한림대학교 HALLYM UNIVERSITY

■ Representative Publications (2011 ~ present)

1) Jo H, Jang HY, Youn GS, Kim D, Lee CY, Jang JH, Choi SY, Jun JG, Park J. 2018. Hindsiipropane B alleviates HIV-1 Tat-induced inflammatory responses by suppressing HDAC6-NADPH oxidase-ROS axis in astrocytes. BMB Rep. 51:394-399.

2) Youn GS, Cho H, Kim D, Choi SY, Park J. 2017. Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes. Redox Biol. 12:978-986.

3) An SY, Youn GS, Kim H, Choi SY, Park J. 2017. Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-κB activation in poly(I:C)-stimulated astrocytes. BMB Rep. :25-30

4) Youn GS, Lee KW, Choi SY, Park J. 2016. Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-κB/AP-1 signaling pathways in macrophages. Free Radic Biol Med. 97:14-23.

5) Kim H, Youn GS, An SY, Kwon HY, Choi SY, Park J. 2016. 2,3-Dimethoxy-2'-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells. BMB Rep. 49(1):57-62.

6) Park SH, Shin MJ, Kim DW, Park J, Choi SY, Kang YH. 2016. Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein. Int J Mol Med. 37(2):387-397.

7) Youn GS, Ju SM, Choi SY, Park J. 2015. HDAC6 mediates HIV-1 Tat-induced proinflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes. Glia. 63(11):1953-1965.

8) Kim YN, Kim DW, Jo HS, Shin MJ, Ahn EH, Ryu EJ, Yong JI, Cha HJ, Kim SJ, Yeo HJ, Youn JK, Hwang JH, Jeong JH, Kim DS, Cho SW, Park J, Eum WS, Choi SY. 2015. Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-κB and MAPK activation in macrophages and TPA-induced ear edema in mice. Toxicol Appl Pharmacol. 286(2):124-134.

9) Seo WY, Youn GS, Choi SY, Park J. 2015. Butein, a Tetrahydroxychalcone, Suppresses Pro-inflammatory Responses in HaCaT Keratinocytes. BMB Rep. 48(9):495-500.

10) Kim MJ, Park M, Kim DW, Shin MJ, Son O, Jo HS, Yeo HJ, Cho SB, Park JH, Lee CH, Kim DS, Kwon OS, Kim J, Han KH, Park J, Eum WS, Choi SY. 2015. Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson's disease model. Biomaterials. 64:45-56.

11) Yoon CH, Kim SY, Byeon SE, Jeong Y, Lee J, Kim KP, Park J, Bae YS. 2015. p53-Derived Host Restriction of HIV-1 Replication by Protein Kinase R-Mediated Tat Phosphorylation and Inactivation. J Virol. 89(8):4262-4280.

12) Ju SM, Youn GS, Cho YS, Choi SY, Park J. 2015. Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses via suppression of NF-κB activation in the RINm5F beta cells. BMB Rep. 48(3):172-177.

13) Youn GS, Kwon DJ, Ju SM, Rhim H, Bae YS, Choi SY, Park J. 2014. Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and heme oxygenase-1 induction in astrocytes. Toxicol Appl Pharmacol. 280:42-52.

14) Kwon DJ, Bae YS, Ju SM, Youn GS, Choi SY, Park J. 2014. Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages. BMB Rep. 47(6):318-323.

15) Kwon DJ, Bae YS, Ju SM, Youn GS, Choi SY, Park J. 2014. Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages. BMB Reports. 47(6):318-323.

16) Shin MJ, Kim DW, Lee YP, Ahn EH, Jo HS, Kim DS, Kwon OS, Kang TC, Cho YJ, Park J, Eum WS, Choi SY. 2014. Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury. Free Radic Biol Med. 67:195-210.

17) Youn GS, Kwon DJ, Ju SM, Choi SY, Park J. 2013. Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. BMB Reports 46(8):410-415.

18) Kwon DJ, Ju SM, Youn GS, Choi SY, Park J. 2013. Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-κB and AP-1 activation in RAW 264.7 macrophages. Food Chem Toxicol. 58:479-486.

19) Kim MJ, Kim DW, Park JH, Kim SJ, Lee CH, Yong JI, Ryu EJ, Cho SB, Yeo HJ, Hyeon J, Cho SW, Kim DS, Son O, Park J, Han KH, Cho YS, Eum WS, Choi SY. 2013. PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radic Biol Med. 63:432-445.

20) Ju SM, Goh AR, Kwon DJ, Youn GS, Kwon HJ, Bae YS, Choi SY, Park J. 2012. Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells. Mol Cells. 33(4):335-341.

21) Kwon DJ, Bae YS, Ju SM, Goh AR, Youn GS, Choi SY, Park J. 2012. Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-κB and STAT1 activation in HaCaT cells. Biochem Biophys Res Commun. 2012 417(4):1254-1259.

22) Lee SH, Kim DW, Kim HR, Woo SJ, Kim SM, Jo HS, Jeon SG, Cho SW, Park JH, Won MH, Park J, Eum WS, Choi SY. 2012. Anti-inflammatory effects of Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma. Biochem Biophys Res Commun. 417(3):1024-1029

23) Song HY, Ju SM, Seo WY, Goh AR, Lee JK, Bae YS, Choi SY, Park J. 2011. Nox2-based NADPH oxidase mediates HIV-1 Tat-induced up-regulation of VCAM-1/ICAM-1 and subsequent monocyte adhesion in human astrocytes. Free Radic Biol Med. 50(5):576-584.

24) Seo WY, Goh AR, Ju SM, Song HY, Kwon DJ, Jun JG, Kim BC, Choi SY, Park J. 2011. Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells. Biochem Biophys Res Commun. 407:535-540.

25) Kwon DJ, Bae YS, Ju SM, Goh AR, Choi SY, Park J. 2011. Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in HaCaT cells. Biochem Biophys Res Commun. 409:780-785.

26) Kim SY, Sohn EJ, Kim DW, Jeong HJ, Kim MJ, Kang HW, Shin MJ, Ahn EH, Kwon SW, Kim YN, Kwon HJ, Kim TY, Lee KS, Park J, Eum WS, Choi SY. 2011. Transduced PEP-1-FK506BP Ameliorates Atopic Dermatitis in NC/Nga Mice. J Invest Dermatol. 131:1477-1485.

27) Kwon SW, Sohn EJ, Kim DW, Jeong HJ, Kim MJ, Ahn EH, Kim YN, Dutta S, Kim DS, Park J, Eum WS, Hwang HS, Choi SY. 2011. Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model. Biochem Biophys Res Commun. 411::354-359.

■ Awards

1) Fellowship, 1987-1991, Department of Microbiology
University of Alabama at Birmingham

2) Korean National Fellowship, 1981-1983, Department of Biological Sciences
Korea Advanced Institute of Science and Technology

3) Academic Award, 2015. 11. 13, 2015 Annual Meeting of The Korean Society for AIDS
The Korean Society for AIDS

주요연구주제
• Pathogenesis of AIDS by HIV, Development of therapeutic tools using protein transduction technology, Development of therapeutic materials against inflammatory diseases 

■ Societies
• The Korean Society of Virology 
• The Korean Society for Biochemistry and Molecular Biology 
• The Korean Society for Molecular Biology and Cell Biology 
• The Korean Society for AIDS

■ Research interests and current research (Laboratory of Virology and Immunology)

1) Background

The global spread of HIV infection and AIDS continues while current therapies are very limited and effective vaccines are nonexistent. Accordingly, novel therapeutic approaches must be devised to target viral gene functions that regulate virus replication and produce disease. Thus, understanding of viral gene function may not only lead to the elucidating the viral pathogenesis, but also may provide new approaches to inhibit HIV replication and/or preventing disease progression.

2) Elucidation of the role of Tat in the pathogenesis of HIV

Tat is a transcription transactivator produced by the human immunodeficiency virus type 1 (HIV-1) at the early phase of infection and plays an essential role in the expression and replication of the viral genome. Tat protein, which can be secreted from the infected cells, has the ability to enter uninfected cells and exert its activity upon the variety of cellular genes, suggesting Tat may affect various cell types in the central nervous system, potentially contributing to the development of AIDS-associated neurological disease. We are currently studying the biological effects of exogenous Tat on cells from the central nervous system (astrocyte and neuronal cell) and the lymphoid T cells (Jurkat). This study will elucidate the critical role of Tat in molecular pathogenesis of AIDS dementia leading to development of therapeutic tools for this disease.

3) Development of protein transduction technology

Protein therapy is based on the delivery of target proteins into cells instead of traditional chemotherapy to treat human diseases. Based on the recent findings that abnormal activity of cellular proteins is responsible for the generation of a variety of human diseases, development of therapeutic agents could be achieved by regulating the biological activity of these proteins. Nevertheless proteins are superior to other chemicals in the selectivity and efficacy of their action mode, utilization of these proteins as the therapeutic drugs is severely limited due to the difficulty of delivery of therapeutic proteins into cells. To overcome this problem, it is necessary to develop a novel technology by which a variety of biologically active proteins could be delivered into cells. This protein transduction technology is based on the previous findings that exogenous HIV-1 Tat protein was able to translocate through the plasma membrane and to reach both the cytosol and nucleus in the cell. By exploiting this property of Tat, we are currently developing a system for the delivery of biologically functional peptide/protein into target cells or tissues.

4) Directions for the anti-inflammatory drug discovery

- Utilize cell-based assays and in vivo testing strategies for the development of anti-inflammatory drugs.

- is initially directed towards discovering inhibitors from natural products and recombinant proteins.

■ Patents (2015~ 현재)

1) 미국특허등록

(1) Eye drop composition for prevention and treatment of ophthalmic diseases containig fusion protein of FK506 Binding Protein

등록일 2015.2.24 등록번호 8,962,567

2) 국내특허등록

(1) 세포투과성 NQO-1 융합단백질을 포함하는 뇌허혈 치료용 약학조성물

등록일: 2015.11.14 등록번호: 10-1677449

(2) 글루타레독신 1 융합단백질을 함유하는 관절염 예방 및 치료용 약학 조성물

등록일: 2016. 10. 26 등록번호: 10-1671197

(3) 세포투과성 NQO1 융합단백질을 함유하는 뇌허혈 치료용 약학 조성물

등록일: 2016. 11. 14 등록번호: 10-1677449

(4) 세포투과성 PIM2 융합단백질을 포함하는 파킨슨병 예방 및 치료용 약학 조성물

등록일: 2017. 04. 26 등록번호: 10-1732349

(5) PEA15 융합단백질을 함유하는 관절염 예방 및 치료용 약학 조성물

등록일: 2017. 07. 20 등록번호: 10-1761550

(6) 사이토카인 유도 세포자기사멸 저해제 1 융합단백질을 포함하는 항염증 약학 조성물

등록일: 2018. 06. 15 등록번호: 10-1869686

■ 논문

주저자 : 제1저자, 공동저자(교신), 단독

• Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1 [BMB Reports, SCI급, 공동(교신), 2015] 

• Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor [BMB Reports, SCI급, 공동(교신), 2013] 

공동저자 : 공동저자(참여)

•  PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models [Immunobiology, SCI급, 공동(참여), 2018] 

•  Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults [Free Radical Biology and Medicine, SCI급, 공동(참여), 2016] 

■ 주요연구주제
•Transcriptional regulation of human NPC1L1 and PCSK9 genes

• Gene regulation by siRNA, saRNA, CRISPRa and CRISPRi

• Transduction of proteins using CPP

■ 학회활동
• The Korean Society for Molecular Biology and Cell Biology

■ 수상
• 중소기업청장상 (2011) 

Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway. Scientific Reports Aug 17. 8:12407 (2018)

Nonsynonymous Variants in PAX4 and GLP1R are Associated with Type 2 Diabetes in an East Asian Population. Diabetes Sep. 67(9): 1892-1902 (2018)

Understanding the functional role of genistein in the bone differentiation in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis. Scientific Reports Feb 19. 8(1): 3257 (2018)

Refining the accuracy of validated target identification through coding variant fine-2 mapping in type 2 diabetes. Nature Genetics Apr 1. 50(4): 559-571 (2018)

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Plos Medicine Sep 12. 14(9):e1002383 (2017)

A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes Jul;66(7):2019-2032 (2017)

Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Human Molecular Genetics May 1, 26:1770-1784 (2017)

The genetic architecture of type 2 diabetes. Nature August 4. 536: 41-47 (2016)

Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics May 15 25(10):2070-2081 (2016)

Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications Jan 28. 7:10531-10543 (2016)

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Scientific Reports 2016 Jan 20. 6:17958 (2016)

Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome Human Reproduction Mar. 30(3): 723-731 (2015)

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci Human Molecular Genetics Mar. 24(6): 1791-1800 (2015)

Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians Diabetes Jan. 64(1): 291-298 (2015)

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians Human Molecular Genetics Dec. 23(24): 6659-6667 (2014)

Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index Human Molecular Genetics Oct. 23(20): 5492-5504 (2014)

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes PNAS Sep. 111(36):13127-13132 (2014)

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes Nature Genetics April 46(4); 357-363 (2014)

Associations of genetic variants in/near BMI-associated genes with type 2 diabetes: A systematic meta-analysis Clinical Endocrinology Nov. 81(5); 702-710 (2014)

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility Nature Genetics March 46(3); 234-244 (2014)

Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium Human Molecular Genetics June 23(11):3054-3068 (2014)

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico Nature Feb 6;506(7486):97-101 (2014)

Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci Hypertension Nov;62(5):853-859 (2013)

Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders Nature Genetics June; 45(6), 621-631 (2013)

Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India Diabetes May;62(5):1746-55 (2013)

Genetics of Type 2 Diabetes in East Asian Populations. Current Diabetes Reports December; 12, 686-696 (2012)

Meta-Analysis Identifies Multiple Loci Associated with Kidney Function-Related Traits in East Asian Populations. Nature Genetics July; 44, 904-909 (2012)

A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval. American Journal of Human Genetics July; 91, 180-184 (2012)

Meta-analysis identifies common variants associated with body mass index in east Asians. Nature Genetics March; 44, 307-311 (2012)

A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women. Diabetes February; 61, 531-541 (2012)

Meta-analysis of Genome-Wide Association Studies Identifies 8 New Loci for Type 2 Diabetes in East Asians. Nature Genetics January; 44, 67-72 (2012)

Large-Scale Genome-Wide Association Study in East Asians Identify New Genetic Loci Influencing Metabolic Traits. Nature Genetics October; 43, 990-995 (2011)

Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk. Nature October; 478, 103-109 (2011)

Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nature Genetics June; 43, 531-538 (2011)

Biological, clinical and population relevance of 95 loci for blood lipids. Nature August; 466, 707-713 (2010)

Identification of New Genetic Risk Variants for Type 2 Diabetes. PLoS Genetics September; 6(9), e1001127 (2010)

A large scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nature Genetics 41, 527-534 (2009)

■ 주요연구주제
• 유전체연구

■ 학술활동

• 2017-현재 한국유전학회 Genes & Genomics 편집위원장

• 2014-2016 한국유전학회 Genes & Genomics 편집간사

• 2015-현재 한국유전학회 이사

• 2012-2016 한국유전체학회 운영위원

• 2012-2014 한국유전체학회 소식지 편집위원장

• 2012-현재 생화학분자생물학회 BMB Reports 편집위원

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53 (2018) Oncogene. Epub ahead of print

Expression of Lrig1, a negative regulator of EGFR, is dynamically altered during different stages of gastric carcinogenesis (2018) Am J Pathol. Epub ahead of print

Gomisin G suppresses the growth of colon cancer cells by attenuation of Akt phosphorylation and arrest of cell cycle progression (2018) Biomol Ther. Epub ahead of print

PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models (2018) Immunobiology. Epub ahead of print.

PEP-1-glutaredoxin 1 protects against hippocampal neuronal cell damage from oxidative stress via regulation of MAPK and apoptosis signaling pathway (2018) Mol Med Rep. 18:2216-2228

Gomisin G inhibits the growth of triple-negative breast cancer cells by suppressing AKT phosphorylation and decreasing cyclin D1 (2018) Biomol Ther. 36:322-327

B cell-intrinsic mTORC1 promotes germinal center-defining transcription factor gene expression, somatic hypermutation, and memory B cell generation in humoral immunity. (2018) J Immunol. 200:2627-2639.

CD11b regulates antibody class switching via inducing AID (2017) Mol Immunol. 87:47-59

Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway (2017) Mol Brain. 10:1

Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults (2016) Free Radic Biol Med. 97:2501262

Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kB/AP-1 signaling pathways in macrophages (2016) Free Radic Biol Med. 97:14-23

Aronia melanocarpa Concentrate Ameliorates Pro-Inflammatory Responses in HaCaT Keratinocytes and 12-O-Tetradecanoylphorbol-13-Acetate-Induced Ear Edema in Mice (2016) J Med Food. 19:654-662

Tat-ATOX1 inhibits streptozotocin-induced cell death in pancreatic RINm5F cells and attenuates diabetes in a mouse model (2016) Int J Mol Med. 38:217-224

Extracellular release of CD11b by TLR9 stimulation in macrophages (2016) PLoS One. 11:e0150677

Rapamycin-resistant and torin-sensitive mTOR signaling promotes survival and proliferation of leukemic cells (2016) BMB Rep. 49:63-68

Monoclonal antibodies against the human respiratory syncytial virus obtained by immunization with epitope peptieds and CpG-DNA-liposome complex (2015) Monoclon Antib Immunodiagn Immunother. 34:101-109

Tat-antioxidant 1 protects against stress-induced hippocampal HT-22 cells death and attenuate ischaemic insult in animal model (2015) J. Cell. Mol. Med. 19:1333-1345

Effect of respiratory syncytial virus on hepatocellular carcinoma cell lines (2015) BMB Rep. 48:565-570

Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways (2015) Mol. Cell. Biol. 35:1299-1313

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells (2014) J. Exp. Med. 211:2281-2295.

Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer (2014) Gut Liver. 8: 1-9

Crosstalk between Akt and p38α pathways in macrophages downstream of Toll-like receptor signaling (2013) Mol. Cell. Biol. 33: 4152-4156

Requirement for Rictor in homeostasis and function of mature B lymphoid cells (2013) Blood. 122: 2369-2379

Cdc42 promotes host defenses against fatal infection (2013) Infect. Immun. 81:2714-2723

STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation (2013) J. Immunol. 191:678-687

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1 and regulatory T cell induction (2013) Blood. 121:3619-3630

Effects of cancer-associated Epha3 mutations on lung cancer (2012) J. Natl. Caner Inst. 104:1083-1098

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia (2012) J. Exp. Med. 209:713-728

A “Tsc, Tsc” keeps the kids quie(scen)t and holds off ROS (2011) Nat. Immunol. 12:811-812

Control of macrophage responses on hydrophobic and hydrophilic carbon nanostructures (2011) Carbon. 49:2092-2103

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways (2010) Immunity. 32: 743-753

■ 주요연구주제
• PI3K/mTOR signaling networks and immunity

• Immunoediting factors and tumor microenvironment

• Immunophenotyping and pathogen infection service of genetically engineered mice

■ 학회활동
• 생화학분자생물학회 운영위원회

• 한국실험동물학회 학술위원회

• American Association of Immunology 회원

microRNA와 autophagy

- 윤부줄기세포(limbal stem cells)에서 microRNA에 의한 줄기세포 특성 및 autophagy 조절기전 연구

- 각막상피세포(corneal epithelial cells)에서 microRNA에 의한 각막세포재생, 신생혈관형성, autophagy 조절기전 연구

- MicroRNA에 의한 암세포의 성장, 전이, 세포사멸 기전연구

■ 논문 (2010년 이후)

ㆍ Kaplan N, Dong Y, Wang S, Yang W, Park JK, Wang J, Fiolek E, White BP, Chandel NS, Peng H, Lavker RM. FIH‐1 engages novel binding partners to positively influence epithelial proliferation via p63. FASEB J, 2020 Jan; 34: 525-539.

ㆍ Seo HA, Moeng S, Sim S, Kuh HJ, Choi SY, Park JK. MicroRNA-Based Combinatorial Cancer Therapy: Effects of MicroRNAs on the Efficacy of Anti-Cancer Therapies. Cells. 2019 Dec 20;9(1). pii: E29.

ㆍ Nam S, Khawar IA, Park JK, Chang S, Kuh HJ. Cellular context-dependent interaction between cancer and stellate cells in hetero-type multicellular spheroids of pancreatic tumor. Biochem Biophys Res Commun. 2019 Jul 12;515(1):183-189.

ㆍ Seo HA, Hwang CY, Moeng S, Park JK. An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells. J Vis Exp. 2019 May 21;(147)

ㆍ Moeng S, Seo HA, Hwang CY, Cipolla GA, Lee DJ, Kuh HJ, Park JK. MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide. Anticancer Res. 2018 Nov;38(11):6309-6316.

ㆍ Park JK, Seo JS, Lee SK, Chan KK, Kuh HJ. Combinatorial antitumor activity of oxaliplatin with epgenetic modifying agents, 5-Aza-CdR and FK228, in human gastric cancer cells. Biomol Ther (Seoul). 2018 Nov 1;26(6):591-598.

ㆍ Khawar IA, Park JK, Jung ES, Lee MA, Chang S, Kuh HJ, Three dimensional mixed-cell spheroids mimic stroma-mediated chemoresistance and invasive migration in hepatocellular carcinoma, Neoplasia 2018 2018 Jul 4;20(8):800-812.

ㆍ Park JK, Doseff A, Schmittgen TD. MicroRNAs targeting caspase-3 and -7 in panc-1 cells. Int J Mol Sci. 2018 Apr 16;19(4). pii: E1206 (co-corresponding).

ㆍ Cipolla GA, Park JK, Lavker RM, Petzl-Erler ML. Crosstalk between Signaling Pathways in Pemphigus: A Role for Endoplasmic Reticulum Stress in p38 Mitogen-Activated Protein Kinase Activation? Front Immunol. 2017 Sep 5; 8: 1022.

ㆍ Peng H, Park JK, Lavker RM. Eyeing Autophagy and Macropinocytosis in the Corneal/Limbal Epithelia. Autophagy. 2017 May 4;13(5):975-977. (co 1st author).

ㆍ Peng H, Park JK, Lavker RM. Autophagy and Macropinocytosis: Keeping an Eye on the Corneal/limbal Epithelia. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):416-423. (co 1st author).

ㆍ Park JK, Peng H, Yang W, Katsnelson J, Volpert O, Lavker RM. microRNA-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J. 2017 Jan 1; 31(1):256-265.

ㆍ Park JK, Peng H, Katsnelson J, Yang W, Kaplan N, Dong Y, Rappoport JZ, He C, Lavker RM. microRNAs-103/107 coordinately regulate macropinocytosis and autophagy. J Cell Biol. 2016 Dec 5;215(5):667-685.

ㆍ Kim JH, Badawi M, Park JK, Jiang J, Mo X, Roberts LR, Schmittgen TD. Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. Int J Oncol. 2016 Nov;49(5):2037-2045. 

ㆍ Cipolla GA, Park JK, de Oliveira LA, Lobo-Alves SC, de Almeida RC, Farias TD, de S Lemos D, Malheiros D, Lavker RM, Petzl-Erler ML. A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. Biochim Biophys Acta. 2016 Oct;1859(10):1306-13. 

ㆍ Park JK, Yang W, Katsnelson J, Lavker RM, Peng H. microRNAs enhance keratinocyte proliferative capacity in a stem cell-enriched epithelium. PLoS One. 2015; 10(8): e0134853.

ㆍ Peng H, Park JK, Katsnelson J, Kaplan N, Yang W, Getsios S, Lavker RM. microRNA-103/107 family regulates multiple epithelial stem cell characteristics. Stem Cells. 2015; 33(5):1642-56. (co 1st author).

ㆍ Lee SH, Nam JK, Park JK, Lee JH, Min DS, Kuh HJ. Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model. Oncol Rep. 2014; 32(4):1427-34.

ㆍ Kim TW, Cui R, Jeon YJ, Lee JH, Lee JH, Sim HS, Park JK, Fadda P, Tili E, Nakanishi H, Huh MI, Kim SH, Cho JH, Sung BH, Peng Y, Lee TJ, Luo Z, Sun HL, Wei H, Alder H, Oh JS, Shim KS, Ko SB, Croce CM. Long-range interaction and correlation between MYC enhancer and oncogenic lncRNA CARLo-5. Proc Natl Acad Sci U S A. 2014; 18;111(11):4173-8.

ㆍ Elgamal OA, Park JK, Gusev Y, Azevedo-Pouly AC, Jiang J, Roopra A, Schmittgen TD. Tumor Suppressive Function of mir-205 in Breast Cancer Is Linked to HMGB3 Regulation. PLoS One. 2013; 2;8(10):e76402. (co 1st author).

ㆍ Park JK, Kogure T, Nuovo GJ, Jiang J, He L, Kim JH, Phelps MA, Papenfuss TL, Croce CM, Patel T, Schmittgen TD. miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Cancer Res. 2011; 71(24): 7608-16.

ㆍ Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD. miR-132 and miR-212 are increased in pancreatic adenocarcinoma and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011; 406(4): 518-23.

ㆍ Henry JC, Park JK, Jiang J, Kim JH, Nagorney DM, Roberts LR, Banerjee S, Schmittgen TD. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2010; 403(1): 120-5. (co 1st author).

학회활동

2018 ~ 현재, Oncology Letters, Editorial Board Member  

2006 – 현재, 미국 암학회 (AACR)

2012 – 현재, 미국 안과 및 시과학회 (ARVO)

미국 고든 리서치 세미나 의장 (Cornea, Biology & Pathobiology of the Gordon Research Seminar, 2016년)