한림대학교 HALLYM UNIVERSITY

주요 논문
Increased Calbindin D28k Expression via Long-Term Alternate-Day Fasting Does Not Protect against Ischemia-Reperfusion Injury: A Focus on Delayed Neuronal Death, Gliosis and Immunoglobulin G Leakage. Int. J. Mol. Sci. 22, 644 (2021)

Aesculetin Inhibits Airway Thickening and Mucus Overproduction Induced by Urban Particulate Matter through Blocking Inflammation and Oxidative Stress Involving TLR4 and EGFR. Antioxidants, 10, 494 (2021) 

Therapeutic Effects of Decursin and Angelica gigas Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage. Molecules, 26, 2161 (2021)

Astragalin Inhibits Cigarette Smoke-Induced Pulmonary Thrombosis and Alveolar Inflammation and Disrupts PAR Activation and Oxidative Stress-Responsive MAPK-Signaling. Int. J. Mol. Sci. 22, 3692 (2021)

Anti-Obesity Effect of Erigeron annuus (L.) Pers. Extract Containing Phenolic Acids. Foods, 10, 1266 (2021)

Populus tomentiglandulosa Extract Is Rich in Polyphenols and Protects Neurons, Astrocytes, and the Blood-Brain Barrier in Gerbil Striatum Following Ischemia-Reperfusion Injury. Molecules, 26, 5430 (2021)

Aesculetin Accelerates Osteoblast Differentiation and Matrix-Vesicle-Mediated Mineralization Int. J. Mol. Sci. 22, 12391 (2021)

Ischemia-Induced Cognitive Impairment Is Improved via Remyelination and Restoration of Synaptic Density in the Hippocampus after Treatment with COG-Up® in a Gerbil Model of Ischemic Stroke. Vet. Sci. 8, 321 (2021)

Pre-Treatment with Laminarin Protects Hippocampal CA1 Pyramidal Neurons and Attenuates Reactive Gliosis Following Transient Forebrain Ischemia in Gerbils. Mar. Drugs. 2020, 18, 52 (2020)

A Combination of Korean Red Ginseng Extract and Glycyrrhiza glabra L. Extract Enhances Their Individual Anti-Obesity Properties in 3T3-L1 Adipocytes and C57BL/6J Obese Mice. J Med Food. 23(3), 215–223 (2020)

Preclinical Research on a Mixture of Red Ginseng and Licorice Extracts in the Treatment and Prevention of Obesity, Nutrients, 12(9), 2744 (2020)

Experimental Pretreatment with Chlorogenic Acid Prevents Transient Ischemia-Induced Cognitive Decline and Neuronal Damage in the Hippocampus through Anti-Oxidative and Anti-Inflammatory Effects, Molecules, 25, 3578 (2020)

Pretreated Oenanthe Javanica extract increases anti-inflammatory cytokines, attenuates gliosis, and protects hippocampal neurons following transient global cerebral ischemia in gerbils. Neural Regen Res. 14(9):1536-1543 (2019)

Protective Effects and Mechanisms of Pourthiaea villosa (Thunb.) Decne. Extract on Hydrogen Peroxide-Induced Skin Aging in Human Dermal Fibroblasts, J Med Food. 22 (8), 841–850 (2019) 

Anti-Obesity Effect of Extract from Nelumbo Nucifera L., Morus Alba L., and Raphanus Sativus Mixture in 3T3-L1 Adipocytes and C57BL/6J Obese Mice, Foods, 8(5), (2019)

Erigeron annuus (L.) Pers. Extract Inhibits Reactive Oxygen Species (ROS) Production and Fat Accumulation in 3T3-L1 Cells by Activating an AMP-Dependent Kinase Signaling Pathway, Antioxidants(Basel). 8(5), (2019)

Pretreatment of Populus tomentiglandulosa protects hippocampal CA1 pyramidal neurons from ischemia-reperfusion injury in gerbils via increasing SODs expressions and maintaining BDNF and IGF-I expressions, Chin J Nat Med. 17(6): 424-434 (2019)

Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress, Exp Neurol. 320:112983 (2019)

Synergistic action of Erigeron annuus L. Pers and Borago officinalis L. enhances anti-obesity activity in a mouse model of diet-induced obesity. Nutr Res. 69: 58 (2019)

Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia, 
Sci Rep. 9(1):13032 (2019)

A 2-Min Transient Ischemia Confers Cerebral Ischemic Tolerance in Non-Obese Gerbils, but Results in Neuronal Death in Obese Gerbils by Increasing Abnormal mTOR Activation-Mediated Oxidative Stress and Neuroinflammation, Cells, 8(10) (2019)

저서

식품학개론, 라이프사이언스, 2021

식품화학 길라잡이, 라이프사이언스, 2015

식품저장학, 고려대학교출판부, 2012

재미있는 식품화학, 수학사 , 2011

생화학, 녹문당, 2008

특허

두메부추 및 오이풀 추출물의 제조방법 및 상기 추출물을 유효성분으로 포함하는 비만 및 비만으로부터 유도된 대사증후군 개선용 조성물(제10-2200260-0000, 2021)

퀘르시트린과 스피레오시드 그리고 이들의 혼합물을 유효성분으로 포함하는 비만 개선, 예방 또는 치료용 조성물(제10-2007465-0000, 2019) 

현사시나무 추출물을 유효성분으로 함유하는 허혈성 뇌혈관 질환 예방용 조성물 (제10-1852583-0000, 2018)

유산균(Lactobacillus rhamnosus HK-9) 발효 길경추출물을 유효성분으로 포함하는 비만 개선 및 치료용 조성물 (제10-1781186-0000, 2017)

오이풀 추출물을 유효성분으로 포함하는 당뇨 및 당뇨합병증 예방 또는 개선용 조성물 (제10-1737854-0000, 2017)

수상

근정포장(2019.05)

대통령 표창 (2010.05)

한국연구재단이사장 표창(2021.06)

제21회 오뚜기 함태호 학술상(2019.10)

제26회 과학기술 우수논문상(2016.07)

강원지방중소기업청장 표창(2015.12)

뉴트리라이트 학술상 수상(2013.11)

강원도지사 표창(2011.12)

Google Scholar

■ 천연물연구

- UPLC, MPLC, HSCCC 및 open column chromatography를 이용한 천연물로부터 유효물질의 분리/정제/구조결정
- 신규 On-line bioassay 및 enzyme binding assay (UF)를 활용하여 신속한 생리활성 물질의 검색
- 반응표면분석법 (RSM)을 이용한 최적화 추출공정 개발 및 Scale up 공정 연구
- CYP450 효소를 이용한 천연물과 의약품간의 약물상호작용 (Drug-Drug Interaction, DDI) 연구
- 천연물의 생물전환(biotransformation) 대사체 연구 (PCA & Metabolites)
- 유효물질을 기반으로 한 흡수증대를 갖는 제형 개발 (Solubility, PAMPA 개선)
- 효소합성법 (Enzymatic synthesis method)를 이용한 폴리페놀 유도체의 친환경 합성법 개발

■ 주요 연구 천연물
- 감초/단삼/짚신나물/미역취/차즈기/멀꿀나무/다릅나무/털장구채/산옥잠화/쥐오줌풀/곤충 효소 가수분해물 (yellow worm)/천마/MACA의 생리활성 성분의 구조규명 연구 및 원료표준화 (CMC) 연구

■ 기능성(생리활성) 연구 분야
- 당뇨 및 당뇨합병증 치료소재 개발 (합성화합물 포함한 천연물소재)
- 개별인정형 건강기능식품 소재 개발 (식후혈당, 체지방감소, 뼈/관절 건강, 혈중중성지방개선)
- 천연물로부터 기능성화장품 소재 개발 (미백/주름/자외선차단/탈모방지)
- 천연물 유효물질의 합성유도체로부터 통증 치료 소재
-  암세포 특이적 세포사 물질(합성신약) 연구

■ 논문 
1. Ischemia-Induced Cognitive Impairment Is Improved via Remyelination and Restoration of Synaptic Density in the Hippocampus after Treatment with COG-Up® in a Gerbil Model of Ischemic Stroke. Veterinary Sciences 8 (12), 321 (2021)
2. Asaronic acid inhibits ER stress sensors and boosts functionality of ubiquitin-proteasomal degradation in 7β-hydroxycholesterol-loaded macrophages. Phytomedicine 92, 153763 (2021)
3. Purple corn extract alleviates 2, 4-dinitrochlorobenzene-induced atopic dermatitis-like phenotypes in BALB/c mice. Animal cells and systems 25 (5), 272-282 (2021)
4. Extracts from the Leaves of Cissus verticillata Ameliorate High-Fat Diet-Induced Memory Deficits in Mice. Plants 10 (9), 1814 (2021)
5. Separation and Identification of Antioxidants and Aldose Reductase Inhibitors in Lepechinia meyenii (Walp.) Epling (2021) 
6. Metformin‑induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells. Scientific Reports 11 (1), 1-13 (2021)
7. The  Anti-Inflammatory and  the Antinociceptive Effects of Mixed Agrimonia pilosa Ledeb.  and Salvia miltiorrhiza Bunge  Extract. Plants 10 (6), 1234 (2021)
8. Cissus verticillata Extract Decreases Neuronal Damage Induced by Oxidative Stress in HT22 Cells and Ischemia in Gerbils by Reducing the Inflammation and Phosphorylation of MAPKs. Plants 10 (6), 1217 (2021)
9. Defatted Seeds of Oenothera biennis as a Potential Functional Food Ingredient for Diabetes. Foods 10 (3), 538 (2021)
10.  Purple corn extract (PCE) alleviates cigarette smoke (CS)-induced DNA damage in rodent blood cells by activation of AMPK/Foxo3a/MnSOD pathway. Animal Cells and Systems 25 (1), 65-73 (2021)
11.  Valeriana rigida Ruiz & Pav. Root Extract: A New Source of Caffeoylquinic Acids with Antioxidant and Aldose Reductase Inhibitory Activitie. Foods 10 (5), 1079 (2021)
12.  Effect of Extract and Synthesized Derivatives of Isolated Compound from Symplocos chinensis f. Pilosa Ohwi on Neuropathic Pain in Mice. Molecules 26 (6), 1639 (2021)
13.  Increased Calbindin D28k Expression  via Long-Term Alternate-Day  Fasting  Does  Not  Protect against Ischemia-Reperfusion Injury:  A  Focus on Delayed Neuronal Death,  Gliosis and Immunoglobulin G Leakage. International Journal of Molecular Sciences 22 (2), 644 (2021)
14.  Chemical Composition of a Novel Distillate from Fermented Mixture of Nine Anti-Inflammatory Herbs and Its UVB-Protective Efficacy in Mouse Dorsal Skin via Attenuating Collagen Disruption and Inflammation. Molecules 26 (1), 124 (2021)
15.  Efficient Separation of Phytochemicals from Muehlenbeckia volcanica (Benth.) Endl. by Polarity-Stepwise Elution Counter-Current Chromatography and Their Antioxidant, Antiglycation, and Aldose Reductase Inhibition Potentials. Molecules 26 (1), 224 (2021)
16.  Licochalcone A inhibits hypoxia-inducible factor-1α accumulation by suppressing mitochondrial respiration in hypoxic cancer cells. Biomedicine & Pharmacotherapy 133, 111082 (2021)
17.  Linarin and its aglycone acacetin abrogate actin ring formation and focal contact to bone matrix of bone-resorbing osteoclasts through inhibition of alpha v beta 3 integrin and core-linked CD44. PHYTOMEDICINE (2020)
18.  Constituents from Solidago virgaurea var. gigantea and their inhibitory effect on lipid accumulation. FITOTERAPIA (2020)
19.  Retention mechanism of pH-peak-focusing in countercurrent chromatographic separation of baicalin and wogonoside from Scutellaria baicalensis Georgi. JOURNAL OF SEPARATION SCIENCE (2020)
20.  An Off-Line DPPH-GC-MS Coupling Countercurrent Chromatography Method for Screening, Identification, and Separation of Antioxidant Compounds in Essential Oil. ANTIOXIDANTS (2020)
21.  Asaronic Acid Inhibited Glucose-Triggered M2-Phenotype Shift Through Disrupting the Formation of Coordinated Signaling of IL-4R alpha-Tyk2-STAT6 and GLUT1-Akt-mTOR-AMPK. NUTRIENTS (2020)
22.  Acute and subchronic toxicity study of nonpolar extract of licorice roots in mice. FOOD SCIENCE  NUTRITION (2020)
23.  Anti-obesity effect of Melandrium firmum Rohrbach extract in 3T3-L1 cells and high-fat diet-induced obese C57BL/6N mice. FOOD SCIENCE  NUTRITION (2020)
24.  Antinociceptive effect of chrysin in diabetic neuropathy and formalin-induced pain models. ANIMAL CELLS AND SYSTEMS (2020)
25.  Discovery of Epinastine-NSAID Hybrids as Potential Anti-inflammatory Agents: Synthesis and In Vitro Nitric Oxide Production Inhibitory Activity Study (2020)
26.  Melandrium firmum Extract Promotes Hair Growth by Modulating 5 alpha-Reductase Activity and Gene Expression in C57BL/6J Mice. ANNALS OF DERMATOLOGY (2019)
27.  Affinity measurement of ligands in Perilla frutescens extract towards alpha-glucosidase using affinity-based ultrafiltration-high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)
28.  Antinociceptive effect of single components isolated from Agrimonia pilosa ledeb. Extract. Scientia Pharmaceutica (2019)
29.  Asaronic Acid Attenuates Macrophage Activation toward M1 Phenotype through Inhibition of NF-kappa B Pathway and JAK-STAT Signaling in Glucose-Loaded Murine Macrophages. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2019)
30.  Liposomal formulation and pharmacokinetic study of CPD409, a novel sodium channel blocker. Journal of Pharmaceutical Investigation. Journal of Pharmaceutical Investigation (2019)
31.  Effects of resveratrol and oxyresveratrol on hippocampal cell death induced by kainic acid. ANIMAL CELLS AND SYSTEMS (2019)
32.  Target guided isolation of potential tyrosinase inhibitors from Otholobium pubescens (Poir.) JW Grimes by ultrafiltration, high-speed countercurrent chromatography and preparative HPLC. INDUSTRIAL CROPS AND PRODUCTS (2019)
33.  Fermented dried Citrus unshiu peel extracts exert anti-inflammatory activities in LPS-induced RAW264.7 macrophages and improve skin moisturizing efficacy in immortalized human HaCaT keratinocytes. PHARMACEUTICAL BIOLOGY (2019)
34.  Aldose Reductase, Protein Glycation Inhibitory and Antioxidant of Peruvian Medicinal Plants: The Case of Tanacetum parthenium L. and Its Constituents. MOLECULES (2019)
35.  Chemical Compositions of the Volatile Oils and Antibacterial Screening of Solvent Extract from Downy Lavender. FOODS (2019)
36.  Novel aldose reductase inhibitory and antioxidant chlorogenic acid derivatives obtained by heat treatment of chlorogenic acid and amino acids. Food Chemistry (2018)
37.  Lipid-Lowering Effects of Medium-Chain Triglyceride-Enriched Coconut Oil in Combination with Licorice Extracts in Experimental Hyperlipidemic Mice. Journal of Agricultural and Food Chemistry (2018)
38.  Pistafolin B is the major aldose reductase inhibitor of the pods of tara [Caesalpinia spinose (Molina) Kuntze] Industrial Crops and Products (2018)
39.  Anti-Nociceptive Effect and Standardization from Mixture of Agrimonia pilosa Ledeb and Salvia miltiorrhiza Bunge Extracts. Journal of Medicinal Food (2018)
40.  Antioxidant activity and inhibitory effects of 2-hydroxy-3-methylcyclopent-2-enone isolated from ribose-histidine Maillard reaction products on aldose reductase and tyrosinase. Food and Function (2018)
41.  An: In vitro affinity-based method for studying herb-drug interactions for direct identification of cytochrome P450 1A2, 3A4, and 2C9 specific ligands from herbal extracts using ultrafiltration-high performance liquid chromatography. RSC Advances (2018)
42.  Anti-glycation, carbonyl trapping and anti-inflammatory activities of chrysin derivatives. Molecules (2018) 
43.  Antiobesity Effect of Astilbe chinensis Franch. et Savet. Extract through Regulation of Adipogenesis and AMP-Activated Protein Kinase Pathways in 3T3-L1 Adipocyte and High-Fat Diet-Induced C57BL/6N Obese Mice. Evidence-based Complementary and Alternative Medicine (2018)
44.  Evaluation of aldose reductase, protein glycation, and antioxidant inhibitory activities of bioactive flavonoids in Matricaria recutita L. and their structure-activity relationship. Journal of Diabetes Research (2018)
45.  Screening In Vitro Targets Related to Diabetes in Herbal Extracts from Peru: Identification of Active Compounds in Hypericum laricifolium Juss. by Offline High-Performance Liquid Chromatography. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
46.  Characterization of DHDP, a novel aldose reductase inhibitor isolated from Lysimachia christinae. JOURNAL OF FUNCTIONAL FOODS (2017)
47.  Anti-Obesity Effect of the Above-Ground Part of Valeriana dageletiana Nakai ex F. Maek Extract in High-Fat Diet-Induced Obese C57BL/6N Mice. NUTRIENTS (2017)
48.  Protein Tyrosine Phosphatase 1β (PTP1β) Inhibitory Compounds Isolated from Prunella vulgaris. Chemistry of Natural Compounds (2017)
49.  Alantolactone and Isoalantolactone Prevent Amyloid β(25-35)-induced Toxicity in Mouse Cortical Neurons and Scopolamine-induced Cognitive Impairment in Mice. PHYTOTHERAPY RESEARCH (2017)
50.  Bioactivity-guided isolation and identification of anti-adipogenic compounds from Sanguisorba officinalis L. FASEB JOURNAL (2017)
51.  Screening of Peruvian Medicinal Plants for Tyrosinase Inhibitory Properties: Identification of Tyrosinase Inhibitors in Hypericum laricifolium Juss. MOLECULES (2017)
52.  Phytochemical Analysis of Agrimonia pilosa Ledeb, Its Antioxidant Activity and Aldose Reductase Inhibitory Potential. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
53.  Rapid High Performance Liquid Chromatography Determination and Optimization of Extraction Parameters of the -Asarone Isolated from Perilla frutescens L. MOLECULES (2017)
54.  Analytical Method for the Validation of Three Polyphenols as a Marker Compound for the Standardization of Solidago virgaurea subsp gigantea Extracts and Antiadipogenesis of Harvesting Time and Location. JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY (2017)
55.  Anti-obesity effect of Solidago virgaurea var. gigantea extract through regulation of adipogenesis and lipogenesis pathways in high-fat diet-induced obese mice (C57BL/6N) FOOD  NUTRITION RESEARCH (2017)
56.  Antidiabetic Effect of Fresh Nopal (Opuntia ficus-indica) in Low-Dose Streptozotocin-Induced Diabetic Rats Fed a High-Fat Diet. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2017)
57.  Chemo-enzymatic synthesis of vinyl and L-ascorbyl phenolates and their inhibitory effects on advanced glycation end products. FOOD CHEMISTRY (2017)
58.  Competitive binding experiments can reduce the false positive results of affinity-based ultrafiltration-HPLC: A case study for identification of potent xanthine oxidase inhibitors from Perilla frutescens extract. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)
59.  Comprehensive evaluation of the antioxidant capacity of Perilla frutescens leaves extract and isolation of free radical scavengers using step-wise HSCCC guided by DPPH-HPLC. INTERNATIONAL JOURNAL OF FOOD PROPERTIES (2017)
60.  Comprehensive profiling of minor tyrosinase inhibitors from Gastrodia elata using an off-line hyphenation of ultrafiltration, high-speed countercurrent chromatography, and high-performance liquid chromatography. JOURNAL OF CHROMATOGRAPHY A (2017)
61.  Enzymatic Synthesis of a Novel Kaempferol-3-O-beta-D-glucopyranosyl(1 -> 4)-O-alpha-D-glucopyranoside Using Cyclodextrin Glucanotransferase and Its Inhibitory Effects on Aldose Reductase, Inflammation, and Oxidative Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2017)
62.  Inhibitory Activities of Stauntonia hexaphylla Leaf Constituents on Rat Lens Aldose Reductase and Formation of Advanced Glycation End Products and Antioxidant. BIOMED RESEARCH INTERNATIONAL (2017)
63.  Investigation of the antioxidant and aldose reductase inhibitory activities of extracts from Peruvian tea plant infusions. FOOD CHEMISTRY (2017)
64.  Rapid Identification and Isolation of Inhibitors of Rat Lens Aldose Reductase and Antioxidant in Maackia amurensis. BIOMED RESEARCH INTERNATIONAL (2017)
65.  Synergetic hepatoprotective effects of korean red ginseng and pueraria radix on the liver damaged-induced by carbon tetrachloride (CCL4) in mice. Natural Product Sciences (2017)
66.  alpha-Asarone blocks 7 beta-hydroxycholesterol-exposed macrophage injury through blocking elF2 alpha phosphorylation and prompting beclin-1-dependent autophagy. ONCOTARGET (2017) 

■ 주요 특허 등록 
1. 코르너스 오블롱가 추출물을 이용한 항염증용 조성물, 제10-2226439-0000, 2021
2. 코르너스 오블롱가 추출물을 이용한 궤양성 대장염 개선용 조성물, 제10-2226448-0000, 2021
3. 유통기한이 향상되고 오메가-3가 증가된 생들기름 제조방법, 제10-2249821-0000, 2021
4. 노루궁뎅이버섯 가수분해물을 유효성분으로 포함하는 항산화 및 항비만 조성물, 제10-2144513-0000, 2020
5. 로로통 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2109498-0000, 2020
6. 소목(Caesalpinia eriostachys Benth) 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2088768-0000, 2020
7. Combretum farinosum Kunth 추출물을 유효성분으로 함유하는 통증 예방 또는 치료용 조성물, 제10-2073796-0000, 2020
8. 신규한 크리신 유도체 화합물을 유효성분으로 포함하는 당뇨합병증의 예방 또는 치료용 약학 조성물, 제10-2032739-0000, 2019
9. 짚신나물 및 단삼의 추출물을 유효성분으로 포함하는 조성물 및 이의 제조방법, 제10-2009669-0000, 2019
10. 사이클로덱스트린 글루카노트랜스퍼레이즈를 이용한 수용성이 증대된 아스트라갈린의 당전이 화합물의 제조방법 및 이로부터 제조된 아스트라갈린의 당전이 화합물을 함유하는 조성물, 제10-1986789-0000, 2019
11. 코코넛 오일의 상온 유동성 개선방법, 제10-1978158-0000, 2019
12. 미역취 추출물을 함유하는 항비만 식품 조성물 및 이의 제조방법, 제10-1952257-0000, 2019
13. 짚신나물 및 단삼의 추출물을 유효성분으로 포함하는 조성물 및 이의 제조방법, 제10-1952242-0000, 2019
14. 멀꿀 나무 추출물을 함유하는 당뇨합병증의 예방 또는 치료용 약학 조성물, 제10-1883870-0000, 2018
15. 페루산 포라덴드론 콰드랭귤러 식물 추출물을 함유하는 당뇨합병증의 예방 또는 치료용, 제10-1880164-0000, 2018
16. 야관문 추출물을 유효성분으로 포함하는 피부미백용 조성물, 제10-1876319-0000, 2018
17. 5원 헤테로사이클릭 유도체, 이의 제조방법 및 이를 포함하는 약제학적 조성물, 제10-1844984-0000, 2018
18. 미역취 추출물을 함유하는 항비만 식품 조성물 및 이의 제조방법, 제10-1754149-0000, 2017
19. 차즈기 추출물을 포함하는 콜레스테롤 대사 관련 혈관질환 개선용 식품 조성물 및 이의 제조방법, 제10-1733048-0000, 2017

- 식품가공저장학 (Food Processing & Preservation) 노봉수외 공저, 2015, 수학사

주요 논문

- Jeong, H.M.; Lee, Y.; Shin, Y.J.; Woo, S.H.; Kim, J.S.; Jeong, D.W.; Shin, S.; Jeon, S.H.; Shim, J.H. Development of an enzymatic encapsulation process for a cycloamylose inclusion complex with resveratrol. Food Chem. 2021, 345, 128777.

- Woo, S.H.; Kim, J.S.; Jeong, H.M.; Shin, Y.J.; Hong, J.S.; Choi, H.D.; Shim, J.H. Development of freeze-thaw stable starch through enzymatic modification. Foods 2021, 10.

- Shin, Y.J.; Woo, S.H.; Jeong, H.M.; Kim, J.S.; Ko, D.S.; Jeong, D.W.; Lee, J.H.; Shim, J.H. Characterization of novel alpha-galactosidase in glycohydrolase family 97 from Bacteroides thetaiotaomicron and its immobilization for industrial application. Int. J. Biol. Macromol. 2020, 152, 727-734.

- Koo, Y.S.; Ko, D.S.; Jeong, D.W.; Shim, J.H. Development and application of cyclodextrin hydrolyzing mutant enzyme which hydrolyzes β- and γ‑CD selectively. J. Agric. Food Chem. 2017, 65, 2331-2336.

- Kim, N.R.; Jeong, D.W.; Ko, D.S.; Shim, J.H. Characterization of novel thermophilic alpha-glucosidase from Bifidobacterium longum. J. Biol. Macromol. 2017, 99, 594-599.

- Choung, W.J.; Hwang, S.H.; Ko, D.S.; Kim, S.B.; Kim, S.H.; Jeon, S.H.; Choi, H.D.; Lim, S.S.; Shim, J.H. Enzymatic synthesis of a novel kaempferol-3-O-beta-d-glucopyranosyl-(1->4)-O-alpha-D-glucopyranoside using cyclodextrin glucanotransferase and its inhibitory effects on aldose reductase, inflammation, and oxidative stress. J. Agric. Food Chem. 2017, 65, 2760-2767.

- Lee, H.W.; Jeon, H.Y.; Choi, H.J.; Kim, N.R.; Choung, W.J.; Koo, Y.S.; Ko, D.S.; You, S.; Shim, J.H. Characterization and application of BiLA, a psychrophilic alpha-amylase from Bifidobacterium longum. J. Agric. Food Chem. 2016, 64, 2709-2718.

- Jeon, H.Y.; Kim, N.R.; Lee, H.W.; Choi, H.J.; Choung, W.J.; Koo, Y.S.; Ko, D.S.; Shim, J.H. Characterization of a novel maltose-forming alpha-amylase from Lactobacillus plantarum subsp. plantarum ST-III. J. Agric. Food Chem. 2016, 64, 2307-2314.

- Koo, Y.S.; Lee, H.W.; Jeon, H.Y.; Choi, H.J.; Choung, W.J.; Shim, J.H. Development and characterization of cyclodextrin glucanotransferase as a maltoheptaose-producing enzyme using site-directed mutagenesis. Protein Eng. Des. Sel. 2015, 28, 531-537.

■ 연구분야
만성질환 관련 식생활 위험요인 분석
청년 식생활 개선을 위한 중재연구
푸드 리터러시 지표 개발과 측정 
푸드 리터러시 향상을 위한 중재연구 
혼합연구방법을 이용한 건강증진 프로그램 개발 
 
■ 논문 (최근 5년)

· Ko E, Jang E, Sim J, Jeong M, Park S. Evaluating the effectiveness of a food literacy pilot program for university students: using a mixed-methods research approach. Nutrition Research and Practice 2024 (In press) 

· Jang E, Ko E, Sim J, Jeong M, Park S. Mukbang media: correlations with the dietary behavior of children and adolescents in Korean. Nutrition Research and Practice 2024 (In press)

· Jung S, Lee Y, Kim K and Park S. Association of the dietary inflammatory index with sarcopenic obesity and frailty in older adults. BMC Geriatrics, 2024

· Sim J, Lim J, Lee H, Park S, Shin D. A 3-month nutrition and exercise program improved hallux strength among senior daycare center users in Korea: a cluster randomized controlled trial. Frontiers in Public Health, 2024

· Sim J, Lim J, Ko E, Jang E, Jeong M, Park S. Development of a frailty prevention program including nutrition and exercise interventions for older adults in senior daycare centers in South Korea: using a mixed methods research design. Nutrition Research and Practice 2024;18(3):372-386

· Jeong S, Jeong J-Y, Park S. Changes in food sufficiency among Korean adults in urban and rural areas during the COVID-19 pandemic: an analysis of the 7th and 8th Korea National Health and Nutrition Examination Survey. Epidemiology and Health, 45 2024

· Yoo H, Jo E, Lee H, Ko E, Jang E, Sim J, Park S. Level of happiness and its association with food literacy among Seoul citizens: results from Seoul Food Survey 2021. Nutrition Research and Practice 2024;18(1):119-131

· Jung S, Seo J, Kim JY, Park S. Associations of Ultra-Processed Food Intake with Body Fat and Skeletal Muscle Mass by Sociodemographic Factors, Diabetes & Metabolism Journal, 2024 

· Jung S, Kim J-Y, Park S. Eating patterns in Korean adults, 1998–2018: increased energy contribution of ultra‑processed foods in main meals and snacks. European Journal of Nutrition, 2024

· Jung S, Jang E, Lee H, Kim J-Y, Park S. Higher consumption of ultra-processed food is associated with cardiovascular risk in Korean adults: KNHANES 2016–2018. Frontiers in Nutrition, 2023

· Jeong S, Lee H, Jung S, Kim J-Y, Park S. Higher energy consumption in the evening is associated with increased odds of obesity and metabolic syndrome: findings from the 2016-2018 Korea National Health and Nutrition Examination Survey (7th KNHANES). Epidemiology and Health 45, 2023

· Yoo H, Jo E, Lee H, Ko E, Jang E, Sim J, Park S. Who has a high level of food literacy, and who does not?: a qualitative study of college students in South Korea. Nutrition Research and Practice 2023;17(6):1155-1169

· Yoo H, Jo E, Lee H, Ko E, Jang E, Sim J, Kim K, Park S.  The level of food literacy and its association with food intake and obesity status among Seoul citizens: results from Seoul Food Survey 2021. Nutrition Research and Practice 2023;17(5): 945-958 

· Lee S, Park S, Kim K. Food literacy and its relationship with food intake: a comparison between adults and older adults using 2021 Seoul Food Survey data. Epidemiology and Health 45, 2023

· Lee H, Park S. Regional differences in the associations of diet quality, obesity, and possible sarcopenia using the seventh Korea National Health and Nutrition Examination Survey (2016-2018). Epidemiology and Health 45, 2023

· Ko E, Jang E, Sim J, Jeong M, Park S. Development of a campus-based intervention program to strengthen food literacy among university students: A qualitative formative study, Korean J Community Nutr 28(6): 495~508, 2023

·  Cho YJ, Park S et al. The Gangwon Obesity and Metabolic Syndrome Study: Methods and Initial Baseline Data. Journal of Obesity and Metabolic Syndrome 2022; 31: 303-312

·  Jung S, Par S. Positive association of unhealthy plant-based diets with the incidence of abdominal obesity: Comparison of baseline, most recent, and cumulative average diets. Epidemiology and Health 44, 2022

·  Jo J, Yoo H, Kim K, Kim S, Kim CK, Lee H, Jeong J, Park S. Who has experienced better or worse health conditions since the outbreak of COVID-19?: Results from a representative cross-sectional survey in Seoul. Nutrition Research and Practice 2022;16:e50 

· Yoo H, Jo E, Lee H, Park S. Development of a food literacy assessment tool for healthy, joyful, and sustainable diet in South Korea. Nutrients 2022; 14, 1507

· Jung S, Park S, Kim JY. Comparison of dietary share of ultra-processed foods assessed with a FFQ against a 24-h dietary recall in adults: Results from KNHANES 2016. Public Health Nutrition 2022;25(5):1166-1175

· Jo E, Shim JE, Ryou HJ, Kim K, Song SJ, Kim HJ, Ahn JS, Kwon K, Lee HY, Park S. Using service design tools in community nutrition research: a case study in developing dietary guidelines for young adults. Korean Journal of Community Nutrition 2022;27(3):177-191 [Korean]

 · Park S, Jung S, Yoon H. The role of nutritional status in the relationship between diabetes and health-related quality of life. Nutrition Research and Practice 2022;16(4):505-516 

· Park S, Hwang JY, Shim JE, Kim K. Basic concepts and detailed dimensions of food security and related indicators for policy development and evaluation. Korean J Community Nutr 2021;26(6):429-440 [Korean]

· Yoo H L, Jo E, Kim K, Park S. Defining food literacy and its application to nutrition interventions: A scoping review. Korean J Community Nutr  2021; 26(2):77-92 [Korean]

· Park S, Kim H-J, Kim K. Do where the elderly live matter? Factors associated with diet quality among Korean elderly population living in urban versus rural areas. Nutrients 2020; 12, 1314

· Park S, Sung E. "You gotta have something to chew on" - Perceptions of stress-induced eating and weight gain among office workers in South Korea. Public Health Nutrition 2020; 24(3): 499-511

■ 저서 및 편역서  

· Gittelsohn J, Park S. “School and Community-Based Interventions,” in Pediatric Obesity: Etiology, Pathogenesis and Treatment (Freemark M, editor, 2nd Edition), 2018; Humana Press: New York
· 생활 속의 영양학, 라이프사이언스, 2021
· 노인간호학, 메디컬사이언스, 2022
· 지역사회영양학, 파워북, 2023

Google Scholar

■ 연구 분야

- 스핑고지질 대사체 중심의 질환(피부 & 암) 기전 연구 및 치료제 개발

- 피부장벽기능의 이해: 영양학적 접근

- 물질 분석 및 분석법 개발

■ 주요 논문

1. Shin KO et al., Activation of SIRT1 enhances epidermal permeability barrier formation through ceramide synthase 2- and 3-dependent mechanisms. J Invest Dermatol 40:1435-1438, 2020

2. Lee J et al., Cathelicidin-related antimicrobial peptide regulates CD73 expression in mouse Th17 Cells via p38. Cells 9:1561, 2020

3. Shin KO et al., Both sphingosine kinase 1 and 2 coordinately regulate cathelicidin antimicrobial peptide production during keratinocyte differentiation. J Invest Dermatol 139:492-494, 2019

4. Park K et al., ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. PNAS 113: E1334-42, 2016 (Note: This article was featured in Cell Chemical Biology 23(3): 313-314, 2016)

5. Park K et al., Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway. J Biol Chem 286: 34121-30, 2011

See more contributions to science: https://pubmed.ncbi.nlm.nih.gov/?term=kyungho+park&sort=date

■ 수상

2014 미국피부과학회/일본피부과학회 Junior Faculty Award

2014 미국피부과학회 Research Fellow Award

2011 제6회 국제 세라마이드학회 Speaker Award

■ 홈페이지

www.phdlass.com

Google Scholar

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- MJ Kuchan et al. Infant rhesus macaque brain α-tocopherol stereoisomer profile is differentially impacted by the source of α-tocopherol in infant formula. Journal of Nutrition 2020; 150(9): 2305-2313.

- J Correnti et al. Liver-specific ceramide reduction alleviates steatosis and insulin resistance in alcohol-fed mice. Journal of Lipid Research 2020; 61(7): 983-994.

- S Jeon et al. Alcohol effects on hepatic lipid metabolism (*). Journal of Lipid Research 2020; 61(4): 470-479. (*Selected in a special virtual issue from ASBMB)

- S Jeon et al. 13C-lutein is differentially distributed in tissues of an adult rhesus macaque following a single oral administration: a pilot study. Nutrition Research, 2019; 61: 102-108.

- S Jeon et al. Relationships of carotenoid-related gene expression and serum cholesterol and lipoprotein levels to retina and brain lutein deposition in infant rhesus macaques following 6 months of breastfeeding or formula feeding. Archives of Biochemistry and Biophysics 2018; 654: 97-104.

- S Jeon et al. Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques (*). Journal of Nutrition 2018; 148(1): 31-39. (*Selected as a featured article)

See more journal publications:

https://scholar.google.com/citations?user=qOlE9RQAAAAJ&hl=en