한림대학교 HALLYM UNIVERSITY

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독 
- piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels vea activation of alpha-secretase and matrix metalloproteinase=9 [Journal of Functional Foods, SCI급, 공동(교신), 2016]
- Inhibition of mitochondrial clearance and Cu/Zn-SOD activity enhance 6-hydroxydopamine-induced neuronal apoptosis [Molecular Neurobiology, SCI급 공동(교신), 2016]
- Beta-amyloid oligomers induce early loss of presynaptic proteins in primary neurons by caspase-dependent and proteasome-dependent mechanisms[Neuroreport, SCI급, 공동(교신), 2014]
- Phlorotannin-rich Ecklonia cava reduces the production of beta-amyloid by modulating alpha- and gamma-secreta expression and activity [Neurotoxicology, 공동(교신), 2013] 

공동저자 : 공동저자(참여) 
- Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonist attenuate tumor growth via polarization of nuetrophils toward an antitumor phenotype [Onciommunology, SCI급, 공동(참여), 2016]
- LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission[CELL DEATH AND DIFFERENTIATION, SCI급, 공동(참여), 2014]
- Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus[Neuroscience Research, SCI급, 공동(참여), 2014]
- Impairment fo autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation [Plos One, 공동(참여), 2013]
- S1 pocket of glutamate carboxypeptidase II: a new binding site for amyloid-β degradation [Biochemical and Biophysical Research Communications, 공동(참여), 2013]
- The effect of P2X7 receptor activation on nuclear factor-kappa B phosphorylation induced by status epilepticus in the rat hippocampus [Hippocampus, 공동(참여), 2013]
- Endothelial transient receptor potential conical channel (TRPC)-3 activation induces vasogenic edema formation in the rat piriform cortex following status epilepticus [Cellular and molecular Neurobiology, 공동(참여), 2013] 

■ 주요연구주제
- 알츠하이머 치매의 신약 후보 물질 발굴
- 알츠하이머 치매의 바이오마커 발굴
- 퇴행성신경질환 유래 세포사멸 기전 분석

■ 학회활동
- 대한 해부학회
- 대한 뇌신경과학회
- 미국 신경과학회

주저자 : 제1저자, 공동저자(교신), 단독

Endothelin-1 induces LIMK2-mediated programmed necrotic neuronal death independent of NOS activity.[Mol Brain, SCI급, 공동(교신), 2015]

P2X7 receptor-mediated PARP1 activity regulates astroglial death in the rat hippocampus following status epilepticus. [Front Cell Neurosci, SCI급, 공동(교신), 2015]

Endoplasmic reticulum (ER) stress protein responses in relation to spatio-temporal dynamics of astroglial responses to status epilepticus in rats. [Neuroscience, SCI급, 공동(교신), 2015]

Endothelial NOS activation induces the blood-brain barrier disruption via ER stress following status epilepticus. [Brain Res, SCI급, 공동(교신), 2015]

LIM kinase-2 induces programmed necrotic neuronal death via dysfunction of DRP1-mediated mitochondrial fission. [Cell Death Differ, SCI급, 공동(제1), 2014]

PARP1 activation/expression modulates regional-specific neuronal and glial responses to seizure in a hemodynamic-independent manner. [Cell Death Dis, SCI급, 공동(제1), 2014]

공동저자 : 공동저자(참여)

Assessment at the single-cell level identifies neuronal glutathione depletion as both a cause and effect of ischemia-reperfusion oxidative stress. [J Neurosci, SCI급, 공동(참여), 2015]

Cellular and regional specific changes in multidrug efflux transporter expression during recovery of vasogenic edema in the rat hippocampus and piriform cortex. [BMB Rep, SCI급, 공동(참여), 2015]

Hyperforin attenuates microglia activation and inhibits p65-Ser276 NFκB phosphorylation in the rat piriform cortex following status epilepticus. [Neurosci Res, SCI급, 공동(참여), 2014]

주요연구주제

ER stress, Mitochondrial mitopathy, Neurological disease

학회활동

대한 해부학회

미국 신경과학회

주저자 : 제1저자, 공동저자(교신), 단독

Down-regulation of Tet2 prevents TSDR demethylation in IL2 deficient regulatory T cells[Biochemical and Biophysical Research Communications, SCI급, 공동(교신), 2014]

주요연구주제

T 세포 분화

자가면역질환

면역조절

학회활동

대한 면역학회

미국 면역학회

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독
- Ischemic preconditioning inhibits expression of Na+/H+ exchanger 1(NHE1) in the gerbil hippocampal CA1 region after transient forebrain ischemia[J Neuro Sci, SCI급, 공동(교신), 2015]

공동저자 : 공동저자(참여)
- Neuroprotection and reduced gliosis by atomoxetine pretreatment in a gerbil model of transient cerebral ischemia [J Neurol Sci, SCI급, 공동(참여), 2015]
- Time interval after ischemic preconditioning affects neuroprotection and gliosis in the gerbil hippocampal CA1 region induced by transient cerebral ischemia [Neurol Res, SCI급, 공동(참여), 2015]
- Delayed hoppocampal neuronal death in young gerbil following transient global cerebral ischemia is related to higer and longer-term expression of p63 in the ischemic hippocampus[Neural Regen Res, SCI급, 공동(참여), 2015]
- Comparison of immunoreactivities of Calbidin-D28k, calretinin and parvalbumine in the striatum between young, adult and aged mice, rats and gerbils [Neurochen Res, SCI급, 공동(참여), 2015]
- Ethanol extract of Oenanthe javanica increases cell poliferation and neuroblast differentiation in the adolescent rat dentate gyrus [Neural Regen Res, SCI급, 공동(참여), 2015]
- Changes in the expression of DNA-binding/differentiation protein inhibitors in neurons and glial cells of the gerbil hippocampys following transient global cerebral ischemia [Mol Med Rep, SCI급, 공동(참여), 2015]
- Decreased insulin-like growth factor-I and its receptor expression in the hippocampus and somatosensory cortex of the aged mouse[Neurochem Res, SCI급, 공동(참여), 2014]
- Anti-inflammatory effect of tanshinone I in neuroprotection against cerebral ischemia-reperfusion injury in the gerbil hippocampus[Neurochem Res, SCI급, 공동(참여), 2014]
- Accelerated and exacerbated effects of high dietary fat on neuronal damage induced by transient cerebral ischemia in the gerbil septum[Endocrinol Metab, KCI등재, 공동(참여), 2014]
- Effects of ischemic preconditioning on VEGF and pFIk-1 immunoreactivities in the gerbil ischemic hippocampus after transient cerebral ischemia[J Neurol Sci, SCI급, 공동(참여), 2014]
- Hippophae rhamnoides L. leaves extract enhances cell proliferation and neuroblast differentiation through upregulation of intrinsic factors in the dentate gyrus of the aged gerbil[Chin Med J, SCI급, 공동(참여), 2014]
- Long-term administretion of scopolamine interferes with nerve cell proliferation, differentiation and migration in adult mouse hippocapal dentate gyrus, but it does not induced cell death[Neural Regen Res, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 노화에 따른 중추신경계의 기능적 및 형태학적 변화
- 노화에 따른 위장관계의 기능적 및 형태학적 변화
- 평활근의 수축기전

■ 학회활동
- 대한생리학회
- 한국실험동물학회
- 미국췌장학회
- 국제췌장확회
- 미국신경과학회

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독
- Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death [Biochem. Biophys. Res. Comm, SCI급, 공동(교신), 2015]
- The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells[Korean J Physiol. Pharmacol., SCI급, 공동(교신), 2014]

공동저자 : 공동저자(참여)
- Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease. [BMB Reports, SCI급, 공동(참여), 2015]
- The effects of PEP-1-FK506BP on dry eye disease in a rat model. [BMB Reports, SCI급, 공동(참여), 2015]
- Down-regulation of MAPK/NF-κB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model.[International Immunopharmacology, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 인슐린분비세포의 세포사를 억제하는 PEP-1-HO-1 융합단백질의 영향 및 기전연구
- 세포침투성 PEP-1-PON1의 항당뇨병 효능 및 기전연구
- 근세포의 포도당흡수에 대한 자색옥수수추출액의 영향 및 기전연구

■ 학회활동
- 대한 생리학회
- 한국 생화학 분자생물학회
- 미국 췌장학회
- 한국 노화학회

■ 논문
주저자 : 제1저자, 공동저자(교신), 단독
- Manipulation of Rat Movement via Nigrostriatal Stimulation Controlled by Human Visually Evoked Potentials [Scientific Reports, SCI급, 공동(교신), 2017]

- Decoding intravesical pressure from local field potentials in rat lumbosacral spinal cord [Journal of neural engineering, SCI급, 공동(교신), 2016]

- Development of wireless neural interface system [Biomedical Engineering Letters, KCI, 공동(교신), 2016]

- Increased immunoreactivity of c-Fos in the spinal cord of the aged mouse and dog[Molecular Medicine Reports, SCI급, 공동(교신), 2015]

- Comparison of arylalkylamine N-acetyltransferase and melatonin receptor type 1B immunoreactivity between young adult and aged canine spinal cord[Journal of Veterinary Science, SCI급, 공동(교신), 2014]

공동저자 : 공동저자(참여)

- Rostral agranular insular cortex lesion with motor cortex stimulation enhances pain modulation effect on neuropathic pain model [Neural plasticity, SCI급, 공동(참여), 2016]

- Neuromodulation methods for animal locomotion control [Biomedical Engineering Letters, KCI, 공동(참여), 2016]

- Neuroprotection of posttreatment with risperidone, an atypical antipsychotic drug, in rat and gerbil models of ischemic stroke and the maintenance of antioxidants in a gerbil model of ischemic stroke[JOURNAL OF NEUROSCIENCE RESEARCH, SCI급, 공동(참여), 2014]

- A hybrid NIRS-EEG system for self-paced brain computer interface with online motor imagery[Journal of Neuroscience Methods, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 뇌-기계 접속

■ 학회활동
- 한국뇌신경과학회
- 대한의용생체공학회
- 대한생리학회
- BRC Int’l conference

주저자 : 제1저자, 공동저자(교신), 단독

Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats [Neuroendocrinology, SCI급, 공동(교신), 2015]

A water-ethanol extract from the mushroom Phellinus igniarius (Piwep) reduces transient cerebral ischemia-induced neuronal death [International Journal of Medicinal Mushrooms, SCI급, 공동(교신), 2015]

Inhibition of NADPH oxidase activation reduces EAE-induced white matter damage in mice [Journal of Neuroinflammation, SCI급, 공동(교신), 2015]

Adipose-Derived Mesenchymal Stem Cells Reduce Neuronal Death After Transient Global Cerebral Ischemia Through Prevention of Blood-Brain Barrier Disruption and Endothelial Damage[Stem Cells Translational Medicine, SCI급, 공동(교신), 2015]

Cytidine 5'-diphosphocholine (CDP-choline) adversely effects on pilocarpine seizure-induced hippocampal neuronal death [Brain Research, SCI급, 공동(교신), 2015]

"A Mushroom Extract Piwep from Phellinus igniarius Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibiting Immune Cell Infiltration in the Spinal Cord[BioMed Research International, SCI급, 공동(교신), 2014]"

Colchicine induced intraneuronal free zinc accumulation and dentate granule cell degeneration[Metallomics, SCI급, 공동(교신), 2014]

Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus[J Trace Elem Med Biol, SCI급, 공동(교신), 2014]

EAAC1 Gene Deletion Increases Neuronal Death and Blood Brain Barrier Disruption after Transient Cerebral Ischemia in Female Mice[IJMS, SCI급, 공동(교신), 2014] 

1. 주요연구주제
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경손상의 기전 연구
- 중추신경계 내에서 아연 (Zinc)의 생리, 해부, 병리적 역할
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경재생의 기전 연구 
- 뇌졸중, 외상성 뇌손상, 간질, 저혈당증 후에 발생하는 신경손상에 줄기세포의 투여가 미치는 영향
- 다발성 경화증의 발병기전 및 치료
2. 학회활동
- 대한 생리학회 이사
- 세계 신경과학회 정 회원 

■ 논문
주저자: 제1저자, 공동저자(교신), 단독 
- Effect of Wnt3a on keratinocytes utilizing in vitro and bioinformatics analysis[Int J Mol Sci, SCI급, 공동교신, 2014] 
- Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer’s disease[Nutrition Research & Practice, SCIE급, 교신, 2014]
- Scant Extracellular NAD Cleaving Activity of Human Neutrophils is Down-Regulated by fMLP via FPRL1(Extracellular NAD cleaving activity, fMLP, FPRL1, Human neutrophils)[Korean J Physiol Pharmacol, SCIE급, 교신, 2014] 

공동저자: 공동저자(참여) 
- Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death [BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급, 공동(참여), 2015] 
- Methoxy Poly(ethylene glycol)-Poly(lactide) Nanoparticles Encapsulating Quercetin Act as an Effective Anticancer Agent by Inducing Apoptosis in Breast Cancer [PHARMACEUTICAL RESEARCH, SCI급, 공동(참여), 2015] 
- Flow cytometric measurement of respiratory burst activity and surface expression of neutrophils for septic patient prognosis [Cytometry. Part B, Clinical cytometry, SCI급, 공동(참여), 2015] 
- Impact of serial measurements of lysophosphatidylcholine on 28-day mortality prediction in patients admitted to the intensive care unit with severe sepsis or septic shock[Journal of Critical Care, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 패혈증의 치료제에 대한 연구와 그 기전에 대한 연구 

■ 학회활동
- 대한 약리학회
- 미국 약리학회

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Effect of histamine receptors agonists or antagonists administered intracerebroventricularly and intrathecally on the blood glucose level in immobilization stress model [ANIMAL CELLS AND SYSTEMS, SCI급, 공동(교신), 2015] 
- Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model [The Korean Journal of Physiology & Pharmacology, SCI급, 공동(교신), 2015] 
- Involvement of alpha(2)-adrenergic receptor in the regulation of the blood glucose level induced by immobilization stress [ARCHIVES OF PHARMACAL RESEARCH, SCI급, 공동(교신), 2015] 
- Temporal expression of hippocampal lysophosphatidic acid receptors and their roles in kainic acid-induced neurotoxicity[Genes Genom, SCI급, 공동(교신), 2014]
- Ghrelin administered spinally increases the blood glucose level in mice[Peptides, SCI급, 공동(교신), 2014] 
- The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice[The Korean Journal of Physiology & Pharmacology, SCI급, 단독, 2014]
- Effects of nateglinide and repaglinide administered intracerebroventricularly on the CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice[Brain Research Bulletin, SCI급, 공동(교신), 2014] 
- Effect of tolbutamide, glyburide and glipizide administered supraspinally on CA3 hippocampal neuronal cell death and hyperglycemia induced by kainic acid in mice[Brain Research, SCI급, 공동(교신), 2014] 
- The modulatory role of alpha-melanocyte stimulating hormone administered spinally in the regulation of blood glucose level in D-glucose-fed and restraint stress mouse models[Neuropeptides, SCI급, 공동(교신), 2014] 
- Pertussis Toxin Administered Spinally Induces a Hypoglycemic Effect on Normal and Diabetic Mice[Pharmacology, SCI급, 공동(교신), 2014] 
- Involvement of a2-adrenergic receptor in the regulationof the blood glucose level induced by immobilization stress[Arch. Pharm. Res., SCI급, 공동(교신), 2014] 
- Role of corticotropin-releasing hormone receptor 1 in the regulation of nociception in mice[Animal Cells and Systems, SCI급, 공동(교신), 2014]
- Effect of pertussis and cholera toxins administered supraspinally on CA3 hippocampal neuronal cell death and the blood glucose level induced by kainic acid in mice[Neuroscience Research, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Activation of spinal α2 adrenergic receptors induces hyperglycemia in mouse though activating sympathetic outflow[European Journal of Pharmacology, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 통증과 오피오이드 시스템에 관련한 신호전달 메커니즘 규명
- 카이닉 산에 의산 신경세포 손상 모델에서의 신경세포 사멸 및 보호효과 관련 메커니즘 규명
- 통증과 당대사 관련 메커니즘 규명
- 중추신경계와 당대사의 상호 관련 메커니즘 규명

2. 학회활동
- 대한 약리학회 이사
- 대한 뇌신경학회 정회원
- 스트레스학회 정회원
- 대한 당뇨학회 정회원

■ 논문
주저자: 제1저자, 공동저자(교신), 단독 
- Morus alba Accumulates Reactive Oxygen Species to Initiate Apoptosis via FOXO-Caspase 3-Dependent Pathway in Neuroblastoma Cells. [Molecules and Cells, SCI급, 공동(교신), 2015] 
- PLGA-Loaded Gold-Nanoparticles Precipitated with Quercetin Downregulate HDAC-Akt Activities Controlling Proliferation and Activate p53-ROS Crosstalk to Induce Apoptosis in Hepatocarcinoma Cells. [Molecules and Cells, SCI급, 공동(교신), 2015] 
- Induction of apoptosis by Dioscorea nipponica Makino extracts in human SH-SY5Y neuroblastoma cells via mitochondria-mediated pathway[Animal Cells and Systems, SCI급, 공동(교신), 2014] 
- Application of in Utero Electroporation of G-Protein Coupled Receptor (GPCR) Genes, for Subcellular Localization of Hardly Identifiable GPCR in Mouse Cerebral Cortex[Molecues and Cells, SCI급, 공동(교신), 2014] 
 

공동저자: 공동저자(참여) 
- Enhancement of Short-Term Memory by Methyl-6-(Phenylethynyl)-Pyridine in the BTBR T+tf/J Mouse Model of Autism Spectrum Disorder. [Endocrinol Metab, KCI등재, 공동(참여), 2015]
- MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling.[Cell Death and Diseases, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 신경발달에 관여하는 뇌 유전자의 기능 연구
- GPCR 수용체의 분자약리학적 작용기전연구
- 뇌신경 발달장애 연구 동물모델 개발

■ 학회활동
- 미국 신경과학회 정회원
- 한국 뇌신경과학회 이사
- 한국 분자세포생물학회 이사
- 대한 약리학회 정회원
- 한국 통합생물학회 이사

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Lysophosphatidic acid activates β-catenin/T cell factor signaling, which contributes to the suppression of apoptosis in H19-7 cells. [Mol Med Rep, SCI급, 공동(교신), 2013] 
- Human group V secretory phospholipase A2 is associated with lipid rafts and internalized in a flotillin dependent pathway. [Int J Mol Med, SCI급, 공동(교신), 2013]
 
2. 공동저자: 공동저자(참여) 
- The Stimulatory Effect of Essential Fatty Acids on Glucose Uptake Involves Both Akt and AMPK Activation in C2C12 Skeletal Muscle Cells[KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY, SCI급, 공동(참여), 2014] 
- Lys1110 of TRPM2 is critical for channel activation. [Biochem J, SCI급, 공동(참여), 2013]
- Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice [Peptides, SCI급, 공동(참여), 2013]

1. 주요연구주제
- 사람 호중구에서 라이소지질의 작용기전 
- 사람 호중구에서 CGRP의 작용기전 

2. 학회활동
- 대한 약리학회
- 미국 중환자학회

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(교신), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Purple perilla extracts with alpha-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages [INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, SCI급, 공동(참여), 2015] 
- Anti-diabetic effect of purple corn extract on C57BL/KsJ db/db mice [NUTRITION RESEARCH AND PRACTICE, SCI급, 공동(참여), 2015] 
- A functional egg yolk powder containing an antibody against Niemann-Pick C1-like1 (NPC1L1) lowers cholesterol levels in high cholesterol diet induced hypercholesterolemic SD rats [FOOD SCIENCE AND BIOTECHNOLOGY, SCI급, 공동(참여), 2015] 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Purple Perilla Extracts Allay ER Stress in Lipid-Laden Macrophages[PLOS ONE, SCI급, 공동(참여), 2014] 
- Rubus coreanus Miquel ameliorates scopolamine-induced memory impairments in ICR mice. [J Med Food, SCI급, 공동(참여),2014] 

1. 주요연구주제
- Molecular mechanism of cellular and organismal Aging (세포 및 조직 노화의 분자기전 연구) 
- Molecular mechanism for regulation of ROS, DNA damage, and DNA repair during aging (노화과정에서 활성산소, 유전자손상 및 복구 조절기전 연구)
- Mechanism for regulation of aging by FOXO (전사인자 FOXO에 의한 노화조절기전 연구)
- Development of anti-aging materials and medicine (항노화물질 및 의약개발)

2. 학회활동
- 한국 노화학회 
- 한국 생화학-분자생물학회 
- International Association of Gerontology and Geriatrics (세계노인과학회)

1. 주저자: 제1저자, 공동저자(교신), 단독 
- IkappaB kinase r/nuclear Factor-kappaB-essential modulator (IKKgamma/NEMO) facilitates RhoA GTPase activation, which, in turn, activates Rho-associated kinase (ROCK) to phosphorylate IKKbeta in response to transforming growth factor (TGF)-beta1[J. Biol. Chem., SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [Tumor Biology, SCI급, 공동(참여), 2015] 
- PV.1 suppresses the expression of FoxD5b during neural induction in Xenopus embryos[Mol Cells, SCI급, 공동(참여), 2014] 
- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Report, SCI급, 공동(참여), 2014] 
- Rab3a promotes brain tumor initiation and progression[Mol Biol Rep, SCI급, 공동(참여), 2014] 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1[Tumour Biol, SCI급, 공동(참여), 2014] 
- Transcriptional activation of p21(WAF¹/CIP¹) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[Mol Biol Rep, SCI급, 공동(참여), 2014] 

1. 주요연구주제
- Rho GTPases에 의한 신호전달 
- RhoA-mediated regulation of inflammatory signal transduction by TGF-β, ROS, insulin, and amyloid-β.
- Tumorigenesis by ROS mediated by RhoA GTPase
- RhoA-mediated phagocytosis and ROS production mechanisms in macrophages
- Neurite outgrowth of PC12 cells mediated by RhoA activity.
- Change of endothelial cells regulated by Rho GTPases depending on ageing
2. 학회활동
- 생화학분자생물학회 대의원 
- 한국 분자세포생물학회 정회원 
- 한국 노화학회 정회원 
- 세포생물학회 정회원

1. 주저자: 제1저자, 공동저자(교신), 단독 
- PLK-1 Targeted Inhibitors and Their Potential against Tumorigenesis [BIOMED RESEARCH INTERNATIONAL, SCI급, 공동(교신), 2015] 
- PV.1 Suppresses the Expression of FoxD5b during Neural Induction in Xenopus Embryos[Molecules and Cells, SCI급, 공동(교신), 2014] 
- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Reports, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Irradiation induces glioblastoma cell senescence and senescence-associated secretory phenotype. [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- Rab3a promotes brain tumor initiation and progression[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(참여), 2014] 

1. 주요연구주제
- 척추동물 모델을 이용한 배의 초기발생과에서의 신호전달과 전사조절 기전연구 
- 척추동물 원시배발생과 신경발생에 관여하는 유전자의 탐색과 기능분석

 
2. 학회활동
- 한국 분자세포생물학회 정회원/제노프스분과 분과장 
- 생화학분자생물학회 정회원 
- 한국생명과학회 정회원/강원지부장 

■ 논문

주저자: 제1저자, 공동저자(교신), 단독 
- Epidermal growth factor receptor variant III renders glioma cancer cells less differentiated by JAGGED1 [TUMOR BIOLOGY, SCI급, 공동(교신), 2015] 
- Rab3a promotes brain tumor initiation and progression[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(교신), 2014] 

공동저자: 공동저자(참여) 
- IRF7 promotes glioma cell invasion by inhibiting AGO2 expression [TUMOR BIOLOGY, SCI급, 공동(참여), 2015] 
- PV.1 Suppresses the Expression of FoxD5b during Neural Induction in Xenopus Embryos[MOLECULES AND CELLS, SCI급, 공동(참여), 2014] 
- Transcriptional activation of p21(WAF1/CIP1) is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts[MOLECULAR BIOLOGY REPORTS, SCI급, 공동(참여), 2014] 
- PV.1 induced by FGF-Xbra functions as a repressor of neurogenesis in Xenopus embryos[BMB Reports, SCI급, 공동(참여), 2014] 
- Mechanism for Antioxidant Activity of Nardostachys chinensis root Extract[Journal of Applied Biological Chemistry, KCI등재, 공동(참여), 2014] 

■ 주요연구주제
- 다양한 세포에서 단백질체학을 이용한 특정 수식화된 단백질의 (post-translational modification)의 대량분리와 기능분석(Lysine methylation methylation, sumolyation, Acetylation, Phosphorylation, O-GlcNAc modification...) 
- 새로운 단백질수식 확인 및 수식화된 단백질분리를 위한 단백질체학 기술개발 (Development of new technology to isolate and identify novel post-translational modifications)
- 인체질병 또는 중요한 세포내 핵심단백질의 새로운수식의 발굴 및 수식과 기능을 종합한 단백질기능 지도작성 (construction of multisite modification map) 
- 세포내 특정 핵심단백질과의 상호작용 단백질분리 및 기능분석
- 단백질체학을 이용한 질병의 조기진단을위한 인체질환 특이적 단백질 바이오마커 (biomarker) 발굴
- 특정 단백질의수식이 뇌종양세포 및 뇌종양줄기세포 발생에 미치는 영향분석

■ 학회활동
- 생화학분자생물학회 정회원 
- 한국 분자세포생물학회 정회원 

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Phosphatidylinositol-Glycan-Phospholipase D is Involved in Neurodegeneration in Prion Disease [PLOS One, SCI급, 공동(교신), 2015] 
- Nε-Carboxymethyl Modification of Lysine Residues in Pathogenic Prion Isoforms [Molecular Neurobiology, SCI급, 공동(교신), 2015] 
- RARB and STMN2 polymorphisms are not associated with sporadic Creutzfeldt-Jakob disease (CJD) in the Korean population[Molecular Biology Reports, SCI급, 공동(교신), 2014] 
- Genetic studies in human prion diseases[Journal of Korean Medical Science, SCI급, 공동(교신), 2014]
- Dysfunction of mitochondrial dynamics in the brains of scrapie-infected mice[Biochemical and Biophysical Research Communications, SCI급, 공동(교신), 2014] 
- Deficiency of prion protein induces impaired autophagic flux in neurons[Froitier in Aging Neuroscience, SCI급, 공동(교신), 2014]
 
2. 공동저자: 공동저자(참여) 
- Mass Spectrometric Identification of Citrullination Sites and Immunohistochemical Detection of Citrullinated Glial Fibrillary Acidic Protein in Alzheimer’s Disease Brains[Journal of Neuroscience Research, SCI급, 공동(참여), 2015] 
- Upregulation of Connexin 43 Expression Via C-Jun N-Terminal Kinase Signaling in Prion Disease [Journal of Alzheimer's Disease, SCI급, 공동(참여), 2015]
- Lysosomal Trafficking of TGFBIp via Caveolae-Mediated Endocytosis [PLOS One, SCI급, 공동(참여), 2015] 
- Stability and Reproducibility Underscore Utility of RT-QuIC for Diagnosis of Creutzfeldt-Jakob Disease [Molecular Neurobiology, SCI급, 공동(참여), 2015] 
- Auraptene Increases the Production of Amyloid-β via c-Jun N-Terminal Kinases-Dependent Activation of γ-Secretase [Journal of Alzheimer's Disease, SCI급, 공동(참여), 2015] 
- ATBF1 is a Novel Amyloid-β Protein Precursor (AβPP) Binding Protein that Affects AβPP Expression.[Jornal of Alzheimer's disease, SCI급, 공동(참여), 2015] 
- Pathology of SSLOW, a transmissible and fatal synthetic prion protein disorder, and comparison with naturally occurring classical transmissible spongiform encephalopathies[Neuropathology and Applied Neurobiology, SCI급, 공동(참여), 2014] 
- Tunicamycin induces paraptosis potentiated by inhibition of BRAFV600E in FRO anaplastic thyroid carcinoma cells[Anticancer Research, SCI급, 공동(참여), 2014]
- Stearoyl coenzyme a desaturase 1 is associated with hepatitis C virus replication complex and regulates viral replication[Journal of Virology, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 프리온 질환에서 퇴행성 신경변화에 대한 병리기전 
- 프리온 질환의 조기 진단 기법 및 치료제 개발
- 노화에 따른 퇴행성 신경변화에서 내인성 레트로바이러스의 역할 구명 

2. 학회활동
- 대한 바이러스학회
- 미국 바이러스학회
- 미국 신경과학회
- 유럽연합 프리온학회
- 아시아-태평양 프리온학회
- 대한민국 의학한림원

■ 논문

주저자: 제1저자, 공동저자(교신), 단독 

- Detection of organophosphate bound butyrylcholinesterase using a monoclonal antibody[Applied Biological Chemistry, SCIE급, 공동(교신), 2017

- Generation of a monoclonal antibody that has reduced binding activity to VX-inactivated butyrylcholinesterase (BuChE) compared to BuChE by phage display. [Biotechnology and Bioprocess Engineering, SCI급, 공동(교신), 2017]

- Evaluation of ImmuneMed scrub typhus rapid test kit, for diagnosis of scrub typhus [JOURNAL OF VECTOR BORNE DISEASES, SCI급, 공동(교신), 2016]

- Clinical Evaluation of Rapid Diagnostic Test Kit for Scrub Typhus with Improved Performance[Journal of Korean Medical Science, SCI급, 공동(교신), 2016]

- Clinical Evaluation of Rapid Diagnostic Test Kit Using the Polysaccharide as a Genus-Specific Diagnostic Antigen for Leptospirosis in Korea, Bulgaria, and Argentina[Journal of Korean Medical Science, SCI급, 공동(교신), 2016]

공동저자: 공동저자(참여) 
- Identification of Leptospira species of Korean Isolates using Phylogenetic Analysis of Polymerase Chain Reaction-amplified 16S rDNA and LipL32 Genes[Journal of Bacteriology and Virology, KCI등재, 공동(참여), 2014] 

■ 주요연구주제
- 항바이러스물질 연구 및 개발 
- 급성열성질환 진단키트개발, 제조 및 마케팅 
- 60Hz 자기장 노출에 대한 동물 생체 영향 분석 

■ 학회활동
- 대한미생물학회 평의원, 이사, 회장, 이사장 
- 한국미생물학회연합 회장
- 대한면역학회 이사
- 대한바이러스학회 평의원
- 미국미생물학회 회원
- 한국전자파학회 전자장과 생체관계연구회 위원
- 생체전자파학회 회원
- 중앙약사심의위원회 위원
- 한국전력공사 전자계 자문위원
- KISTI 강원 과학기술정보 클러스터협의회 자문위원
- 강원 바이오산업 인력양성사업단 산학협력위원회 위원
- 새누리당 정책자문위원회 위원(교육과학기술)

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Effect of respiratory syncytial virus on the growth of hepatocellular carcinoma cell-lines [BMB Reports, SCI급, 공동(교신), 2015] 
- Monoclonal Antibodies Against the Human Respiratory Syncytial Virus Obtained by Immunization with Epitope Peptides and CpG-DNA-liposome Complex [Monoclonal antibodies in immunodiagnosis and immunotherapy, SCI급, 공동(교신), 2015] 
- Perspective of peptide vaccine composed of epitope peptide, CpG-DNA, and liposome complex without carriers. [Advances in Protein Chemistry and Structural Biology, SCI급, 공동(교신), 2015] 
- Production of epitope-specific antibodies by immunization with synthetic epitope peptide formulated with CpG-DNA-liposome complex without carriers [Methods in Molecular Biology, SCOPUS, 공동(교신), 2015] 
- Therapeutic effect of a TM4SF5-specific peptide vaccine against colon cancer in a mouse model[BMB reports, SCI급, 공동(교신), 2014] 
- Expression of UNC93A induced by CpG-DNA-liposome complex in mice[Journal of the Korean Society for Applied Biological Chemistry, SCI급, 공동(교신), 2014] 
- Monoclonal antibody targeting of the cell surface molecule TM4SF5 inhibits the growth of hepatocellular carcinoma[Cancer Research, SCI급, 공동(교신), 2014] 
- Effect of epitope-CpG-DNA-liposome complex without carriers on vaccination of respiratory syncytial virus infection[Journal of the Korean Society for Applied Biological Chemistry, SCI급, 공동(교신), 2014] 
- Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model[Oncotarget, SCI급, 공동(교신), 2014]
 
2. 공동저자: 공동저자(참여) 
- Middle Ear Response of Muc5ac and Muc5b Mucins to Nontypeable Haemophilus influenzae[JAMA Otolaryngology-Head & Neck Surgery, SCI급, 공동(참여), 2015] 
- Efficient doxorubicin delivery using deaggregated and carboxylated nanodiamonds for cancer cell therapy [Nanoscience and Nanotechnology Letters, SCI급, 공동(참여), 2015] 
- NADPH oxidase activation contributes to native low-density lipoprotein-induced proliferation of human aortic smooth muscle cells [EXPERIMENTAL AND MOLECULAR MEDICINE, SCI급, 공동(참여), 2015] 
- Liposome-Encapsulated CpG Enhances Antitumor Activity Accompanying the Changing of Lymphocyte Populations in Tumor via Intratumoral Administration [NUCLEIC ACID THERAPEUTICS, SCI급, 공동(참여)] 
- Suberoylanilide hydroxamic acid induces ROS-mediated cleavage of HSP90 in leukemia cells [CELL STRESS CHAPERONES, SCI급, 공동(참여), 2015] 
- The LRP1-independent mechanism of PAI-1-inudced migration in CpG-ODN activated macrophages[INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, SCI급, 공동(참여), 2014] 
- The PDZ-binding motif of the avian NS1 protein affects transmission of the 2009 influenza A(H1N1) virus[Biochemical and Biophysical Research Communications, SCI급, 공동(참여), 2014]
- Plasminogen activator inhibitor-1 regulates infiltration of macrophages into melanoma via phosphorylation of FAK-Tyr(925)[BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, SCI급, 공동(참여), 2014] 
- Inhibition of Pseudomonas aeruginosa with a recombinant RNA-based viral vector expressing human β-defensin 4[BMC Microbiology, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 선천면역
- 백신개발
- 항체개발

2. 학회활동
- 대한 바이러스학회 평의원
- 대한 미생물학회 평의원
- 생화학분자생물학회 운영위원, 강원분회장, BMB reports 편집위원
- 대한 면역학회 평의원
- World Journal of Immunology, Editorial Board

1. 주저자: 제1저자, 공동저자(교신), 단독 
- The Elevation of Annals of Rehabilitation Medicine to the Status of an International Journal After Adopting an English-Only Policy. [Annals of Rehabilitation Medicine, SCOPUS, 단독, 2015] 
- Evidence of the Internationalization of Clinical Endoscopy Based on Journal Metrics. [Clinical Endoscopy, SCOPUS, 단독, 2015]
- How much progress has been made in journal metrics two years after the citation analysis of the Korean Journal of Urology? [Korean Journal of Urology, SCOPUS, 단독, 2015] 
- Using Journal Article Tag Suite extensible markup language for scholarly journal articles written in Korean[Science Editing, 국내일반, 공동(교신), 2014] 
- Ethical Issue in Preparing Manuscript on Esthetic Patients[Archives of Aesthetic Plastic Surgery, KCI등재, 단독, 2014] 
- 의학교육에서 컴퓨터바탕검사와 문항은행 데이터베이스 구축[Korean Medical Education Review, KCI후보, 단독, 2014]
- Correlation among the citation indices of Korean scientific journals listed in international databases[Science Editing, 국내일반, 공동(교신), 2014] 
- Increase in frequency of citation by SCIE journals of non-Medline journals after listing in an open access full-text database[Science Editing, 국내일반, 공동(교신), 2014] 
- How Far Has the International Neurourology Journal Progressed Since Its Transformation Into an English Language Journal?[International Neuroruology Journal, SCI급, 단독, 2014] 
- 학술지에 적용하는 새 정보기술: ORCID, CrossMark, and FundRef[Journal of the Korean Medical Association, SCI급, 단독, 2014]
- Journal Metrics-Based Position of Diabetes & Metabolism Journal after the Change of Its Text Language to English[Diabetes and Metabolism Journal, SCI급, 단독, 2014] 
- Parasitic Diseases as the Cause of Death of Prisoners of War during the Korean War (1950-1953)[Korean Journal of Parasitology, SCI급, 단독, 2014]
- What Happened When CrossCheck Was Not Used for a Month in Journal of Neurogastroenterology and Motility?[Journal of Neurogastroenterology and Motility, SCI급, 단독, 2014] 
- How Journal Metrics Illustrate the Transformation of Archives of Plastic Surgery into an International Journal.[Archives of Plastic Surgery, SCI급, 단독, 2014]
- Journal Article Tag Suite 1.0: National Information Standards Organization standard of journal extensible markup language[Science Editing, 국내일반, 단독, 2014] 
- Uploading garbage files to the DOI system of a journal: a new type of misconduct[Learned Publishing, SCI급, 공동(교신), 2014]
- 국제 수준 학술지로 도약과 의사소통술[Korean Journal of Medical Education, KCI등재, 단독, 2014]
- Coding practice of the Journal Article Tag Suite extensible markup language[Science Editing, 국내일반, 단독, 2014] 
- "What is the position of Clinical and Experimental Reproductive Medicine in its scholarly journal network based on journal metrics?[Clinical and Experimental Reproductive Medicine, SCI급, 단독, 2014]"
- Asian Science Editors’ Conference and Workshop 2014[European Science Editing, SCI급, 단독, 2014]
 
2. 공동저자: 공동저자(참여) 
- Human Infections with Spirometra decipiens Plerocercoids Identified by Morphologic and Genetic Analyses in Korea [Korean Journal of Parasitology, SCI급, 공동(참여), 2015]
- Cross-reactivity of Toxocariasis with Crude Antigen of Toxascaris leonina Larvae by ELISA [Journal of Korean Medical Science, SCI급, 공동(참여), 2015] 
- 개 회충 게놈 응용 사례에서 공개용 분석 툴을 사용한 드래프트 게놈 어셈블리 생성[TIISE Transactions on Computing Practices, KCI등재, 공동(참여), 2014] 

1. 주요연구주제
- Epidemiology and genetic biology of toxocariasis
- Computerized adaptive testing in evaluation of medical education
- Consultation for the globalization of the medical journal from Korea

2. 학회활동
- Korean Society for Parasitology (Korea)
- The Korean Society of Medical Education (Korea)
- Korean Council of Science Editors (Korea)

■ 저서

- 보건사업기획. 제3판. 계축문화사, 2015.  

- 건강증진의 이론과 접근방법. 계축문화사, 2012.  

- 신공중보건: 건강사회를 향한 도전. 계축문화사, 2017. 

■ 주요연구주제

- 지역보건 

- 건강증진 

- 건강행태 

■ 학회활동

- 대한예방의학회 

- 한국보건행정학회 

- 농촌의학‧지역보건학회

1. 주저자: 제1저자, 공동저자(교신), 단독 
- Structural factors of the Middle East respiratory syndrome Coronavirus outbreak as a public health crisis in Korea and future response strategies. [J Prev Med Public Health, SCOPUS, 단독, 2015] 
- Relationship between Metabolic Syndrome and Lower Urinary Tract Symptoms: Hallym Aging Study [BIOMED RESEARCH INTERNATIONAL, SCI급, 공동(교신), 2015] 
- Trend of suicide rates according to urbanity among adolescents by gender and suicide method in Korea, 1997-2012 [International Journal of Environmental Research and Public Health, SCI급, 공동(교신), 2015] 
- Gender differences in adiponectin levels and body composition in older adults: Hallym aging study[BMC Geriatrics, SCI급, 공동(교신), 2014] 
- Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: The Hallym Aging Study[Genes and Genomics, SCI급, 공동(교신), 2014] 
 
2. 공동저자: 공동저자(참여) 
- Cohort Profile: Community-based prospective cohort from the National Cancer Center, Korea [Int J Epidemiol, SCI급, 공동(참여), 2015] 
- Vegetable intake, but not fruit intake, was associated with a reduction in the risk of cancer incidence and mortality in middle-aged Koran men [J Nutrition, SCI급, 공동(참여), 2015] 
- A genome-wide association study of copy-number variation identifies putative loci associated with osteoarthritis in Koreans. [BMC Musculoskeletal Disorders. SCI급, 공동(참여), 2015] 
- Household and area income levels are associated with smoking status in the Korean adult population [BMC Public Health, SCI급, 공동(참여), 2015] 
- Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk[NATURE GENETICS, SCI급, 공동(참여), 2014] 
- Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian populations[Hypertension Research, SCI급, 공동(참여), 2014] 
- Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians[International Journal of Cancer, SCI급, 공동(참여), 2014]
- Population-Attributable Causes of Cancer in Korea: Obesity and Physical Inactivity[PLOS ONE, SCI급, 공동(참여), 2014]
- Association between BMI, Smoking, and Alcohol with Prostate Cancer Mortality in the Asia Cohort Consortium[American J Epidemiology, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 자살예방을 위한 코호트 구축 연구
- 지역사회 건강수준 평가연구 
- 지역사회기반 노인연구: 한림노년연
- 유전체 코호트 구축사업: 검진자코호트 구축 
- 시료은행 구축

2. 학회활동
- 한국 역학회
- 대한 예방의학회
- Society for Epidemiology Research 
- Gerontological Society of America 

■ 논문

주저자: 제1저자, 공동저자(교신), 단독 
- Effects of an empowerment program for self-management among rural older adults with hypertension in South Korea [Australian Journal of Rural Health, SCI급, 공동(교신), 2015] 
- 만성 질환 관리 평가 도구를 이용한 보건소 만성 질환 관리 수준 평가 [보건행정학회지, KCI 등재, 공동(제일), 2014] 
 
공동저자: 공동저자(참여) 
- Older adults’ perception of chronic illness management in South Korea [Journal of Preventive Medicine and Public Health, SCOPUS 및 KCI 등재, 공동(참여), 2014]
- Do Not Resuscitate (DNR)와 Advance Directives (AD)에 대한 환자 보호자와 의료인의 인식 [한국호스피스완화의료학회지, KCI 등재, 공동(참여), 2014] 
- 델파이 법을 이용한 일차의료 개념 정의: 이차 출판 [보건행정학회지, KCI 등재, 공동(참여), 2014] 

■ 주요 연구 주제
- 일차의료
- 만성 질환 관리 평가 
- 보건의료 관리 연구 일반

■ 학회 활동
- 대한예방의학회
- 한국보건행정학회
- 한국건강형평성학회
- 한국농촌의학지역보건학회

- 주저자: 제1저자, 공동저자(교신), 단독 Anti-adipogenic Effects in 3T3-L1 Cells of Acetone Extracts and Fractions from Styrax japonica Fruit. [Food Sci Biotechnology, SCI급, 공동(교신), 2015]

Anti-apoptotic effects of silk fibroin hydrolysate in RIN5F cell on high glucose condition. [Animal Cells and System, SCI급, 공동(교신), 2015]

Anti-obesity Effects of the Stem Bark of Japanese Horse Chestnut (Aesulus turbinate) in 3T3-L1 Preadipocytes. [Food Sci Biotechnology, SCI급, 공동(교신), 2014]

- 공동저자: 공동저자(참여) Helicobacter apodemus sp. nov., a new Helicobacter species identified from the gastrointestinal tract of striped field mice in Korea. [Journal of Veterinary Science, SCI급, 공동(참여), 2015]

Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride. [Genes & Genomics, SCI급, 공동(참여), 2015]

Comparison of N-methyl-D-aspartate receptor subunit 1 and 4-hydroxynonenal in the hippocampus of natural and chemical-induced aging accelerated mice. [Neurochem Res, SCI급, 공동(참여), 2014]

Genetic risk assessment for cardiobascular disease wuth seven genes associated with plasma C-reactive protein concentrations in Asian populations. [Hypertension Research, SCI급, 공동(참여), 2014]

1. 주요연구주제
- 신경질환관련 모델동물의 개발
- 난청 마우스 모델동물에서 transmenbrane inner ear 유전자의 기능에 관한 연구
- 당뇨병 치료를 위한 치료제 및 기능성 식품 개발

2. 학회활동
- 질환모델동물연구회 회장 
- Lab. Anim. Res. 편집위원장 
- 한국유전체학회 회원 
- 한국분자세포생물학회 회원

■ 논문
주저자: 제1저자, 공동저자(교신), 단독 
- Risk Prediction of Pulmonary Tuberculosis Using Genetic and Conventional Risk Factors in Adult Korean Population [PLoS One, SCI급, 공동(교신), 2017]
- Identification of somatic mutations using whole-exome sequencing in Korean patients with acute myeloid leukemia [BMC Medical Genetics, SCI급, 공동(교신), 2017]
- Genetic Effect of Transforming growth factor alpha Gene Variants to the Risk of Nonsyndromic Cleft Lip with or without Palate in Korean Populations [The Cleft Palate-Craniofacial Journal, SCI급, 공동(교신), 2015]
- Interactions of Genetic and Non-genetic Factors on Plasma hs-CRP Concentration in a Korean Community-based Cohort Study [Genes & Genomics, SCI급, 공동(교신), 2015] 
- Male-specific genetic effect on hypertension and metabolic disorders[Human Genetics, SCI급, 공동(교신), 2014] 
- Genetic risk assessment for cardiovascular disease with seven genes associated with plasma C-reactive protein concentrations in Asian populations[Hypertension Research, SCI급, 공동(교신), 2014] 

공동저자: 공동저자(참여) 
- Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: The Hallym Aging Study [Genes & Genomics, SCI급, 공동(참여), 2015] 
- Investigation of Parental Transmission of RUNX2 Single Nucleotide Polymorphism and Its Association With Nonsyndromic Cleft Lip With or Without Palate[Cleft Palate-Craniofacial Journal, SCI급, 공동(참여), 2014] 

■ 주요연구주제
- 유전체역학
- 유전체 연관성 연구(GWAS, WES, WGS)
- 질병위험예측 

■ 학회활동
- American Society of Human Genetics
- International Human Genome Organization
- European Society of Human Genetics
- 한국 유전체학회

1. 주저자: 제1저자, 공동저자(교신), 단독 
- The Cytotoxicity of Kahweol in HT-29 Human Colorectal Cancer Cells Is Mediated by Apoptosis and Suppression of Heat Shock Protein 70 Expression. [Biomolecules and Therapeutics, SCI급, 공동(제1), 2016]
- Laparoscopic treatment for post-cholecystectomy Mirizzi syndrome. [Korean J Hepatobiliary Pancreat Surg, 공동(제1), 2013]

2. 공동저자: 공동저자(참여) 
- Comparison of endoscopic submucosal dissection and surgical resection for treating gastric subepithelial tumours. [Scand J Gastroenterol, SCI급, 공동(참여), 2016]
- Phase II study of docetaxel, oxaliplatin, and S-1 therapy in patients with metastatic gastric cancer. [Gastric Cancer, SCI급, 공동(참여), 2016]
- One-year experience with single incision laparoscopic cholecystectomy in a single center: without the use of inverse triangulation. [Ann Surg Treat Res, SCI급, 공동(참여), 2016] 
- Second-Line Irinotecan, Leucovorin, and 5-Fluorouracil for Gastric Cancer Patients after Failed Docetaxel and S-1. [Gastroenterol Res Pract , SCI급, 공동(참여), 2016] 
- HIPK2 expression in progression of cutaneous epithelial neoplasm. [International Journal of Dermatology, SCI급, 공동(참여), 2015]
- 3,4,5-Trihydroxycinnamic acid increases heme-oxygenase-1 (HO-1) and decreases macrophage infiltration in LPS-induced septic kidney. [Molecular And Cellular Biology, SCI급, 공동(참여), 2014]
- Geldanamycin attenuates 3‑nitropropionic acid‑induced apoptosis and JNK activation through the expression of HSP 70 in striatal cells. [International Journal of Molecular Medicine, SCI급, 공동(참여), 2014]
- Factors that affect surgery after endoscopic resection of early gastric cancer patients. [Korean Journal of Clinical Oncology, 공동(참여), 2013]
- Outcome of transilluminated powered phlebectomy for varicose vein: review of 299 patients (447 limbs). [Surgery Today, SCI급, 공동(참여), 2013]

1. 주요연구주제
- 의학교육-역량개발
- 평가도구 개발
- 교수법

2. 학회활동
- 대한 의학교육학회 회원
- 대한 의사협회 평생회원 
- 대한 외과학회 평생회원
- 대한 위암학회 평생회원
- 대한 종양외과학회 평생회원

1) Heung-Chul Kim*, Won-Keun Kim*, Jin Sun No, Seung-Ho Lee, Se Hun Gu, Sung-Tae Chong, Terry A. Klein, and Jin-Won Song, Urban Rodent Surveillance, Climatic Association and Genomic Analysis of Seoul Virus Collected at U.S. Army Garrison, Seoul, Republic of Korea, 2006-2010, American Journal of Tropical Medicine and Hygiene, 99(2): 470-476. 2018 *Equal contribution

2) Won-Keun Kim*, Jin Sun No*, Seung-Ho Lee, Dong Hyun Song, Daesang Lee, Jeong-Ah Kim, Se Hun Gu, Sunhye Park, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, Michael R. Wiley, Gustavo Palacios, Jin-Won Song, Multiplex PCR-based next-generation sequencing and global diversity of Seoul virus in humans and rats, Emerging Infectious Diseases, 24(2): 249-257. 2018 *Equal contribution

3) Heung-Chul Kim*, Won-Keun Kim*, Terry A. Klein, Sung-Tae Chong, Peter V. Nunn, Jeong-Ah Kim, Seung-Ho Lee, Jin Sun No and Jin-Won Song, Hantavirus Surveillance and Genetic Diversity Targeting Small Mammals at Camp Humphreys, a US Military Installation and new expansion site, Republic of Korea, PLoS One, 12(4): e0176514. 2017 *Equal contribution

4) Seung-Ho Lee*, Won-Keun Kim*, Jin Sun No, Jeong-Ah Kim, Jin Il Kim, Se Hun Gu, Heung-Chul Kim, Terry A. Klein, Manseong Park and Jin-Won Song, Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea, Scientific Reports, 7: srep44369. 2017 *Equal contribution

5) Dong Hyun Song*, Won-Keun Kim*, Se Hun Gu, Daesang Lee, Jeong-Ah Kim, Jin Sun No, Seung-Ho Lee, Michael R. Wiley, Gustavo Palacios, Jin-Won Song, Seong Tae Jeong, Sequence-Independent, Single-Primer Amplification Next-Generation Sequencing of Hantaan virus cell culture-based isolates, American Journal of Tropical Medicine and Hygiene, 96: 389-394. 2017 *Equal contribution

6) Jeong-Ah Kim, Won-keun Kim, Jin Sun No, Seung-Ho Lee, Sook-YoungLee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Man-Seong Park, Heung Chul Kim, Terry A. Klein, and Jin-Won Song, Genetic Diversity and Reassortment of Hantaan Virus Tripartite RNA Genomes in Nature, the Republic of Korea, PLOS Neglected Tropical diseases, 10(6): e0004650. 2016

7) Sook-Young Lee, Jeong-Hoon Kim, Tae-Kun Seo, Jin Sun No, Hankyeom Kim, Won-keun Kim, Han-Gu Choi, Sung-Ho Kang, Jin-Won Song, Genetic and Molecular Epidemiological Characterization of a Novel Adenovirus in Antarctic Penguins Collected between 2008 and 2013, PLOS One, 11(6): e0157032, 2016.

8) Won-Keun Kim, Jeong-Ah Kim, Dong Hyun Song, Daesang Lee, Yong Chul Kim, Sook-Young Lee, Seung-Ho Lee, Jin Sun No, Ji Hye Kim, Jeong Hoon Kho, Se Hun Gu, Seong Tae Jeong, Michael Wiley, Heung-Chul Kim, Terry A. Klein, Gustavo Palacios , and Jin-Won Song, Phylogeographic analysis of Hemorrhagic Fever with Renal Syndrome (HFRS) Patients and Natural Hosts using Multiplex PCR-based Next Generation Sequencing, Scientific Reports, 6: srep26017. 2016

9) Jin Sun No*, Won-keun Kim*, Jeong-Ah Kim, Seung-Ho Lee, Sook-Young Lee, Ji Hye Kim, Jeong Hoon Kho, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, and Jin-Won Song, Detection of Hantaan virus RNA from anti-Hantaan virus IgG seronegative rodents in a highly endemic area, the Republic of Korea, Microbiology and Immunology, 60(4): 268-271. 2016 *Equal contribution

10) Jie Xu, Xiomara Mercado-López, Jennifer T. Grier, Won-keun Kim, Lauren F. Chun, Edward B. Irvine, Yoandris Del Toro Duany, Alison Kell, Sun Hur, Michael Galr Jr., Arjun Raj, Carolina B. López, Identification of a Natural Viral RNA Motif That Optimizes Sensing of Viral RNA by RIG-I, mBio, 6 (5): e01265-15. 2015

11) Terry A. Klein, Heung-Chul Kim, Sung-Tae Chong, Jeong-Ah Kim,Sook-YoungLee, Won-Keun Kim, Peter V. Nunn, Jin-Won Song, Hantaan Virus Surveillance Targeting Small Mammals at Nightmare Range, a High Elevation Military Training Area, Gyeonggi Province, Republic of Korea, PLOS One, 10(4): e0118483. 2015

12) Won-keun Kim, Deepika Jain, Melissa D. Sánchez, Cynthia J. Koziol-White, Krystal Matthews, Moyar Q. Ge, Angela Haczku, Reynold A. Panettieri Jr., Matthew B. Frieman, and Carolina B. López, Deficiency of ­­­­­MDA5 Results in Exacerbated Chronic Post-Viral Lung Inflammation, American Journal of Respiratory and Critical Care Medicine, 189 (4): 437-448. 2014

[http://bric.postech.ac.kr/myboard/read.php?id=38494&idauthorid=24053&Board=HBS_TREATISE&ttype=&skin=hbs_treatise]

13) Karla Tapia*, Won-keun Kim*, Yan Sun, Xiomara Mercado-López, Emily Dunay, Megan Wise, Michael Adu, and Carolina B. López, Defective viral genomes arising in vivo provide critical danger signals for the triggering of lung anti-viral immunity, PLOS Pathogen, 9(10): e1003703. 2013 *Equal contribution [Featured Research]

14) Xiomara Mercado-López, Christopher R. Cotter, Won-keun Kim, Yan Sun, Luis Muñoz, Karla Tapia, and Carolina B. López, Highly Immunostimulatory RNA Derived from a Sendai Virus Defective Interfering Viral Genome, Vaccine, 31(48): 5713-5721. 2013

15) Christopher R. Cotter, Won-keun Kim, Marie L. Nguyen, Jacob S. Yount, Carolina B. López, John A. Blaho, and Thomas M. Moran, The virion host shutoff protein of Herpes Simples Virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling, Journal of Virology, 85(23): 12662-12672. 2011

16) Byung O. Lee, Joyce E. Jones, Cory J. Peters, David Whitacre, Lars Frelin, Janice Hughes, Won-keun Kim, and David R. Milich, Identification of a unique double-negative regulatory T-cell population, Immunology, 134: 434-447. 2011

■ Research Interests
1) Virus-host interaction: Virology, Immunology, Epidemiology 
2) Next-generation sequencing: Comparative genomics
3) Metagenomic analysis of virome

■ Awards
1) Travel Award,  37th Annual Meeting American Society for Virology, Maryland, USA, July14th-18th, 2018
2) Travel Award, International Union of Microbiological Societies 2017, Singapore, July 17th-21st,2017
3) Best Poster Award, 2016 The Korean Society of Chemical Biological & Radiological Defense Conference, Seoul, Republic of Korea, December 9rd,2016
4) Best Research Award, 2016 KU HT·BT Research Festival, Seoul, Republic of Korea, November 22nd,2016
5) Travel Award, X International Conference on HFRS, HPS and Hantaviruses, Colorado, USA, May 31st-June3rd,2016
6) Best Poster Award, 2014 The Korean Society of Chemical Biological & Radiological Defense Conference, Seoul, Republic of Korea, December 3rd,2014
7) Best Presentation Award, The 2014 Fall Conference of The Korean Association of Immunologists, Seoul, Republic of Korea, November 6th-7th,2014
8) Outstanding Oral Presentation Award, 2014 The Federation of Korean Microbiological Societies Conference, Ilsan, Republic of Korea, October 30th-31st,2014
9) AAI Abstract Trainee Award, The 98th AAI Annual Meeting–IMMUNOLOGY 2011, San Francisco, CA, May 13-17, 2011