jeong-Ah Kim, Jin Il Kim, Se Hun Gu, Heung-Chul Kim, Terry A. Klein, Manseong Park and Jin-Won Song Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea, Scientific Reports, 7: srep44369 (2017) *Equal contribution [KU BK21 Best research award, Korea University Brain Korea 21]
[http://science.ytn.co.kr/program/program_view.php?s_mcd=0082&s_hcd=0006&key=201703271155517458]

10) Dong Hyun Song*, Won-Keun Kim*, Se Hun Gu, Daesang Lee, Jeong-Ah Kim, Jin Sun No, Seung-Ho Lee, Michael R. Wiley, Gustavo Palacios, Jin-Won Song, Seong Tae Jeong Sequence-Independent, Single-Primer Amplification Next-Generation Sequencing of Hantaan virus cell culture-based isolates, American Journal of Tropical Medicine and Hygiene, 96: 389-394 (2017) *Equal contribution 

11) Jeong-Ah Kim, Won-keun Kim, Jin Sun No, Seung-Ho Lee, Sook-YoungLee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Man-Seong Park, Heung Chul Kim, Terry A. Klein, and Jin-Won Song, Genetic Diversity and Reassortment of Hantaan Virus Tripartite RNA Genomes in Nature, the Republic of Korea, PLoS Neglected Tropical diseases, 10(6): e0004650 (2016)

12) Sook-Young Lee, Jeong-Hoon Kim, Tae-Kun Seo, Jin Sun No, Hankyeom Kim, Won-keun Kim, Han-Gu Choi, Sung-Ho Kang, Jin-Won Song, Genetic and Molecular Epidemiological Characterization of a Novel Adenovirus in Antarctic Penguins Collected between 2008 and 2013, PLoS One, 11(6): e0157032 (2016)

13) Won-Keun Kim, Jeong-Ah Kim, Dong Hyun Song, Daesang Lee, Yong Chul Kim, Sook-Young Lee, Seung-Ho Lee, Jin Sun No, Ji Hye Kim, Jeong Hoon Kho, Se Hun Gu, Seong Tae Jeong, Michael Wiley, Heung-Chul Kim, Terry A. Klein, Gustavo Palacios, and Jin-Won Song, Phylogeographic analysis of Hemorrhagic Fever with Renal Syndrome (HFRS) Patients and Natural Hosts using Multiplex PCR-based Next Generation Sequencing, Scientific Reports, 6: srep26017 (2016)
[http://science.ytn.co.kr/program/program_view.php?s_mcd=0082&s_hcd=&key=201605261101459441&page=1]

14) Jin Sun No*, Won-keun Kim*, Jeong-Ah Kim, Seung-Ho Lee, Sook-Young Lee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, and Jin-Won Song, Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in a highly endemic area, the Republic of Korea, Microbiology and Immunology, 60(4): 268-271 (2016) *Equal contribution

15) Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Galr Jr., Arjun Raj, Carolina B. López, Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I, mBio, 6 (5): e01265-15 (2015)

16) Terry A. Klein, Heung-Chul Kim, Sung-Tae Chong, Jeong-Ah Kim, Sook-Young Lee, Won-Keun Kim, Peter V. Nunn, Jin-Won Song, Hantaan Virus Surveillance Targeting Small Mammals at Nightmare Range, a High Elevation Military Training Area, Gyeonggi Province, Republic of Korea, PLoS One, 10(4): e0118483 (2015)

17) Won-keun Kim, Deepika Jain, Melissa D. Sánchez, Cynthia J. Koziol-White, Krystal Matthews, Moyar Q. Ge, Angela Haczku, Reynold A. Panettieri Jr., Matthew B. Frieman, and Carolina B. López, Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation, American Journal of Respiratory and Critical Care Medicine, 189 (4): 437-448 (2014)
[http://bric.postech.ac.kr/myboard/read.php?id=38494&idauthorid=24053&Board=HBS_TREATISE&ttype=&skin=hbs_treatise]

18) Xiomara Mercado-López, Christopher R. Cotter, Won-keun Kim, Yan Sun, Luis Muñoz, Karla Tapia, and Carolina B. López, Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Interfering Viral Genome, Vaccine, 31(48): 5713-5721 (2013)

19) Karla Tapia*, Won-keun Kim*, Yan Sun, Xiomara Mercado-López, Emily Dunay, Megan Wise, Michael Adu, and Carolina B. López, Defective viral genomes arising in vivo provide critical danger signals for the triggering of lung anti-viral immunity, PLoS Pathogen, 9(10): e1003703 (2013) *Equal contribution [Featured Research]

20) Byung O. Lee, Joyce E. Jones, Cory J. Peters, David Whitacre, Lars Frelin, Janice Hughes, Won-keun Kim, and David R. Milich, Identification of a unique double-negative regulatory T-cell population, Immunology, 134(4): 434-447 (2011)

21) Christopher R. Cotter, Won-keun Kim, Marie L. Nguyen, Jacob S. Yount, Carolina B. López, John A. Blaho, and Thomas M. Moran, The virion host shutoff protein of Herpes Simples Virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling, Journal of Virology, 85(23): 12662-12672 (2011)

Research Interests

1) Development of antivirals

2) Next-generation sequencing: Comparative genomics

3) Virus-host interaction: Virology, Immunology, Epidemiology

4) Metagenomic analysis of virome

Grants

1) Agency of Defense Development, Acquisition and sequence analysis of biological threat agents, 2020.06-2022.06

2) National Research Foundation of Korea, Metagenomic study and molecular screening of rodent (Apodemus agrarius)-borne biothreat viruses using next-generation sequencing and targeted RT-PCR, 2019-2021

3) Novelgen, Study of antiviral therapeutics against emerging bio-threat viruses using Single-Chain Variable Fragment (scFv), 2019-2021

Patents

1) Hantavirus Whole Genome Sequence Identification Methods Using a Multiplex PCR-based Next-Generation Sequencing and Uses Thereof (Patent number: 10-1815105)

■Publication listing: https://scholar.google.co.kr/citations?user=hGxGE20AAAAJ&hl=en

■Selected publications:a

◦ Choe YJ, Smit MA, Mermel LA. Seasonality of respiratory viruses and bacterial pathogens. Antimicrob Resist Infect Control. 2019;8:125.

◦ Choe YJ, Choe SA, Cho SI. Trends in Infectious Disease Mortality, South Korea, 1983-2015. Emerg Infect Dis. 2018;24(2):320-327.

◦ Choe YJ, Lee YH, Cho SI. Increasing mumps incidence rates among children and adolescents in the Republic of Korea: age-period-cohort analysis. Int J Infect Dis. 2017;57:92-97

◦ Choe YJ, Min K, Cho SI. Spatial distribution of mumps in South Korea, 2001-2015: identifying clusters and population risk factors. Epidemiol Infect. 2017;145(10):2122-2128

◦ Choe YJ, Lee HJ, Lee H, et al. Emergence of antibiotic-resistant non-vaccine serotype pneumococci in nasopharyngeal carriage in children after the use of extended-valency pneumococcal conjugate vaccines in Korea. Vaccine. 2016;34(40):4771-6.

■주요연구주제

◦ 감염역학

◦ 백신학

◦ 모자보건

■학회활동

◦ 한국역학회

◦ 대한소아감염학회

◦ Infectious Disease Society of America