의예·의학과

강태천
  • 분야

    해부학

  • 성명

    국문 강태천

  • 직위

    교수

  • 연구실

    의학과 3층 3315

  • 연락처

    033-248-2524

  • 이메일

학력

-1996-1998 서울대학교 수의과대학(수의학박사-신경해부학)

-1993-1995 서울대학교 수의과대학(수의학석사-해부학)

-1987-1991 서울대학교 수의과대학(수의학사-수의학) 

주요경력

2017.9~2019.3 의과대학 학생부학장/의예과장

 

1999-현재 한림대학교 의과대학 해부신경생물학교실. 전임강사, 조교수, 부교수, 교수

 

1998-1999 서울대학교 의과대학 해부학교실. 박사후과정 

연구 및 저서

주저자 : 제1저자, 공동저자(교신), 단독

Nuclear factor-erythroid 2-realted factor 2(Nrf2) and mitochondrial dynamics/mitophagy in neurological diseases, [Antioxidants, SCI급 ,단독 ,2020]
Src/CK2/PTEN-Mediated GluN2B and CREB Dephosphorylations Regulate the Responsiveness to AMPA Receptor Antagonists in Chronic Epilepsy Rats, [International journal of molecular sciences, SCI급 ,교신 ,2020]
CDDO-Me distinctly regulates regional specific astroglial responses to status epilepticus via ERK1/2-Nrf2, PTEN-PI3K?AKT and NFκB signaling pathways, [Antioxidants, SCI급 ,교신 ,2020]
PLPP/CIN-mediated Mdm2 dephosphorylation increases seizure susceptibility via abrogating PSD95 ubiquitination, [Experimental Neurology, SCI급 ,교신 ,2020]
Epigallocatechin-3-Gallate and PEDF 335 Peptide, 67LR Activators, Attenuate Vasogenic Edema, and Astroglial Degeneration Following Status Epilepticus, [Antioxidants, SCI급 ,교신 ,2020]
PTEN Is Required for The Anti-Epileptic Effects of AMPA Receptor Antagonists in Chronic Epileptic Rats, [International journal of molecular sciences, SCI급 ,교신 ,2020]
Blockade of 67-kDa laminin receptor facilitates AQP4 down-regulation and BBB disruption via ERK1/2- and p38 MAPK-mediated PI3K/AKT activations, [Cells, SCI급 ,교신 ,2020]
CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFκB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus., [Cells, SCI급 ,교신 ,2020]
The Regional Specific Alterations in BBB Permeability are Relevant to the Di erential Responses of 67-kDa LR Expression in Endothelial Cells and Astrocytes Following Status Epilepticus, [International journal of molecular sciences, SCI급 ,교신 ,2019]
TRPC6-Mediated ERK1/2 Activation Increases Dentate Granule Cell Resistance to Status Epilepticus Via Regulating Lon Protease-1 Expression and Mitochondrial Dynamics, [Cells, SCI급 ,교신 ,2019]
CDDO-Me selectively attenuates CA1 neuronal death induced by status epilepticus via facilitating mitochondrial fission independent of LONP1, [Cells, SCI급 ,교신 ,2019]
PLPP/CIN-mediated NEDD4-2 S448 dephosphorylation regulates neuronal excitability via GluA1 ubiquitination, [Cell death and disease, SCI급 ,교신 ,2019]
Roscovitine Attenuates Microglia Activation and Monocyte Infiltration via p38 MAPK Inhibition in the Rat Frontoparietal Cortex Following Status Epilepticus., [Cells, SCI급 ,교신 ,2019]
Blockade of AMPA Receptor Regulates Mitochondrial Dynamics by Modulating ERK1/2 and PP1/PP2A-Mediated DRP1-S616 Phosphorylations in the Normal Rat Hippocampus, [Frontiers in cellular neusosicence, SCI급 ,교신 ,2019]
Dysfunction of 67-kDa laminin receptor distupts BBB intergrity via impaired dystrophin/AQP4 complex and p38 MAPK/VEGF activation following status epilepticus, [Frontiers in cellular neuroscience, SCI급 ,교신 ,2019]
Perampanel Affects Up-Stream Regulatory Signaling Pathways of GluA1 Phosphorylation in Normal and Epileptic Rats., [Frontiers in cellular neuroscience, SCI급 ,교신 ,2019]
CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus, [International journal of molecular sciences, SCI급 ,공동(교신) ,2019]
PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-kB and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus, [Frontiers in molecular neuroscience, SCI급 ,공동(교신) ,2019]
The differential roles of PEA15 phosphorylations in reactive astrogliosis and astroglial apoptosis following status epilepticus., [Neuroscience Research, SCI급 ,교신 ,2018]
Differential Roles of Mitochondrial Translocation of Active Caspase-3 and HMGB1 in Neuronal Death Induced by Status Epilepticus, [Frontiers in cellular neuroscience, SCI급 ,교신 ,2018]
Suppression of nucleocytoplasmic p27Kip1export attenuates CDK4-mediated neuronal death induced by status epilepticus, [Neuroscience Research, SCI급 ,교신 ,2018]
Nucleocytoplasmic p27Kip1 Export Is Required for ERK1/2-Mediated Reactive Astroglial Proliferation Following Status Epilepticus, [Frontiers in cellular neuroscience, SCI급 ,교신 ,2018]
P2RX7-MAPK1/2-SP1 axis inhibits MTOR independent HSPB1-mediated astroglial autophagy, [Cell death & disease, SCI급 ,공동(교신) ,2018]
TRPC6-mediated ERK1/2 activation regulates neuronal excitability via subcellular Kv4.3 localization in the rat hippocampus, [Frontiers in cellular neuroscience, SCI급 ,교신 ,2017]
TRPC3- and ETB receptor-mediated PI3K/AKT activation induces vasogenic edema formation following status epilepticus, [Brain Research, SCI급 ,교신 ,2017]
Leptomycin B attenuates neuronal death via PKA- and PP2B-mediated ERK1/2 activation in the rat hippocampus following status epilepticus, [Brain Research, SCI급 ,교신 ,2017]
p47Phox/CDK5/DRP1- mediated mitochondrial fission evokes PV cell degeneration in the rat dentate gyrus following status epilepticus, [Frontiers in cellular neuroscience, SCI급 ,교신 ,2017]
PLPP/CIN Regulates Seizure Activity by the Differential Modulation of Calsenilin Binding to GluN1 and Kv4.2 in Mice, [Frontiers in molecular neuroscience, SCI급 ,교신 ,2017]
TRPC6-mediated ERK1/2 phosphorylation prevents dentate granule cell degeneration via inhibiting mitochondrial elongation, [Neuropharmacology, SCI급 ,교신 ,2017]
Sustained HSP25 Expression Induces Clasmatodendrosis via ER Stress in the Rat Hippocampus, [Frontiers in cellular neuroscience, SCI급 ,교신 ,2017]
Positive feedback role of TRPC3 in TNF-α-mediated vasogenic edema formation induced by status epilepticus independent of ETB receptor activation, [Neuroscience, SCI급 ,교신 ,2016]
LeptomycinB ameliorates vasogenic edema formation induced by status epilepticus via inhibiting p38MAPK/VEGF pathway, [Brain research, SCI급 ,교신 ,2016]
PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins, [Scientific reports, SCI급 ,교신 ,2016]
Miotochondrial translocation of high mobility group box 1 facilitates LIM kinase 2-mediated programmed necrotic neuronal death, [Frontiers in Cellular Neuroscience, SCI급 ,교신 ,2016]

The role of TRPC6 in seizure susceptibility and seizure-related neuronal damage in the rat dentate gyrus. [Neuroscience. SCI급, 공동(교신), 2015]

Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity [Mol Brain. SCI급, 공동(교신), 2015]

Mannitol induces selective astroglial death in the CA1 region of the rat hippocampus following status epilepticus [BMB reports, SCI급, 공동(교신), 2015]

ETB RECEPTOR-MEDIATED MMP-9 ACTIVATION INDUCES VASOGENIC EDEMA VIA ZO-1 PROTEIN DEGRADATION FOLLOWING STATUS EPILEPTICUS [Neuroscience, SCI급, 공동(교신), 2015]

Blockade of endothelin B receptor improves the efficacy of levetiracetam in chronic epileptic rats [Seizure, SCI급, 공동(교신), 2015]

Cellular and regional specific changes in multidrug efflux transporter expression during recovery of vasogenic edema in the rat hippocampus and piriform cortex [BMB reports, SCI급, 공동(교신), 2015]

"LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission[Cell death and differentiation, SCI급, 공동(교신), 2014]

OVER-EXPRESSION OF LAMININ CORRELATES TO RECOVERY OF VASOGENIC EDEMA FOLLOWING STATUS EPILEPTICUS[Neuroscience, SCI급, 공동(교신), 2014]

PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner.[Cell Death Dis, SCI급, 공동(교신), 2014]

Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus.[Neurosci Res., SCI급, 공동(교신), 2014]

 

공동저자 : 공동저자(참여)

Opioid Analgesics and Depressive Symptoms in Burn Patients: What Is the Real Relationship?, [Clin Psychopharmacol Neurosci., SCI급 ,공동(참여) ,2016]

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition), [Autophagy, SCI급 ,공동(참여) ,2016]

Association Study of DKK2 Polymorphisms with Alcohol Dependence and Alcohol-Related Harm.[Alcohol Clin Exp Res, SCI급, 공동(참여), 2014]

Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury.[Free Radic Biol Med., SCI급, 공동(참여), 2014]

Association Between HTR7 Genetic Polymorphisms and Alcohol Dependence, Using the Alcohol Use Disorders Identification Test (AUDIT).[Alcohol Clin Exp Res, SCI급, 공동(참여), 2014] 

기타

 

경력

1999-현재 한림대학교 의과대학 해부신경생물학교실. 전임강사, 조교수, 부교수, 교수

1998-1999 서울대학교 의과대학 해부학교실. 박사후과정

 

주요연구주제

 

뇌전증(간질) 발생기전 

김민주
  • 분야

    신경생물학

  • 성명

    국문 김민주

  • 직위

    부교수

  • 연구실

    의학관 3층 3316

  • 연락처

    033-248-2523

  • 이메일

학력

-2003-2006 Ph.D. 한림대학교 의과대학

-2001-2003 M.S. 한림대학교 의과대학

-1995-2001 M.D. 한림대학교 의과대학

주요경력

-2020 ~ 현재 교수, 한림대학교 의과대학 해부신경생물학 교실

-2015~2020 부교수, 한림대학교 의과대학 해부신경생물학 교실

-2011-2015 조교수, 한림대학교 의과대학 해부신경생물학교실

-2009-2011 연구조교수, 한림대학교 의과대학 해부신경생물학교실

-2008-2009 선임연구원, 질병관리본부 국립보건원 생명의과학센터뇌질환팀

-2005-2008 공중보건의, 질병관리본부 국립보건원 생명의과학센터뇌질환팀

-2001-2005 기초의학전임조교, 한림대학교 의과대학

연구 및 저서

주저자 : 제1저자, 공동저자(교신), 단독 

CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus, [International journal of molecular sciences, SCI급 ,공동(교신) ,2019]
Trichostatin A and Sirtinol Regulate the Expression and Nucleocytoplasmic Shuttling of Histone Deacetylases in All-Trans Retinoic Acid-Induced Differentiation of Neuroblastoma Cells., [J Mol Neurosci, SCI급 ,교신 ,2018]
Piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels via activation of alpha-secretase and matrix metalloproteinase-9, [Journal of Functional Foods, SCI급 ,교신 ,2016]
Inhibition of Mitochondrial Clearance and Cu/Zn-SOD Activity Enhance 6-Hydroxydopamine-Induced Neuronal Apoptosis., [Molecular Neurobiology, SCI급 ,교신 ,2016]

 

piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels vea activation of alpha-secretase and matrix metalloproteinase=9 [Journal of Functional Foods, SCI급, 공동(교신), 2016]

Inhibition of mitochondrial clearance and Cu/Zn-SOD activity enhance 6-hydroxydopamine-induced neuronal apoptosis [Molecular Neurobiology, SCI급 공동(교신), 2016]

Beta-amyloid oligomers induce early loss of presynaptic proteins in primary neurons by caspase-dependent and proteasome-dependent mechanisms[Neuroreport, SCI급, 공동(교신), 2014]

Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secreta expression and activity [Neurotoxicology, 공동(교신), 2013] 

 

공동저자 : 공동저자(참여) 

PLPP/CIN-mediated Mdm2 dephosphorylation increases seizure susceptibility via abrogating PSD95 ubiquitination, [EXPERIMENTAL NEUROLOGY, SCI급 ,공동(참여) ,2020]
PLPP/CIN-mediated NEDD4-2 S448 dephosphorylation regulates neuronal excitability via GluA1 ubiquitination., [Cell Death & Disease, SCI급 ,공동(참여) ,2019]
PLPP/CIN Regulates Seizure Activity by the Differential Modulation of Calsenilin Binding to GluN1 and Kv4.2 in Mice., [Frontiers in Molecular Neuroscience, SCI급 ,공동(참여) ,2017]
Leptomycin B ameliorates vasogenic edema formation induced by status epilepticus via inhibiting p38 MAPK/VEGF pathway., [Brain Research, SCI급 ,공동(참여) ,2016]
PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins, [Scientific reports, SCI급 ,공동(참여) ,2016]
Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of neutrophils toward an antitumor phenotype., [Oncoimmunology, SCI급 ,공동(참여) ,2016]Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of nuetrophils toward an antitumor phenotype [Onciommunology, SCI급, 공동(참여), 2016]

LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission[CELL DEATH AND DIFFERENTIATION, SCI급, 공동(참여), 2014]

Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus[Neuroscience Research, SCI급, 공동(참여), 2014]

Impairment fo autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation [Plos One, 공동(참여), 2013]

S1 pocket of glutamate carboxypeptidase II: a new binding site for amyloid-β degradation [Biochemical and Biophysical Research Communications, 공동(참여), 2013]

The effect of P2X7 receptor activation on nuclear factor-kappa B phosphorylation induced by status epilepticus in the rat hippocampus [Hippocampus, 공동(참여), 2013]

Endothelial transient receptor potential conical channel (TRPC)-3 activation induces vasogenic edema formation in the rat piriform cortex following status epilepticus [Cellular and molecular Neurobiology, 공동(참여), 2013] 

기타

주요연구주제

알츠하이머 치매의 신약 후보 물질 발굴

알츠하이머 치매의 바이오마커 발굴

퇴행성신경질환 유래 세포사멸 기전 분석

 

학회활동

대한 해부학회

대한 뇌신경과학회

미국 신경과학회

김지은
  • 분야

    해부신경생물학

  • 성명

    국문 김지은

  • 직위

    조교수(연구전임)

  • 연구실

    의학관 3층 3318

  • 연락처

    033-248-2522

  • 이메일

학력

-2007-2010 박사, 한림대학교 의과대학 해부 및 신경생물학 전공

-2005-2007 석사, 한림대학교 의과대학 해부조직학 전공

-2001-2005 학사, 한림대학교 유전공학과 

주요경력

-2016-현재 조교수 (연구전임), 한림대학교 의과대학 해부신경생물학교실

-2012-2016 기금연구조교수, 한림대학교 의과대학 해부신경생물학교실

-2010-2012 연구원, 캘리포니아대학교, VA병원(신경학과)

연구 및 저서

주저자 : 제1저자, 공동저자(교신), 단독

Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity.[Mol Brain, SCI급, 공동(교신), 2015]

P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus. [Front Cell Neurosci, SCI급, 공동(교신), 2015]

Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats. [Neuroscience, SCI급, 공동(교신), 2015]

Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus. [Brain Res, SCI급, 공동(교신), 2015]

LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission. [Cell Death Differ, SCI급, 공동(제1), 2014]

PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner. [Cell Death Dis, SCI급, 공동(제1), 2014]

 

공동저자 : 공동저자(참여)

Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress. [J Neurosci, SCI급, 공동(참여), 2015]

Cellular and regional specific changes in multidrug efflux transporter expression during recovery of vasogenic edema in the rat hippocampus and piriform cortex. [BMB Rep, SCI급, 공동(참여), 2015]

Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus. [Neurosci Res, SCI급, 공동(참여), 2014]

기타

주요연구주제

ER stress, Mitochondrial mitopathy, Neurological disease

 

학회활동

대한 해부학회

미국 신경과학회

오권익
  • 분야

    병리학

  • 성명

    국문 오권익

  • 직위

    교수

  • 연구실

    의학관 3층 3307

  • 연락처

    033-248-2564

  • 이메일

학력

-2001-2003 서울대학교 의과대학 병리학교실 병리학 박사

-1999-2001 서울대학교 의과대학 병리학교실 병리학 석사

-1989-1996 서울대학교 의과대학 졸업 

주요경력

2020.7~현재 대학원의학과장/연구부학장

 

2018.9~2020.6 교무부학장/의학과장

 

2012.9~2014.8 의과대학 연구부학장

 

2004-현재 한림대학교 병리학교실 조교수, 부교수

 

2002-2004 서울대학교 의과대학 병리학교실 조교 

연구 및 저서

주저자 : 제1저자, 공동저자(교신), 단독

Lysophosphatidylcholine aggravates contact hypersensitivity by promoting neutrophil infiltration and IL17 expression, [BMB Reports, SCI급 ,교신 ,2020]
IL2 is required for the functional maturation of regulatory T cells, [Animal Cells and Systems, SCI급 ,교신 ,2017]

Vitamin C enhances the expression of IL17 in a Jmjd2-dependent manner, [BMB Rep., SCI급 ,교신 ,2017]

DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases., [Molecules and Cells, SCI급 ,교신 ,2016]

Vitamin C facilitates demethylation of the Foxp3 enhancer in a Tet-dependent manner, [The Journal of Immunology, SCI급 ,교신 ,2016]

Down-regulation of Tet2 prevents TSDR demethylation in IL2 deficient regulatory T cells[Biochemical and Biophysical Research Communications, SCI급, 공동(교신), 2014]

 

공동저자: 공동저자(참여) 

The mTORC1/4E-BP/eIF4E Axis Promotes Antibody Class$$Switching in B Lymphocytes, [The Journal of Immunology, SCI급 ,공동(참여) ,2019]

기타

주요연구주제

T 세포 분화

자가면역질환

면역조절

 

학회활동

대한 면역학회

미국 면역학회

권혁일
  • 분야

    생리학

  • 성명

    국문 권혁일

  • 직위

    교수

  • 연구실

    의학관 4층 3409

  • 연락처

    033-248-2584

  • 이메일

학력

-1988-1992 단국대학교 이학박사

-1982-1985 연세대학교 이학석사

-1978-1982 연세대학교 이학사

 

주요경력

-2008-2009 미국 밴더빌트대학교 의대 방문교수

-2004-2008 한림대학교 의과대학 기초의학학장보

-1994-1996 미국 로체스터대학교 의대 방문교수

-1989-현재 한림대학교 의과대학 교수 

연구 및 저서

주저자 : 제1저자, 공동저자(교신), 단독

PEP-1-paraoxonase 1 fusion protein prevents cytokine-induced cell destruction and impaired insulin secretion in rat insulinoma cells, [BMB REPORTS, SCI급 ,공동(교신) ,2018]

Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress, [Cell Biol Int, SCI급 ,교신 ,2017]

Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death [Biochem. Biophys. Res. Comm, SCI급, 공동(교신), 2015]

The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells[Korean J Physiol. Pharmacol., SCI급, 공동(교신), 2014]

 

공동저자 : 공동저자(참여)

MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages, [BMB Reports, SCI급 ,공동(참여) ,2020]
Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model, [BMB REPORTS, SCI급 ,공동(참여) ,2018]
Alteration of Lysophosphatidylcholine-Related Metabolic Parameters in the Plasma of Mice with Experimental Sepsis, [Inflammation, SCI급 ,공동(참여) ,2017]
Tat-ATOX1 inhibits streptozotocin-induced cell death in pancreatic RINm5F cells and attenuates diabetes in a mouse model., [Int. J. Mol. Med., SCI급 ,공동(참여) ,2016]
Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults., [Free Radical Biology and Medicine, SCI급 ,공동(참여) ,2016]
2,3-Dimethoxy-2'-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells., [BMB Reports, SCI급 ,공동(참여) ,2016]

Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease. [BMB Reports, SCI급, 공동(참여), 2015]

The effects of PEP-1-FK506BP on dry eye disease in a rat model. [BMB Reports, SCI급, 공동(참여), 2015]

Down-regulation of MAPK/NF-κB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model.[International Immunopharmacology, SCI급, 공동(참여), 2014] 

 

기타

주요연구주제

인슐린분비세포의 세포사를 억제하는 PEP-1-HO-1 융합단백질의 영향 및 기전연구

세포침투성 PEP-1-PON1의 항당뇨병 효능 및 기전연구

근세포의 포도당흡수에 대한 자색옥수수추출액의 영향 및 기전연구

 

학회활동

대한 생리학회

한국 생화학 분자생물학회

미국 췌장학회

한국 노화학회

안은희
  • 분야

    생리학

  • 성명

    국문 안은희

  • 직위

    조교수

  • 연구실

    의학관 4층 3410호

  • 연락처

    033-248-2583

  • 이메일

학력

- 한림대학교 박사 2014

- 한림대학교 석사 2012

- 한림대학교 학사 2010

주요경력

2015-2016 미국 하버드 의과대학, 신경과 Fellow

2016-2020 미국 에모리 의과대학, 신경병리학과 Fellow

2021-2021 미국 에모리 의과대학, 신경병리학과 임상강의교수

2021년 3월~ 한림대학교 의과대학 생리학 교실, 전임교수(조교수)

연구 및 저서

■ 논문

1. Mitochondrial dysfunction triggers the pathogenesis of Parkinson’s disease in neuronal C/EBPβ transgenic mice, Molecular Psychiatry, 2021 Dec;26(12):7838-7850, IF:15.992; Ahn EH, Lei K, Kang SS, Wang ZH, Liu X, Hong W, Wang YT, Edgington-Mitchell LE, Jin L, Ye K. (주저자)

 

2. Gut inflammation triggers C/EBPβ/δ-secretase-dependent gut-to-brain propagation of Aβ and Tau fibrils in Alzheimer's disease, The EMBO Journal, 2021 Sep 1;40(17):e106320, IF: 11.6; hen C, Zhou Y, Wang H, Alam A, Kang SS, Ahn EH, Liu X, Jia J, Ye K. 

 

3. C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis, Molecular Cancer Therapeutics,  2021 Sep;20(9):1640-1652, IF: 6.261; Lei K, Kang SS, Ahn EH, Chen C, Liao J, Liu X, Li H, Edgington-Mitchell LE, Jin L, Ye K.

 

4. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies, Science Advances, 2021 Apr 16;7(16):eabe4499, IF: 14.39; Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z, Ye K.

 

5. Netrin-1 amd its receptor DCC modulate survival and death of dopamine neurons and Parkinson’s disease features, The EMBO Journal, 2021, 2021 Feb 1;40(3):e105537, IF: 11.6; Jasmin M, Ahn EH, Voutilainen MH, Fombonne J, Guix C, Viljakainen T, Kang SS, Yu LY, Saarma M, Mehlen P, Ye K. (주저자)

 

6. BDNF and Netrin-1 repression by C/EBPβ in the gut triggers Parkinson's disease pathologies, associated with constipation and motor dysfunctions, Progress in Neurobiology, 2021 Mar;198:101905, IF: 11.685; Ahn EH, Kang SS, Liu X, Cao X, Choi SY, Musazzi L, Mehlen P, Ye K. (주저자)

 

7. ApoE4 inhibition of VMAT2 in the locus coeruleus exacerbates Tau pathology in Alzheimer's disease, Acta Neuropathologica, 2021 Jul;142(1):139-158, IF: 18.174; Kang SS, Ahn EH, Liu X, Bryson M, Miller GW, Weinshenker D, Ye K. 

 

8. Targeting both BDNF/TrkB pathway and delta-secretase for treating Alzheimer's disease, Neuropharmacology, 2021 Oct 1;197:108737, IF: 5.25; Liao J, Chen C, Ahn EH, Liu X, Li H, Edgington-Mitchell LE, Lu Z, Ming S, Ye K.

 

9. Delta-secretase cleavage of Tau mediates its pathology and propagation in Alzheimer's disease, Experimental & molecular medicine, 2020 Aug;52(8):1275-1287, IF: 7.69 Kang SS, Ahn EH,Ye K. 
      

10. Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model, Science Advances, IF: 14.136; 2020 Jul 29;6(31):eaba0466, Chen C, Ahn EH, Kang SS, Liu X, Alam A, Ye K.  

 

11. Initiation of Parkinson's disease from gut to brain by δ-secretase, Cell Research, 2020 Jan;30(1):70-87, IF: 25.617; Ahn EH, Kang SS, Liu X, Chen G, Zhang Z, Chandrasekharan B, Alam AM, Neish AS, Cao X, Ye K. (주저자)

 

12. Norepinephrine metabolite DOPEGAL activates AEP and pathological Tau aggregation in locus coeruleus, The Journal of clinical investigation, 2020 Jan 2;130(1):422-437, IF: 14.808; Kang SS, Liu X, Ahn EH, Xiang J, Manfredsson FP, Yang X, Luo HR, Liles LC, Weinshenker D, Ye K.

 

13. Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease, PNAS, 2020 Sep 29;117(39):24503-24513, IF: 11.205; Ahn EH, Kang SS, Qi Q, Liu X, Ye K. (주저자)

 

14. Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma, Journal of hematology & oncology, 2020 Oct 21;13(1):141, IF: 14.57; Lei K, Gu X, Alvarado AG, Du Y, Luo S, Ahn EH, Kang SS, Ji B, Liu X, Mao H, Fu H, Kornblum HI, Jin L, Li H, Ye K. 

 

15. C/EBPβ mediates NQO1 and GSTP1 anti-oxidative reductases expression in glioblastoma, promoting brain tumor proliferation, Redox Biology, 2020 Jul;34:101578, IF: 11.799; Lei K, Xia Y, Wang XC, Ahn EH, Jin L, Ye K.

 

16. Delta-secretase-cleaved Tau antagonizes TrkB neurotrophic signalings, mediating Alzheimer's disease pathologies, PNAS, 2019 Apr 30;116(18):9094-9102, IF: 9.58; Xiang J, Wang ZH, Ahn EH, Liu X, Yu SP, Manfredsson FP, Sandoval IM, Ju G, Wu S, Ye K.

 

17. α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's disease, The EMBO Journal, 2018 Jun 15;37(12):e98878, IF: 11.227; Kang SS, Ahn EH, Zhang Z, Liu X, Manfredsson FP, Sandoval IM, Dhakal S, Iuvone PM, Cao X, Ye K. 

 

18. Asparagine endopeptidase cleaves α-synuclein and mediates pathologic activities in Parkinson's disease, Nature Structural & molecular biology, 2017 Aug;24(8):632-642, IF: 13.333; Zhang Z, Kang SS, Liu X, Ahn EH, Zhang Z, He L, Iuvone PM, Duong DM, Seyfried NT, Benskey MJ, Manfredsson FP, Jin L, Sun YE, Wang JZ, Ye K.  

 

19. Tat-ATOX1 inhibits streptozotocin-induced cell death in pancreatic RINm5F cells and attenuates diabetes in a mouse model, International journal of molecular medicine, 2016 Jul;38(1):217-24, Ahn EH, Kim DW, Shin MJ, Ryu EJ, Yong JI, Chung SY, Cha HJ, Kim SJ, Choi YJ, Kim DS, Cho SW, Lee K, Cho YS, Kwon HY, Park J, Eum WS, Choi SY. (주저자)

 

20. Protective effects of Tat-NQO1 against oxidative stress-induced HT-22 cell damage, and ischemic injury in animals, BMB Report,2016 Nov;49(11):617-622, Jo HS, Kim DS, Ahn EH, Kim DW, Shin MJ, Cho SB, Park JH, Lee CH, Yeo EJ, Choi YJ, Yeo HJ, Chung CS, Cho SW, Han KH, Park J, Eum WS, Choi SY.

 

21. Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease, BMB Report, 2015 Jul;48(7):395-400, Eom SA, Kim DW, Shin MJ, Ahn EH, Chung SY, Sohn EJ, Jo HS, Jeon SJ, Kim DS, Kwon HY, Cho SW, Han KH, Park J, Eum WS, Choi SY. 

 

22. Tat-antioxidant 1 protects against stress-induced hippocampal HT-22 cells death and attenuate ischaemic insult in animal model, Journal of cellular and molecular medicine, 2015 Jun;19(6):1333-45, Kim SM, Hwang IK, Yoo DY, Eum WS, Kim DW, Shin MJ, Ahn EH, Jo HS, Ryu EJ, Yong JI, Cho SW, Kwon OS, Lee KW, Cho YS, Han KH, Park J, Choi SY. 

 

23. Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-κB and MAPK activation in macrophages and TPA-induced ear edema in mice, Toxicol and applied pharmacology, 2015 Jul 15;286(2):124-34, Kim YN, Kim DW, Jo HS, Shin MJ, Ahn EH, Ryu EJ, Yong JI, Cha HJ, Kim SJ, Yeo HJ, Youn JK, Hwang JH, Jeong JH, Kim DS, Cho SW, Park J, Eum WS, Choi SY.

 

24. Tat-fused recombinant human SAG prevents dopaminergic neurodegeneration in a MPTP-induced Parkinson's disease model, Molecules and cells, 2014 Mar;37(3):226-33, Sohn EJ, Shin MJ, Kim DW, Ahn EH, Jo HS, Kim DS, Cho SW, Han KH, Park J, Eum WS, Hwang HS, Choi SY. 

 

25. Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury, Free radical biology & medicine, IF: 6.17; 2014 Feb;67:195-210, Shin MJ, Kim DW, Lee YP, Ahn EH, Jo HS, Kim DS, Kwon OS, Kang TC, Cho YJ, Park J, Eum WS, Choi SY. 

 

26. PEP-1-PEA-15 protects against toxin-induced neuronal damage in a mouse model of Parkinson's disease, Free radical biology & medicine, IF: 6.17; 2014 Jun;1840(6):1686-700, Ahn EH, Kim DW, Shin MJ, Kim HR, Kim SM, Woo SJ, Eom SA, Jo HS, Kim DS, Cho SW, Park J, Eum WS, Choi SY. (주저자)

 

27. Neuroprotective effects of PEP-1-carbonyl reductase 1 against oxidative-stress-induced ischemic neuronal cell damage, Free radical biology & medicine, IF: 6.17; 2014 Apr;69:181-96, Kim YN, Jung HY, Eum WS, Kim DW, Shin MJ, Ahn EH, Kim SJ, Lee CH, Yong JI, Ryu EJ, Park J, Choi JH, Hwang IK, Choi SY.  

 

28. Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress by increasing its transduction efficiency, BMB Report, 2013 Nov;46(11):561-6, Ahn EH, Kim DW, Shin MJ, Jo HS, Eom SA, Kim DS, Park EY, Park JH, Cho SW, Park J, Eum WS, Son O, Hwang HS, Choi SY. (주저자)

 

29. PEP-1-ribosomal protein S3 protects dopaminergic neurons in an MPTP-induced Parkinson's disease mouse model, Free radical biology & medicine, IF: 6.17; 2013 Feb;55:36-45, Ahn EH, Kim DW, Shin MJ, Kim YN, Kim HR, Woo SJ, Kim SM, Kim DS, Kim J, Park J, Eum WS, Hwang HS, Choi SY. (주저자)

 

30. Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson's disease, Biochimie, 2012 Nov;94(11):2448-56, Kim MJ, Kim DW, Jeong HJ, Sohn EJ, Shin MJ, Ahn EH, Kwon SW, Kim YN, Kim DS, Park J, Eum WS, Hwang HS, Choi SY. 

 

31. PEP-1-metallothionein-III protein ameliorates the oxidative stress-induced neuronal cell death and brain ischemic insults, Biochimica et biophysica acta, 2012 Oct;1820(10):1647-55, Sohn EJ, Kim DW, Kim MJ, Jeong HJ, Shin MJ, Ahn EH, Kwon SW, Kim YN, Kim DS, Han KH, Park J, Hwang HS, Eum WS, Choi SY.

 

32. PEP-1-heat shock protein 27 protects from neuronal damage in cells and in a Parkinson's disease mouse model, The FEBS journal, 2012 Jun;279(11):1929-42, Lee YP, Kim DW, Kang HW, Hwang JH, Jeong HJ, Sohn EJ, Kim MJ, Ahn EH, Shin MJ, Kim DS, Kang TC, Kwon OS, Cho SW, Park J, Eum WS, Choi SY.

 

33. Anti-inflammatory effect of transduced PEP-1-cyclophilin A in Raw264.7 cells and 12-O-tetradecanoylphorbol-13-acetate-induced mice, Life sciences, 2011 Dec 5;89(23-24):896-904, Lee MJ, Kim DW, Sohn EJ, Jeong HJ, Shin MJ, Kang HW, Ahn EH, Kwon SW, Kim YN, Won MH, Kim J, Cho SW, Kang TC, Han KH, Park J, Eum WS, Choi SY. 

 

34. Transduced PEP-1-FK506BP inhibits the inflammatory response in the Raw 264.7 cell and mouse models, Immunobiology, 2011 Jul;216(7):771-81, Kim SY, Jeong HJ, Kim DW, Kim MJ, An JJ, Sohn EJ, Kang HW, Shin MJ, Ahn EH, Kwon SW, Kim DS, Cho SW, Park J, Eum WS, Choi SY. 

 

35. Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model, Biochemical and biophysical research communications, 2011 Jul 29;411(2):354-9, Kwon SW, Sohn EJ, Kim DW, Jeong HJ, Kim MJ, Ahn EH, Kim YN, Dutta S, Kim DS, Park J, Eum WS, Hwang HS, Choi SY.

 

36. Chlorogenic Acid Improves Neuroprotective Effect of PEP-1-Ribosomal Protein S3 Against Ischemic Insult. Experimental neurobiology, 2011 Dec;20(4):169-75, Ahn EH, Kim DW, Shin MJ, Kwon SW, Kim YN, Kim DS, Lim SS, Kim J, Park J, Eum WS, Hwang HS, Choi SY.  (주저자)

 

37. Transduced PEP-1-FK506BP ameliorates atopic dermatitis in NC/Nga mice, The Journal of investigative dermatology, 2011 Jul;131(7):1477-85, IF: 6.314; Kim SY, Sohn EJ, Kim DW, Jeong HJ, Kim MJ, Kang HW, Shin MJ, Ahn EH, Kwon SW, Kim YN, Kwon HJ, Kim TY, Lee KS, Park J, Eum WS, Choi SY.

 

38. Levosulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-2-methoxybenzamide, enhances the transduction efficiency of PEP-1-ribosomal protein S3 in vitro and in vivo, BMB report, 2011 May;44(5):329-34, Ahn EH, Kim DW, Kim DS, Woo SJ, Kim HR, Kim J, Lim SS, Kang TC, Kim DJ, Suk KT, Park J, Luo Q, Eum WS, Hwang HS, Choi SY. (주저자)

 

39. Imipramine enhances neuroprotective effect of PEP-1-Catalase against ischemic neuronal damage, BMB Report, 2011 Oct;44(10):647-52, Kim DW, Kim DS, Kim MJ, Kwon SW, Ahn EH, Jeong HJ, Sohn EJ, Dutta S, Lim SS, Cho SW, Lee KS, Park J, Eum WS, Hwang HS, Choi SY.

 

40. Protective effects of transduced PEP-1-Frataxin protein on oxidative stress-induced neuronal cell death, Journal of the neurological sciences, 2010 Nov 15;298(1-2):64-9, Kim MJ, Kim DW, Yoo KY, Sohn EJ, Jeong HJ, Kang HW, Shin MJ, Ahn EH, An JJ, Kwon SW, Kim YN, Won MH, Cho SW, Park J, Eum WS, Choi SY.  

 

41. Transduced PEP-1-ribosomal protein S3 (rpS3) ameliorates 12-O-tetradecanoylphorbol-13-acetate-induced inflammation in mice, Toxicology, 2010 Oct 29;276(3):192-7, Ahn EH, Kim DW, Shin MJ, Kim HR, Kim SM, Woo SJ, Eom SA, Jo HS, Kim DS, Cho SW, Park J, Eum WS, Choi SY. (주저자)

 

42. Transduced human PEP-1-catalase fusion protein attenuates ischemic neuronal damage, Free radical biology & medicine, 2009 Oct 1;47(7):941-52, IF: 6.17; Kim DW, Jeong HJ, Kang HW, Shin MJ, Sohn EJ, Kim MJ, Ahn EH, An JJ, Jang SH, Yoo KY, Won MH, Kang TC, Hwang IK, Kwon OS, Cho SW, Park J, Eum WS, Choi SY. 

 

43. Transduced HSP27 protein protects neuronal cell death by enhancing FALS-associated SOD1 mutant activity, BMB Report,2009 Mar 31;42(3):136-41, An JJ, Lee YP, Kim DW, Sohn EJ, Jeong HJ, Kang HW, Shin MJ, Kim MJ, Ahn EH, Jang SH, Kang JH, Kang TC, Won MH, Kwon OS, Cho SW, Lee KS, Park J, Eum WS, Choi SY.

 

 

■ 특허권

1. Pharmaceutical composition for Skin cancer containing GADD45a fusion protein, KR20160011257A, South Korea, 2014, Inventor: Choi S.Y., Park J., Han K.H., Kang T.C., Kwon H.J., Eum W.S., Shin M.J., Ahn E.H.,Sohn O.R., Park M.Y., Jang S.H., Kim D.W. 

 

2. Pharmaceutical composition for Parkinson's Disease containing PON1 fusion protein, KR20150114107A, South Korea, 2014, Inventor: Choi S.Y., Park J., Hwang H.S., Eum W.S., Shin M.J., Ahn E.H., Jo S.W., Kim D.S., Kwon H.I., Kim D.W.

 

3. Pharmaceutical composition for arthritis containing FK506 binding protein fusion protein, KR20140108411A, South Korea, 2013, Inventor: Choi S.Y., Kim H.Y., Kim S.J., Park J, Eum W.S., Kim D.W., Ahn E.H.

 

4. Pharmaceutical composition for parkinson's disease containing rpS3 fusion protein, KR101347734B1, South Korea, 2012, Inventor: Choi S.Y., Kim D.W., Eum W.S., Hwang H.S., Park J, Han K.H., Kim J., Ahn E.H.

 

5. Pharmaceutical composition for parkinson's disease containing PEA-15 fusion protein, KR20130134530A, South Korea, 2012, Inventor: Choi S.Y., Kim D.W., Ahn E.H., Eum W.S., Hwang H.S., Park J., Jo Y.S., Kim D.S.

 

6. A pharmaceutical composition containing cell-transducing rps3 fusion protein for preventing and treating neurological disorders, KR20120035566A, South Korea, 2010, Inventor: Kim D.W., Kim D.S., Park J., Ahn E.H., Eum W.S., Choi S.Y.

기타

■주요 연구 주제: Parkinson’s disease, Alzhemier, Brain Tumor와 같은 뇌질환에 대한 분자생물학적 기전 연구 및 신경퇴행성 질환 진단 가능한 진단 키트 계발

 

■학회 활동

1. 한국뇌신경과학회, 정회원 2022~

2. 한국분자세포생물학회, 정회원 2022~

3. 한국당과학회, 국제협력위원, 2022~

4. 대한치매학회, 정회원 2021~

5. K-BioX, Emory University, 2020-2022

 

■수상 및 연구비 수주

1. Nrf (한국연구재단), 우수신진연구, 생명기반, 2022-2027 (7억 5천만원)

2. Nrf (한국연구재단), 기본연구, 의약학단, 2021-2020 (5천5백만원)

3. 건강보험공단 의대생지원 프로젝트, 2021.07월-2021.12월 (1천2백만원)

4. Sponsored AAAS/Science Memberships Award, Emory University School of Medicine (U.S.) 2020-2022

5. CHDI Foundation Support, Harvard Medical School(U.S.), 2015-2016 ($ 42,000.60)

6. 한림대학교, 최고논문상 수상, 2010

7. 한국과학영재프로그램, 의약품개발분야 수상자, 2009-2010 (연구비상금내역:3천만원): 단백질 침투기술을 이용한 콜라겐 마스크팩

서상원
  • 분야

    생리학

  • 성명

    국문 서상원

  • 직위

    교수

  • 연구실

    의학관 6층 3610

  • 연락처

    033-248-2508

  • 이메일

학력

-1998-2001 박사 (PhD.) 텍사스 주립대학

-1989-1991 석사 (M.S.) 한림대학교

-1982-1988 의학사 (M.D.) 한림대학교

주요경력

2018.7~현재 의과대학장

 

2014.9~2018.6 의과대학 대외교류부학장, 한림중개의과학연구원장

 

2009-현재 교수, 한림대학교 의과대학 생리학교실

 

2005-2009 조교수, 캘리포니아 주립대학 신경과 (U. of California, San Francisco, USA)

 

2001-2005 박사후 연구원 (Postdoc, 신경과, U. of California, San Francisco, USA)

 

1998-2001 텍사스주립대학 교육 및 연구 조교 (UTMB, Galveston, Texas, USA)

 

1997-1998 덴마크 올후스 대학 연구원 (Aarhus University, Denmark)

 

1996-1997 텍사스주립대학 연구원 (U. of Texas, Dallas, USA)

 

1994-1996 워싱턴 대학 의과대학 신경과 연구원 (Washington University, St. Louis, MO, USA)

 

1991-1994 대한민국 해군 군의관, 대위 (해양의학 적성 훈련원)

 

1988-1991 한림대학교 의과대학 생리학 교실 교육 및 연구 조교 

연구 및 저서

주저자 : 제1저자, 공동저자(교신), 단독

Zinc in the brain: Friend or foe?, [International Journal of Molecular Sciences, SCI급 ,교신 ,2020]
Effects of transient receptor potential cation 5 (Trpc5) inhibitor, nu6027, on hippocampal neuronal death after traumatic brain injury, [International Journal of Molecular Sciences, SCI급 ,교신 ,2020]
Zinc transporter 3 modulates cell proliferation and neuronal differentiation in the adult hippocampus, [STEM CELLS, SCI급 ,교신 ,2020]
An inhibitor of the sodium?hydrogen exchanger-1 (Nhe-1), amiloride, reduced zinc accumulation and hippocampal neuronal death after ischemia, [International Journal of Molecular Sciences, SCI급 ,교신 ,2020]
A Novel Zinc Chelator, 1H10, Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Zinc Toxicity and AMPK Activation, [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, SCI급 ,교신 ,2020]
The transient receptor potential melastatin 7 (TRPM7) inhibitors suppress seizure-induced neuron death by inhibiting zinc neurotoxicity, [International Journal of Molecular Sciences, SCI급 ,공동(교신) ,2020]
Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure, [FRONTIERS IN NEUROSCIENCE, SCI급 ,공동(교신) ,2020]
Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant, N-Acetyl-l-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death, [International journal of molecular sciences, SCI급 ,공동(교신) ,2020]
Role of Excitatory Amino Acid Carrier 1 (EAAC1) in Neuronal Death and Neurogenesis After Ischemic Stroke., [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE, SCI급 ,공동(교신) ,2020]
The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury, [CELLS, SCI급 ,교신 ,2019]
Alcohol dependence treating agent, acamprosate, prevents traumatic brain injury-induced neuron death through vesicular zinc depletion, [Translational Research, SCOPUS ,교신 ,2019]
Carvacrol Attenuates Hippocampal Neuronal Death after Global Cerebral Ischemia via Inhibition of Transient Receptor Potential Melastatin 7, [CELLS, SCI급 ,교신 ,2018]
Antimicrotubule Agent-Induced Zinc Neurotoxicity, [BIOLOGICAL PHARMACEUTICAL BULLETIN, SCI급 ,교신 ,2018]
Effects of protocatechuic acid (PCA) on global cerebral ischemia-induced hippocampal neuronal death, [International Journal of Molecular Sciences, SCOPUS ,교신 ,2018]
Unexpected Effects of Acetylcholine Precursors on Pilocarpine Seizure-Induced Neuronal Death, [CURRENT NEUROPHARMACOLOGY, SCI급 ,교신 ,2018]
Acetylcholine precursor, citicoline (cytidine 5-diphosphocholine), reduces hypoglycaemia-induced neuronal death in rats, [JOURNAL OF NEUROENDOCRINOLOGY, SCI급 ,교신 ,2018]
Combined Treatment With Dichloroacetic Acid and Pyruvate Reduces Hippocampal Neuronal Death After Transient Cerebral Ischemia, [FRONTIERS IN NEUROLOGY, SCI급 ,교신 ,2018]
EAAC1 gene deletion reduces adult hippocampal neurogenesis after transient cerebral ischemia, [SCIENTIFIC REPORTS, SCI급 ,교신 ,2018]
Zinc Promotes Adipose-Derived Mesenchymal Stem Cell Proliferation and Differentiation towards a Neuronal Fate, [STEM CELLS INTERNATIONAL, SCI급 ,교신 ,2018]
Inhibition of NADPH Oxidase Activation by Apocynin Rescues Seizure-Induced Reduction of Adult Hippocampal Neurogenesis, [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, SCI급 ,공동(교신) ,2018]
Protective effects of protocatechuic acid on seizure-induced neuronal death, [International Journal of Molecular Sciences, SCOPUS ,공동(교신) ,2018]
Human Placenta-Derived Mesenchymal Stem Cells Reduce Mortality and Hematoma Size in a Rat Intracerebral Hemorrhage Model in an Acute Phase, [STEM CELLS INTERNATIONAL, SCI급 ,공동(교신) ,2018]
Administration of placenta-derived mesenchymal stem cells counteracts a delayed anergic state following a transient induction of endogenous neurogenesis activity after global cerebral ischemia, [BRAIN RESEARCH, SCI급 ,공동(교신) ,2018]
Administration of protocatechuic acid reduces traumatic brain injury-induced neuronal death, [International Journal of Molecular Sciences, SCI급 ,교신 ,2017]
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure, [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, SCI급 ,교신 ,2017]
ZnT3 gene deletion reduces colchicine-induced dentate granule cell degeneration, [International Journal of Molecular Sciences, SCI급 ,교신 ,2017]
The emerging role of zinc in the pathogenesis of multiple sclerosis, [International Journal of Molecular Sciences, SCI급 ,교신 ,2017]
The cancer chemotherapeutic agent paclitaxel (Taxol) reduces hippocampal neurogenesis via down-regulation of vesicular zinc, [SCIENTIFIC REPORTS, SCI급 ,교신 ,2017]
Effect of adipose-derived mesenchymal stem cell administration and mild hypothermia induction on delayed neuronal death after transient global cerebral Ischemia, [Critical Care Medicine, SCI급 ,교신 ,2017]
Prevention of hypoglycemia-induced hippocampal neuronal death by N-acetyl-l-cysteine (NAC), [Amino Acids, SCI급 ,교신 ,2017]
Administration of zinc plus cyclo-(His-pro) increases hippocampal neurogenesis in rats during the early phase of streptozotocin-induced diabetes, [International Journal of Molecular Sciences, SCI급 ,교신 ,2017]
Late treatment with choline alfoscerate (L-alpha glycerylphosphorylcholine, alpha-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment, [BRAIN RESEARCH, SCI급 ,공동(교신) ,2017]
ZINC PLUS CYCLO-(HIS-PRO) PROMOTES HIPPOCAMPAL NEUROGENESIS IN RATS, [NEUROSCIENCE, SCI급 ,교신 ,2016]
Zinc transporter 3 (ZnT3) gene deletion reduces spinal cord white matter damage and motor deficits in a murine MOG-induced multiple sclerosis model, [Neurobiology of Disease, SCOPUS ,교신 ,2016]
Decreased cysteine uptake by EAAC1 gene deletion exacerbates neuronal oxidative stress and neuronal death after traumatic brain injury, [AMINO ACIDS, SCI급 ,교신 ,2016]
2'-5' oligoadenylate synthetase-like 1 (OASL1) deficiency suppresses central nervous system damage in a murine MOG-induced multiple sclerosis model, [Neuroscience Letters, SCI급 ,공동(교신) ,2016]

Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats [Neuroendocrinology, SCI급, 공동(교신), 2015]

A water-ethanol extract from the mushroom Phellinus igniarius (Piwep) reduces transient cerebral ischemia-induced neuronal death [International Journal of Medicinal Mushrooms, SCI급, 공동(교신), 2015]

Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice [Journal of Neuroinflammation, SCI급, 공동(교신), 2015]

Adipose-Derived Mesenchymal Stem Cells Reduce Neuronal Death After Transient Global Cerebral Ischemia Through Prevention of Blood-Brain Barrier Disruption and Endothelial Damage[Stem Cells Translational Medicine, SCI급, 공동(교신), 2015]

Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death [Brain Research, SCI급, 공동(교신), 2015]

"A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord[BioMed Research International, SCI급, 공동(교신), 2014]"

Colchicine induced intraneuronal free zinc accumulation and dentate granule cell degeneration[Metallomics, SCI급, 공동(교신), 2014]

Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus[J Trace Elem Med Biol, SCI급, 공동(교신), 2014]

EAAC1 Gene Deletion Increases Neuronal Death and Blood Brain Barrier Disruption after Transient Cerebral Ischemia in Female Mice[IJMS, SCI급, 공동(교신), 2014] 

 

공동저자: 공동저자(참여) 

Phenotypic Discovery of Neuroprotective Agents by Regulation of Tau Proteostasis via Stress-Responsive Activation of PERK Signaling, [Angewandte Chemie - International Edition, SCI급 ,공동(참여) ,2020]
Early-life stress induces EAAC1 expression reduction and attention-deficit and depressive behaviors in adolescent rats, [CELL DEATH DISCOVERY, SCI급 ,공동(참여) ,2020]
Distinct dual roles of p-Tyr42 RhoA GTPase in tau phosphorylation and ATP citrate lyase activation upon different A beta concentrations, [REDOX BIOLOGY, SCI급 ,공동(참여) ,2020]
Changes in plasma lipoxin A4, resolvins and CD59 levels after ischemic and traumatic brain injuries in rats, [KOREAN JOURNAL OF PHYSIOLOGY PHARMACOLOGY, SCI급 ,공동(참여) ,2020]
Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model, [Alzheimer's Research and Therapy, SCOPUS ,공동(참여) ,2019]
Transitions in Problematic Internet Use: A One-Year Longitudinal Study of Boys, [PSYCHIATRY INVESTIGATION, 국제일반 ,공동(참여) ,2019]
Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells, [FASEB JOURNAL, SCI급 ,공동(참여) ,2019]
Effects of glycemic variability and hyperglycemia in acute ischemic stroke on post-stroke cognitive impairments, [Journal of Diabetes and its Complications, SCOPUS ,공동(참여) ,2018]
Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015), [AUTOPHAGY, SCI급 ,공동(참여) ,2016]

 

기타

1. 주요연구주제
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경손상의 기전 연구
- 중추신경계 내에서 아연 (Zinc)의 생리, 해부, 병리적 역할
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경재생의 기전 연구 
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경손상에 줄기세포의 투여가 미치는 영향
- 다발성 경화증의 발병기전 및 치료
2. 학회활동
- 대한 생리학회 이사
- 세계 신경과학회 정 회원 

서홍원
  • 분야

    약리학, 신경약리학

  • 성명

    국문 서홍원

  • 직위

    교수

  • 연구실

    의학과 4층 3412

  • 연락처

    033-248-2614

  • 이메일

학력

-1979-1983 학사 생의약 화학, Oral Roberts University, Tulsa, Oklahoma, USA

-1983-1985 석사 약리학, Oral Roberts University, Tulsa, Oklahoma, USA

-1985-1989 박사 신경약리학, Medical college of Wisconsin, Milwaukee, WI, USA 

주요경력

-2007-현재 소장, 한림대학교 의과대학 천연의약연구소

-2002-현재 교수, 한림대학교 의과대학 약리학교실

-1997-2000 부교수, 한림대학교 의과대학 약리학교실

-1992–1997 조교수, 한림대학교 의과대학 약리학교실

-1989-1992 박사후과정, Neuropharmacology Section, Laboratory of Molecular and Integrative Neuroscience, NIEHS/NIH

-1958-1989 교육조교, Medical College of Wisconsin, USA

-1983-1985 교육조교, Oral Roberts University. USA

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

The role of spinally located dopamine D2 receptors in the regulation of the blood glucose level in mice, [Pharmacological Reports, SCI급 ,교신 ,2020]
The modulatory role of β-amyloid in the regulation of nociception in mice, [Acta Neurobiol Exp, SCI급 ,교신 ,2020]
Antinociceptive effect of chrysin in diabetic neuropathy and formalin-induced pain models, [ANIMAL CELLS AND SYSTEMS, SCI급 ,교신 ,2020]
The Molecular Signatures of Acute immobilization induced Antinociception and Chronic immobilization induced Antinociceptive Tolerance, [Experimental Neurobiology, SCI급 ,교신 ,2019]
Antinociceptive Effect of Single Components Isolated from Agrimonia pilosa Ledeb. Extract, [Scientia Pharmaceutica, 국제일반 ,교신 ,2019]
Effects of resveratrol and oxyresveratrol on hippocampal cell death induced by kainic acid, [ANIMAL CELLS AND SYSTEMS, SCI급 ,교신 ,2019]
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models, [Neuropeptides, SCI급 ,교신 ,2018]
Characterization of changes of pain behavior and signal transduction system in food-deprived mice, [ANIMAL CELLS AND SYSTEMS, SCI급 ,교신 ,2018]
Anti-Nociceptive Effect and Standardization from Mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge Extracts, [Journal of Medicinal Food, SCI급 ,공동(교신) ,2018]
The activation of α2-adrenergic receptor in the spinal cord lowers sepsis-induced mortality, [Korean J Physiol Pharmacol, SCI급 ,교신 ,2017]
The Modulatory Roles of Oxyntomodulin and Glucagon-Like Peptide 1 Administered Spinally in the Regulation of the Blood Glucose Level, [Neurochemical Journal, SCI급 ,교신 ,2017]
Spinal beta-adrenergic receptors' activation increases the blood glucose level in mice, [ANIMAL CELLS AND SYSTEMS, SCI급 ,교신 ,2017]
Effect of pertussis toxin pretreated centrally on blood glucose level induced by stress, [Korean J Physiol Pharmacol, SCI급 ,제1저자 ,2016]
Effects of 5,7-dihroxytryptamine administered supraspinally or spinally on the blood glucose level in D-glucose-fed and immobilization stress models, [Animal Cells and Systems, SCI급 ,교신 ,2016]
Blood glucose regulation mechanism in depressive disorder animal model during hyperglycemic states, [Brain Research Bulletin, SCI급 ,교신 ,2016]
Characterization of temporal expressions of FOXO and pFOXO proteins in the hippocampus by kainic acid in mice: involvement of NMDA and non-NMDA receptors., [Arch Pharm Res, SCI급 ,교신 ,2016]
Depletion of Norepinephrine of the Central Nervous System Down-regulates the Blood Glucose level in D-glucose-fed and Restraint Stress Models, [Neuroscience Letters, SCI급 ,교신 ,2016]
Effect of D-glucose feeding on mortality induced by sepsis, [KOREAN JOURNAL OF PHYSIOLOGY PHARMACOLOGY, SCI급 ,교신 ,2016]

Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model [ANIMAL CELLS AND SYSTEMS, SCI급, 공동(교신), 2015] 
Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model [The Korean Journal of Physiology & Pharmacology, SCI급, 공동(교신), 2015] 
Involvement of alpha(2)-adrenergic receptor in the regulation of the blood glucose level induced by immobilization stress [ARCHIVES OF PHARMACAL RESEARCH, SCI급, 공동(교신), 2015] 
Temporal expression of hippocampal lysophosphatidic acid receptors and their roles in kainic acid-induced neurotoxicity[Genes Genom, SCI급, 공동(교신), 2014]
Ghrelin administered spinally increases the blood glucose level in mice[Peptides, SCI급, 공동(교신), 2014] 
The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice[The Korean Journal of Physiology & Pharmacology, SCI급, 단독, 2014]
Effects of nateglinide and repaglinide administered intracerebroventricularly on the CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice[Brain Research Bulletin, SCI급, 공동(교신), 2014] 
Effect of tolbutamide, glyburide and glipizide administered supraspinally on CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice[Brain Research, SCI급, 공동(교신), 2014] 
The modulatory role of alpha-melanocyte stimulating hormone administered spinally in the regulation of blood glucose level in D-glucose-fed and restraint stress mouse models[Neuropeptides, SCI급, 공동(교신), 2014] 

Pertussis Toxin Administered Spinally Induces a Hypoglycemic Effect on Normal and Diabetic Mice[Pharmacology, SCI급, 공동(교신), 2014] 
Involvement of a2-adrenergic receptor in the regulationof the blood glucose level induced by immobilization stress[Arch. Pharm. Res., SCI급, 공동(교신), 2014] 
Role of corticotropin-releasing hormone receptor 1 in the regulation of nociception in mice[Animal Cells and Systems, SCI급, 공동(교신), 2014]
Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice[Neuroscience Research, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 

Liposomal formulation and pharmacokinetic study of CPD409, a novel sodium channel blocker, [Journal of Pharmaceutical Investigation, KCI ,공동(참여) ,2019]
Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase, [FOOD FUNCTION, SCI급 ,공동(참여) ,2018]

Activation of spinal α2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow[European Journal of Pharmacology, SCI급, 공동(참여), 2014]

기타

1. 주요연구주제
- 통증과 오피오이드 시스템에 관련한 신호전달 메커니즘 규명
- 카이닉 산에 의산 신경세포 손상 모델에서의 신경세포 사멸 및 보호효과 관련 메커니즘 규명
- 통증과 당대사 관련 메커니즘 규명
- 중추신경계와 당대사의 상호 관련 메커니즘 규명


2. 학회활동
- 대한 약리학회 이사
- 대한 뇌신경학회 정회원
- 스트레스학회 정회원
- 대한 당뇨학회 정회원

허성오
  • 분야

    약리학

  • 성명

    국문 허성오

  • 직위

    교수

  • 연구실

    의학관 4층 3413

  • 연락처

    033-248-2615

  • 이메일

학력

-1980-1985 서울대학교 (이학사-분자생물학)

-1985-1987 서울대학교 (이학석사-세포생물학)

-1988-1993 Cornell University Weil Cornell Medical College, USA (이학박사-신경과학) 

주요경력

-2021.10 - 국가신약개벌재단 R&D사업화본부 본부장

-2019 - 현재 과기정통부 혁신형의사과학자 사업단 추진위원장

-2019 - 현재 한림 의대 약리학교실 주임교수

-2019 - 현재 한국뇌신경과학회 회장

-2018 - 2019 2019세계뇌과학총회(IBRO) 조직위원장

-2018 - 2019 아시아오세아니아 신경과학회 (FAONS)회장 

-2016-현재 한국연구재단 국책연구본부 뇌•첨단의공학분야 단장

-2014-2015 대한뇌협회 총무이사

-2013-현재 대한약리학회 편집위원

-2011-2012 한림대학교 의과대학 부학장 (대외교류)

-2009-2012 한림대학교 의과대학 약리학교실 주임교수

-2010-2011 한국분자세포생물학회 뇌신경발생학분과 회장

-2008-2011 한림대학교 대학원 의학과장

-2006-현재 한국분자세포생물학회 편집위원

-2004-2005 미국 스크립스 연구소 방문교수

-2000-2004 한림대학교 환경안전관리부장

-1997-현재 한림대학교 의과대학 조교수 부교수 교수

-1993-1997 미국 슬로안케터링 연구소 박사후 연구원

-1988-1993 미국 코넬대학교 의과대학 장학조교

-1987-1988 서울대학교 의과대학 약리학교실 조교 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

- Azoxystrobin Impairs Neuronal Migration and Induces ROS Dependent Apoptosis in Cortical Neurons, [International Journal of Molecular Sciences, SCI급 ,교신 ,2021]
- Identification and prevention of heterotopias in mouse neocortical neural cell migration incurred by surgical damages during utero electroporation procedures, [Animal Cells and Systems, KCI ,공동(교신) ,2020]
- Targeting the Difficult-to-Drug CD71 and MYCN with Gambogic Acid and Vorinostat in a Class of Neuroblastomas., [Cellular Physiology and Biochemistry, SCI급 ,교신 ,2019]
- Farnesylation-defective Rheb Increases Axonal Length Independently of mTORC1 Activity in Embryonic Primary Neurons, [EXPERIMENTAL NEUROBIOLOGY, SCI급 ,교신 ,2019]
- HeLa E-Box Binding Protein, HEB, Inhibits Promoter Activity of the Lysophosphatidic Acid Receptor Gene Lpar1 in Neocortical Neuroblast Cells, [Molecules and Cells, SCI급 ,공동(교신) ,2019]
- DEFECTIVE NEURONAL MIGRATION AND INHIBITION OF BIPOLAR$$TO MULTIPOLAR TRANSITION OF MIGRATING NEURAL CELLS BY$$MESODERM-SPECIFIC TRANSCRIPT, MEST, IN THE DEVELOPING$$MOUSE NEOCORTEX, [Neuroscience, SCI급 ,교신 ,2017]
- Oxyresveratrol activates parallel apoptotic and autophagic cell death pathways in neuroblastoma cells, [Biochimica et biophysica acta, SCI급 ,교신 ,2016]
- 18 alpha-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis, [BIOCHEMICAL PHARMACOLOGY, SCI급 ,교신 ,2016]
- Angelica polymorpha Maxim Induces Apoptosis of Human SH-SY5Y Neuroblastoma Cells by Regulating an Intrinsic Caspase Pathway, [MOLECULES AND CELLS, SCI급 ,교신 ,2016]
- Depletion of inositol polyphosphate 4-phosphatase II suppresses callosal axon formation in the developing mice, [molecules and Cells, SCI급 ,공동(교신) ,2016]

- Morus alba Accumulates Reactive Oxygen Species to Initiate Apoptosis via FOXO-Caspase 3-Dependent Pathway in Neuroblastoma Cells. [Molecules and Cells, SCI급, 공동(교신), 2015] 
- PLGA-Loaded Gold-Nanoparticles Precipitated with Quercetin Downregulate HDAC-Akt Activities Controlling Proliferation and Activate p53-ROS Crosstalk to Induce Apoptosis in Hepatocarcinoma Cells. [Molecules and Cells, SCI급, 공동(교신), 2015] 
- Induction of apoptosis by Dioscorea nipponica Makino extracts in human SH-SY5Y neuroblastoma cells via mitochondria-mediated pathway[Animal Cells and Systems, SCI급, 공동(교신), 2014] 
- Application of in Utero Electroporation of G-Protein Coupled Receptor (GPCR) Genes, for Subcellular Localization of Hardly Identifiable GPCR in Mouse Cerebral Cortex[Molecues and Cells, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 

- Src-mediated phosphorylation of beta Pix-b regulates dendritic spine morphogenesis, [JOURNAL OF CELL SCIENCE, SCI급 ,공동(참여) ,2019]
- Global Analysis of Intercellular Homeodomain Protein Transfer, [CELL REPORTS, SCI급 ,공동(참여) ,2019]
Augmented reduction in colonic inflammatory markers of dextran sulfate sodiuminduced colitis with a combination of 5-- aminosalicylic acid and AD-lico™ from Glycyrrhiza inflata, [Animal Cells and Systems, KCI ,공동(참여) ,2018]

- Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder. [Endocrinol Metab, KCI등재, 공동(참여), 2015]

- MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling.[Cell Death and Diseases, SCI급, 공동(참여), 2014] 

 

기타

1. 주요연구주제
- 신경발달에 관여하는 뇌 유전자의 기능 연구
- GPCR 수용체의 분자약리학적 작용기전연구
- 뇌신경 발달장애 연구 동물모델 개발


2. 학회활동
- 미국 신경과학회 정회원
- 한국 뇌신경과학회 이사
- 한국 분자세포생물학회 이사
- 대한 약리학회 정회원
- 한국 통합생물학회 이사

이종호
  • 분야

    약리학

  • 성명

    국문 이종호

  • 직위

    교수

  • 연구실

    의학관 4층 3414

  • 연락처

    033-248-2616

  • 이메일

학력

-1995-2002 이학박사(약리학)미국 밴더빌트대학교 의과대학 약리학과

-1988-1990 의학석사(미생물학) 한림대학교 의과대학 미생물학교실

-1982-1988 의학사, 한림대학교 의과대학 의학과

주요경력

2013.9~2017.8 의과대학 학생부학장

 

2008.9~2013.8 의과대학 기초의학학장보

 

2002-현재 교수, 한림대학교 의과대학 의학과 약리학교실

 

1995-2002 연구조교, 미국 밴더빌트대학교 의과대학 약리학과

 

1994-1995 서울 강동구 보건소 근무의사

 

1991-1994 공중보건의, 국립보건원

 

1988-1991 교육조교, 한림대학교 의과대학 의학과 미생물학교실 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

- A Cortisol Study; Facial Hair and Nails, [Journal of Steroids & Hormonal Science, SCI급 ,교신 ,2016]

- Embedded Dental Cortisol Content: A Pilot Study, [Endocrinology & Metabolic Syndrome, SCI급 ,교신 ,2016]

- Lysophosphatidic acid activates β-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells. [Mol Med Rep, SCI급, 공동(교신), 2013] 
- Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillin dependent pathway. [Int J Mol Med, SCI급, 공동(교신), 2013]
 
2. 공동저자: 공동저자(참여) 

- G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b, [Journal of Immunology, SCI급 ,공동(참여) ,2018]

- The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells[KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, SCI급, 공동(참여), 2014] 
- Lys1110 of TRPM2 is critical for channel activation. [Biochem J, SCI급, 공동(참여), 2013]
- Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice [Peptides, SCI급, 공동(참여), 2013]

기타

1. 주요연구주제
- 사람 호중구에서 라이소지질의 작용기전 
- 사람 호중구에서 CGRP의 작용기전 


2. 학회활동
- 대한 약리학회
- 미국 중환자학회

유승진
  • 분야

    면역대사학, 노화, 대사질환, 유전학

  • 성명

    국문 유승진

  • 직위

    조교수

  • 연구실

    의학관 3411

  • 연락처

    033-248-2613

  • 이메일

학력

이학박사: 알버트 아인슈타인 의과대학 유전학전공 (2015)

 

의학석사: 서울대학교 의과대학 의학과 약리학교실 (2007)

 

이학사: 고려대학교 생명과학부 (2004)

주요경력

2020.07-2022.02 예일대학교 의과대학 선임연구원

 

2015.07-2020.06 예일대학교 의과대학 박사후 연구원

 

2008.07-2009.07 알버트 아인슈타인 의과대학 석사후 연구원

 

2007.12-2008.05 동아제약 바이오텍연구소 연구원

연구 및 저서

연구실 홈페이지 [https://sites.google.com/view/ryus-ima-lab]

 

■PUBLICATIONS

 

1. Olga Spadaro, Yun-Hee Youm, Irina Shchukina, Seungjin Ryu, Sviatoslav Sidorov, Anthony Ravussin, Kim Nguyen, Ekatirina Aladyeva, Alexander N. Predeus, Steven R. Smith, Eric Ravussin, Craig Galban, Maxim N.Artyomov, and Vishwa Deep Dixit. Caloric restriction in humans reveals immunometabolic regulators of healthspan. Science, 2022; 375(6581):671-677. PMID: 35143297

2. Emily L Goldberg, Irina Shchukina, Yun-Hee Youm, Seungjin Ryu, Takeshi Tsusaka, Kyrlia C Young, Christina D. Camell, Tamara Dlugos, Maxim N. Artyomov, and Vishwa Deep Dixit. IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2. Cell Metabolism, 2021; 33(11):2277-2287. PMID: 34473956

3. Seungjin Ryu*, Jeehae Han, Trina Norden-Krichmar, Quanwei Zhang, Seunggeun Lee, Gil Atzmon, Nir Barzilai, Zhengdong Zhang, Nicholas J. Schork, and Yousin Suh*. Genetic signature of human longevity in PKC and NF-κB signaling. Aging Cell. 2021; 20(7):e13362. PMID: 34197020 (*Co-corresponding author)

4. Seungjin Ryu, Irina Shchukina, Yun-Hee Youm, Hua Qing, Brandon K. Hilliard, Tamara Dlugos, Xinbo Zhang, Yuki Yasumoto, Carmen J. Booth, Carlos Fernández-Hernando, Yajaira Suárez, Kamal M. Khanna, Tamas L. Horvath, Marcelo O. Dietrich, Maxim N. Artyomov, Andrew Wang, and Vishwa Deep Dixit. Ketogenic diet restrains aging-induced exacerbation of coronavirus infection in mice. eLife. 2021;10:e66522. PMID: 34151773

5. Seungjin Ryu, Inkyung Baek, and Hyunjeong Liew. Sumoylated α-synuclein translocates into the nucleus by karyopherin α6. Molecular & Cellular Toxicology. 2019; 15(1):103-109

6. Anthony Ravussin, Yun-Hee Youm, Jil Sander, Seungjin Ryu, Kim Nguyen, Luis Varela, Gerald I. Shulman, Sviatoslav Sidorov, Tamas L. Horvath, Joachim L. Schultze, and Vishwa Deep Dixit. Loss of Nucleobindin-2 causes insulin-resistance in obesity without impacting satiety or adiposity. Cell Reports. 2018. 24(5):1085-1092. PMID: 30067966

7. Seungjin Ryu*, Jeehae Han*, Trina Norden-Krichmar, Nicholas J. Schork, and Yousin Suh. Effective discovery of rare variants by pooled target capture sequencing: A comparative analysis with individually indexed target capture sequencing. Mutation Research. 2018. 809: 24-31. PMID: 29677560

8. Catherine Manix Feintuch, Archana Tare, Lucas R. Cusumano, Jacqueline Benayoun, Seungjin Ryu, Alick Sixpence, Karl Seydel, Miriam Laufer, Terrie Taylor, Yousin Suh, and Johanna P. Daily. Type I Interferon Receptor Variants in Gene Regulatory Regions are Associated with Susceptibility to Cerebral Malaria in Malawi. American Journal of Tropical Medicine and Hygiene. 2018. 98(6): 1692-1698. PMID: 29677560

9. Seungjin Ryu, Gil Atzmon, Nir Barzilai, Nalini Raghavachari, and Yousin Suh. Genetic landscape of APOE in human longevity revealed by high-throughput sequencing. Mechanisms of Ageing and Development. 2016. 155: 7-9. PMID: 26930295

10. Seungjin Ryu, Francesca Teles, Tommaso Russo, Michael G. Rosenfeld, and Yousin Suh. An epigenomic role of Fe65 in the cellular response to DNA damage. Mutation Research. 2015. 776: 40-47. PMID: 26255939

11. Jeehae Han*, Seungjin Ryu*, David M. Moskowitz, Devorah Rothenberg, Daniel J. Leahy, Gil Atzmon, Nir Barzilai, and Yousin Suh. Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next generation sequencing. Mechanisms of Ageing and Development. 2013. 134(10): 478-85. PMID: 23376243 (*Co-first author)

 

■PUBLICATIONS (In Progress)

 

1. Seungjin Ryu, Sviatoslav Sidorov, Akiko Iwasaki, Andrew Wang, and Vishwa Deep Dixit. SPARC links energy balance to inflammatory interferon-response in macrophages. (Under revision in Immunity)

2. Seungjin Ryu, Olga Spadaro, Aileen H. Lee, Sonia Caprio, Eric Ravussin, Christopher Morrison, Steven R. Smith, Eric Ravussin, Irina Shchukina, Andrew Wang , Maxim N. Artyomov, Yun-Hee Youm, and Vishwa Deep Dixit. Adipocyte-derived SPARC controls immunometabolic setpoint of healthspan. (Under review in Cell Metabolism)

3. Brenda Gonzalez*, Archana Tare*, Seungjin Ryu*, Simon C. Johnson, Matt Kaeberlein, and Yousin Suh. Discovery and functional genomics of nuclear-encoded mitochondrial gene variants in Ashkenazi Jewish centenarians implicates mitochondrial pathways in human longevity (*Co-first author) (Under review in GeroScience)

기타

2019. Keystone Symposia Scholarship for "Integrating Metabolism and Immunity" Meeting

2019. Glenn Foundation for Medical Research Postdoctoral Fellowship in Aging Research

2013. Glenn/AFAR Scholarships for Research in the Biology of Aging

2012. Mogam Scholarship. The Mogam Science Scholarship Foundation

이재용
  • 분야

    생화학

  • 성명

    국문 이재용

  • 직위

    교수

  • 연구실

    의학관 4층 3421

  • 연락처

    033-248-2543

  • 이메일

학력

 

-1991 미국미시간대학교 (앤아버) 의과대학 생화학과 의학박사 (Ph.D.in Medical Science)

-1982 한국과학기술원 생물공학과, 이학석사

-1980 서울대학교 공업화학과 학사 

주요경력

2010. 3~2018. 8. 31 : 지역혁신센터장

 

2009-현재 식의약품의 효능평가 및 기능성소재개발센터 소장 (한림대학교)

 

2010-2011 한국노화학회 회장

 

2008-2009 한국노화학회 부회장

 

2004-2006 한국노화학회 운영위원장

 

2002-2004 한국노화학회지 편집위원장

 

2002-현재 한림대학교 의과대학 생화학교실 교수

 

1997-2002 한대학교 의과대학 생화학교실 부교수

 

1995-1997 미국 존스홉킨스대학교 의과대학 의학유전학과 조교수

 

1994 –1995 미국 존스홉킨스대학교 의과대학 의학유전학 박사후 연구원

 

1991 -1994 미국 하워드휴지 의학연구소 (미시간대학교 내) 박사후 연구원

 

1985-1991 미국 미시간 대학교 의과대학 생화학과 연구조교

 

1982-1985 한국과학기술원 (현 생명공학연구원) 연구원 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

- Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in$$rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway, [Animal Cells and Sytems, SCI급 ,교신 ,2021]

- Anti-obesity effect of Solidago virgaaurea extract in high-fat diet-fed SD rat, [ANIMAL CELLS AND SYSTEMS, SCI급 ,교신 ,2016]

- FOXO3a Activation by oxyresveratrol of Morus bombycis koidzumi extract mediates antioxidant activity, [Animal Cells and Systems, SCI급 ,공동(교신) ,2016]
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(교신), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 

- Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos, [Animal Cells and Systems, SCOPUS ,공동(참여) ,2020]

- Liposomal formulation and pharmacokinetic study of CPD409, a novel sodium channel blocker, [Journal of Pharmaceutical Investigation, KCI ,공동(참여) ,2019]

- Effects of resveratrol and oxyresveratrol on hippocampal cell death induced by kainic acid, [Animal Cells and Systems, SCI급 ,공동(참여) ,2019]

- Affinity measurement of ligands in Perilla frutescens extract towards α-$$glucosidase using affinity-based ultrafiltration-high-performance liquid$$chromatograph, [J of Chromatography B, SCI급 ,공동(참여) ,2019]

- Ventx1.1 as a Direct Repressor of Early Neural Gene zic3 in Xenopus laevis, [Molecules and Cells, SCI급 ,공동(참여) ,2018]

- Antiobesity Effect of Astilbe chinensis Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice, [Evidence Based Complement Alternat Med, SCI급 ,공동(참여) ,2018]

- Effect of isoflavone-enriched whole soy milk powder supplementation on bone metabolism in ovariectomized mice, [Nutrition Research and Practice, KCI ,공동(참여) ,2018]

- Anti-glycation, Carbonyl Trapping and Anti-inflammatory Activities of Chrysin Derivatives, [MOLECULES, SCI급 ,공동(참여) ,2018]

- Xbra and Smad-1 cooperate to activate the transcription of neural repressor ventx1.1 in Xenopus embryos, [SCIENTIFIC REPORTS, SCI급 ,공동(참여) ,2018]

- Analytical Method for the Validation of Three Polyphenols as a Marker Compound for the Standardization of Solidago virgaurea subsp. gigantea Extracts and Antiadipogenesis of Harvesting Time and Location, [Journal of Analytical Methods in Chemistry, SCI급 ,공동(참여) ,2017]

- Wnt3A Induces GSK-3b Phosphorylation and β-Catenin Accumulation Through RhoA/ROCK, [JOURNAL OF CELLULAR PHYSIOLOGY, SCI급 ,공동(참여) ,2017]

- Competitive binding experiments can reduce the false positive resultsof affinity-based ultrafiltration-HPLC: A case study for identificationof potent xanthine oxidase inhibitors from Perilla frutescens extract, [J Chromatogr B Analyt Technol Biomed Life Sci., SCI급 ,공동(참여) ,2017]

- Rapid High Performance Liquid Chromatography Determination and Optimization of Extraction Parameters of the α-Asarone Isolated from Perilla frutescens L., [molecules, SCI급 ,공동(참여) ,2017]

- Anti-obesity effect of Solidago virgaurea var. gigantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice, [Food & Nutrition Research, SCI급 ,공동(참여) ,2017]

- RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation, [Free Radical Biology and Medicine, SCI급 ,공동(참여) ,2017]

- Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype, [Tumor Biology, SCI급 ,공동(참여) ,2016]

- xCyp26c Induced by Inhibition of BMP Signaling Is Involved in Anterior-Posterior Neural Patterning of Xenopus laevis, [Molecules and Cells, SCI급 ,공동(참여) ,2016]

- Screening of Korean natural products for anti-adipogenesis properties and isolation of kaempferol-3-o-rutinoside as a potent anti-adipogenetic compound from Solidago virgaurea, [Molecules, SCI급 ,공동(참여) ,2016]

- Optimization of extraction parameters of PTP1 beta (protein tyrosine phosphatase 1 beta), inhibitory polyphenols, and anthocyanins from Zea mays L. using response surface methodology (RSM), [BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, SCI급 ,공동(참여) ,2016]

- Purple perilla extracts with alpha-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages [INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SCI급, 공동(참여), 2015] 
- Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice [NUTRITION RESEARCH AND PRACTICE, SCI급, 공동(참여), 2015] 
- A functional egg yolk powder containing an antibody against Niemann-Pick C1-like1 (NPC1L1) lowers cholesterol levels in high cholesterol diet induced hypercholesterolemic SD rats [FOOD SCIENCE AND BIOTECHNOLOGY, SCI급, 공동(참여), 2015] 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Purple Perilla Extracts Allay ER Stress in Lipid-Laden Macrophages[PLOS ONE, SCI급, 공동(참여), 2014] 
- Rubus coreanus Miquel ameliorates scopolamine-induced memory impairments in ICR mice. [J Med Food, SCI급, 공동(참여),2014] 

기타

1. 주요연구주제
- Molecular mechanism of cellular and organismal Aging (세포 및 조직 노화의 분자기전 연구) 
- Molecular mechanism for regulation of ROS, DNA damage, and DNA repair during aging (노화과정에서 활성산소, 유전자손상 및 복구 조절기전 연구)
- Mechanism for regulation of aging by FOXO (전사인자 FOXO에 의한 노화조절기전 연구)
- Development of anti-aging materials and medicine (항노화물질 및 의약개발)


2. 학회활동
- 한국 노화학회 
- 한국 생화학-분자생물학회 
- International Association of Gerontology and Geriatrics (세계노인과학회)

박재봉
  • 분야

    생화학

  • 성명

    국문 박재봉

  • 직위

    교수

  • 연구실

    의학관 4층 3419

  • 연락처

    033-248-2542

  • 이메일

학력

-1986-1992 한국과학기술원 (박사)

-1981-1983 한국과학기술원 (석사)

-1977-1981 서울대학교 (학사)

주요경력

 1993-1996 University of Washington (Howard Hughes Medical Institute, Postdoc  Fellow and Reseach Associate

 2002-2003          The Scripps Research Institute, Research Associate

 2018-2021 현재    한림중개의과학연구원 원장

 2017–2021 현재    세포분화 및 노화연구소 소장

 2021 현재 Biomedicines (IF=6.081) Editorial Board Member

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

- Yoon-Beom Lee, Jung K Min , Jae-Gyu Kim, Kim Cuong Cap, Rokibul Islam, Abu J Hossain, Oyungerel Dogsom, Amir Hamza, Shohel Mahmud, Dae R Choi , Yong-Sun Kim, Young-Ho Koh, Hyun-A Kim, Won-Suk Chung, Sang W Suh, Jae-Bong Park. Multiple functions of pyruvate kinase M2 in various cell types. J Cell Physiol (2021) doi: 10.1002/jcp.30536. (IF=6.384).

 

- Kim JG, Mahmud S, Min JK, Lee YB, Kim H, Kang DC, Park HS, Seong J, Park JB. RhoA GTPase phosphorylated at tyrosine 42 by src kinase binds to β-catenin and contributes transcriptional regulation of vimentin upon Wnt3A. Redox Biology 40:101842 (2021). (IF=11.799)

 

- Kim Cuong Cap, Yeon-Joo Jung, Bo Young Choi, Seung Jae Hyeon, Jae-Gyu Kim, Jung-Ki Min, Rokibul Islam, Abu Jubayer Hossain, Won-Suk Chung, Sang Won Suh,Hoon Ryu, and Jae-Bong Park. Distinct dual roles of p-Tyr42 RhoA GTPase in Tau phosphorylation and ATP citrate lyase activation upon different Aβ concentrations. Redox Biology 32:101446 (2020) (IF=11.799)

 

- Cap KC, Kim JG, Hamza A, Park JB. P-Tyr42 RhoA GTPase amplifies superoxide formation through p47phox, phosphorylated by ROCK. Biochem. Biophys. Res. Commun. 523: 972-978 (2020) (IF=3.575)

 

- Eun-Kyoung Choi, Jae-Gyu Kim, Hee-Jun Kim, Jung-Yoon Cho, Hwalrim Jeong, Yohan Park, Rokibul Islam, Cuong Kim Cap, and Jae-Bong Park. Regulation of RhoA GTPase and novel target proteins for ROCK. Small GTPases 11, 95-102 (2020)  (Review paper)

 

- Islam R, Kim JG, Park Y, Cho JY, Cap KC, Kho AR, Chung WS, Suh SW, Park JB. Insulin induces phosphorylation of pyruvate dehydrogenase through RhoA activation pathway in HepG2 cells. FASEB J. 33: 2072-2083 (2019). (IF=5.391)

 

- Kim JG, Islam R, Cho JY, Jeong H, Cap KC, Park Y, Hossain AJ, Park JB. Regulation of RhoA GTPase and various transcription factors in the RhoA pathway. J. Cell. Physiol. 233: 6381-6392 ( 2018). (Review paper) (IF=5.546)

 

- Jae-Gyu Kim, Kyoung-Chan Choi, Chnag-Won Hong, Hwee-Seon Park, Eun-Kyoung Choi, Yong-Sun, Kim, and Jae-Bong Park. Tyr42 phosphorylation of RhoA GTPase promotes tumorigenesis through nuclear factor (NF)-κB. Free Radic. Biol. Med. 112, 69-83 (2017) (IF=7.376)

 

- Jae-Gyu Kim, Hyung-Joo Kwon, Guang Wu, Yohan Park, Jae-Yong Lee, Jaebong Kim, Sung-Chan Kim, Myoen Choe, Seung Goo Kang, Goo-Young Seo, Pyeung-Hyeun Kim, and Jae-Bong Park. RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation. Free Radic. Biol. Med. 103, 57-68 (2017) (IF=7.376)

 

- Hee-Jun Kim, Hong-Seok Choi, Jeong-Ho Park, Mo-Jong Kim, Hyoung-gon Lee, Robert B. Petersen, Yong-Sun Kim, Jae-Bong Park, Eun-Kyoung Choi,  Regulation of RhoA activity by the cellular prion protein. Cell Death Dis. 8, e2668 (2018) (IF=8.469)

 

- Kim JG, Kim MJ, Choi WJ, Moon MY, Kim HJ, Lee JY, Kim J, Kim SC, Kang SG, Seo GY, Kim PH, Park JB. Wnt3A Induces GSK-3β phosphorylation and β-catenin accumulation through RhoA/ROCK. J. Cell. Physiol. 232, 1104-1113 (2017) (IF=6.384) 

 

- Kim JS, Kim JG, Moon MY, Jeon CY, Won HY, Kim HJ, Jeon YJ, Seo JY, Kim JI, Kim J, Lee JY, Kim PH, Park JB. Transforming growth factor-beta1 regulates macrophage migration via RhoA. Blood 108: 1821-1829 (2006) (IF=22.11) 


 
2. 공동저자: 공동저자(참여) 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [Tumor Biology, SCI급, 공동(참여), 2015] 


- PV.1 suppresses the expression of FoxD5b during neural induction in Xenopus embryos[Mol Cells, SCI급, 공동(참여), 2014] 


- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Report, SCI급, 공동(참여), 2014] 


- Rab3a promotes brain tumor initiation and progression[Mol Biol Rep, SCI급, 공동(참여), 2014] 


- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1[Tumour Biol, SCI급, 공동(참여), 2014] 


- Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[Mol Biol Rep, SCI급, 공동(참여), 2014] 

기타

1. 주요연구주제: Small GTPases에 의한 신호전달 
(1) Rho GTPase-mediated regulation of signaling transduction in inflammatory and tumorigenesis by several factors including TGF-β, ROS, insulin, Wnt and EGF.
(2) p-Tau by Amyloid beta through RhoA activation. 


2. 학회활동
- 생화학분자생물학회 대의원, 
- 한국분자세포생물학회 정회원, 
- 한국노화학회 정회원, 
- 세포생물학회 정회원, 
- 한국뇌신경과학회 정회원

김재봉
  • 분야

    생화학

  • 성명

    국문 김재봉

  • 직위

    교수

  • 연구실

    의학관 4층 3418

  • 연락처

    033-248-2544

  • 이메일

학력

-1994 박사 (Ph.D.) 생화학, 매릴랜드주립대학, College Park,MD., USA

-1987 석사수료 농화학, 경북대학교

-1985 학사 농화학, 경북대학교 

주요경력

2014.09~2020.06 의과대학 대학원의학과장/연구부학장

 

2008-현재 교수, 한림대학교 의과대학 의학과 생화학교실

 

2003-2007 부교수, 한림대학교 의과대학 의학과 생화학교실

 

1999-2003 조교수, 한림대학교 의과대학 의학과 생화학교실

 

1994-1999 박사후 연수과정, 방문연구원, 미국보건연구소 프레드릭소재미국립암연구소

 

1990-1994 연구조교, 매릴랜드주립대학, College Park,MD., USA

 

1988-1990 교육조교, 매릴랜드주립대학, College Park,MD., USA.

 

1985-1987 교육조교, 경북대학교 농과대학 농화학과 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 
- PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis [BIOMED RESEARCH INTERNATIONAL, SCI급, 공동(교신), 2015] 
- PV.1 Suppresses the Expression of FoxD5b during Neural Induction in Xenopus Embryos[Molecules and Cells, SCI급, 공동(교신), 2014] 
- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Reports, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype. [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Rab3a promotes brain tumor initiation and progression[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(참여), 2014] 

기타

1. 주요연구주제
- 척추동물 모델을 이용한 배의 초기발생과에서의 신호전달과 전사조절 기전연구 
- 척추동물 원시배발생과 신경발생에 관여하는 유전자의 탐색과 기능분석

 
2. 학회활동
- 한국 분자세포생물학회 정회원/제노프스분과 분과장 
- 생화학분자생물학회 정회원 
- 한국생명과학회 정회원/강원지부장 

김성찬
  • 분야

    동물분자세포생물학

  • 성명

    국문 김성찬

  • 직위

    교수

  • 연구실

    의학관 4층 3417

  • 연락처

    033-248-2545

  • 이메일

학력

-1997-2002 서울대학교박사. 동물분자세포생물학전공

-1995-1997 서울대학교석사. 동물생명공학전공

-1987-1994 영남대학교학사. 동물자원과학전공 

주요경력

-2021.6 ~ 현재 의과대학 학생부학장/의예과장

-2007-현재 한림대학교 의학과 생화학교실, 조교수, 부교수, 교수

-2005-2007 미국 텍사스 사우스웨스턴 메디컬센터 생화학과 선임연구원 (Senior Research Associate, Dept. of Biochemisty, Unversity of Texas Southwestern Medical Center, Dallas, USA)

-2002-2005 미국 텍사스 사우스웨스턴 메디컬센터 생화학과 박사후연구원 (Post-Doctoral Fellow, Dept. of Biochemisty, University of Texas Southwestern Medical Center, Dallas, USA)

-2002-2002 서울대학교 BK 21 박사후연구원

-2000-2002 서울대학교 조교

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

A cell-autonomous positive-signaling circuit associated with the PDGF-NO-ID4-regulatory axis in glioblastoma cells, [BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급 ,공동(교신) ,2017]
Cloning and Characterization of an Endoglucanase Gene from Actinomyces sp. KNG 40, [Asian-Australasian journal of animal sciences, SCI급 ,제1저자 ,2016]
FOXO3a activation by oxyresveratrol of Morus bombycis koidzumi extract mediates antioxidant activity, [Animal cells and systems., SCI급 ,공동(교신) ,2016]
LIM domain only 2 induces glioma invasion via cytosolic p27KIP1, [Tumor Biology, SCI급 ,공동(교신) ,2016]
Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype, [Tumor Biology, SCI급 ,공동(교신) ,2016]

Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(교신), 2015] 
Rab3a promotes brain tumor initiation and progression[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여)

Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos, [Animal Cells and Systems, SCI급 ,공동(참여) ,2020]
Galectin-9 Induced by Dietary Prebiotics Regulates Immunomodulation to Reduce Atopic Dermatitis Symptoms in 1-Chloro-2,4-Dinitrobenzene (DNCB)-Treated NC/Nga Mice, [JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, SCI급 ,공동(참여) ,2020]
Galectin-9 Induced by Dietary Probiotic Mixture Regulates Immune Balance to Reduce Atopic Dermatitis Symptoms in Mice, [FRONTIERS IN IMMUNOLOGY, SCI급 ,공동(참여) ,2020]
Ventx1.1 as a Direct Repressor of Early Neural Gene zic3 in Xenopus laevis, [MOLECULES AND CELLS, SCI급 ,공동(참여) ,2018]
Anti-Inflammatory Effects of a Mixture of Lactic Acid Bacteria and Sodium Butyrate in Atopic Dermatitis Murine Model, [Journal of Medicinal Food, KCI ,공동(참여) ,2018]
Xbra and Smad-1 cooperate to activate the transcription of neural repressor ventx1.1 in Xenopus embryos, [SCIENTIFIC REPORTS, SCI급 ,공동(참여) ,2018]
흰 쥐에서 복합 유산균과 다시마가 항비만 및 장내 미생물에 미치는 영향, [생명과학회지, KCI ,공동(참여) ,2017]
Wnt3A Induces GSK-3 beta Phosphorylation and beta-Catenin Accumulation Through RhoA/ROCK, [JOURNAL OF CELLULAR PHYSIOLOGY, SCI급 ,공동(참여) ,2017]
RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-kappa B activation, [FREE RADICAL BIOLOGY AND MEDICINE, SCI급 ,공동(참여) ,2017]
Anti-obesity effect of Solidago virgaaurea extract in high-fat diet-fed SD rat, [Animal Cells and Systems, SCI급 ,공동(참여) ,2016]
xCyp26c Induced by Inhibition of BMP Signaling Is Involved in Anterior-Posterior Neural Patterning of Xenopus laevis, [Molecules and Cells, SCI급 ,공동(참여) ,2016]

IRF7 promotes glioma cell invasion by inhibiting AGO2 expression [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
PV.1 Suppresses the Expression of FoxD5b during Neural Induction in Xenopus Embryos[MOLECULES AND CELLS, SCI급, 공동(참여), 2014] 
Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Reports, SCI급, 공동(참여), 2014] 
Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(참여), 2014] 

기타

1. 주요연구주제
- 다양한 세포에서 단백질체학을 이용한 특정 수식화된 단백질의 (post-translational modification)의 대량분리와 기능분석(Lysine methylation methylation, sumolyation, Acetylation, Phosphorylation, O-GlcNAc modification...) 
- 새로운 단백질수식 확인 및 수식화된 단백질분리를 위한 단백질체학 기술개발 (Development of new technology to isolate and identify novel post-translational modifications)
- 인체질병 또는 중요한 세포내 핵심단백질의 새로운수식의 발굴 및 수식과 기능을 종합한 단백질기능 지도작성 (construction of multisite modification map) 
- 세포내 특정 핵심단백질과의 상호작용 단백질분리 및 기능분석
- 단백질체학을 이용한 질병의 조기진단을위한 인체질환 특이적 단백질 바이오마커 (biomarker) 발굴
- 특정 단백질의수식이 뇌종양세포 및 뇌종양줄기세포 발생에 미치는 영향분석


2. 학회활동
- 생화학분자생물학회 정회원 
- 한국 분자세포생물학회 정회원 

김용선
  • 분야

    바이러스학

  • 성명

    국문 김용선

  • 직위

    연구석좌교수

  • 연구실

    의학관 5층 3516

  • 연락처

    031-380-1987

  • 이메일

학력

-1985-1989 뉴욕주립대학교(이학박사-병리학)

-1980-1982 중앙대학교(의학석사-예방의학)

-1972-1978 가톨릭대학교(의학사-의학) 

주요경력

2016. 4 ~ 2018. 2 의무 부총장 

 

2015-현재 한림대의료원 국제화 및 연구강화위원장

 

2008-2014 한림대학교 의무부총장

 

2014 아시아-태평양 프리온학회 회장

 

2006 한국노화학회 회장

 

2006 한국미생물학회연합회 회장

 

2006-2007 대한바이러스학회 회장

 

2004-2008 한림대학교 의과대학장

 

1994-현재 한림대학교 일송생명과학연구소 소장

 

1982-1990 뉴욕주립 발달장애연구소 박사 후 연구원 및 선임연구원

 

1981-1982 가톨릭의과대학 부속 성모병원 인턴 및 내과수련의 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

Re-transmissibility of mouse-adapted ME7 scrapie strain to ovine PrP transgenic mice, [Journal of veterinary science, SCI급 ,교신 ,2019]
The frequency of Merkel cell polyomavirus in whole blood from immunocompetent and immunosuppressed patients with kidney disease and healthy donors, [Microbial pathogenesis, SCI급 ,교신 ,2019]
Ultra-efficient Amplification of Abnormal Prion Protein by Modified Protein Miosfolding Cycle Amplification with Electric Current., [Moleular Neurobiology, SCI급 ,단독 ,2018]
Cellular Prion Protein Combined with Galectin-3 and-6 Affects the Infectivity Titer of an Endogenous Retrovirus Assayed in Hippocampal Neuronal Cells, [PLOS ONE, SCI급 ,공동(교신) ,2016]
Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea, [Journal of Clinical Neurology, SCI급 ,공동(교신) ,2016]

Phosphatidylinositol-Glycan-Phospholipase D is Involved in Neurodegeneration in Prion Disease [PLOS One, SCI급, 공동(교신), 2015] 
Nε-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms [Molecular Neurobiology, SCI급, 공동(교신), 2015] 
RARB and STMN2 polymorphisms are not associated with sporadic Creutzfeldt-Jakob disease (CJD) in the Korean population[Molecular Biology Reports, SCI급, 공동(교신), 2014] 
Genetic studies in human prion diseases[Journal of Korean Medical Science, SCI급, 공동(교신), 2014]
Dysfunction of mitochondrial dynamics in the brains of scrapie-infected mice[Biochemical and Biophysical Research Communications, SCI급, 공동(교신), 2014] 
Deficiency of prion protein induces impaired autophagic flux in neurons[Froitier in Aging Neuroscience, SCI급, 공동(교신), 2014]
 
2. 공동저자: 공동저자(참여) 

RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity , [International journal of molecular sciences, SCI급 ,공동(참여) ,2020]
Vimentin citrullination probed by a novel monoclonal antibody serves as a specific indicator for reactve astrocytes in neurodegeneration, [Neuropathology and applied neurobiology, SCI급 ,공동(참여) ,2020]
In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation., [Molecular neurobiology, SCI급 ,공동(참여) ,2019]
Gerstmann-Sträussler-Scheinker Disease (Pro102Leu) Presenting as Rapidly Progressive Dementia, [J Korean Neurol Assoc, SCI급 ,공동(참여) ,2019]
Prolonged follicular helper T cell responses in ME7 scrapie-infected mice, [Prion, SCI급 ,공동(참여) ,2018]
Myelin Basic Protein Citrullination, a Hallmark of central Nervous System Demyelination, Assessed by Novel Monoclonal Antibodies in Prion Diseases, [Moleular Neurobiology, SCI급 ,공동(참여) ,2018]
Calsenilin, a Presenilin Interactor, Regulates RhoA Signaling and Neurite Outgrowth., [International Journal of Molecular Sciences, SCI급 ,공동(참여) ,2018]
Trichloroethylene and Parkinson’s Disease: Risk Assessment, [Moleular Neurobiology, SCI급 ,공동(참여) ,2018]
The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, SCI급 ,공동(참여) ,2017]
Induction of Peptidylarginine Deiminase 2 and 3 by Dibutyryl cAMP via cAMP-PKA Signaling in Human Astrocytoma U-251MG cells, [JOURNAL OF NEUROSCIENCE RESEARCH, SCI급 ,공동(참여) ,2017]
Self-propagating, protease-resistant, recombinant prion protein conformers with or without in vivo pathogenicity, [PLOS PATHOGENS, SCI급 ,공동(참여) ,2017]
Regulation of RhoA activity by the cellular prion protein, [CELL DEATH  DISEASE, SCI급 ,공동(참여) ,2017]
Impaired spleen structure and chemokine expression in ME7 scrapie-infected mice, [IMMUNOBIOLOGY, SCI급 ,공동(참여) ,2016]
Prion protein-deficient mice exhibit decreased CD4 T and LTi cell numbers and impaired spleen structure, [Immunobiology, SCI급 ,공동(참여) ,2016]
Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356, [Autophagy, SCI급 ,공동(참여) ,2016]

Mass Spectrometric Identification of Citrullination Sites and Immunohistochemical Detection of Citrullinated Glial Fibrillary Acidic Protein in Alzheimer’s Disease Brains[Journal of Neuroscience Research, SCI급, 공동(참여), 2015] 
Upregulation of Connexin 43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease [Journal of Alzheimer's Disease, SCI급, 공동(참여), 2015]
Lysosomal Trafficking of TGFBIp via Caveolae-Mediated Endocytosis [PLOS One, SCI급, 공동(참여), 2015] 
Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease [Molecular Neurobiology, SCI급, 공동(참여), 2015] 
Auraptene Increases the Production of Amyloid-β via c-Jun N-Terminal Kinases-Dependent Activation of γ-Secretase [Journal of Alzheimer's Disease, SCI급, 공동(참여), 2015] 
ATBF1 is a Novel Amyloid-β Protein Precursor (AβPP) Binding Protein that Affects AβPP Expression.[Jornal of Alzheimer's disease, SCI급, 공동(참여), 2015] 
Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies[Neuropathology and Applied Neurobiology, SCI급, 공동(참여), 2014] 
Tunicamycin induces paraptosis potentiated by inhibition of BRAFV600E in FRO anaplastic thyroid carcinoma cells[Anticancer Research, SCI급, 공동(참여), 2014]
Stearoyl coenzyme a desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replication[Journal of Virology, SCI급, 공동(참여), 2014]

기타

1. 주요연구주제
- 프리온 질환에서 퇴행성 신경변화에 대한 병리기전 
- 프리온 질환의 조기 진단 기법 및 치료제 개발
- 노화에 따른 퇴행성 신경변화에서 내인성 레트로바이러스의 역할 구명 


2. 학회활동
- 대한 바이러스학회
- 미국 바이러스학회
- 미국 신경과학회
- 유럽연합 프리온학회
- 아시아-태평양 프리온학회
- 대한민국 의학한림원

권형주
  • 분야

    면역학

  • 성명

    국문 권형주

  • 직위

    교수

  • 연구실

    의학관 5층 3513

  • 연락처

    033-248-2635

  • 이메일

학력

-1994-1998 연세대학교(이학박사-생화학과)

-1988-1990 연세대학교(이학석사-생화학과)

-1983–1987 서울대학교(농학사-농화학과) 

주요경력

-2012-2014 한림대학교 연구처장, 산학협력단장

-2008-현재 한림대학교 의과학연구소 소장

-2010–2012 한림대학교 실험동물센터장

-2010-현재 한림대학교 의과대학 의학과 미생물학교실 교수

-2005-2009 한림대학교 의과대학 의학과 미생물학교실 부교수

-2004–2006 한국생명공학연구원 겸임연구원

-2002–2005 연세대학교 생명과학기술연구원 연구교수

-1998–2001 인디아나대학 의과대학 Walther Oncology Center 박사 후 연구원

-1998-1998 연세대학교 생명과학연구소 박사후 연구원

-1991-1992 한국생명공학연구원 세포생물학연구실 연구원 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 
Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines [BMB Reports, SCI급, 공동(교신), 2015] 
Monoclonal Antibodies Against the Human Respiratory Syncytial Virus Obtained by Immunization with Epitope Peptides and CpG-DNA-liposome Complex [Monoclonal antibodies in immunodiagnosis and immunotherapy, SCI급, 공동(교신), 2015] 
Perspective of peptide vaccine composed of epitope peptide, CpG-DNA, and liposome complex without carriers. [Advances in Protein Chemistry and Structural Biology, SCI급, 공동(교신), 2015] 
Production of epitope-specific antibodies by immunization with synthetic epitope peptide formulated with CpG-DNA-liposome complex without carriers [Methods in Molecular Biology, SCOPUS, 공동(교신), 2015] 
Therapeutic effect of a TM4SF5-specific peptide vaccine against colon cancer in a mouse model[BMB reports, SCI급, 공동(교신), 2014] 
Expression of UNC93A induced by CpG-DNA-liposome complex in mice[Journal of the Korean Society for Applied Biological Chemistry, SCI급, 공동(교신), 2014] 
Monoclonal antibody targeting of the cell surface molecule TM4SF5 inhibits the growth of hepatocellular carcinoma[Cancer Research, SCI급, 공동(교신), 2014] 
Effect of epitope-CpG-DNA-liposome complex without carriers on vaccination of respiratory syncytial virus infection[Journal of the Korean Society for Applied Biological Chemistry, SCI급, 공동(교신), 2014] 
Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model[Oncotarget, SCI급, 공동(교신), 2014]
MERS-CoV and SARS-CoV-2 replication can be inhibited by targeting the interaction between the viral spike protein and the nucleocapsid protein, [Theranostics, SCI급 ,공동(교신) ,2021]
Adeno-Associated Virus D-Sequence-Mediated Suppression of Expression of a Human Major Histocompatibility Class II Gene: Implications in the Development of Adeno-Associated Virus Vectors for Modulating Humoral Immune Response, [HUMAN GENE THERAPY, SCI급 ,제1저자 ,2020]
CD83 expression regulates antibody production in response to influenza A virus infection, [VIROLOGY JOURNAL, SCI급 ,교신 ,2020]
A pilot study of the antiviral activity of anionic and cationic polyamidoamine dendrimers against the Middle East respiratory syndrome coronavirus, [JOURNAL OF MEDICAL VIROLOGY, SCI급 ,공동(교신) ,2020]
Small Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Fusion by Targeting Cavities on Heptad Repeat Trimers, [Biomolecules & Therapeutics, SCI급 ,공동(교신) ,2020]
Abdominal and Pelvic Organ Failure Induced by Intraperitoneal Influenza A Virus Infection in Mice, [FRONTIERS IN MICROBIOLOGY, SCI급 ,공동(교신) ,2020]
CpG-DNA induces bacteria-reactive IgM enhancing phagocytic activity against Staphylococcus aureus infection, [BMB Reports, SCI급 ,교신 ,2019]
Production of a Monoclonal Antibody Targeting the M Protein of MERS-CoV for Detection of MERS-CoV Using a Synthetic Peptide Epitope Formulated with a CpG?DNA?Liposome Complex, [International Journal of Peptide Research and Therapeutics, SCI급 ,교신 ,2019]
Anti-Bacterial Effect of CpG-DNA Involves Enhancement of the Complement Systems, [International Journal of Molecular Sciences, SCI급 ,교신 ,2019]
Generation and characterization of a monoclonal antibody against MERS-CoV targeting the spike protein using a synthetic peptide epitope-CpG-DNA-liposome complex, [BMB Reports, SCI급 ,교신 ,2019]
Production of anti-c-Myc monoclonal antibody inhibiting DNA binding of c-Myc and Max dimer by epitope peptide-CpG-DNA-liposome complex without carriers, [International Journal of Peptide Research and Therapeutics, SCI급 ,교신 ,2019]
Gomisin G Suppresses the Growth of Colon Cancer Cells by Attenuation of AKT Phosphorylation and Arrest of Cell Cycle Progression, [Biomolecules & Therapeutics, SCI급 ,교신 ,2019]
Peritoneal Cells Mediate Immune Responses and Cross-Protection Against Influenza A Virus, [Frontiers in Immunology, SCI급 ,공동(교신) ,2019]
Gomisin G Inhibits the Growth of Triple-Negative Breast Cancer Cells by Suppressing AKT Phosphorylation and Decreasing Cyclin D1, [Biomolecules & Therapeutics, SCI급 ,교신 ,2018]
A peptide-CpG-DNA-liposome complex vaccine targeting TM4SF5 suppresses growth of pancreatic cancer in a mouse allograft model, [OncoTargets and Therapy, SCI급 ,공동(교신) ,2018]
CpG-DNA exerts antibacterial effects by protecting immune cells and producing bacteria-reactive antibodies, [Scientific Reports, SCI급 ,공동(교신) ,2018]
A novel monoclonal antibody targets mucin1 and attenuates growth in pancreatic cancer model, [International Journal of Molecular Sciences, SCI급 ,공동(교신) ,2018]
A Mucin1 C-terminal Subunit-directed Monoclonal Antibody Targets Overexpressed Mucin1 in Breast Cancer, [Theranostics, SCI급 ,공동(교신) ,2018]
Expression and characterization of transmembrane and coiled-coil domain family 3, [BMB Reports, SCI급 ,교신 ,2016]
Effect of a monoclonal antibody against human relaxin-2 on cancer cell growth inhibition, [Applied Biological Chemistry, SCI급 ,교신 ,2016]
Extracellular Release of CD11b by TLR9 Stimulation in Macrophages, [PLOS ONE, SCI급 ,교신 ,2016]
Anti-metastatic effect of the TM4SF5-specific peptide vaccine and humanized monoclonal antibody on colon cancer in a mouse lung metastasis model, [Oncotarget, SCI급 ,공동(교신) ,2016]

 
2. 공동저자: 공동저자(참여) 

Targeting TM4SF5 with anti?TM4SF5 monoclonal antibody suppresses the growth and motility of human pancreatic cancer cells, [Oncology Letters, SCI급 ,공동(참여) ,2020]
Decursinol Angelate Ameliorates Dextran Sodium Sulfate-Induced Colitis by Modulating Type 17 Helper T Cell Responses, [BIOMOLECULES THERAPEUTICS, SCI급 ,공동(참여) ,2019]
Production of an anti-TM4SF5 monoclonal antibody and its application in the detection of TM4SF5 as a possible marker of a poor prognosis in colorectal cancer, [International Journal of Oncology, SCI급 ,공동(참여) ,2018]
Evaluation of immunomodulatory effects of zearalenone in mice, [JOURNAL OF IMMUNOTOXICOLOGY, SCI급 ,공동(참여) ,2017]
CD11b regulates antibody class switching via induction of AID, [MOLECULAR IMMUNOLOGY, SCI급 ,공동(참여) ,2017]
RhoA GTPase oxidation stimulates cell proliferation via nuclear factor-κB activation, [Free Radical Biology and Medicine, SCI급 ,공동(참여) ,2017]

Middle Ear Response of Muc5ac and Muc5b Mucins to Nontypeable Haemophilus influenzae[JAMA Otolaryngology-Head & Neck Surgery, SCI급, 공동(참여), 2015] 
Efficient doxorubicin delivery using deaggregated and carboxylated nanodiamonds for cancer cell therapy [Nanoscience and Nanotechnology Letters, SCI급, 공동(참여), 2015] 
NADPH oxidase activation contributes to native low-density lipoprotein-induced proliferation of human aortic smooth muscle cells [EXPERIMENTAL AND MOLECULAR MEDICINE, SCI급, 공동(참여), 2015] 
Liposome-Encapsulated CpG Enhances Antitumor Activity Accompanying the Changing of Lymphocyte Populations in Tumor via Intratumoral Administration [NUCLEIC ACID THERAPEUTICS, SCI급, 공동(참여)] 
Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells [CELL STRESS CHAPERONES, SCI급, 공동(참여), 2015] 
The LRP1-independent mechanism of PAI-1-inudced migration in CpG-ODN activated macrophages[INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, SCI급, 공동(참여), 2014] 
The PDZ-binding motif of the avian NS1 protein affects transmission of the 2009 influenza A(H1N1) virus[Biochemical and Biophysical Research Communications, SCI급, 공동(참여), 2014]
Plasminogen activator inhibitor-1 regulates infiltration of macrophages into melanoma via phosphorylation of FAK-Tyr(925)[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급, 공동(참여), 2014] 
Inhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4[BMC Microbiology, SCI급, 공동(참여), 2014]

기타

1. 주요연구주제
- 선천면역
- 백신개발
- 항체개발

2. 학회활동
- 대한 바이러스학회 평의원
- 대한 미생물학회 평의원
- 생화학분자생물학회 운영위원, 강원분회장, BMB reports 편집위원
- 대한 면역학회 평의원
- World Journal of Immunology, Editorial Board

김원근
  • 분야

    바이러스학

  • 성명

    국문 김원근

  • 직위

    조교수

  • 연구실

    의학관 3512

  • 연락처

    033-248-2632

  • 이메일

학력

- 2007-2013 마운트 시나이 아이칸 의과대학 (이학박사-미생물학)
- 1997-2005 성균관대학교 (이학사-유전공학)

주요경력

- 2018-현 한림대학교 의과대학 미생물학교실 조교수


- 2013-2018 고려대학교 의과대학 미생물학교실 연구강사


- 2013-2013 펜실베니아대학 수의과대학 병리생물학교실 박사 후 연구원


- 2010-2013 펜실베니아대학 수의과대학 병리생물학교실 객원연구원


- 2007 유타대학 의과대학 혈액학교실 연구원


- 2006-2007 샌디에고 백신연구소 연구원

연구 및 저서

1) Geum-Young Lee*, Won-Keun Kim*, Jin Sun No*, Hayne Cho Park, Yongjin Yi, Seung-Chan Cho, Jingyeong Lee, Seung-Ho Lee, Kyungmin Park, Jongwoo Kim, and Jin-Won Song, Clinical and immunological predictors of hemorrhagic fever with renal syndrome outcome during the early phase, Viruses, 14(3), 595; https://doi.org/10.3390/v14030595 (2022) *Equal contribution

 

2) Geum-Young Lee*, Won-Keun Kim*, Seungchan Cho, Kyungmin Park, Jongwoo Kim, Seung-Ho Lee, Jingyeong Lee, Young-Sun Lee, Ji Hoon Kim, Kwan Soo Byun, and Jin-Won Song, Genotyping and Molecular Diagnosis of Hepatitis A Virus in Patients Using Multiplex PCR-Based Next-Generation Sequencing, Microorganisms, 10(1), 100; https://doi.org/10.3390/microorganisms10010100 (2022) *Equal contribution

 

3) Yong Jin Yi, Minsun Kang, Won-Keun Kim, Kyungmin Huh, Jonas Klingström, Jin-Won Song, Jaehun Jung, Association between hemorrhagic fever with renal syndrome and cancers, International Journal of Infectious Diseases, https://doi.org/10.1016/j.ijid.2021.10.014 (2021)

 

4) Seung-Ho Lee, Sung-Tae Chong, Heung-Chul Kim, Terry A. Klein, Kyungmin Park, Jingyeong Lee, Jeong-Ah Kim, Won-Keun Kim, and Jin-Won Song, Surveillance and Molecular Identification of Borrelia species in Ticks collected at U.S. Army Garrison Humphreys, Republic of Korea, 2018-2019, Journal of Medical Entomology, tjab170, https://doi.org/10.1093/jme/tjab170 (2021)

 

5) Seung-Ho Lee, Kijin Kim, Jong Woo Kim, Jin Sun No, Kyungmin Park, Shailesh Budhathoki, Seung Ho Lee, Jingyeong Lee, Seung Hye Cho, Geum-Young Lee, Jusun Hwang, Heung-Chul Kim, Terry A. Klein, Chang-Sub Uhm, Won-Keun Kim*, Jin-Won Song*, Discovery and Genetic Characterization of Novel Paramyxoviruses Belonging to The Genus Henipavirus in Crocidura species in The Republic of Korea, Viruses, 13(10), 2020; https://doi.org/10.3390/v13102020 (2021) *Co-correspondence

 

6) Seungchan Cho*, Won-Keun Kim*, Jin Sun No*, Jaehun Jung, Yongjin Yi, Hyane Cho Park, Seung-Ho Lee, Geum-Young Lee, Kyungmin Park, Jeong-Ah Kim, Jongwoo Kim, Jingyeong Lee, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Jin-Won Song, Urinary Genome Detection and Tracking of Hantaan Virus from Hemorrhagic Fever with Renal Syndrome Patients Using Multiplex PCR-based Next-generation Sequencing, PLoS Neglected Tropical Diseases, 15(9):e0009707 (2021) *Equal contribution

 

7) Seung-Ho Lee, Jin Sun No, Kijin Kim, Shailesh Budhathoki, Kyungmin Park, Geum Young Lee, Seungchan Cho, Hyeok Sun Choi, Bong-Hyun Kim, Seunghee Cho, Jong Woo Kim, Jin Gyeong Lee, Seung Hye Cho, Heung-Chul Kim, Terry A. Klein, Chang-Sub Uhm, Won-Keun Kim*, Jin-Won Song*, Novel Paju Apodemus Paramyxovirus 1 and 2, Harbored by Apodemus agrarius in The Republic of Korea, Virology, 562: 40-49 (2021) *Co-correspondence

 

8) Kyungmin Park*, Won-Keun Kim*, Seung-Ho Lee, Jongwoo Kim, Jingyeong Lee, Seungchan Cho, Geum-Young Lee, Jin Sun No, Keun Hwa Lee, and Jin-Won Song, A novel genotype of Hantaan Orthohantavirus harbored by Apodemus agrarius chejuensis as a potential etiologic agent of Hemorrhagic Fever with Renal Syndrome in Republic of Korea, PLoS Neglected Tropical Diseases, 15(5):e0009400 (2021) *Equal contribution

 

9) Kyungmin Park, Seung-Ho Lee, Jongwoo Kim, Jingyeong Lee, Geum-Young Lee, Seungchan Cho, Seung Ho Lee, Kkothanahreum Park, Jin Sun No, Shailesh Budhathoki, Yu-Jin Kim, Young-Su Kim, Heung-Chul Kim, Terry A. Klein, Won-Keun Kim, and Jin-Won Song, Multiplex PCR-based Nanopore Sequencing and Epidemiological Surveillance of Hantaan orthohantavirus in Apodemus agrarius, Republic of Korea, Viruses, 13(5), 847 (2021)

 

10) Gunsup Lee, Shailesh Budhathoki, Geum-Young Lee, Kwang-ji Oh, Yeon Kyoung Ham, Young Jun Kim, Ye Rin Lim, Phuong Thi Hoang, Yongjun Lee, Seok-Won Lim, Jun-Mo Kim, Seungchan Cho, Tai-Hyun Kim, Jin-Won Song, Sukchan Lee* and Won-Keun Kim*, Broad-spectrum antiviral activity of 3D8, a nucleic acid-hydrolyzing single chain variable fragment (scFv), targeting SARS-CoV-2 and multiple coronaviruses in vitro, Viruses, 13(4), 650 (2021) *Co-correspondence

 

11) Seungchan Cho, Jon C. Allison, Kkothanahreum Park, Jin Sun No, Seung-Ho Lee, Kyungmin Park, Jongwoo Kim, Terry A. Klein, Heung-Chul Kim, Won-Keun Kim, Jin-Won Song, A Clinical Case of Scrub typhus in The United States Forces Korea Patient with Eschar and Genetic Identification of Orientia tsutsugamushi using Multiplex PCR-based Next-generation Sequencing, Pathogens, 10(4), 424, https://doi.org/10.3390/pathogens10040424 (2021)

 

12) Byoung Kwon Park, Jinsoo Kim, Sangkyu Park, Dongbum Kim, Minyoung Kim, Kyeongbin Baek, Joon-Yong Bae, Man-Seong Park, Won-Keun Kim, Younghee Lee, Hyung-Joo Kwon, MERS-CoV and SARS-CoV-2 replication can be inhibited by targeting the interaction between the viral spike protein and the nucleocapsid protein, Theranostics, 11(8):3853-3867 (2021)

 

13) Won-Keun Kim, Seungchan Cho, Seung-Ho Lee, Jin Sun No, Geum-Young Lee, Kyungmin Park, Daesang Lee, Seong Tae Jeong and Jin-Won Song, Genomic Epidemiology and Active Surveillance to Investigate Outbreaks of Hantaviruses, Frontiers in Cellular and Infection Microbiology, doi: 10.3389/fcimb.2020.532388, (2021) Review

 

14) Geum-Young Lee*, Won-Keun Kim*, Kyungmin Park*, Seung-Ho Lee, Jusun Hwang, Jin Sun No, Seungchan Cho, Daesang Lee, Dong-Hyun Song, Se Hun Gu, Man-Seong Park, Seung Tae Jung, Young-Su Kim, and Jin-Won Song, Phylogeographic Diversity and Hybrid Zone of Hantaan orthohantavirus Collected in Gangwon Province, Republic of Korea, PLoS Neglected Tropical Diseases, 14(10): e0008714 (2020) *Equal contribution

 

15) Won-Keun Kim, Coronavirus disease (COVID)-19 사태에 대한 현황과 고찰, 방재 저널 (Journal of Disaster Prevention, ISSN 1976-4294, 22 (2), 20-31 (2020)

http://www.kodipa.or.kr/HyAdmin/view.php?&bbs_id=bo01&page=&doc_num=131

 

16) Seung-Ho Lee*, Jin Sun No*, Won-Keun Kim*, Ewa Gajda, Agnieszka Perec-Matysiak, Jeong-Ah Kim, Joanna Hildebrand, Richard Yanagihara, and Jin-Won Song, Molecular epidemiology and genetic diversity of orthohantaviruses in small mammals in western Poland, American Journal of Tropical Medicine and Hygiene, 103(1): 193-199 (2020) *Equal contribution

 

17) Seung-Ho Lee*, Won-Keun Kim*, Kyungmin Park, Jin Sun No, Geum Young Lee, Heung-Chul Kim, Terry A. Klein, Mi-Sook Min, Seo-Jin Lee, Jusun Hwang, Man-Seong Park, and Jin-Won Song, Genetic Diversity and Phylogeography of Jeju Orthohantavirus (Hantaviridae) in the Republic of Korea, Virology, 543:13-19 (2020) *Equal contribution

 

18) Won-Keun Kim, Jin Sun No, Daesang Lee, Jaehun Jung, Hayne Park, Yongjin Yi, Jeong-Ah Kim, Seung-Ho Lee, Yujin Kim, Sunhye Park, Seungchan Cho, Geum-Young Lee, Dong Hyun Song, Se Hun Gu, Kkothanahreum Park, Heung-Chul Kim, Michael R. Wiley, Patrick S. G. Chain, Seong Tae Jeong, Terry A. Klein, Gustavo Palacios, and Jin-Won Song, Active Targeted Surveillance to Identify Sites of Emergence of Hantavirus, Clinical Infectious Diseases, Mar. 20th, 70(3) 464-473 (2020)

 

19) Jin Sun No*, Won-Keun Kim*, Seungchan Cho*, Seung-Ho Lee, Jeong-Ah Kim, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Michael R. Wiley, Gustavo Palacios, and Jin-Won Song, “Comparison of targeted next-generation sequencing for whole-genome sequencing of Hantaan orthohantavirus in Apodemus agrarius lung tissues, Scientific Reports, 9: 16631 (2019) *Equal contribution

 

20) Heung-Chul Kim*, Won-Keun Kim*, Jin Sun No, Seung-Ho Lee, Se Hun Gu, Sung-Tae Chong, Terry A. Klein, and Jin-Won Song, Urban Rodent Surveillance, Climatic Association and Genomic Analysis of Seoul Virus Collected at U.S. Army Garrison, Seoul, Republic of Korea, 2006-2010, American Journal of Tropical Medicine and Hygiene, 99(2): 470-476 (2018) *Equal contribution

 

21) Won-Keun Kim*, Jin Sun No*, Seung-Ho Lee, Dong Hyun Song, Daesang Lee, Jeong-Ah Kim, Se Hun Gu, Sunhye Park, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, Michael R. Wiley, Gustavo Palacios, Jin-Won Song, Multiplex PCR-based next-generation sequencing and global diversity of Seoul virus in humans and rats, Emerging Infectious Diseases, 24(2): 249-257 (2018) *Equal contribution

[http://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=52844&idauthorid=24053&ttype=2]

 

22) Heung-Chul Kim*, Won-Keun Kim*, Terry A. Klein, Sung-Tae Chong, Peter V. Nunn, Jeong-Ah Kim, Seung-Ho Lee, Jin Sun No and Jin-Won Song, Hantavirus Surveillance and Genetic Diversity Targeting Small Mammals at Camp Humphreys, a US Military Installation and new expansion site, Republic of Korea, PLoS One, 12(4): e0176514 (2017) *Equal contribution

 

23) Seung-Ho Lee*, Won-Keun Kim*, Jin Sun No, Jeong-Ah Kim, Jin Il Kim, Se Hun Gu, Heung-Chul Kim, Terry A. Klein, Manseong Park and Jin-Won Song Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea, Scientific Reports, 7: srep44369 (2017) *Equal contribution [KU BK21 Best research award, Korea University Brain Korea 21]

[http://science.ytn.co.kr/program/program_view.php?s_mcd=0082&s_hcd=0006&key=201703271155517458]

 

24) Dong Hyun Song*, Won-Keun Kim*, Se Hun Gu, Daesang Lee, Jeong-Ah Kim, Jin Sun No, Seung-Ho Lee, Michael R. Wiley, Gustavo Palacios, Jin-Won Song, Seong Tae Jeong Sequence-Independent, Single-Primer Amplification Next-Generation Sequencing of Hantaan virus cell culture-based isolates, American Journal of Tropical Medicine and Hygiene, 96: 389-394 (2017) *Equal contribution

 

25) Jeong-Ah Kim, Won-keun Kim, Jin Sun No, Seung-Ho Lee, Sook-YoungLee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Man-Seong Park, Heung Chul Kim, Terry A. Klein, and Jin-Won Song, Genetic Diversity and Reassortment of Hantaan Virus Tripartite RNA Genomes in Nature, the Republic of Korea, PLoS Neglected Tropical diseases, 10(6): e0004650 (2016)

 

26) Sook-Young Lee, Jeong-Hoon Kim, Tae-Kun Seo, Jin Sun No, Hankyeom Kim, Won-keun Kim, Han-Gu Choi, Sung-Ho Kang, Jin-Won Song, Genetic and Molecular Epidemiological Characterization of a Novel Adenovirus in Antarctic Penguins Collected between 2008 and 2013, PLoS One, 11(6): e0157032 (2016)

 

27) Won-Keun Kim, Jeong-Ah Kim, Dong Hyun Song, Daesang Lee, Yong Chul Kim, Sook-Young Lee, Seung-Ho Lee, Jin Sun No, Ji Hye Kim, Jeong Hoon Kho, Se Hun Gu, Seong Tae Jeong, Michael Wiley, Heung-Chul Kim, Terry A. Klein, Gustavo Palacios, and Jin-Won Song, Phylogeographic analysis of Hemorrhagic Fever with Renal Syndrome (HFRS) Patients and Natural Hosts using Multiplex PCR-based Next Generation Sequencing, Scientific Reports, 6: srep26017 (2016)

[http://science.ytn.co.kr/program/program_view.php?s_mcd=0082&s_hcd=&key=201605261101459441&page=1]

 

28) Jin Sun No*, Won-keun Kim*, Jeong-Ah Kim, Seung-Ho Lee, Sook-Young Lee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, and Jin-Won Song, Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in a highly endemic area, the Republic of Korea, Microbiology and Immunology, 60(4): 268-271 (2016) *Equal contribution

 

29) Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Galr Jr., Arjun Raj, Carolina B. López, Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I, mBio, 6 (5): e01265-15 (2015)

 

30) Terry A. Klein, Heung-Chul Kim, Sung-Tae Chong, Jeong-Ah Kim, Sook-Young Lee, Won-Keun Kim, Peter V. Nunn, Jin-Won Song, Hantaan Virus Surveillance Targeting Small Mammals at Nightmare Range, a High Elevation Military Training Area, Gyeonggi Province, Republic of Korea, PLoS One, 10(4): e0118483 (2015)

 

31) Won-keun Kim, Deepika Jain, Melissa D. Sánchez, Cynthia J. Koziol-White, Krystal Matthews, Moyar Q. Ge, Angela Haczku, Reynold A. Panettieri Jr., Matthew B. Frieman, and Carolina B. López, Deficiency of MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation, American Journal of Respiratory and Critical Care Medicine, 189 (4): 437-448 (2014)[http://bric.postech.ac.kr/myboard/read.php?id=38494&idauthorid=24053&Board=HBS_TREATISE&ttype=&skin=hbs_treatise]

 

32) Xiomara Mercado-López, Christopher R. Cotter, Won-keun Kim, Yan Sun, Luis Muñoz, Karla Tapia, and Carolina B. López, Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Interfering Viral Genome, Vaccine, 31(48): 5713-5721 (2013)

 

33) Karla Tapia*, Won-keun Kim*, Yan Sun, Xiomara Mercado-López, Emily Dunay, Megan Wise, Michael Adu, and Carolina B. López, Defective viral genomes arising in vivo provide critical danger signals for the triggering of lung anti-viral immunity, PLoS Pathogens, 9(10): e1003703 (2013) *Equal contribution [Featured Research]

 

34) Byung O. Lee, Joyce E. Jones, Cory J. Peters, David Whitacre, Lars Frelin, Janice Hughes, Won-keun Kim, and David R. Milich, Identification of a unique double-negative regulatory T-cell population, Immunology, 134(4): 434-447 (2011)

 

35) Christopher R. Cotter, Won-keun Kim, Marie L. Nguyen, Jacob S. Yount, Carolina B. López, John A. Blaho, and Thomas M. Moran, The virion host shutoff protein of Herpes Simples Virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling, Journal of Virology, 85(23): 12662-12672 (2011)

기타

■ Research Interests
1) Development of antivirals
2) Next-generation sequencing: Comparative genomics
3) Virus-host interaction: Virology, Immunology, Epidemiology 
4) Metagenomic analysis of virome

 

■ Patents
1) Composition for detecting Hepatitis A virus comprising multiplex primer set, kit for diagnosing Hepatitis A and method for obtaining Hepatitis A virus whole genome sequence (Patent number: 10-2207348) ‘다중 복합 프라이머 세트를 포함하는 A형 간염 바이러스 검출용 조성물, A형 간염 진단용 키트 및 A형 간염 바이러스의 전장 유전체 서열 획득 방법’

2) Hantavirus Whole Genome Sequence Identification Methods Using a Multiplex PCR-based Next-Generation Sequencing and Uses Thereof (Patent number: 10-1815105) ‘멀티플렉스 PCR-기반된 차세대 시퀀싱을 이용한 한타바이러스 전장 유전체 서열 획득 방법 및 이의 용도’ 

 

■ Community activities
1) Won-Keun Kim, 보이지 않는 바이러스 전쟁, 그 최전방에 자리한 백신 ‘mRNA 백신, 인류에게 생명의 메신저가 되다’ , 성대신문, Mar., 15th, 2021 

2) Won-Keun Kim, 모더나·화이자가 '픽'한 'mRNA'…아이진·에스티팜 '주목', 한국 경제 TV, Aug., 24th, 2020 https://www.wowtv.co.kr/NewsCenter/News/Read?articleId=A202008240264

3) Won-Keun Kim, 바이러스 VS 인간 2부 ‘백신 X’, SBS 스폐셜, May 3rd, 2020 

4) Won-Keun Kim, 인수공통병의 발생 동향과 향후 전망, BRIC View 동향리포트, BRIC View 2019-R11, Nov. 5th, 2019 

5) Won-Keun Kim, mRNA 백신- 백신학의 새로운 시대, BRIC View 리뷰논문요약, BRIC View 2019-R11, May 23rd, 2019

허선
  • 분야

    기생충학

  • 성명

    국문 허선

  • 직위

    교수

  • 연구실

    의학관 5층 3504

  • 연락처

    033-248-2652

  • 이메일

학력

-1976-1982 M.D., Seoul National University College of Medicine, Seoul, Korea

-1986-1988 M.Sc. (Parasitology), Seoul National University Seoul, Korea

-1988-1990 Ph.D. (Parasitology), Seoul National University Seoul, Korea 

주요경력

-1988-Present Instructor, Assistant Professor, Associate Professor and Professor, Dept. of Parasitology, College of Medicine, Hallym University, Chuncheon, Korea

-2002-Present Director Institute of Medical Education, Hallym University, Chuncheon, Korea

-2005-Present Editor, Journal of Educational Evaluation for Health Professions

-2011-Present Board member, Korean Council of Science Editor

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

Was the number of submissions to scholarly journals in Korea affected by the COVID-19 pandemic?, [Science Editing, SCOPUS ,단독 ,2021]
Korean editors’ and researchers’ experience in preprint and attitudes towards the preprint policy, [Science Editing, SCOPUS ,교신 ,2021]
Development Status of the Korean Journal of Child Studies 4 Years After the Suggestions made in 2016, [e Korean Journal of ChildStudies, KCI ,단독 ,2020]
How Annals of Dermatology Has Improved the Scientific Quality and Ethical Standards of its Articles in the Two-Year Period since October 2018, [Annals of dermatololgy, SCI급 ,단독 ,2020]
Position of Ultrasonography in the scholarly journal network based on bibliometrics and developmental strategies for it to become a top-tier journal, [Ultrssonography, SCI급 ,단독 ,2020]
Influence of the COVID-19 pandemic on Asian scholarly journal editors’ daily life, work, and opinions on future journal development, [Science Editing, SCOPUS ,교신 ,2020]
Cause-of-death statistics in 2018 in the Republic of Korea, [Journal of the Korean Medical Association, SCOPUS ,교신 ,2020]
Changes in bibliographic information associated with Korean scientific journals from 2011 to 2019, [Science Editing, SCOPUS ,교신 ,2020]
GAAP: A Genome Assembly + Annotation Pipeline, [Biomed Research International, SCI급 ,제1저자 ,2019]
Goodness of fit of the items used in the 2nd cycle of evaluation and accreditation of medical schools by the Korea Institute of Medical Education and Evaluation based on the Rasch model, [Journal of Educational Evaluation for Health Professions, SCOPUS ,교신 ,2019]
Korean medical students’ knowledge about and attitudes towards plagiarism according to their commission of plagiarism, [Science Editing, SCOPUS ,교신 ,2019]
How many retracted articles indexed in KoreaMed were cited 1 year after retraction notification, [Science Editing, SCOPUS ,교신 ,2019]
Child injury death statistics from 2006 to 2016 in the Republic of Korea, [Journal of the Korean Medical Association, SCOPUS ,교신 ,2019]
Current and planned adoption of data sharing policies by editors of Korean scholarly journals, [Science Editing, SCOPUS ,교신 ,2019]
Journal Metrics of Infection & Chemotherapy and Current Scholarly Journal Publication Issues, [Infection & Chemotherapy, SCOPUS ,단독 ,2018]
Cause-of-death statistics in 2016 in the Republic of Korea, [Journal of the Korean Medical Association, SCOPUS ,단독 ,2018]
Journal metrics of Clinical and Molecular Hepatology based on the Web of Science Core Collection, [Clinical and Molecular Hepatology, SCOPUS ,단독 ,2018]
The relationship of individual examinee characteristics and acceptability of smart device-based testing to test score in the practice test of the Korea Emergency Medicine Technician Licensing Examination, [Journal of Educational Evaluation for Health Professions, SCOPUS ,교신 ,2018]
Bibliometric analysis of publications from North Korea indexed in the Web of Science Core Collection from 1978 to July 2018, [Science Editing, SCOPUS ,교신 ,2018]
Comparison of the patterns of duplicate articles between KoreaMed and PubMed journals published from 2004 to 2009 according to the categories of duplicate publications, [Science Editing, SCOPUS ,교신 ,2018]
The rapid internationalization of Annals of Pediatric Endocrinology & Metabolism as evidenced by journal metrics., [Annals of Pediatrics Endocrinology and metabolism, KCI ,단독 ,2017]
Usefulness of DETECT program to assess internal structure of dimensionality in simulated data and results of Korean Nursing Licensing Examination., [Journal of educational evaluation for health professions, SCOPUS ,교신 ,2017]
$$Bibliometric and content analysis of medical articles in the PubMed database published by North Korean authors from 1997 to July 2017, [Science Editing, SCOPUS ,교신 ,2017]
Infant, maternal, and perinatal mortality statistics in the Republic of Korea, 2014., [Journal of the Korean Medical Association, SCOPUS ,교신 ,2017]
Bibliometric analysis of publications from North Korea indexed in the Web of Science Core Collection from 1988 to 2016, [Science Editing, SCOPUS ,교신 ,2017]
Characteristics of Retractions from Korean Medical Journals in the KoreaMed Database: A Bibliometric Analysis., [PLOS One, SCI급 ,제1저자 ,2016]
Promotion of the Journal of Exercise Rehabilitation to the$$international level based on journal metrics, [Journal of Exercise Rehabilitation, KCI ,단독 ,2016]
Journal of Gastric Cancer's Promotion to International Journal from the Perspective of Biliometric Analysis., [Journal of Gastric Cancer, SCOPUS ,단독 ,2016]
Analysis of the suitability of the Korean Federation of Science and Technology Societies journal evaluation tool, [Learned Publishing, SCI급 ,교신 ,2016]
Cause-of-death statistics in the Republic of Korea, 2014., [Journal of the Korean Medical Association, SCOPUS ,교신 ,2016]
How to promote the Korean Journal of Child Studies to an international journal, [Korean Journal of Child Stuies, KCI ,교신 ,2016]
Draft Genome of Toxocara canis, a Pathogen Responsible for Visceral Larva Migrans, [Korean Journal of Parasitology, SCI급 ,공동(교신) ,2016]

The Elevation of Annals of Rehabilitation Medicine to the Status of an International Journal After Adopting an English-Only Policy. [Annals of Rehabilitation Medicine, SCOPUS, 단독, 2015] 
Evidence of the Internationalization of Clinical Endoscopy Based on Journal Metrics. [Clinical Endoscopy, SCOPUS, 단독, 2015]
How much progress has been made in journal metrics two years after the citation analysis of the Korean Journal of Urology? [Korean Journal of Urology, SCOPUS, 단독, 2015] 
Using Journal Article Tag Suite extensible markup language for scholarly journal articles written in Korean[Science Editing, 국내일반, 공동(교신), 2014] 
Ethical Issue in Preparing Manuscript on Esthetic Patients[Archives of Aesthetic Plastic Surgery, KCI등재, 단독, 2014] 
의학교육에서 컴퓨터바탕검사와 문항은행 데이터베이스 구축[Korean Medical Education Review, KCI후보, 단독, 2014]
Correlation among the citation indices of Korean scientific journals listed in international databases[Science Editing, 국내일반, 공동(교신), 2014] 
Increase in frequency of citation by SCIE journals of non-Medline journals after listing in an open access full-text database[Science Editing, 국내일반, 공동(교신), 2014] 
How Far Has the International Neurourology Journal Progressed Since Its Transformation Into an English Language Journal?[International Neuroruology Journal, SCI급, 단독, 2014] 
학술지에 적용하는 새 정보기술: ORCID, CrossMark, and FundRef[Journal of the Korean Medical Association, SCI급, 단독, 2014]
Journal Metrics-Based Position of Diabetes & Metabolism Journal after the Change of Its Text Language to English[Diabetes and Metabolism Journal, SCI급, 단독, 2014] 
Parasitic Diseases as the Cause of Death of Prisoners of War during the Korean War (1950-1953)[Korean Journal of Parasitology, SCI급, 단독, 2014]
What Happened When CrossCheck Was Not Used for a Month in Journal of Neurogastroenterology and Motility?[Journal of Neurogastroenterology and Motility, SCI급, 단독, 2014] 
How Journal Metrics Illustrate the Transformation of Archives of Plastic Surgery into an International Journal.[Archives of Plastic Surgery, SCI급, 단독, 2014]
Journal Article Tag Suite 1.0: National Information Standards Organization standard of journal extensible markup language[Science Editing, 국내일반, 단독, 2014] 
Uploading garbage files to the DOI system of a journal: a new type of misconduct[Learned Publishing, SCI급, 공동(교신), 2014]
국제 수준 학술지로 도약과 의사소통술[Korean Journal of Medical Education, KCI등재, 단독, 2014]
Coding practice of the Journal Article Tag Suite extensible markup language[Science Editing, 국내일반, 단독, 2014] 
"What is the position of Clinical and Experimental Reproductive Medicine in its scholarly journal network based on journal metrics?[Clinical and Experimental Reproductive Medicine, SCI급, 단독, 2014]"
Asian Science Editors’ Conference and Workshop 2014[European Science Editing, SCI급, 단독, 2014]
 
2. 공동저자: 공동저자(참여) 

Transitions in Problematic Internet Use: A One-Year Longitudinal Study of Boys, [PSYCHIATRY INVESTIGATION, SCI급 ,공동(참여) ,2019]
Molecular Identification of Anisakis Larvae Extracted by Gastrointestinal Endoscopy from Health Check-up Patients in Korea, [KOREAN JOURNAL OF PARASITOLOGY, SCI급 ,공동(참여) ,2019]
Molecular Genetic Findings of Spirometra decipiens and S. ranarum in Korea, [Korean Journal of Parasitology, SCI급 ,공동(참여) ,2018]
How do medical students differ in their interpersonal needs?, [BMC Medica Education, SCI급 ,공동(참여) ,2017]
Decreased Total Antioxidant Activity in Major Depressive Disorder Patients Non-Responsive to Antidepressant Treatment., [Psychiatry investigation, SCI급 ,공동(참여) ,2016]

Human Infections with Spirometra decipiens Plerocercoids Identified by Morphologic and Genetic Analyses in Korea [Korean Journal of Parasitology, SCI급, 공동(참여), 2015]
Cross-reactivity of Toxocariasis with Crude Antigen of Toxascaris leonina Larvae by ELISA [Journal of Korean Medical Science, SCI급, 공동(참여), 2015] 
개 회충 게놈 응용 사례에서 공개용 분석 툴을 사용한 드래프트 게놈 어셈블리 생성[TIISE Transactions on Computing Practices, KCI등재, 공동(참여), 2014] 

기타

1. 주요연구주제
- Epidemiology and genetic biology of toxocariasis
- Computerized adaptive testing in evaluation of medical education
- Consultation for the globalization of the medical journal from Korea


2. 학회활동
- Korean Society for Parasitology (Korea)
- The Korean Society of Medical Education (Korea)
- Korean Council of Science Editors (Korea)

김동현
  • 분야

    역학

  • 성명

    국문 김동현

  • 직위

    교수

  • 연구실

    의학관 5층 3510

  • 연락처

    033-248-2660

  • 이메일

학력

1993-1997 서울대학교 역학(Epidemiology) 박사

1990-1991 Uniformed Services University of the Health Sciences 보건학 석사

1980-1987 서울대학교 의과대학 의학 학,석사

주요경력

2021.10 ~ 현재 단계적 일상회복지원위원회(경제민생분과) 위원

 

2021.5 ~ 현재 보건복지부 손실보상심의위원회 위원

 

2021.3 ~ 현재 강원도 감염병관리위원회 위원장

 

2020.6 ~ 현재 강원도 통합건강증진사업지원단 단장

 

2020.4 ~ 현재 보건복지부 생활방역위원회 위원

 

2020.4 ~ 현재 질병관리청 감염병위기관리전문위원회 위원

 

2020.4 ~ 현재 질병관리청 백신분야 전문가 자문위원회 위원

 

2018-현재   한림대학교 의과대학 보건과학대학원장

2018-2020  대한민국 역학 학회장

1999-2001  하버드대학교 보건대학원 교환교수

1995-현재   한림대학교 의과대학 교수

1992-1995  서울대학교 의과대학 예방의학 전공의

1989-1990  US Army Medical Research Unit-Republic of Korea 역학 분야 연구원

 

연구 및 저서

[논문]

Folate, alcohol, ADH1B and ALDH2 and colorectal cancer risk, [Public Health Nutrition, SCI급 ,교신 ,2020]

 

Understanding and interpretation of case fatality rate of coronavirus disease 2019, [Journal of Korean Medical Science, SCI급 ,교신 ,2020]

 

Absence of pain in subjects with advanced radiographic knee osteoarthritis, [BMC Musculoskeletal Disorders, SCI급 ,공동(참여) ,2020]

 

Identification of novel loci and new risk variant in known loci for colorectal cancer risk in East Asians, [CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, SCI급 ,공동(참여) ,2020]

 

Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk, [Europena J Cancer Prevention, SCI급 ,공동(참여) ,2019]

 

Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer, [GASTROENTEROLOGY, SCI급 ,공동(참여) ,2019]

 

지역 간 건강수준 및 건강행태 변이요인 연구 : 지역사회건강조사와 지역 특성 연계자료를 기반으로, [대한보건연구, KCI ,교신 ,2017]

 

지역사회건강조사의 자가보고 키, 몸무게 그리고 체질량지수의 정확성, [Journal of Health Informatics and Statistics, KCI ,교신 ,2017]

 

Identification of pleiotropic genetic variants affecting osteoporosis risk in a Korean elderly cohort, [Journal of Bone and Mineral Metabolism, SCI급 ,공동(참여) ,2017]

 

Relationships between cognitive function and body composition among community dwelling older adults: a cross-sectional study, [BMC Geriatrics, SCI급 ,공동(교신) ,2017]

 

지역사회기반 공중보건정책 강화방안, [보건행정학회지, KCI ,단독 ,2016]

 

Gender Differences in Sleep Disturbance among Elderly Koreans: Hallym Aging Study, [Journal of Korean Medical Science, SCI급 ,교신 ,2016]

 

Evaluation Study on the Effectiveness of Suicide Prevention Program among the Elderly Living Alone?Case of Nowon-gu, Seoul, [Korean Public Health Research, KCI ,교신 ,2016]

 

Quercetin intake, MATE1 polymorphism, and metabolic syndrome in Korean population: Hallym aging study, [Food Science and Biotechnology, KCI ,공동(참여) ,2016]

 

Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk, [GASTROENTEROLOGY, SCI급 ,공동(참여) ,2016]

 

Body Composition, Sarcopenia, and Suicidal Ideation in Elderly Koreans: Hallym Aging Study, [Journal of Korean Medical Science, SCI급 ,공동(참여) ,2016]

 

Cohort Profile: The Korean Genome and Epidemiology Study (KoGES) Consortium, [Int J Epidemiol, SCI급 ,공동(참여) ,2016]

 

The prevalence of periarticular lesions detected on magnetic resonance imaging in middle-aged and elderly persons: a cross-sectional study, [BMC Musculoskeletal Disorders, SCI급 ,공동(참여) ,2016]

 

Structural factors of the Middle East respiratory syndrome Coronavirus outbreak as a public health crisis in Korea and future response strategies. (J Prev Med Public Health, 2015)

 

Relationship between Metabolic Syndrome and Lower Urinary Tract Symptoms: Hallym Aging Study (BIOMED RESEARCH INTERNATIONAL, 2015)

 

Trend of suicide rates according to urbanity among adolescents by gender and suicide method in Korea, 1997-2012 International (Journal of Environmental Research and Public Health, 2015)

 

Gender differences in adiponectin levels and body composition in older adults: (Hallym aging studyBMC Geriatrics, 2014)

 

Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: (The Hallym Aging StudyGenes and Genomics, 2014)

 

Cohort Profile: Community-based prospective cohort from the National Cancer Center, Korea Int (J Epidemiol, 2015)

 

Vegetable intake, but not fruit intake, was associated with a reduction in the risk of cancer incidence and mortality in middle-aged Koran men (J Nutrition, 2015)

 

A genome-wide association study of copy-number variation identifies putative loci associated with osteoarthritis in Koreans. (BMC Musculoskeletal Disorders. 2015)

 

Household and area income levels are associated with smoking status in the Korean adult population (BMC Public Health, 2015)

 

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk (NATURE GENETICS, 2014)

 

Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian (populationsHypertension Research, 2014)

 

Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East (AsiansInternational Journal of Cancer, 2014)

 

Population-Attributable Causes of Cancer in Korea: Obesity and Physical (InactivityPLOS ONE, 2014)

 

Association between BMI, Smoking, and Alcohol with Prostate Cancer Mortality in the Asia Cohort ConsortiumAmerican (J Epidemiology, 2014)

기타

[주요연구주제]

 

1. 자살예방을 위한 코호트 구축 연구

2. 지역사회 건강수준 평가연구

3. 지역사회기반 노인연구: 한림노년연

4. 유전체 코호트 구축사업: 검진자코호트 구축

5. 시료은행 구축

 

 

[학회활동]

 

1. 한국 역학회

2. 대한 예방의학회

3. Society for Epidemiology Research

4. Gerontological Society of America 

사진없음
  • 분야

    의료관리

  • 성명

    국문 최용준

  • 직위

    교수

  • 연구실

    의학관 3608

  • 연락처

    033-248-2666

  • 이메일

학력

-2002–2006 서울대학교(박사-의료관리학)

-2000–2002 서울대학교(석사-의료관리학)

-1988–1995 서울대학교(학사-의학) 

주요경력

-2015–현재 건강보험심사평가원 객원 연구 위원

-2015–현재 보건행정학회지 심사 위원

-2015–현재 사회 보건학 협동 과정 주임 교수

-2014–현재 사단 법인 시민건강증진연구소 감사

-2011–2012 한국사회정책 편집 위원

-2011–2012 사단 법인 시민건강증진연구소 연구원

-2006–2012 한국건강형평성학회 운영 위원

-2002-현재 사회의학연구소 연구 위원

-1999–2002 서울대학교 의과대학 의료관리학교실 전공의

-1998-1999 서울대학교 병원 수련의 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

- A pilot study of team-based primary health care for people with disabilities in South Korea, [JOURNAL OF INTERPROFESSIONAL CARE, SCI급 ,교신 ,2019]
- How Much Do Older Adults Living Alone in Rural South Korea Know About Dementia?, [예방의학회지, KCI ,교신 ,2018]
- 일차의료기관의 고혈압·당뇨병 환자 포괄평가 및 계획수립 시간과 수가, [대한의사협회지, SCOPUS ,교신 ,2017]
- 농촌 지역 독거노인 말벗 도우미 가정방문의 효과, [정신보건과 사회사업, KCI ,교신 ,2016]
- The ecology of medical care in Korea, [Journal of Korean Medical Sciences, SCI급 ,교신 ,2016]
- Current status of health services research in primary care in Korea, [Journal of the Korean Medical Association, SCOPUS ,교신 ,2016]
- Effects of an empowerment program for self-management among rural older adults with hypertension in South Korea, [AUSTRALIAN JOURNAL OF RURAL HEALTH, SCI급 ,교신 ,2016]

- Effects of an empowerment program for self-management among rural older adults with hypertension in South Korea [Australian Journal of Rural Health, SCI급, 공동(교신), 2015] 

- 만성 질환 관리 평가 도구를 이용한 보건소 만성 질환 관리 수준 평가 [보건행정학회지, KCI 등재, 공동(제일), 2014] 
 
2. 공동저자: 공동저자(참여) 

- The New Diagnosis-Related Group Reimbursement System and Laboratory Test Quality in Korea: Analysis of External Quality Assessment Results, [HEALTHCARE, SCI급 ,공동(참여) ,2020]

- 고위험신생아 임종에 대한 신생아 중환자실 간호사의 대처 경험, [보건정보통계학회지, KCI ,공동(참여) ,2019]

- Primary Care Comprehensiveness Can Reduce Emergency Department Visits and Hospitalization in People with Hypertension in South Korea, [INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, SCI급 ,공동(참여) ,2018]

- Origins and Evolution of Social Medicine and Contemporary Social Medicine in Korea, [예방의학회지, KCI ,공동(참여) ,2017]
- Older adults’ perception of chronic illness management in South Korea [Journal of Preventive Medicine and Public Health, SCOPUS 및 KCI 등재, 공동(참여), 2014]
- Do Not Resuscitate (DNR)와 Advance Directives (AD)에 대한 환자 보호자와 의료인의 인식 [한국호스피스완화의료학회지, KCI 등재, 공동(참여), 2014] 
- 델파이 법을 이용한 일차의료 개념 정의: 이차 출판 [보건행정학회지, KCI 등재, 공동(참여), 2014] 

기타

1. 주요 연구 주제
- 일차의료
- 만성 질환 관리 평가 
- 보건의료 관리 연구 일반


2. 학회 활동
- 대한예방의학회
- 한국보건행정학회
- 한국건강형평성학회
- 한국농촌의학지역보건학회

서준교
  • 분야

    의학유전학

  • 성명

    국문 서준교

  • 직위

    교수

  • 연구실

    자연과학관 3층 7310

  • 연락처

    033-248-2692

  • 이메일

학력

1991-1994 Nagoya 대학교(박사-분자유전학)

1989-1991 Nagoya 대학교(석사-유전학)

1984-1988 경북대학교(학사-동물자원과학) 

주요경력

2012-현재 실험동물센터장

2012-2018 의과대학 교학부학장/의학과장

2010-2011 The University of British Columbia 의과대학 방문교수

2009-2010 실험동물센터장

2008-2010 의학과 교학학장보/의학과장

2007-2009 중앙실험관 실험동물부장

2004-2006 한림대학교 학생생활관장

2002-2003 The Johns Hopkins 의과대학 방문교수

1996-현재 의과대학 의학유전학교실 전임강사, 조교수, 부교수, 교수

1995-1996 The Johns Hopkins 의과대학 HHMI 연구원

1994-1995 일본 국립정신신경센터 신경연구소 연구원  

연구 및 저서

- 주저자: 제1저자, 공동저자(교신), 단독

Sex differences in glucose metabolism of streptozotocin-induced diabetes inbred mice (C57BL/6J), [Applied Biological Chemistry, SCI급 ,교신 ,2020]
The Wild Mouse (Micromys minutus): Reservoir of a Novel Campylobacter jejuni Strain, [FRONTIERS IN MICROBIOLOGY, SCI급 ,공동(교신) ,2020]
Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet, [Biochemical and Biophysical Research Communications, SCI급 ,공동(교신) ,2020]
Delayed onset of obesity and glucose tolerance in interleukin 18 deficient mice by single housed condition, [APPLIED BIOLOGICAL CHEMISTRY, SCI급 ,교신 ,2019]
Comparing the Superficial Vasculature of the Central Nervous System in Six Laboratory Animals: A Hypothesis About the Role of the "Circle of Willis", [ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, SCI급 ,공동(교신) ,2019]
Applicability of vital staining and tissue clearing to vascular anatomy and melanocytes' evaluation of temporal bone in six laboratory species, [ANATOMIA HISTOLOGIA EMBRYOLOGIA, SCI급 ,공동(교신) ,2019]
Genetic and morphometric characteristics of Korean wild mice (KWM/Hym) captured at Chuncheon, South Korea, [Laboratory Animal Research, KCI ,교신 ,2018]
Aged black garlic extract regulates lipid metabolism by inhibiting lipogenesis and promoting lipolysis in mature 3T3-L1 adipocytes, [Food Sci Biotechnol, SCI급 ,교신 ,2018]
Improving glycemic control in model mice with type 2 diabetes by increasing superoxide dismutase (SOD) activity using silk fibroin hydrolysate (SFH), [BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급 ,교신 ,2017]
Over-expression of myosin7A in cochlear hair cells of circling mice, [Laboratory Animal Research, KCI ,교신 ,2017]
Comparing the Organs and Vasculature of the Head and Neck in Five Murine Species, [IN VIVO, SCI급 ,공동(교신) ,2017]
Rapid and efficient identification of the mouse leptin receptor mutation (C57BL/KsJ-db/db) by tetra-primer amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) analysis, [Laboratory Animal Research, KCI ,교신 ,2016]

Anti-adipogenic Effects in 3T3-L1 Cells of Acetone Extracts and Fractions from Styrax japonica Fruit. [Food Sci Biotechnology, SCI급, 공동(교신), 2015]

Anti-apoptotic effects of silk fibroin hydrolysate in RIN5F cell on high glucose condition. [Animal Cells and System, SCI급, 공동(교신), 2015]

Anti-obesity Effects of the Stem Bark of Japanese Horse Chestnut (Aesulus turbinate) in 3T3-L1 Preadipocytes. [Food Sci Biotechnology, SCI급, 공동(교신), 2014]

 

- 공동저자: 공동저자(참여)

Metagenomic Analysis of the Gut Microbiota of Wild Mice, a Newly Identified Reservoir of Campylobacter, [FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, SCI급 ,공동(참여) ,2021]
Silk Fibroin Promotes the Regeneration of Pancreatic beta-Cells in the C57BL/KsJ-Lepr(db/db) Mouse, [MOLECULES, SCI급 ,공동(참여) ,2020]
Clusterin is highly expressed in tubular complexes during spontaneous pancreatitis of spontaneous hypertensive rats, [JOURNAL OF VETERINARY MEDICAL SCIENCE, SCI급 ,공동(참여) ,2018]
Complete Genome Sequencing and Comparative Genomic Analysis of Helicobacter Apodemus Isolated From the Wild Korean Striped Field Mouse (Apodemus agrarius) for Potential Pathogenicity, [FRONTIERS IN PHARMACOLOGY, SCI급 ,공동(참여) ,2018]
Insulin effect on hearing recovery in idiopathic sudden sensorineural hearing loss: Retrospective study of 145 patients, [Clin Otolaryngol, SCI급 ,공동(참여) ,2017]
Reduction of dynamin 1 in the hippocampus of aged mice is associated with the decline in hippocampaln dependent memory, [Molecular Medicine Reports, SCI급 ,공동(참여) ,2016]
Fine tuning of Rac1 and RhoA alters cuspal shapes by remolding the cellular geometry, [SCIENTIFIC REPORTS, SCI급 ,공동(참여) ,2016]Helicobacter apodemus sp. nov., a new Helicobacter species identified from the gastrointestinal tract of striped field mice in Korea. [Journal of Veterinary Science, SCI급, 공동(참여), 2015]

Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride. [Genes & Genomics, SCI급, 공동(참여), 2015]

Comparison of N-methyl-D-aspartate receptor subunit 1 and 4-hydroxynonenal in the hippocampus of natural and chemical-induced aging accelerated mice. [Neurochem Res, SCI급, 공동(참여), 2014]

Genetic risk assessment for cardiobascular disease wuth seven genes associated with plasma C-reactive protein concentrations in Asian populations. [Hypertension Research, SCI급, 공동(참여), 2014]

 

기타

■ 주요 연구 주제

1. 모델 동물을 활용한 난청 발병 기전 연구

2. 당뇨병 발병 기전 연구 및 치료제 개발

3. 야생 유래 근교계 마우스 개발 및 활용

■ 학회활동

1. 한국실험동물학회 이사(2019-2023)

2. 한국실험동물학회 부회장(2021-2023)

3. Laboratory Animal Research 편집위원장(2008-2015) 

박지완
  • 분야

    의학유전학

  • 성명

    국문 박지완

  • 직위

    교수

  • 연구실

    자연과학관 3층 7313

  • 연락처

    033-248-2691

  • 이메일

학력

◦ 2000-2005 Johns Hopkins Bloomberg School of Public Health, USA (PhD, 유전역학)

 

◦ 1987-1989 서울대학교 보건대학원 (석사)

 

◦ 1983-1987 고려대학교 (학사)

주요경력

-2018-현재 한림대학교 의과대학 의학과 교수

-2009-2018 한림대학교 의과대학 의학과 조교수/부교수

-2006-2009 삼성 생명과학연구소 책임연구원/성균관대학교 의과대학 연구교수

-2006-2007 서울대학교 생물정보학 강사

-2005-2006 Johns Hopkins 보건대학원 박사후연구원/강사

-2000-2005 2000-2005 Johns Hopkins 보건대학원 조교/연구원

-1990-1992 미육군 의학연구소 연구원

 

연구 및 저서

1. 주저자: 제1저자, 공동저자(교신), 단독 

- The Liability Threshold Model for Predicting the Risk of Cardiovascular Disease in Patients with Type 2 Diabetes: A Multi-Cohort Study of Korean Adults, [Metabolites, SCI급 ,공동(교신) ,2020]

 

- Identification of pleiotropic genetic variants affecting osteoporosis risk in a Korean elderly cohort [Journal of Bone and Mineral Metabolism, SCI급, 공동(교신), 2019] 

 

- Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia [BMC Medical Genetics, SCI급, 공동(교신), 2017]

 

- Risk prediction of pulmonary tuberculosis using genetic and conventional risk factors in adult Korean population [PLoS One, SCI급, 공동(교신), 2017]

 

- Genetic Effect of Transforming growth factor alpha Gene Variants to the Risk of Nonsyndromic Cleft Lip with or without Palate in Korean Populations [The Cleft Palate-Craniofacial Journal, SCI급, 공동(교신), 2015]


- Interactions of Genetic and Non-genetic Factors on Plasma hs-CRP Concentration in a Korean Community-based Cohort Study [Genes & Genomics, SCI급, 공동(교신), 2015] 


- Male-specific genetic effect on hypertension and metabolic disorders[HUMAN GENETICS, SCI급, 공동(교신), 2014] 


- Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian populations[HYPERTENSION RESEARCH, SCI급, 공동(교신), 2014] 


 
2. 공동저자: 공동저자(참여) 

- Pan-cancer analysis of whole genomes [Nature, SCI급, 공동(참여), 2020]

 

- Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: The Hallym Aging Study [Genes & Genomics, SCI급, 공동(참여), 2015] 


- Investigation of Parental Transmission of RUNX2 Single Nucleotide Polymorphism and Its Association With Nonsyndromic Cleft Lip With or Without Palate[CLEFT PALATE-CRANIOFACIAL JOURNAL, SCI급, 공동(참여), 2014] 

기타

1. 주요연구주제
- 유전체 역학
- 유전체 연관성 연구
- 질병위험예측 

2. 학회활동
- American Society of Human Genetics
- International Human Genome Organization
- 한국 유전체학회

 

3. 수상

2018 보건의료기술진흥 유공자 복지부 장관상 수상

임만섭
  • 분야

    의학교육학, 외과학

  • 성명

    국문 임만섭

  • 직위

    조교수

  • 연구실

    의학관 6층 3611호

  • 연락처

    033-248-2511

  • 이메일

학력

강원대학교 의과대학(박사-약리학)

한림대학교 의과대학(석사-외과학)

한림대학교 의과대학(학사) 

주요경력

2021-현재 교육부학장

2018-2021 의과대학 대외교류부학장

2021-현재 한림대학교 의과대학 의학교육학교실 부교수

2016-2021 한림대학교 의과대학 의학교육학교실 조교수

2013-2016 한림대학교성심병원 외과 조교수

2011-2013 한림대학교성심병원 외과 임상조교수

2008-2011 한림대학교성심병원 외과 임상강사

2005-2008 군의관, 대한민국 해군

2001-2005 한림대학교 강동성심병원 외과 전공의

2000-2001 삼육의료원 서울병원 수련의

연구 및 저서

[논문]

Comparison of the Effects of Sugammadex, Neostigmine, and Pyridostigmine on Postoperative Nausea and Vomiting: A Propensity Matched Study of Five Hospitals., [JOURNAL OF CLINICAL MEDICINE, SCI급 ,제1저자 ,2020]

Consideration of Migraines Among Risk Factors for Postoperative Nausea and Vomiting, [JOURNAL OF CLINICAL MEDICINE, SCI급 ,제1저자 ,2020]

Transient Receptor Potential Melastatin 2 (TRPM2) Inhibition by Antioxidant,N-Acetyl-l-Cysteine, Reduces Global Cerebral Ischemia-Induced Neuronal Death, [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, SCI급 ,공동(참여) ,2020]

Role of Excitatory Amino Acid Carrier 1 (EAAC1) in Neuronal Death and Neurogenesis After Ischemic Stroke, [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, SCI급 ,공동(참여) ,2020]

Effects of Cerebrolysin on Hippocampal Neuronal Death After Pilocarpine-Induced Seizure, [FRONTIERS IN NEUROSCIENCE, SCI급 ,공동(교신) ,2020]

The Transient Receptor Potential Melastatin 7 (TRPM7) Inhibitors Suppress Seizure-Induced Neuron Death by Inhibiting Zinc Neurotoxicity., [INTERNATIONAL JOURNAL OF MOLECULAR SCIENCE, SCI급 ,공동(교신) ,2020]

Goodness of fit of the items used in the 2nd cycle of evaluation and accreditation of medical schools by the Korea Institute of Medical Education and Evaluation based on the Rasch model, [Journal of Educational Evaluation for Health Professions, KCI ,제1저자 ,2019]

Korean medical students’ knowledge about and attitudes towards plagiarism according to their commission of plagiarism, [Science Editing, KCI ,제1저자 ,2019]

Association between cholelithiasis and sialolithiasis Two longitudinal follow-up studies, [MEDICINE, SCI급 ,공동(참여) ,2019]

Increased risk of gallstones after gastrectomy A longitudinal follow-up study using a national sample cohort in korea, [MEDICINE, SCI급 ,공동(참여) ,2019]

Bidirectional association between gallstones and renal stones: Two longitudinal follow-up studies using a national sample cohort, [SCIENTIFIC REPORTS, SCI급 ,공동(참여) ,2019]

Increased risk of appendectomy in patients with gastroesophageal reflux disease: A nested case-control study using a national sample cohort, [Medicine, SCOPUS ,공동(참여) ,2018]

Developing the Korean Association of Medical Colleges graduate outcomes of basic medical education based on “the role of Korean doctor, 2014”, [Korean Journal of Medical Education, KCI ,공동(참여) ,2018]

Physical Activity, Sedentary Habits, Sleep, and Obesity are Associated with Asthma, Allergic Rhinitis, and Atopic Dermatitis in Korean Adolescents, [YONSEI MEDICAL JOURNAL, SCI급 ,제1저자 ,2017]

Leisure sedentary time is differentially associated with hypertension, diabetes mellitus, and hyperlipidemia depending on occupation, [BMC PUBLIC HEALTH, SCI급 ,제1저자 ,2017]

Quercetin-3-O-b-D-Glucuronide Suppresses Lipopolysaccharide-Induced JNK and ERK Phosphorylation in LPS-Challenged RAW264.7 Cells, [Biomolecules & Therapeutics, KCI ,공동(참여) ,2016]

Comparison of endoscopic submucosal dissection and surgical resection for treating gastric subepithelial tumours, [SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, SCI급 ,공동(참여) ,2016]

Phase II study of docetaxel, oxaliplatin, and S-1 therapy in patients with metastatic gastric cancer, [GASTRIC CANCER, SCI급 ,공동(참여) ,2016]

One-year experience with single incision laparoscopic cholecystectomy in a single center: without the use of inverse triangulation, [ANNALS OF SURGICAL TREATMENT AND RESEARCH, SCI급 ,공동(참여) ,2016]

Second-Line Irinotecan, Leucovorin, and 5-Fluorouracil for Gastric Cancer Patients after Failed Docetaxel and S-1, [GASTROENTEROLOGY RESEARCH AND PRACTICE, SCI급 ,공동(참여) ,2016]

The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression. (Biomolecules and Therapeutics, 2016)

Laparoscopic treatment for post-cholecystectomy Mirizzi syndrome. (Korean J Hepatobiliary Pancreat Surg, 2013)

Comparison of endoscopic submucosal dissection and surgical resection for treating gastric subepithelial tumours. (Scand J Gastroenterol, 2016)

Phase II study of docetaxel, oxaliplatin, and S-1 therapy in patients with metastatic gastric cancer. (Gastric Cancer, 2016)

One-year experience with single incision laparoscopic cholecystectomy in a single center: without the use of inverse triangulation. (Ann Surg Treat Res, 2016)

Second-Line Irinotecan, Leucovorin, and 5-Fluorouracil for Gastric Cancer Patients after Failed Docetaxel and S-1. (Gastroenterol Res Pract , 2016)

HIPK2 expression in progression of cutaneous epithelial neoplasm. (International Journal of Dermatology, SCI급, 공동(참여), 2015)

3,4,5-Trihydroxycinnamic acid increases heme-oxygenase-1 (HO-1) and decreases macrophage infiltration in LPS-induced septic kidney. (Molecular And Cellular Biology, 2014)

Geldanamycin attenuates 3‑nitropropionic acid‑induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells. (International Journal of Molecular Medicine, 2014)

Factors that affect surgery after endoscopic resection of early gastric cancer patients. (Korean Journal of Clinical Oncology, 2013)

Outcome of transilluminated powered phlebectomy for varicose vein: review of 299 patients (447 limbs). (Surgery Today, 2013)

기타

[주요연구주제]

의학교육-역량개발

평가도구 개발

교수법

 

[학회활동]

대한 의학교육학회 회원

대한 의사협회 평생회원

대한 외과학회 평생회원

대한 위암학회 평생회원

대한 종양외과학회 평생회원

한국의과대학·의학전문대학원협회 전문위원

이혜은
  • 분야

    직업환경의학

  • 성명

    국문 이혜은

  • 직위

    부교수

  • 연구실

    의학관 3303-3

  • 연락처

    033-248-2663

  • 이메일

학력

2001. 이화여자대학교 의학사

2004. 서울대학교 보건대학원 석사

2011. 서울대학교 보건대학원 박사

주요경력

2007-2012 한국산업안전보건공단 산업안전보건연구원 연구위원

2012-2017 가톨릭대학교 서울성모병원 직업환경의학과 임상조교수

2017-2018 경희의료원 직업환경의학과 임상조교수

2018-2021 Harvard T.H Chan School of Public Health, Department of Social and Behavioral Science, Visiting Scientist

기타

2016. 혜산 산업보건학술상 수상

이민호
  • 분야

    분자미생물학

  • 성명

    국문 이민호

  • 직위

    조교수

  • 연구실

    의과대학 3514

  • 연락처

    033-248-2633

  • 이메일

학력

2009-2012 중앙대학교(이학박사-분자미생물학)

2007-2009 중앙대학교(이학석사-분자미생물학)

2001-2007 중앙대학교(이학사-생명과학)

주요경력

2021-현재

한림대학교 의과대학 미생물학교실 조교수

2016-2021

중앙대학교 생명과학과 연구전담교수

2015-2016

Canada University of British Columbia Michael Smith Laboratories 리서치펠로우

2013-2016

중앙대학교 생명과학과 리서치펠로우

2012-2013

중앙대학교 마이크로바이오믹스 연구소 전임연구원

연구 및 저서

1. Regulator of ribonuclease activity modulates the pathogenicity of Vibrio vulnificus

Lee, J., Shin, E., Park, J., Lee M.*, Lee, K.*

Journal of Microbiology, 2021, 59(12), Accepted. (*Co-correspondence)

 

2. Trans-acting regulators of ribonuclease activity

Lee, J., Lee, M.*, Lee, K.*

Journal of Microbiology, 2021, 59(4), pp. 341–359. (*Co-correspondence)

 

3. Endoribonuclease-mediated control of hns mRNA stability constitutes a key regulatory pathway for Salmonella Typhimurium pathogenicity island 1 expression

Lee, M.*, Ryu, M.*, Joo, M.*, Seo, Y.-J.*, Lee, J., Kim, H.-M., Shin, E., Yeom, J.-H., Kim, Y.-H., Bae, J., Lee, K.

PLoS Pathogens, 2021, 17(2), e1009263. (*Equal contribution)

 

4. The coordinated action of RNase III and RNase G controls enolase expression in response to oxygen availability in Escherichia coli

Lee, M.*, Joo, M.*, Sim, M.*, Sim, S.-H.*, Kim, H.-L.*, Lee, J., Ryu, M., Yeom, J.-H., Hahn, Y., Ha, N.-C., Cho, J.-C., Lee, K.

Scientific Reports, 2019, 9(1), 17257. (*Equal contribution)

 

5. Divergent rRNAs as regulators of gene expression at the ribosome level

Song, W.*, Joo, M.*, Yeom, J.-H.*, Shin, E.*, Lee, M.*, Choi, H.-K., Hwang, J., Kim, Y.-I., Seo, R., Lee, J.E., Moore, C.J., Kim, Y.-H., Eyun, S., Hahn, Y., Bae, J., Lee, K.

Nature Microbiology, 2019, 4(3), pp. 515–526. (*Equal contribution)

 

6. Stoichiometry and mechanistic implications of the MacAB-TolC tripartite efflux pump

Jo, I., Hong, S., Lee, M., Song, S., Kim, J.-S., Mitra, A.K. Hyun, J., Lee, K., Ha, N.-C.

Biochemical and Biophysical Research Communications, 2017, 494(3-4), pp. 668–673.

 

7. Functional implications of hexameric assembly of RraA proteins from Vibrio vulnificus

Song, S., Hong, S., Jang, J., Yeom, J.-H., Park, N., Lee, J., Lim, Y., Jeon, J.-Y., Choi, H.-K., Lee, M., Ha, N.-C., Lee, K.

PLoS ONE, 2017, 12(12), e0190064.

 

8. Crystal Structure of a Soluble Fragment of the Membrane Fusion Protein HlyD in a Type I Secretion System of Gram-Negative Bacteria

Kim, J.-S., Song, S., Lee, M., Lee, S., Lee, K., Ha, N.-C.

Structure, 2016, 24(3), pp. 477–485.

 

9. Functional analysis of Vibrio vulnificus RND efflux pumps homologous to Vibrio cholerae VexAB and VexCD, and to Escherichia coli AcrAB

Lee, S., Yeom, J.-H., Seo, S., Lee, M., Kim, S., Bae, J., Lee, K., Hwang, J.

Journal of Microbiology, 2015, 53(4), pp. 256–261.

 

10. Functional conservation of RNase III-like enzymes: Studies on a Vibrio vulnificus ortholog of Escherichia coli RNase III

Lee, M.*, Ahn, S.*, Lim, B., Lee, D.-H., Lee, K.

Current Microbiology, 2014, 68(4), pp. 413–418. (*Equal contribution)

 

11. Modulation of RNase E activity by alternative RNA binding sites

Kim, D., Song, S., Lee, M., Go, H., Shin, E., Yeom, J.-H., Ha, N.-C., Lee, K., Kim, Y.-H.

PLoS ONE, 2014, 9(3), e90610.

 

12. The α-Barrel Tip Region of Escherichia coli TolC Homologs of Vibrio vulnificus Interacts with the MacA Protein to Form the Functional Macrolide-Specific Efflux Pump MacAB-TolC

Lee, M.*, Kim, H.-L.*, Song, S., Joo, M., Lee, S., Kim, D., Hahn, Y., Ha, N.-C., Lee, K.

Journal of Microbiology, 2013, 51(2), pp. 154-159. (*Equal contribution)

 

13. Membrane Fusion Proteins of Type I Secretion System and Tripartite Efflux Pumps Share a Binding Motif for TolC in Gram-Negative Bacteria

Lee, M.*, Jun, S.-Y.*, Yoon, B.-Y., Song, S., Lee, K., Ha, N.-C.

PLoS ONE, 2012, 7(7), e40460. (*Equal contribution)

 

14. Assembly and Channel Opening of Outer Membrane Protein in Tripartite Drug Efflux Pumps of Gram-negative Bacteria

Xu, Y., Moeller, A., Jun, S.-Y., Lee, M., Yoon, B.-Y., Kim, J.-S., Lee, K., Ha, N.-C.

Journal of Biological Chemistry, 2012, 287(15), pp. 11740-11750.

 

15. RNase G Participates in Processing of the 5′-end of 23S Ribosomal RNA

Song, W., Lee, M., Lee, K.

Journal of Microbiology, 2011, 49(3), pp. 508-511.

 

16. Funnel-like Hexameric Assembly of the Periplasmic Adapter Protein in the Tripartite Multidrug Efflux Pump in Gram-negative Bacteria

Xu, Y.*, Lee, M.*, Moeller, A., Song, S., Yoon, B.-Y., Kim, H.-M., Jun, S.-Y., Lee, K., Ha, N.-C.

Journal of Biological Chemistry, 2011, 286(20), pp. 17910-17920. (*Equal contribution)

 

17. Studies on a Vibrio vulnificus Functional Ortholog of Escherichia coli RNase E Imply a Conserved Function of RNase E-like Enzymes in Bacteria

Lee, M., Yeom, J.-H., Jeon, C.O., Lee, K.

Current Microbiology, 2011, 62(3), pp. 861-865.

 

18. Expression of Divergent LSU rRNA Genes in the Vibrio vulnificus CMCP6 Genome During Both Infection and Non-Pathogenic Stages

Kim, H.-L., Ryou, S.-M., Lee, M., Lee, J.-W., Lee, K., Bae, J.

Current Microbiology, 2011, 62(1), pp. 133-138.

 

19. Upregulation of RNase E activity by mutation of a site that uncompetitively interferes with RNA binding

Go, H., Moore, C.J., Lee, M., Shin, E., Jeon, C.O., Cha, C.-J., Han, S.H., Kim, S.-J., Lee, S.-W., Lee, Y., Ha, N.-C., Kim, Y.-H., Cohen, S. N., Lee, K.

RNA Biology, 2011, 8(6), pp. 1022-1034.

 

20. Functional Relationships between the AcrA Hairpin Tip Region and the TolC Aperture Tip Region for the Formation of the Bacterial Tripartite Efflux Pump AcrAB-TolC

Kim, H.-M.*, Xu, Y.*, Lee, M.*, Piao, S., Sim, S.-H., Ha, N.-C., Lee, K.

Journal of Bacteriology, 2010, 192(17), pp. 4498-4503. (*Equal contribution)

 

21. Effects of Escherichia coli RraA Orthologs of Vibrio vulnificus on the Ribonucleolytic Activity of RNase E In Vivo

Lee, M., Yeom, J.-H., Sim, S.-H., Ahn, S., Lee, K.

Current Microbiology, 2009, 58(4), pp. 349-353.

기타

주요연구주제

- 병원성 미생물의 감염 기작의 분자적 연구

- 병원성 미생물의 RNA 안정성 및 환경 적응 기작의 분자적 연구

- 미생물의 RNA 상호작용

- 항생제 내성 그람 음성균의 치료제 개발

 

학회활동

- 한국미생물학회 정회원

- 한국미생물·생명공학회 정회원

콘텐츠 담당자 : 의예ㆍ의학과

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  • e-Mail :de2500@hallym.ac.kr