대학/대학원

대학/대학원

바이오메디컬학과

최수영
  • 분야

    생화학

  • 성명

    국문 최수영

  • 직위

    연구석좌교수

  • 연구실

    생명과학관 8409호실

  • 연락처

    033-248-2112

  • 이메일

학력

• 1986 테네시대학교(미국 녹스빌) (박사-생화학)
• 1982 연세대학교(이학석사-생화학)
• 1980 연세대학교(이학사-생화학) 

 

개인 홈페이지 

주요경력

•2019.03 – 현재 한림대학교 연구석좌교수

•2017.1.1 – 2017.12.31 한국유전학회 이사
•2016.8.11 – 현재  국가생명공학육성기본계획 기획위원
•2016.1.1 – 2017.12.31 한국뇌신경과학회 이사 
•2015.8.5 – 2017.8.6 국가생명공학종합정책심의회 위원
•2015.8.1 – 2018.7.31 한국연구재단 생명과학단 책임전문위원(Chief Review Board)
•2014.1.1 – 2014.12.31 한국생화학분자생물학회 회장
•2013.11.25 – 2017.11.25 강원컨벤션뷰로 이사장
• 2014 – 현재  한국생화학분자생물학회 회장 
• 2013 – 현재  강원도 국제회의산업지원센터 이사장 
• 2012 – 2014 한림대학교 부총장 
• 2011 – 2011 한국생화학분자생물학회 부회장 
• 2010 – 2010 한국뇌신경과학회 회장 
• 2007 – 2010 한림대학교 부총장 
• 2006 – 현재 한국과학기술한림원 정회원 
• 2006 – 2010 생화학분자생물학회학술지(BMB Reports) 편집위원장 
• 2003 – 2007 한림대학교 교무연구처장 
• 2002 – 2013 춘천바이오산업진흥원 이사 
• 2002 – 2003 한림대학교 산학협력단장 
• 1998 – 1999 한림대학교 기획처장 
• 1994 – 1996 한림대학교 교무부처장 
• 1987 – 1988 University of California, Berkeley, U.S.A연구원 

연구 및 저서

■ 논문 (2024년도)

• Protective effect of Tat fused HPCA protein on neuronal cell death caused by ischemic injury Heliyon 10, e23488 (2023) 

 

■ 논문 (2023년도)

• Protective Effects of PEP-1-GSTA2 Protein in Hippocampal Neuronal Cell Damage Induced by Oxidative Stress International Journal of Molecular Sciences 24, 2767 (2023)

• Tat-GSTpi Inhibits Dopaminergic Cells against MPP+-Induced Cellular Damage via the Reduction of Oxidative Stress and MAPK Activation Biomedicines 11, 836 (2023)

• Tat-Thioredoxin-like protein 1 attenuates ischemic brain injury by regulation of MAPKs and apoptosis signaling BMB Reports 56, 234 (2023)

• Tat-RAN attenuates brain ischemic injury in hippocampal HT-22 cells and ischemia animal model Neurochemistry International 167, 105538 (2023)

• Protective effects of cell permeable Tat-PIM2 protein on oxidative stress induced dopaminergic neuronal cell death Heliyon 9, e15945 (2023)

• Protective effect of GK2 fused BLVRA protein against oxidative stress-induced dopaminergic neuronal cell damage FEBS Journal 290, 2923 (2023)

• Synergistic apoptosis by combination of metformin and an O-GlcNAcylation inhibitor in colon cancer cells Cancer Cell International 23, 108 (2023)

• Tat–CIAPIN1 Prevents Pancreatic β-cell Death in hIAPP-Induced RINm5F cells and T2DM Animal Model International Journal of Molecular Sciences 24, 10478 (2023)

 

■ 논문 (2022년도)

• Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers International Journal of Molecular Sciences 23, 930 (2022)

• Neuroprotective Effects of Purpurin Against Ischemic Damage via MAPKs, Bax, and Oxidative Stress Cascades in the Gerbil Hippocampus Molecular Neurobiology 59, 2580 (2022)  Pinus thunbergii bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice Molecular Medicine Reports 25, 100 (2022)

• Astaxanthin Confers a Significant Attenuation of Hippocampal Neuronal Loss Induced by Severe Ischemia‐Reperfusion Injury in Gerbils by Reducing Oxidative Stress Marine Drugs 20, 267 (2022)

•Relationship between neuronal damage/death and astrogliosis in the cerebral motor cortex of gerbil models of mild and severe ischemia and repression injury International Journal of Molecular Sciences 23, 5096 (2022)  Metformin ameliorates olanzapine-induced disturbances in POMC neuron number, axonal projection, and hypothalamic leptin resistance BMB Reports 55, 293 (2022)

•Effects of Brain Factor-7® against motor deficit and oxidative stress in a mouse model of MPTP-induced Parkinson's disease Experimental and Therapeutic Medicine 24, 635 (2022)

•Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic inflammation and microglial activation in female mice Frontiers in Pharmacology 10, 3389 (2022)

•Protective Effects of Topical Administration of Laminarin in Oxazolone‐Induced Atopic Dermatitis‐Like Skin Lesions Marine Drugs 20, 669 (2022)

Therapeutic Administration of Oxcarbazepine Saves Cerebellar Purkinje Cells from Ischemia and Reperfusion Injury Induced by Cardiac Arrest through Attenuation of Oxidative Stress Antioxidants 11, 2450 (2022)  Brain Factor-7® Improves Cognitive Impairment Following Transient Ischemia and Reperfusion Injury in Gerbil Forebrain through Promoting Remyelination and Restoring Cholinergic and Glutamatergic Neurotransmission in the Hippocampus Frontiers in Bioscience 27, 337 (2022)

 

■ 논문 (2021년도)


• Tat-Aldose reductase prevents dopaminergic neuronal cell death by the inhibition of oxidative stress and MAPK activation International Journal of Molecular Medicine  47, 751-760 (2021)   


• Neuronal death in the CNS autonomic control center comes very earlyafter cardiac arrest and is not significantly attenuated by prompt hypothermic treatment in rats Cells   10, 60 (2021)  


• Gynura procumbens root extract ameliorates ischemia-induced neuronal damage in the hippocampal CA1 region by reducing neuroinflammation Nutrients   13, 181 (2021)   


• The role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer International Journal of Molecular Sciences  22, 627 (2021)  


• Tyrosine phosphorylation modulates peroxiredoxin-2 activity in normal and diseased red cells Antioxidants   10, 206( (2021)  


• BDNF and netrin-1 repression by C/EBPβ in the gut triggers Parkinson's disease pathologies, associated with constipation and motor dysfunction Progress in Neurobiology    198, 101905 (2021)   


• Therapeutic Effects of Decursin and Angelica gigas Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage Molecules   26, 2161 (2021)  


• Ischemia-Reperfusion under Hyperthermia Increases Heme Oxygenase-1 in Pyramidal Neurons and Astrocytes with Accelerating Neuronal Loss in Gerbil Hippocampus International Journal of Molecular Sciences  22, 3963 (2021) 


• Neuroprotective effects of salicin in a gerbil model of transient forebrain ischemia by attenuating oxidative stress and activating PI3K/Akt/GSK3β pathway Antioxidants 10, 629 (2021)  


• Protective Role of Transduced Tat-Thioredoxin1 (Trx1) Against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway Biomolecules and Therapeutics  29, 321-330 (2021)


• PEP-1-GLRX1 reduces dopaminergic neuronal cell loss by modulating MAPK and apoptosis signaling in Parkinson’s disease Molecules   (2021)  26, 3329 


• Cissus verticillata extract decreases neuronal damage induced by oxidative stress in HT22 cells and ischemia in gerbils by reducing the inflammation and phosphorylation of MAPKs Plants   10, 1217, (2021) 


• Transduced Tat-PRAS40 prevents dopaminergic neuronal cell death through ROS inhibition and interaction with 14-3-3σ protein Free Radical Biology & Medicine  172, 418-429 (2021)  


• The Hypoxia-Long Noncoding RNA Interaction in Solid Cancers International Journal of Molecular Sciences  22, 7261 (2021) 


• Differences in TNF‑α and TNF‑R1 expression in damaged neurons and activated astrocytes of the hippocampal CA1 region between young and adult gerbils following transient forebrain ischemia Molecular Medicine Reports   24, 625 (2021) 


• Changes in Cyclin D1, cdk4, and Their Associated Molecules in Ischemic Pyramidal Neurons in Gerbil Hippocampus after Transient Ischemia and Neuroprotective Effects of Ischemic Preconditioning by Keeping the Molecules in theIschemic Neurons Biology  10, 719  (2021)  


• Neuroprotective and antiinflammatory effects of Pinus densiflora barkextract in gerbil hippocampus following transient forebrain ischemia Molecules   26,  4592 (2021)  


• Tat-27 ameliorates neuronal damage reducing a-synuclein and inflammatory responses in motor neurons after spinal cord ischemia Neurochemical Research  10, 1007   (2021) 


• Extracts from the Leaves of Cissus verticillata AmeliorateHigh-Fat Diet-Induced Memory Deficits in Mice Plants  10, 1814  (2021) 


• Populus tomentiglandulosa Extract Is Rich in Polyphenols andProtects Neurons, Astrocytes, and the Blood-Brain Barrier inGerbil Striatum Following Ischemia-Reperfusion Injury Molecules   26,  5430 (2021)  


• Anti‐Cancer Activity of Phytochemicals Targeting   Hypoxia‐Inducible Factor‐1 Alpha International Journal of Molecular Sciences  22, 9819 (2021) 


• Tat-CIAPIN1 protein prevents against cytokine-induced cytotoxicity in pancreatic RINm5F β-cells BMB Reports  54, 458-463 (2021)  


• Comparison of Neuronal Death, Blood–Brain Barrier Leakage and Infammatory Cytokine Expression in the Hippocampal CA1 Region Following Mild and Severe Transient Forebrain Ischemia in Gerbils Neurochemical Research  10, 1007   (2021)  


• Tat-thioredoxin1 protects inflammation by inhibiting  pro-inflammatory cytokines and modulating MAPK signaling Experimental and Therapeutic Medicine 22, 1395  (2021)   


• Utilization of an intracellular calcium mobilization assay for the screening of transduced FK506-binding proteins Assay and Drug Development Technologies  19, 442 (2021)  


• Therapeutic Effects of Risperidone against Spinal Cord Injury in a Rat Model of Asphyxial Cardiac Arrest: A Focus on Body Temperature, Paraplegia, Motor Neuron Damage and Neuroinflammation Veterinary Sciences   (2021) 


• OSMI-1 enhances TRAIL-induced apoptosis through ER stress and NF-kB signaling in colon cancer cells International Journal of Molecular Sciences   22, 11073 (2021) 


• The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers International Journal of Molecular Sciences   22, 7261 (2021) 

 

■ 논문 (2020년도)


• The Potential of MicroRNA Modulation as Therapeutic Strategies for Prevailing Over the Resistance of Cancer Cells  9,  29 (2020)


• Therapeutic Hypothermia Improves Hind Limb Motor Outcome and Attenuates Oxidative Stress and Neuronal Damage in the Lumbar Spinal Cord Cardiac Arrest Antioxidants  9, 38 (2020)   


• Differential roles of exogenous protein disulfide isomerase A3 on proliferating cell and neuroblast numbers in the normal and ischemic gerbils Brain and Behavior  DOI:10.1002/brb3.1534 (2020) 


• Indoleamine-2,3-dioxygenase-1 is a molecular target for the protective activity of mood stabilizers against mania-like behavior induced by d-amphetamine Food and Chemical Toxicology  136, 110986 (2020)   


• PEP-1-GLRX1 protein exhibits anti-inflammatory effects by inhibiting the activation of MAPK and NF-κB pathways in Raw 264.7 cells BMB Reports  53, 106-111  (2020) 


• Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling International Journal of Molecular Sciences   21, 267 (2020)  


• Laminarin pretreatment provides neuroprotection against forebrain ischemia/reperfusion injury by reducing oxidative stress and neuroinflammation in aged gerbils Marine Drugs  18, 213 (2020) 


• MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages BMB Reports  53, 223-228 (2020) 


• Fyn Specifically Regulates the Activity of Red Cell Glucose-6-Phosphate-Dehydrogenase Redox Biology    36, 101639 (2020) 


• Extracellular Vesicles (EVs) and Pancreatic Cancer: From the Role of EVs to the Interference with EV-Mediated Reciprocal Communication Biomedicines 8, 267 (2020)  


• Experimental pretreatment with chlorogenic acid prevents transient ischemia-induced cognitive decline and neuronal damage in the hippocampus through anti-oxidative and anti-inflammatory effects Molecules  25, 3578  (2020)  


• Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals Molecules  25, 4701 (2020)  


• N-Adamantyl-4-methylthiazol-2-amine suppresses glutamate-induced autophagic cell death via PI3K/Akt/mTOR signaling pathways in cortical neurons. BMB Reports  53, 527-532  (2020) 


• Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury BMB Reports  53, 582-587 (2020)  


• P27 Protects Neurons from Ischemic Damage by Suppressing Oxidative Stress and Autophagy in the Hippocampus International Journal of Molecular Sciences  21, 9496  (2020) 

 

■ 논문 (2019년도)


• Neuroprotective effects of Tat-ATOX1 protein against MPP+-induced SH-SY5Y cell deaths and in MPTP-induced mouse model of Parkinson’s disease Biochimie   156, 158-168  (2019)  


• Tat-CIAPIN1 inhibits hippocampal neuronal cell damage through the MAPK and apoptotic signaling pathways Free Radical Biology & Medicine  135, 68-78   (2019) 


• Antioxidant properties of fucoidan alleviate acceleration and exacerbation of hippocampal neuronal death following transient global cerebral ischemia in high-fat diet-induced obese gerbils International Journal of Molecular Sciences 20, 554 (2019)


• Fate of Astrocytes in The Gerbil Hippocampus After Transient Global Cerebral Ischemia International Journal of Molecular Science    20,  845   (2019) 


• Protein disulfide-isomerase A3 significantly reduces ischemia-induced damage by oxidative and endoplasmic reticulum stress Neurochemistry International  122,19-30 (2019) 


• Fluoro-Jade B histofluorescence staining detects dentate granule cell death after repeated five-minute transient global cerebral ischemia Metabolic Brain Diseases   34, 951-956  (2019) 


• Protective effects of N,4,5-trimethylthiazol-2-amine hydrochloride on hypoxia-induced -amyloid production in SH-SY5Y cells BMB Reports   52, 439-444 (2019) 


• Transduced Tat-Aldose reductase protects hippocampal neuronal cells against oxidative stress-induced damage Experimental Neurobiology 28, 612-627 (2019)  


• Phosphatidylethanolamine-binding protein 1 ameliorates ischemia-induced inflammation and neuronal damage in the rabbit spinal cord Cells  8, 1370 (2019)  


• Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS- and TPA-induced damages BMB Reports  52, 695-699  (2019)   

 

■ 논문 (2012-2018년도)


• PEP-1-paraoxonase 1 fusion protein prevents cytokine-induced cell destruction and impaired insulin secretion in rat insulinoma cells BMB Reports  51, 538-543  (2018) 


• Effects of Silk Solution Against Laminectomy-induced Dural Adhesion Formation and Inflammation in Rat Model Journal of Neurosurgery / Spine  29, 599-607 (2018) 


• 3-(Naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride attenuates MPP+-induced cytotoxicity by regulating oxidative stress and mitochondrial dysfunction in SH-SY5Y cells BMB Reports   51, 590-595   (2018)  


• Tat-ATOX1 Inhibits Inflammatory Responses via Regulation of MAPK and NF-κB pathways BMB Reports   51, 654-659 (2018) 


• Hindsiipropane B alleviates HIV-1 Tat-induced inflammatory responses by suppressing HDAC6-NADPH oxidase-ROS axis in astrocytes Biochemical Pharmacology 51, 394-399 (2018)


• Melatonin improves cognitive deficits via restoration of cholinergic degeneration in a mouse model of scopolamine-induced amnesia ACS Chemical Neuroscience 9, 2016-2024 (2018)


• PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models Immunobiology 223, 709-717 (2018)


• Effects of scopolamine and melatonin cotreatment on cognition, neuronal damage, and neurogenesis in the mouse dentate gyrus Neurochemical Research 43, 600-608 (2018)


• Phosphatidylethanolamine-binding protein 1 protects CA1 neurons against ischemic damage via ERK-CREB signaling in Mongolian gerbils Neurochemistry International 118, 265-274 (2018)


• Protective effects of Tat-DJ-1 protein against streptozotocin (STZ)-induced diabetes in a mice model BMB Reports 51, 362-367 (2018)


• PEP-1-glutaredoxin 1 protects hippocampal neuronal cells against oxidative stress via regulation of MAPK and apoptotic signal pathways Molecular Medicine Reports 18, 2216-2228 (2018)


• Neuronal loss and gliosis in the rat striatum subjected to 15 and 30 minutes of middle cerebral artery occlusion Metabolic Brain Disease 33, 775-784 (2018)


• Age-dependent decreases in insulin-like growth factor-I and its receptor expressions in the gerbil olfactory bulb Molecular Medicine Reports 17, 8161-8166 (2018)


• Long-term treadmill exercise improves memory impairment through restoration of decreased synaptic adhesion molecule 1/2/3 induced by transient cerebral ischemia in the aged gerbil hippocampus Experimental Gerontology 103, 124-131 (2018)


• The distribution of calbindinD-28k and parvalbumin immunoreactive neurons in the somatosensory area of the pigeon pallium. Anatomia, Histologia, Embryologia 47(1), 64-70 (2018)


• Peroxyredoxin-2: A Novel regulator of iron homeostasis in ineffective erythropoiesis Antioxidants and Redox Signaling 28(1), 1-14 (2018)


• Effects of chronic scopolamine treatment on cognitive impairment and neurofilament expression in the mouse hippocampus Molecular Medicine Reports 17, 1625-1632 (2018)


• Effects of long‑term scopolamine treatment on cognitive deficits and calcium binding proteins immunoreactivities in the mouse hippocampus Molecular Medicine Reports 17, 293-299 (2018)


• Anti-inflammatory and anti-oxidative effects of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on β-amyloid-induced microglial activation BMB Reports 50, 634-639 (2017)


• Neuroprotection and reduced gliosis by pre- and post-treatments of hydroquinone in a gerbil model of transient cerebral ischemia Chemico-Biological Interactions 278, 230-238 (2017)


• Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis Data in Brief 15, 376-381 (2017)


• The location of projection neurons to the biceps brachii muscle in the telencephalon of the pigeon Anatomia, Histologia, Embryologia 46(6), 528-532


• Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension Free Radical Biology & Medicine 112, 376-386 (2017)


• Roles of HIF-1α, VEGF and NF-κB in ischemic preconditioning-mediated neuroprotection of hippocampal CA1 pyramidal neurons against a subsequent transient cerebral ischemia Molecular Neurobiology 54(9), 6984-5998 (2017)


• Immunoreactivities of calbindin-D28k, calretinin and parvalbumin in the somatosensory cortex of rodents during normal aging Molecular Medicine Reports 16(5), 7191-7198 (2016)


• Tat-protein disulfide-isomerase A3: A possible candidate for preventing ischemic damage in the spinal cord Cell Death & Disease 8, e3075 ; doi:10, 1038/cddis.2017.473 (2017)


• Effects of PEP-1-FK506BP on cyst formation in polycystic kidney disease BMB reports 50, 460-465 (2017)


• Atomoxetine protects against NMDA receptor-mediated hippocampal neuronal death following transient global cerebral ischemia Current Neurovascular Research 14, 158-168 (2017)


• Neuroprotective effect of 3-(naphthalen-2-yl(propoxy)methyl)azetidine hydrochloride on brain ischaemia/reperfusion injury Journal of Neuroimmune Pharmacology 12, 447-461 (2017)


• Chronic administration of SUMO-1 has negative effects on novel object recognition memory as well as cell proliferation and neuroblast differentiation in the mouse dentate gyrus Molecular Medicine Reports 16, 3427-3432 (2017)


• N-Adamantyl-4-methylthiazol-2-amine attenuates glutamate-induced oxidative stress and inflammation in brain Neurotoxical Research 32, 107-120 (2017)


• G protein, phosphorylated-GATA4 and VEGF expression in the hearts of transgenic mice overexpressing β1- and β2-adrenergic receptors. Molecular Medicine Reports 15, 4049-4054 (2017)


• Tat-biliverdin reductase A protects INS-1 cells from human islet amyloid polypeptide-induced cytotoxicity by alleviating oxidative stress and ER stress Cell Biology International 41, 514-524 (2017)


• Effects of long-term post-ischemic treadmill exercise on gliosis in the aged gerbil hippocampus induced by transient cerebral ischemia Molecular Medicine Reports 15, 3623-3630 (2017)


• SUMO-1 delays neuronal damage in the spinal cord following ischemia/reperfusion Molecular Medicine Reports 15, 4312-4318 (2017)


• Crosstalk between HDAC6 and Nox2-based NADPH oxidase mediates HIV-1 Tat-induced pro-inflammatory responses in astrocytes Redox Biology 12, 978-986 (2017)


• Tat-DJ-1 enhances cell survival by inhibition of oxidative stress, NF-κB and MAPK activation in HepG2 cells Biotechnology Letters 39, 511-521 (2017)


• Celastrol suppresses expression of adhesion molecules and chemokines by inhibiting JNK-STAT1/NF-kB activation in poly(I:C)-stimulated astrocytes BMB reports 50, 25-30 (2017)


• Tat-HSP22 inhibits oxidative stress-induced hippocampal neuronal cell death by regulation of the mitochondrial pathway Molecular Brain 10, 1-13 (2017)


• Neuroprotective effects of N-adamantyl-4-methylthiazol-2-amine against amyloid β-induced oxidative stress in mouse hippocampus Brain Research Bulletin 128, 22-28 (2017)


• Intravenously infused F3.Olig2 improve memory deficits via restoring demyelination in the aged hippocampus following experimental ischemic stroke Cell Transplantation 25, 2129-2144 (2016)


• Protective effects of Tat-NQO1 against oxidative stress-induced HT-22 cell damage and ischemic injury in an animal model BMB reports 49, 617-622 (2016)


• Cu,Zn-Superoxide Dismutase Increases the Therapeutic Potential of Adipose-derived Mesenchymal Stem Cells by Maintaining Antioxidant Enzyme Levels Neurochemical Research 41, 3300-3307 (2016)


• Tat-DJ-1 inhibits oxidative stress-mediated RINm5F cell death through suppression of NF-κB and MAPK activation Medicinal Chemistry Research 25, 2589-2598 (2016)


• PEP-1-SIRT2-induced matrix metalloproteinase-1 and -13 modulates type II collagen expression via ERK signaling in rabbit articular chondrocytes Experimental Cell Research 348, 201-208 (2016)


• Cytokine-induced apoptosis inhibitor-1 causes dedifferentiation of rabbit articular chondrocytes via the ERK-1/2 and p38 kinase pathways The International Journal of Biochemistry & Cell Biology 80, 10-18 (2016)


• Long-term exercise improves memory deficits via restoration and microvessel damage, and enhancement of neurogenesis in the aged gerbil hippocampus after ischemic stroke Neurorehabilitation & Neural Repair 30, 894-905 (2016)


• Effect of ischemic preconditioning on antioxidant status in the gerbil hippocampal CA1 region after transient forebrain ischemia Neural Regeneration Research 11, 1081-1089 (2016)


• PEP-1-GSTpi protein enhanced hippocampal neuronal cell survival after oxidative damage BMB Reports 49, 382-387 (2016)


• Aronia melanocarpa concentrate ameliorates pro-inflammatory responses in HaCaT karatinocytes and 12-O-tetradecanoylphorbol-13-acetate-induced ear edema in mice Journal of Medicinal Food 19, 654-662 (2016)


• Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults Free Radical Biology & Medicine 97, 250-262 (2016)


• Tat-NOL3 protects against oxidative stress-induced hippocampal neuronal cell death by regulation of apoptotic pathways International Journal of Molecular Medicine 38(1), 225-235


• Tat-ATOX1 inhibits streptozotocin (STZ)-induced pancreatic RINm5F cell death and attenuates diabetes in a mice model International Journal of Molecular Medicine 38(1), 217-224 (2016)


• Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats Molecular Medicine Reports 14(1), 851-856 (2016)


• Transduced Tat-DJ-1 protein inhibits cytokines-induced pancreatic RINm5F cell death BMB Reports 49(5), 297-302 (2016)


• Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kB/AP-1 signalling pathways in macrophages Free Radical Biology & Medicine 97, 14-23 (2016)


• N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons Free Radical Research 50(6), 678-690 (2016)


• Heme Oxygenase-1 protects neurons from ischemic damage by upregulating expression of Cu,Zn-superoxide dismutase, catalase, and brain-derived neurotrophic factor in the rabbit spinal cord Neurochemical Research 41, 869-879 (2016)


• A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission Scientific Reports 6(Article number:22892), 1-11 (2016)


• Blockade of monocyte-endothelial trafficking by transduced tat-superoxide dismutase protein International Journal of Molecular Medicine 37, 387-397 (2016)


• 2,3-dimethoxy-2′-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells" BMB Reports 49(1), 57-62 (2016)


• 2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride alters lipopolysaccharide-induced proinflammatory cytokines and neuronal morphology in mouse fetal brain. Neuropharmacology 102, 32-41 (2016)


• The interplay between peroxyredoxin-2 and Nrf2 is important in limiting oxidative mediated dysfunction in β-thalassemic erythropoiesis Antioxidants and Redox Signaling 23(16) 1284-1297 (2015)


• PEP-1-SIRT2 causes dedifferentiation and COX-2 expression via the MAPK pathways in rabbit articular chondrocytes Experimental Cell Research 339, 351-359 (2015)


• PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury BMB Reports 48, 618-623 (2015)


• The azetidine derivative, KHG26792 protects against ATP-induced activation of NFAT and MAPK pathways through P2X7 receptor in microglia. Neurotoxicology 51, 198-206 (2015)


• Failure in neuroprotection of remote limb ischemic postconditioning in the hippocampus of a gerbil model of transient cerebral ischemia Journal of the Neurological Sciences 358, 377-384 (2015)


• Monocarboxylate transporter 4 plays a significant role in the neuroprotective mechanism of ischemic preconditioning in transient cerebral ischemia Neural Regeneration Research 10, 1604-1611 (2015)


• Effects of low doses of Tat-PIM2 protein against hippocampal neuronal cell survival Journal of Neurological Science 358, 226-235 (2015)


• HDAC6 mediates HIV-1 Tat-induced pro-inflammatory responses by regulating MAPK-NF-kappaB/AP-1 pathways in astrocytes Glia 63(11), 1953-1965 (2015)


• Transcriptional regulation of Niemann-Pick C1 like 1(NPC1L1) gene by liver receptor homolog-1 (LRH-1) BMB Reports 48, 513-518 (2015)


• Butein, a tetrahydroxychalcone, supresses pro-inflammatory responses in HaCaT karatinocytes BMB Reports 48, 495-500 (2015)


• Effective delivery of endogenous antioxidants ameliorates diabetic nephropathy PLoS One 10(6), e0130815 (2015)


• PEP-1-FK506BP12 inhibits matrix metalloproteinase expression in human articular chondrocytes and in a mouse carrageenan-induced arthritis model BMB Reports 48, 407-412 (2015)


• Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson’s disease BMB Reports 48, 395-400 (2015)


• Transduced PEP-1-PON1 proteins regulate microglial activation and dopaminergic neuronal death in a Parkinson’s disease model Biomaterials 64, 45-56 (2015)


• Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-kB and MAPKs activation in macrophages and mice Toxicology and Applied Pharmacology 286, 124-134 (2015)


• Tat-antioxidant 1 protects against stress-induced hippocampal HT-22 cells death and attenuate ischemic insult in animal model Journal of Cellular and Molecular Medicine 19, 1333-1345 (2015)


• Comparison of immunoreactivities of calbindin-D28k, calretinin and paralbumin in the striatum between young and aged mice, rats and gerbils Neurochemical Research 40, 864-872 (2015)


• Transduction of PEP-1-heme oxygenase-1 into insulin-producing INS-1 cells protects them against cytokine-induced cell death


Biochemical Biophysical Research Communication 461, 549-554 (2015)


• Antioxidative effects of ethyl 2-(3-(benzo[d]thiazol-2-yl)ureido)acetate against amyloid β-induced oxidative cell death via NF-κB, GSK-3β, and β-catenin signaling pathways in cultured cortical neurons. Free Radical Research 49, 411-421 (2015)


• Ischemic preconditioning protects neurons and maintains immunoreactivity of kynurenic acid in the gerbil hippocampal CA1 region following transient cerebral ischemia International Journal of Molecular Medicine 35, 1537-1544 (2015)


• Celastrol ameliorates cytokine toxicity and pro-inflammatory immune responses via suppression of NF-κB activation in the RINm5F beta cells BMB Reports 48, 172-177 (2015)


• The effects of PEP-1-FK506BP on dry eye disease in a rat model BMB Reports 48, 151-156 (2015)


• Changes in the expression of DNA-binding/differentiation protein inhibitors in neurons and glial cells of the gerbil hippocampus following transient global cerebral ischemia Molecular Medicine Reports 11, 2477-2485 (2015)


• Tat-Biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-kB pathways in Raw 264.7 cells and edema mouse model Molecular Immunology 63, 355-366 (2015)


• Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus Neurological Research 37, 69-76 (2015)


• Downregulation of MAPK/NF-κB signaling underlies anti-inflammatory response induced by transduced PEP-1-Prx2 proteins in LPS-induced Raw 264.7 and TPA-induced mouse ear edema model International Immunopharmacology 23, 426-433 (2014)


• PEP-1-HO-1 prevents MPTP-induced degeneration of dopaminergic neurons in Parkinson’s disease mouse model BMB Reports 47, 569-574 (2014)


• Toxicity assessment of a novel silk fibroin and poly-methyl-methacrylate composite material Molecular and Cellular Toxicology 10, 277-283 (2014)


• Oenanthe javanica extract increases immunoreactivities of antioxidant enzymes in the rat kidney Chinese Medical Journal 127, 3758-3763 (2014)


• Celastrol ameliorates HIV-1 Tat-induced inflammatory responses via NF-kappaB and AP-1 inhibition and HO-1 induction in astrocytes Toxicology and Applied Pharmacology 280, 42-52 (2014)


• 2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride protects against beta-amyloid-induced activation of the apoptotic cascade in cultured cortical neurons. Cellular and Molecular Neurobiology 34, 963-972


• The expression and secretion of vimentin in the progression of non-alchoholic steatohepatitis BMB Reports 47, 457-462


• Effect of transient cerebral ischemia on the expression of receptor for advanced glycation end products (RAGE) Neurochemical Research 39, 1553-1563 (2014)


• 2-Cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride inhibits microglial activation by suppression of nuclear factor-kappa B and mitogen-activated protein kinase signaling. Journal of Neuroimmune Pharmacology 9, 461-467 (2014)


• Blockage of Interleukin-8 receptor signaling inhibits cyst development in vitro, via suppression of cell proliferation in autosomal polycystic kidney disease Nephrology 19, 471-478 (2014)


• Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-<kappa>B activation in RAW 264.7 macrophages BMB Reports 47, 318-323 (2014)


• Anti-inflammatory mechanisms of N-adamantyl-4-methylthiazol-2-amine in lipopolysaccharide-stimulated BV-2 microglial cells International Immunopharmacology 22, 73-83 (2014)


• The stimulatory effect of fatty acids on glucose uptake involves both Akt and AMPK activation in C2C12 skeletal muscle cells Krean Journal of Phisiology and Pharmacology 18, 255-261 (2014)


• Multiple Roles of the SO42-/Cl-/OH- exchanger Slc26a2 in Chondrocyte functions Journal of Biological Chemistry 289, 1993-2001 (2014)


• Neuroprotective effect of PEP-1-peroxiredoxin2 on CA1 regions in the hippocampus against ischemic insult Biochimica Biophysica Acta (General Subject) 1840, 2321-2330 (2014)


• Effects of N-adamantyl-4-methylthiazol-2-amine on hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. European Journal of Pharmacology 736, 26-34 (2014)


• PEP-1-PEA-15 protects against toxin-induced neuronal damage in a mouse model of Parkinson’s disease Biochimica Biophysica Acta (General Subject) 1840, 1686-1700 (2014)


• Targeting of receptor for advanced glycation end products suppresses cyst growth in polycystic kidney disease Journal of Biological Chemistry 289, 9254-9262 (2014)


• Tat-fused recombinant human SAG prevents dopaminergic neurodegeneration in a MPTP-induced Parkinson’s disease model Molecules and Cells 37, 226-233 (2014)


• Neuroprotective effects of PEP-1-carbonyl reductase 1 (CBR1) against oxidative stress-induced ischemic neuronal cell damage Free Radical Biology & Medicine 69, 181-196 (2014)


• PEP-1-PON1 protein regulates inflammatory response in Raw 264.7 macrophages and ameliorates TPA-induced animal model PLoS One 9(1), e86034 (2014)


• Tat-DJ-1 Protects Neurons from Ischemic Damage in the Ventral Horn of Rabbit Spinal Cord via Increasing Antioxidant Levels Neurochemical Research 39, 187-193 (2014)


• Tat-glyoxalase protein inhibits against ischemic neuronal cell damage and ameliorates ischemic injury Free Radical Biology & Medicine 67, 195-210 (2014)


• Protective effects of skin permeable EGF and FGF1 against ultraviolet-induced skin damage and human skin wrinkles Journal of Cosmetic Dermatology 12(4), 287-295 (2013)


• Fenobam promoted the neuroprotective effect of PEP-1-FK506BP following oxidative stress through increasing its transduction efficiency BMB Reports 46, 561-566 (2013)


• DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: a novel anti-inflammatory function of DJ-1 Neurobiology of Diseases 60, 1-10 (2013)


• Repeated Administration of PEP-1-Cu,Zn-Superoxide Dismutase and PEP-1-Peroxiredoxin-2 to Senescent Mice Induced by D-galactose Improves the Hippocampal Functions Neurochemical Research 38, 2046-2055 (2013)


• PKCδ as a regulator for TGF-β stimulated connective tissue growth factor production in human hepatocarcinoma (HepG2) cells Biochemical Journal 456, 109-118 (2013)


• Suppression of iNOS and COX-2 expression by flavokawain A via blockade of NF-<kappa>B and AP-1 activation in RAW 264.7 macrophages Food and Chemical Toxicology 58, 479-486 (2013)


• Curcumin ameliorates TNF-α-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. BMB Reports. 46, 410-415 (2013)


• Anti-oxidative and anti-inflammatory effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride on glutamate-induced neurotoxicity in rat brain. NeuroToxicology 38, 106-114 (2013)


• Neuroprotective effects of the antioxidant action of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against ischemic neuronal damage in the brain. BMB Reports 46, 370-375 (2013)


• PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages. Free Radical Biology & Medicine 63, 432-445 (2013)


• Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor BMB Report 46, 322-327 (2013)


• The effect of P2X7 receptor activation on nuclear factor-kappa B phosphorylation induced by status epilepticus in the rat hippocampus. Hippocampus. 23, 500-514 (2013)


• Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells Biochimica Biophysica Acta (General Subject) 1830, 4017-4029 (2013)


• Anti-Inflammatory effects of extracts from Caesalpinia sappan L. on skin inflammation Journal of Korean Society Food Science and Nutrition 42, 384-388 (2013)


• Transduced PEP-1-FK506BP ameliorates corneal injury in Botulium toxin A-induced dry eye mouse model BMB Reports 46, 124-129 (2013)


• PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model PLoS One 8(2): e55979 (2012)


• Protective effects of oleic acid against palmitic acid-induced apoptosis in pancreatic AR42J cells and its mechanism Korean Journal of Physiology and Pharmacology 17, 43-50 (2013)


• Oxidative modification of neurofilament-L and neuronal cell death induced by the catechol neurotoxin, tetrahydropapaveroline Toxicology Letter 217, 59-66 (2013)


• Silk proteins stimulate osteoblast differentiation by suppressing the Notch signaling pathway in mesenchymal stem cells Nutrition Research 33, 162-170 (2013)


• Transduced Tat-Glyoxalase protein attenuates streptozotocin-induced diabetes in a mouse model Biochemical Biophysical Research Communication 430, 294-300 (2013)


• PEP-1-ribosomal protein S3 protects dopaminergic neurons in MPTP-induced Parkinson’s disease mouse model. Free Radical Biology & Medicine 55, 36-45 (2013)


• Roles of cysteine residues in the inhibition of human glutamate dehydrogenase by palmitoyl-CoA BMB Reports 45, 707-712 (2012)


• Neuroprotective Effects of PEP-1-Cu,Zn-SOD against Ischemic Neuronal Damage in the Rabbit Spinal Cord. Neurochemical Research 37, 307-313 (2012)


• Effects of Cu,Zn-Superoxide Dismutase on Cell Proliferation and Neuroblast Differentiation in the Mouse Dentate Gyrus Neurochemical Research 37, 261-267 (2012)


• Casuarinin suppresses TARC/CCL17 and MDC/CCL22 production via blockade of NF-<kappa>B and STAT1 activation in HaCaT cells Biochemical Biophysical Research Communication 417, 1254-1259 (2012)


• Tat-Frataxin protects dopaminergic neuronal cells against MPTP-induced toxicity in a mouse model of Parkinson’s disease Biochimie 94, 2448-2456 (2012)


• Differential expression of cell surface markers in response to 2,4-dinitrofluorobenzene in RAW 264.7 and primary immune cells BMB Reports 45, 538-543 (2012)


• PEP-1-p18 prevents neuronal cell death via the inhibition of oxidative stress and Bax expression BMB Reports 45, 532-537 (2012)


• Inhibition of glutamate dehydrogenase and insulin secretion by KHG26377 does not involve ADP-ribosylation by SIRT4 or deacetylation by SIRT3. BMB Reports 45, 458-463 (2012)


• 17β-Estradiol Inhibits Apoptotic Cell Death of Oligodendrocytes by Inhibiting RhoA-JNK3 Activation after Spinal Cord Injury Endocrinology 153, 3815-3827 (2012)


• PEP-1-heat shock protein 27 protects from neuronal damage in cells and in a Parkinson’s disease mouse model FEBS Journal 279, 1929-1942 (2012)


• PEP-1-metallothionein-III protein ameliorates the oxidative stress-induced neuronal cell death and brain ischemic insults Biochimica Biophysica Acta (General Subject) 1820, 1647-1655 (2012)


• Suppression of 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation in mice by transduced Tat-Annexin protein BMB Reports 45, 354-359 (2012)


• Yeast ribosomal protein S3 possesses a β-lyase activity on damaged DNA. FEBS Letters 586, 356-361, (2012)


• Effects of sensitive to apoptosis gene protein on cell proliferation, neuroblast differentiation, and oxidative stress in the mouse dentate gyrus. Neurochemical Research 37, 495-502 (2012)


• Changes of ribosomal protein S3 immunoreactivity and its new expression in microglia in the mice hippocampus after lipopolysaccharide treatment. Cellular and Molecular Neurobiology 32, 577-586 (2012)


• Changes in ribosomal protein S3 immunoreactivity and its protein levels in the gerbil hippocampus following subacute and chronic restraint stress. Neurochemical Research 37, 1428-1435 (2012)


• Transduced Tat-DJ-1 Protein Protects against Oxidative Stress-Induced SH-SY5Y Cell Death and Parkinson Disease in a Mouse Model Molecules and Cells 33, 471-478 (2012)


• Extracellular HIV-1 Tat induces human beta-defensin-2 production via NF-kappaB/AP-1 dependent pathways in human B cells Molecules and Cells 33, 335-341 (2012)


• Enhancement of Anti-Inflammatory Activity of PEP-1-FK506 Binding Protein by Silk Fibroin Peptide Journal of Microbiology and Biotechnology 22, 494-500 (2012)


• Tumor necrosis factor-α-mediated threonine 435 phosphorylation of p65 nuclear factor-κB subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus Journal of Neuroinflammation 9, 6-18 (2012)


• Anti-inflammatory effects of transduced Tat-Annexin protein on ovalbumin-induced airway inflammation in a mouse model of asthma Biochemical Biophysical Research Communication 417, 1024-1029 (2012)

기타

■ 주요연구주제
• 생화학(단백질생화학, 신경생화학) 
• 단백질침투기술( Protein Transduction Technology) 
• 단백질치료(Protein Therapy) 

 

■ 학회활동 및 공공기관 주요활동사항
• 1988.9.1 - 현재 : 한국생화학분자생물학회 정회원
•1990.9.1 - 현재 : 한국분자세포생물학회 정회원
•1992.1.1 - 1992.12.31 : 한국생화학분자생물학회 기획간사
•1994.1.1 - 현재 : 한국유전학회 이사
•1996.1.1 - 1996.12.31 : 한국생화학분자생물학회 총무간사
•1998.1.1 - 1999.12.31 : 한국생화학회분자생물학회 학술지 편집위원
•1999.7.1 - 2000.6.30  : 한국생화학분자생물학회 설악토론회 실무위원장 
•1999.9.1 - 2003.8.31 : 한국생화학분자생물학회 강원지부 지부장
•2000.1.1 - 현재 : 국제신경화학회(International Society of Neurochemistry) 정회원
•2000.1.1 - 2004.8.31 : 한국분자세포생물학회 이사
•2000.1.1 - 2001.12.31 : 한국생화학회분자생물학회 SCI간사
•2000.7.9 - 2010.7.8 : 대한코스메틱 피부과학회 이사
•2001.1.1 - 2004.12.31 : 한국생화학분자생물학회 학술지 편집위원
•2002.1.1 - 2006.12.31 : 한국분자세포생물학회 학회지 편집위원회 위원
•2002.11 - 2013.8 : 춘천바이오산업 진흥원 이사
•2003.1.1 - 2003.12.31 : 한국생화학분자생물학회 간사장
•2006.11 - 현재 : 한국과학기술한림원 정회원
•2007.1.1 - 2009.12.31 : 한국생화학분자생물학회 이사
•2007.1  - 2010.6.30 : 대한퇴행성질환학회 이사 
•2006.1.1 - 2010.4.30 : 생화학분자생물학회 학술지(BMB Reports) 편집위원장
•2010.1.1- 2010.12.31 : 한국뇌신경과학회 회장 
•2010.5.1 - 현재 : 한국생화학분자생물학회 학술지(BMB Reports) 편집위원
•2011.1.1 - 2015.12.31 : 한국생화학분자생물학회 이사 
•2011.1.1 - 2011.12 : 한국생화학분자생물학회 부회장
•2013.11.25 - 2017.11.25 : 강원컨벤션뷰로 이사장
•2014.1.1 - 2014.12.31 : 한국생화학분자생물학회 회장
•2015.8.1 - 2018.7.31 : 한국연구재단 생명과학단 책임전문위원(Chief Review Board)
•2015.8.5 - 2017.8.6 : 국가생명공학종합정책심의회 위원
•2016.1.1 - 2017.12.31 : 한국뇌신경과학회 이사 
•2016.8.11 -현재 : 국가생명공학육성기본계획 기획위원
•2017.1.1 - 2017.12.31 : 한국유전학회 이사

• 2016.01.01. ~ 현재 : 생화학분자생물학회 학술지(BMB Reports) 관리위원장

• 2016.08.11. ~ 2018.08.10. : 국가생명공학육성기본계획 기획위원

 

■ 수상
• 1996. 9. 24 : 제6회 과학기술 우수논문상 (과학기술처) 
• 1999 - 2005 : 일송논문상 (한림대학교)
• 2001. 4. 21 : 대통령 표창 (과학기술진흥유공자) 
• 2004. 4. 28 : 제14회 과학기술 우수논문상 (과학기술처) 
• 2005. 7. 13 : 강원인 대상 수상 (교육학술부문) (MBC 방송국)
• 2006. 5. 25 : BMB Reports 학술지상 (한국생화학회분자생물학회)
• 2008. 5. 8 : BMB Reports 학술지상 (한국생화학회분자생물학회)
• 2010. 12. 22 : 산학업무유공자 대통령상 (중소기업청) 
• 2011. 7. 11 : 강원도 문화상 (학술부문) (강원도) 
• 2011. 10. 12 : 제6회 동곡상 (교육연구부문, 동곡사회복지재단)
• 2012. 5. 31 : BMB Reports 학술지상 (한국생화학회분자생물학회)
• 2013. 10. 8 : 강원도 10대 특허상 우수상 (중소기업청)
• 2014. 5. 14 : BMB Reports 학술지상 (한국생화학회분자생물학회)
• 2015. 5. 14 : 무사강연학술상 (한국생화학회분자생물학회)
• 2015. 2. 25 : 교원업적평가 우수교원상 (한림대학교)
• 2016. 5. 19 : BMB Reports 학술지상 (한국생화학회분자생물학회)
• 2017. 5. 18 : BMB Reports 학술지상 (한국생화학회분자생물학회)
• 2018. 6.  7 : 디아이학술상  (한국생화학회분자생물학회)

• 2019.02.28. 옥조근정훈장 

 

한규형
  • 분야

    분자유전학

  • 성명

    국문 한규형

  • 직위

    교수

  • 연구실

    생명과학관 8401호실

  • 연락처

    033-248-2115

  • 이메일

학력

• 1986 - 1992 Columbia University, USA (Ph.D-생물학과) 
• 1981 - 1984 서울대학교(이학석사-미생물학과) 
• 1977 - 1981 서울대학교(이학사-미생물학과) 

주요경력

• 2009 ~ 2011 바이오메디컬학과장 


• 2005 ~ 2009 생명공학연구소장 


• 1993 ~ 현재Assistant Professor, Associate Professor, Professor, Dept. of Biomedical Science, College of Natural Sciences, Hallym University, Korea 


• 1992 ~ 1993 Post-Doctoral Fellow, Cold Spring Harbor Laboratory, USA

연구 및 저서

■ 논문

 

주저자 : 제1저자, 공동저자(교신), 단독


• Transcriptional regulation of Niemann-Pick C1-like 1 gene by liver receptor homolog-1 [BMB Reports, SCI급, 공동(교신), 2015] 

 

• Cooperative transcriptional activation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 genes by nuclear receptors including Liver-X-Receptor [BMB Reports, SCI급, 공동(교신), 2013] 

 

 

공동저자 : 공동저자(참여)


•  PEP-1-PEA15 suppresses inflammatory responses by regulation of MAPK in macrophages and animal models [Immunobiology, SCI급, 공동(참여), 2018] 


•  Tat-PRAS40 prevent hippocampal HT-22 cell death and oxidative stress induced animal brain ischemic insults [Free Radical Biology and Medicine, SCI급, 공동(참여), 2016] 

기타

■ 주요연구주제
•Transcriptional regulation of human NPC1L1 and PCSK9 genes

• Gene regulation by siRNA, saRNA, CRISPRa and CRISPRi

• Transduction of proteins using CPP


■ 학회활동
• The Korean Society for Molecular Biology and Cell Biology


■ 수상
• 중소기업청장상 (2011) 

조윤신
  • 분야

    유전체학

  • 성명

    국문 조윤신

  • 직위

    교수

  • 연구실

    생명과학관 8407호실

  • 연락처

    033-248-2111

  • 이메일

학력

•1996-2001 University of Illinois at Urbana-Champaign, School of Life Sciences (Ph.D.)

•1984-1986 서강대학교 생물학 전공 (석사)

•1980-1984 서강대학교 생물학 전공 (학사)

주요경력

• 2021-2022 한림대학교 바이오메디컬학과 학과장

• 2017-현재 한국유전학회 Genes & Genomics 편집위원장

• 2015-현재 한국유전학회 이사

• 2012-현재 생화학분자생물학회 BMB Reports 편집위원

• 2021-현재 대한당뇨병학회 Diabetes and Metabolism Journal 편집위원

• 2013-2016 한림대학교 BK21 플러스 과학기술분야 사업팀장

• 2013-현재 질병관리본부 자료·자원활용심의 위원회 위원

• 2013-현재 질병관리본부 보건의료기술 평가관리 전문위원회 위원

• 2012-2015 한국연구재단 생명과학단 전문위원 (Review Board)

• 2013-2014 한림대학교 바이오메디컬학과 학과장

• 2012-현재 한림대학교 바이오메디컬학과 교수

• 2009-2012 질병관리본부 국립보건연구원 유전체센터 보건연구관

• 2001-2004 Post-Doctoral Fellow, University of Pennsylvania School of Medicine  

연구 및 저서

Google Scholar

 

The contribution of common and rare genetic variants to variation in metabolic traits in 288,137 East Asians. Nature Communications (2022) Nov 4, 13(1):6642

 

A saturated map of common genetic variants associated with human height. Nature (2022) Oct 12, 610:704-712

 

Genetic association-based functional analysis detects HOGA1 as a potential gene involved in fat accumulation. Frontiers in Genetics (2022) Aug 12, 13:951025

 

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation. Nature Genetics (2022) May 12, 54:560–572

 

Identification and functional validation of HLA‑C as a potential gene involved in colorectal cancer in the Korean population. BMC Genomics (2022) April 4, 23(1):261

 

The power of genetic diversity in genome-wide association studies of lipids. Nature (2021) December, 600(7890):675-679

 

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Nature Communications (2021) June 9, 12:3505


Identifcation of genetic variants for blood insulin level in sex-stratifed Korean population and evaluation of the causal relationship between blood insulin level and polycystic ovary syndrome. Genes & Genomics (2021) October 1, 43:1105-1117


Cancer-preventive effect of phenethyl isothiocyanate through tumor microenvironment regulation in a colorectal cancer stem cell xenograft model. Phytomedicine (2021) April, 84:153493.


Identification of genetic variants for female obesity and evaluation of the causal role of genetically defined obesity in polycystic ovarian syndrome. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy (2020) Nov 1, 13:4311-4322.


Codon usage trend in genes associated with obesity. Biotechnology Letters (2020) Oct 1, 42(10):1865-1875. 


Identification of type 2 diabetes loci in 433,540 East Asian individuals. Nature (2020) June 11, 582:240–245.


Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature (2019) May 22, 570:71-76.


Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females. BMC Med Genet. (2019) Jun 6, 20(1):99. 


Genetic risk score combining six genetic variants associated with the cellular NRF2 expression levels correlates with Type 2 diabetes in the human population. Genes & Genomics (2019) May 1, 41:537-545.


Hsa-miR-10a-5p downregulation in mutant UQCRB-expressing cells promotes the cholesterol biosynthesis pathway. Scientific Reports Aug 17. 8:12407 (2018)


Nonsynonymous Variants in PAX4 and GLP1R are Associated with Type 2 Diabetes in an East Asian Population. Diabetes Sep. 67(9): 1892-1902 (2018) 


Understanding the functional role of genistein in the bone differentiation in mouse osteoblastic cell line MC3T3-E1 by RNA-seq analysis. Scientific Reports Feb 19. 8(1): 3257 (2018) 


Refining the accuracy of validated target identification through coding variant fine-2 mapping in type 2 diabetes. Nature Genetics Apr 1. 50(4): 559-571 (2018)


Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis. Plos Medicine Sep 12. 14(9):e1002383 (2017) 


A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes Jul;66(7):2019-2032 (2017)


Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels. Human Molecular Genetics May 1, 26:1770-1784 (2017)


The genetic architecture of type 2 diabetes. Nature August 4. 536: 41-47 (2016)


Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics May 15 25(10):2070-2081 (2016)


Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nature Communications Jan 28. 7:10531-10543 (2016)


Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Scientific Reports 2016 Jan 20. 6:17958 (2016)


Genome-wide association study identified new susceptibility loci for polycystic ovary syndrome Human Reproduction Mar. 30(3): 723-731 (2015)


Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci Human Molecular Genetics Mar. 24(6): 1791-1800 (2015)


Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians Diabetes Jan. 64(1): 291-298 (2015)


Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians Human Molecular Genetics Dec. 23(24): 6659-6667 (2014)


Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index Human Molecular Genetics Oct. 23(20): 5492-5504 (2014) 


Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes PNAS Sep. 111(36):13127-13132 (2014)


Loss-of-function mutations in SLC30A8 protect against type 2 diabetes Nature Genetics April 46(4); 357-363 (2014)


Associations of genetic variants in/near BMI-associated genes with type 2 diabetes: A systematic meta-analysis Clinical Endocrinology Nov. 81(5); 702-710 (2014)


Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility Nature Genetics March 46(3); 234-244 (2014)


Genetic determinants of heel bone properties: genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium Human Molecular Genetics June 23(11):3054-3068 (2014)


Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico Nature Feb 6;506(7486):97-101 (2014)


Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci Hypertension Nov;62(5):853-859 (2013)


Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders Nature Genetics June; 45(6), 621-631 (2013)


Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India Diabetes May;62(5):1746-55 (2013)


Genetics of Type 2 Diabetes in East Asian Populations. Current Diabetes Reports December; 12, 686-696 (2012)


Meta-Analysis Identifies Multiple Loci Associated with Kidney Function-Related Traits in East Asian Populations. Nature Genetics July; 44, 904-909 (2012)  


A Common Variant in SLC8A1 Is Associated with the Duration of the Electrocardiographic QT Interval. American Journal of Human Genetics July; 91, 180-184 (2012) 


Meta-analysis identifies common variants associated with body mass index in east Asians. Nature Genetics March; 44, 307-311 (2012)  


A Genome-Wide Association Study of Gestational Diabetes Mellitus in Korean Women. Diabetes February; 61, 531-541 (2012) 


Meta-analysis of Genome-Wide Association Studies Identifies 8 New Loci for Type 2 Diabetes in East Asians. Nature Genetics January; 44, 67-72 (2012)


Large-Scale Genome-Wide  Association Study in East Asians Identify New Genetic Loci Influencing Metabolic Traits. Nature Genetics October; 43, 990-995 (2011)  


Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk. Nature October; 478, 103-109 (2011)


Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. Nature Genetics June; 43, 531-538 (2011) 


Biological, clinical and population relevance of 95 loci for blood lipids. Nature August; 466, 707-713 (2010)


Identification of New Genetic Risk Variants for Type 2 Diabetes. PLoS Genetics September; 6(9), e1001127 (2010)
 
 
A large scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nature Genetics 41, 527-534 (2009)

기타

■ 주요연구주제
• 유전체연구

 

■ 학술활동

• 2017-현재 한국유전학회 Genes & Genomics 편집위원장

 

• 2014-2016 한국유전학회 Genes & Genomics 편집간사

 

• 2015-현재 한국유전학회 이사

 

• 2012-2016 한국유전체학회 운영위원

 

• 2012-2014 한국유전체학회 소식지 편집위원장

 

• 2012-현재 생화학분자생물학회 BMB Reports 편집위원

이근욱
  • 분야

    암생물학 및 면역학

  • 성명

    국문 이근욱

  • 직위

    부교수

  • 연구실

    생명과학관 8411호실

  • 연락처

    033-248-2113

  • 이메일

학력

• 2005 연세대학교 생화학과 (이학박사) 
• 1997 연세대학교 생화학과 (이학석사) 
• 1995 연세대학교 생화학과 (이학사)

주요경력

• 2023 – 현재
한림대학교 바이오메디컬학과 학과장

 

• 2014 – 현재
한림대학교 바이오메디컬학과 (조교수/부교수)

• 2013 – 2014
연세대학교 의과대학 의생명과학부 (연구교수) 

• 2011 – 2013
Department of Pathology, Microbiology &Immunology, Vanderbilt University (Research Instructor) 


• 2006 – 2011 Department of Pathology, Microbiology &Immunology, Vanderbilt University (Research Fellow) 


• 2005 – 2006 한림대학교 의과학연구소 (연구강사)

연구 및 저서

Decursinol angelate mitigates sepsis induced by methicillin-resistant Staphylococcus aureus Infection by modulating the inflammatory responses of macrophages (2021) Int J Mol Sci. 22:10950

 

CD11b deficiency exacerbates methicillin-resistant Staphylococcus aureus-induced sepsis by upregulating inflammatory responses of macrophages (2021) Immune Netw. 21:e13

 

mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes (2019) FASEB J.33:13202-13215

 

Metabolic influence on macrophage polarization and pathogenesis (2019) BMB Rep. 52:360-372

 

Decursinol angelate ameliorates dextran sodium sulfate-induced colitis by modulating type 17 helper T cell responses (2019) Biomol Ther. 27:466-473

 

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53 (2019) Oncogene. 38:1635-1650.

 

Critical role of mTORC2-Akt signaling in TGF-b1-induced myofibroblast differentiation of human pterygium fibroblasts (2019) Invest Ophthalmol Vis Sci. 60:82-92

 

Expression of Lrig1, a negative regulator of EGFR, is dynamically altered during different stages of gastric carcinogenesis (2018) Am J Pathol. 188:2912-2923

 

B cell-intrinsic mTORC1 promotes germinal center-defining transcription factor gene expression, somatic hypermutation, and memory B cell generation in humoral immunity (2018) J Immunol. 200:2627-2639

 

CD11b regulates antibody class switching via inducing AID (2017) Mol Immunol. 87:47-59

 

Rapamycin-resistant and torin-sensitive mTOR signaling promotes survival and proliferation of leukemic cells (2016) BMB Rep. 49:63-68

 

Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways (2015) Mol Cell Biol. 35:1299-1313

 

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells (2014) J Exp Med. 211:2281-2295

 

Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer (2014) Gut Liver. 8:1-9

 

Requirement for Rictor in homeostasis and function of mature B lymphoid cells (2013) Blood. 122:2369-2379

 

Cdc42 promotes host defenses against fatal infection (2013) Infect Immun. 81:2714-2723

 

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia (2012) J Exp Med. 209:713-728.

 

A “Tsc, Tsc” keeps the kids quie(scen)t and holds off ROS (2011) Nat Immunol. 12:811-812.

 

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways (2010) Immunity. 32:743-753.

기타

■ 주요연구주제

- Dissecting the PI3K/PTEN/mTOR signaling network in immunity:

    Part 1) Antibody responses of B cells against pathogen infection

    Part 2) Functional polarization of macrophages in inflammatory diseases and cancer development

 

- Elucidating host-microbiota interactions in the gut homeostasis and inflammation:

    Part 1) Regulation of the monocyte-macrophage waterfall in the context of the gut mucosal host-microbiota interactions

    Part 2) Functional impact of microbial metabolites on immune responses in the gut homeostasis and colitis

 

- Study on the tumor immune microenvironment:

    Part 1) Identification of tumor-derived immunoediting factors

    Part 2) Functional impact of the putative immunoediting factor on shaping tumor microenvironment


■ 학회활동

• 생화학분자생물학회: 대의원
• 한국실험동물학회: 평의원, 총무간사
• 한국분자세포생물학회: 운영위원
• 대한면역학회: 회원
• American Association of Immunologist (AAI) 회원

박종국
  • 분야

    RNA 생물학

  • 성명

    국문 박종국

  • 직위

    부교수

  • 연구실

    생명과학관 8404호실

  • 연락처

    033-248-2114

  • 이메일

학력

2006 – 2012 Ohio State University, USA (Ph.D-약제학과)

2001 – 2003 가톨릭대학교 성의교정 (의학석사-약리학)

1998 – 2001 건국대학교 수의과대학 (수의학석사-수의내과학)

1994 – 1998 건국대학교 수의과대학 (수의학사-수의학)

주요경력

2023 - 현재, 한림대학교 미래융합스쿨 코디네이터 (학장)

 

2023 – 현재, 한림대학교 자연과학대학 바이오메디컬학과 (부교수)

 

2020 - 현재, 한림대학교 미래융합스쿨 의약신소재전공 주임교수)

 

2017 - 2023, 한림대학교 자연과학대학 바이오메디컬학과 (조교수)

 

2012 - 2017, Department of Dermatology at Northwestern University Feinberg School of Medicine (Postdoctoral Fellow)

 

2012 - 2012, Division of Pharmaceutics, College of Pharmacy, The Ohio State University (Postdoctoral Fellow)

연구 및 저서

microRNA와 autophagy

- 윤부줄기세포(limbal stem cells)에서 microRNA에 의한 줄기세포 특성 및 autophagy 조절기전 연구

- 각막상피세포(corneal epithelial cells)에서 microRNA에 의한 각막세포재생, 신생혈관형성, autophagy 조절기전 연구

- MicroRNA에 의한 암세포의 성장, 전이, 세포사멸 기전연구

 

 

■ 논문 (2010년 이후)

ㆍ Yun BD, Choi YJ, Son SW, Cipolla GA, Berti FCB, Malheiros D, Oh T-J, Kuh HJ, Choi SY, Park JK. Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers. Int J Mol Med. 2022; 23(2):930.

 
ㆍ Jang SD, Song JY, Kim HA, Im CN, Khawar IA, Park JK, Kuh HJ. Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages. Cancers (Basel). 2021 Nov 26;13(23):5955.

 
ㆍ Yun BD, Son SW, Choi SY, Kuh HJ, Oh T-J, Park JK. Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha. Int J Mol Med. 2021; 22(18):9819.

 
ㆍ Khawar IA, Ghosh T, Park JK, Kuh HJ. Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines. J. Pharm. Investig. (2021).

 
ㆍ Son SW, Yun BD, Song MG, Lee JK, Choi SY, Kuh HJ, Park JK. The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers. Int J Mol Med. 2021; 22(14):7261.

 
ㆍ Choi YJ, Kim DW, Shin MJ, Yeo HJ, Yeo EJ, Lee LR, Song Y, Kim D-S, Han KH, Park J, Lee KW, Park JK, Eum WS, Choi SY. PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson’s Disease. Molecules. 2021; 26(11):3329.

 
ㆍ Berti FCB, Lobo-Alves SC, Oliveira-Toré CdF, Salviano-Silva A, de Oliveira KB, de Araújo-Souza PS, Park JK, Cipolla GA, Malheiros D. Competing Endogenous RNAs in Cervical Carcinogenesis: A New Layer of Complexity. Processes. 2021; 9(6):991.

 
ㆍ Son SW, Song MG, Yun BD, Park JK. Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer. Biomedicines 2021, 9(3), 263.

 
ㆍ Cho SB, Eum WS, Shin MJ, Yeo HJ, Yeo EJ, Choi YJ, Kwon HJ, Cho SW, Park J, Han KH, Lee KW, Park JK, Kim DS, Kim DW, Choi SY. Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation. Int J Mol Med. 2021 Feb;47(2):751-760.

 
ㆍ Yeo EJ, Eum WS, Yeo HJ, Choi YJ, Sohn EJ, Kwon HJ, Kim DW, Kim DS, Cho SW, Park J, Han KH, Lee KW, Park JK, Shin MJ, Choi SY. Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway. Biomol Ther (Seoul). 2021 Jan 13.

 
ㆍ Lee HY, Son SW, Moeng S, Choi SY, Park JK. The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer. Int J Mol Sci. 2021, 22, 627.


ㆍ Oh MS, Khawar IA, Lee DW, Park JK, Kuh HJ. Three-Dimensional Imaging for Multiplex Phenotypic Analysis of Pancreatic Microtumors Grown on a Minipillar Array Chip. Cancers (Basel). 2020 Dec 7;12(12):3662.
 

ㆍ Park JH, Kim DW, Shin MJ, Park J, Han KH, Lee KW, Park JK, Choi YJ, Yeo HJ, Yeo EJ, Sohn EJ, Kim HC, Shin EJ, Cho SW, Kim DS, Cho YJ, Eum WS, Choi SY. Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury. BMB Rep. 2020 Nov;53(11):582-587.
 

ㆍ Son SW, Lee HY, Moeng S, Kuh HJ, Choi SY, Park JK. Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals. Molecules. 2020 Oct 14;25(20):4701.

 
ㆍ Moeng S, Son SW, Lee JS, Lee HY, Kim TH, Choi SY, Kuh HJ, Park JK. Extracellular Vesicles (EVs) and Pancreatic Cancer: From the Role of EVs to the Interference with EV-Mediated Reciprocal Communication. Biomedicines. 2020 Aug 3;8(8):267.


ㆍ Kim SK, Jang SD, Kim H, Chung S, Park JK, Kuh HJ. Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture Model. Cancers (Basel). 2020 May 21;12(5):1305. Cancers (Basel). 2020 May 21;12(5):1305.


ㆍ Kim SJ, Shin MJ, Kim DW, Yeo HJ, Yeo EJ, Choi YJ, Sohn EJ, Han KH, Park J, Lee KW, Park JK, Cho YJ, Kim DS, Eum WS, Choi SY. Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling. Int J Mol Sci. 2020 Apr 11;21(8):2672.
 

ㆍ Moeng S, Son SW, Seo HA, Lee JS, Kim CK, Kuh HJ, Park JK. Luteolin-regulated MicroRNA-301-3p Targets Caspase-8 and Modulates TRAIL Sensitivity in PANC-1 Cells. Anticancer Res. 2020 Feb;40(2):723-731.

 
ㆍ Youn GS, Park JK, Lee CY, Jang JH, Yun SH, Kwon HY, Choi SY, Park J. MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages. BMB Rep. 2020 Jan 21. pii: 4744.


ㆍ Kaplan N, Dong Y, Wang S, Yang W, Park JK, Wang J, Fiolek E, White BP, Chandel NS, Peng H, Lavker RM. FIH‐1 engages novel binding partners to positively influence epithelial proliferation via p63. FASEB J, 2020 Jan; 34: 525-539.


ㆍ Seo HA, Moeng S, Sim S, Kuh HJ, Choi SY, Park JK. MicroRNA-Based Combinatorial Cancer Therapy: Effects of MicroRNAs on the Efficacy of Anti-Cancer Therapies. Cells. 2019 Dec 20;9(1). pii: E29.


ㆍ Nam S, Khawar IA, Park JK, Chang S, Kuh HJ. Cellular context-dependent interaction between cancer and stellate cells in hetero-type multicellular spheroids of pancreatic tumor. Biochem Biophys Res Commun. 2019 Jul 12;515(1):183-189.


ㆍ Seo HA, Hwang CY, Moeng S, Park JK. An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells. J Vis Exp. 2019 May 21;(147)


ㆍ Moeng S, Seo HA, Hwang CY, Cipolla GA, Lee DJ, Kuh HJ, Park JK. MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide. Anticancer Res. 2018 Nov;38(11):6309-6316.


ㆍ Park JK, Seo JS, Lee SK, Chan KK, Kuh HJ. Combinatorial antitumor activity of oxaliplatin with epgenetic modifying agents, 5-Aza-CdR and FK228, in human gastric cancer cells. Biomol Ther (Seoul). 2018 Nov 1;26(6):591-598.


ㆍ Khawar IA, Park JK, Jung ES, Lee MA, Chang S, Kuh HJ, Three dimensional mixed-cell spheroids mimic stroma-mediated chemoresistance and invasive migration in hepatocellular carcinoma, Neoplasia 2018 2018 Jul 4;20(8):800-812.


ㆍ Park JK, Doseff A, Schmittgen TD. MicroRNAs targeting caspase-3 and -7 in panc-1 cells. Int J Mol Sci. 2018 Apr 16;19(4). pii: E1206 (co-corresponding).


ㆍ Cipolla GA, Park JK, Lavker RM, Petzl-Erler ML. Crosstalk between Signaling Pathways in Pemphigus: A Role for Endoplasmic Reticulum Stress in p38 Mitogen-Activated Protein Kinase Activation? Front Immunol. 2017 Sep 5; 8: 1022.


ㆍ Peng H, Park JK, Lavker RM. Eyeing Autophagy and Macropinocytosis in the Corneal/Limbal Epithelia. Autophagy. 2017 May 4;13(5):975-977. (co 1st author).


ㆍ Peng H, Park JK, Lavker RM. Autophagy and Macropinocytosis: Keeping an Eye on the Corneal/limbal Epithelia. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):416-423. (co 1st author).


ㆍ Park JK, Peng H, Yang W, Katsnelson J, Volpert O, Lavker RM. microRNA-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J. 2017 Jan 1; 31(1):256-265.


ㆍ Park JK, Peng H, Katsnelson J, Yang W, Kaplan N, Dong Y, Rappoport JZ, He C, Lavker RM. microRNAs-103/107 coordinately regulate macropinocytosis and autophagy. J Cell Biol. 2016 Dec 5;215(5):667-685.


ㆍ Kim JH, Badawi M, Park JK, Jiang J, Mo X, Roberts LR, Schmittgen TD. Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. Int J Oncol. 2016 Nov;49(5):2037-2045. 


ㆍ Cipolla GA, Park JK, de Oliveira LA, Lobo-Alves SC, de Almeida RC, Farias TD, de S Lemos D, Malheiros D, Lavker RM, Petzl-Erler ML. A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. Biochim Biophys Acta. 2016 Oct;1859(10):1306-13. 


ㆍ Park JK, Yang W, Katsnelson J, Lavker RM, Peng H. microRNAs enhance keratinocyte proliferative capacity in a stem cell-enriched epithelium. PLoS One. 2015; 10(8): e0134853.


ㆍ Peng H, Park JK, Katsnelson J, Kaplan N, Yang W, Getsios S, Lavker RM. microRNA-103/107 family regulates multiple epithelial stem cell characteristics. Stem Cells. 2015; 33(5):1642-56. (co 1st author).


ㆍ Lee SH, Nam JK, Park JK, Lee JH, Min DS, Kuh HJ. Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model. Oncol Rep. 2014; 32(4):1427-34.


ㆍ Kim TW, Cui R, Jeon YJ, Lee JH, Lee JH, Sim HS, Park JK, Fadda P, Tili E, Nakanishi H, Huh MI, Kim SH, Cho JH, Sung BH, Peng Y, Lee TJ, Luo Z, Sun HL, Wei H, Alder H, Oh JS, Shim KS, Ko SB, Croce CM. Long-range interaction and correlation between MYC enhancer and oncogenic lncRNA CARLo-5. Proc Natl Acad Sci U S A. 2014; 18;111(11):4173-8.


ㆍ Elgamal OA, Park JK, Gusev Y, Azevedo-Pouly AC, Jiang J, Roopra A, Schmittgen TD. Tumor Suppressive Function of mir-205 in Breast Cancer Is Linked to HMGB3 Regulation. PLoS One. 2013; 2;8(10):e76402. (co 1st author).


ㆍ Park JK, Kogure T, Nuovo GJ, Jiang J, He L, Kim JH, Phelps MA, Papenfuss TL, Croce CM, Patel T, Schmittgen TD. miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Cancer Res. 2011; 71(24): 7608-16.


ㆍ Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD. miR-132 and miR-212 are increased in pancreatic adenocarcinoma and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011; 406(4): 518-23.


ㆍ Henry JC, Park JK, Jiang J, Kim JH, Nagorney DM, Roberts LR, Banerjee S, Schmittgen TD. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2010; 403(1): 120-5. (co 1st author).

기타

학회활동

2018 ~ 현재, Oncology Letters, Editorial Board Member  

2006 – 현재, 미국 암학회 (AACR)

2012 – 현재, 미국 안과 및 시과학회 (ARVO)

미국 고든 리서치 세미나 의장 (Cornea, Biology & Pathobiology of the Gordon Research Seminar, 2016년)

 

이찬희
  • 분야

    신경면역학

  • 성명

    국문 이찬희

  • 직위

    조교수

  • 연구실

    생명과학관 8612호

  • 연락처

    033-248-2117

  • 이메일

학력

Undergraduate Degree (B.S., 2011)
Department of Biochemistry
Yonsei University
Seoul, Republic of Korea

 

Graduate Degree (Ph.D., 2016)
Biomedical Science and Engineering Interdisciplinary Program
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea

주요경력

2021 – present Hallym University (Assistant Professor)
2020 – 2021 UT Southwestern Medical Center (Postdoctoral Researcher)
2019 – 2020 University of Ulsan, College of Medicine (Research Assistant Professor)
2016 – 2019 Asan Institute for Life Sciences (Postdoctoral Researcher)

연구 및 저서

■ Publications (2018 ~ present)

ㆍ Metformin ameliorates olanzapine-induced obesity and glucose intolerance by regulating hypothalamic inflammation and microglial activation in female mice, Frontiers in Pharmacology (2022.10)

ㆍ Ginsenoside Rd ameliorates muscle wasting by suppressing the signal transducer and activator of transcription 3 pathway, Journal of Cachexia, Sarcopenia, and muscle (2022.09)

ㆍ Etoposide-induced microRNA-205-5p suppresses proliferation and migration by targeting ERBB4 in MCF-6 cells, Anticancer research (2022.09)

ㆍ Metformin ameliorates olanzapine-induced disturbances in POMC neuron number, axonal projection, and hypothalamic leptin resistance, BMB Reports (2022.06)

ㆍ Exercise, mitohormesis, and mitochondrial ORF of the 12S rRNA type-C (MOTS-c), Journal of Obesity & Metabolic Syndrome (2022.05)

ㆍ Mechanisms of weight control by primary cilia, Molecules and Cells (2022.04)

ㆍ Mitohormesis in hypothalamic Pomc neurons mediates regular exercise-induced high-turnover metabolism, Cell Metabolism (2021.2)

ㆍ Primary cilia mediate early life programming of adiposity through lysosomal regulation in the developing mouse hypothalamus, Nature Communications (2020.11)

ㆍ Cellular contributors to hypothalamic inflammation in obesity, Molecules and Cells (2020.5)

ㆍ Cellular source of hypothalamic macrophage accumulation in diet-induced obesity, Journal of Neuroinflammation (2019.11)

ㆍ Hypothalamic macrophage inducible nitric oxide synthase mediates obesity-associated hypothalamic inflammation, Cell Reports (2018.10)

ㆍ Effects of chronic NAD supplementation on energy metabolism and diurnal rhythm in obese mice, Obesity (2018.9)

ㆍ Exogenous nicotinamide adenine dinucleotide regulates energy metabolism via hypothalamic connecxin 43, Metabolism (2018.9)

ㆍ Role of Angptl4/Fiaf in exercise-induced skeletal muscle AMPK activation, Journal of Applied Physiology (2018.9)

기타

■ Research subjects
ㆍ Neuroscience
ㆍ Neuroinflammation
ㆍ Immunology
ㆍ Obesity & Metabolic diseases


■ Awards and Grants

ㆍ 2022-2025 National Research Foundation of Korea
ㆍ 2018-2021 National Research Foundation of Korea
ㆍ Aug 30th, 2019, Asia-Oceania Conference on Obesity
ㆍ Aug 26th, 2019, Korean Society for Molecular and Cellular Biology
ㆍ Apr 6th, 2019, Korean Society for the Study of Obesity
ㆍ Oct 8th, 2018, Keystone symposia
ㆍ Apr 7th, 2018, Korean Society for the Study of Obesity
ㆍ Apr 26th, 2018, Japan Endocrine Society
ㆍ Dec 1st, 2017, Korean Neuroendocrine Study Group
ㆍ Oct 25th, 2014, Korean Society for the Study of Obesity
ㆍ Oct 25th, 2014, Korean Society for the Study of Obesity
ㆍ Apr 19th, 2014, Korean Society for the Study of Obesity

오상욱
  • 분야

    면역세포치료

  • 성명

    국문 오상욱

  • 직위

    조교수

  • 연구실

    생명과학관 8424호실

  • 연락처

    033-248-2116

  • 이메일

학력

2007 서울대학교 생명과학부 (이학사)

2016 서울대학교 생명과학부 (이학박사)

주요경력

2023-현재 한림대학교 바이오메디컬학과 조교수

2021-2023 Department of Dermatology at the University of Pennsylvania (Research Investigator, Senior)

2017-2021 Department of Dermatology at the University of Pennsylvania (Postdoctoral Fellow)

2016-2017 서울대학교 유전공학연구소 연구원

연구 및 저서

  • Sangwook Oh*, Xuming Mao, Silvio Manfredo-Vieira, Jinmin Lee, Darshil Patel, Eun Jung Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, Patricia Y. Tsao, Christoph T. Ellebrecht, Sami L. Khella, David P. Richman, Kevin C. O’Connor, Uri Herzberg, Gwendolyn K. Binder, Michael C. Milone, Samik Basu, Aimee S. Payne (2023) Precision targeting of autoantigen-specific B-cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T-cells. Nature Biotechnology Sep; 41(9):1229-1238
  • Mihn C Pham, Gianvito Masi, Rosa Patzina, Abeer H Obaid, Seneca R Oxendine, Sangwook Oh, Aimee S Payne, Richard J Nowak, and Kevin C O’Connor (2023) Individual myasthenia gravis autoantibody clones can efficiently mediate multiple mechanisms of pathology. Acta Neuropathologica Aug; 146(2):319-336
  • Gianvito Masi, Minh C. Pham, Tabitha Karatz, Sangwook Oh, Aimee S. Payne, Richard J. Nowak, James F. Howard Jr., Jeffrey T. Guptill, Vern C. Juel, and Kevin C. O’Connor (2023) Clinicoserological insights into patients with immune checkpoint inhibitor-induced myasthenia gravis. Annals of Clinical and Translational Neurology May; 10(5):825-831
  • Fichtner M, Hoehn. KB, Ford EE, Mane-Damas M, Oh S, Waters P, Payne AS, Smith ML, Watson CT, Losen M, Martinez-Martinez P, Nowak RJ, Kleinstein SH, and O’Connor K (2022) Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy. Acta Neuropathologica Communications Oct 28; 10(1):154
  • Sangwook Oh and Aimee S. Payne (2022) Engineering Cell Therapies for Autoimmune Diseases: From Preclinical to Clinical Proof of Concept. Immune Network. Sep 21; 22(5):e37
  • Lee J, Lundgren DK, Mao X, Manfredo-Vieira S, Nunez-Cruz S, Williams EF, Assenmacher CA, Radaelli E, Oh S, Wang B, Ellebrecht CT, Fraietta JA, Milone MC, Payne AS (2020) Antigen specific B-cell depletion for precision therapy of mucosal pemphigus vulgaris. J. Clin. Invest. Aug 30;130(12):6317-6324
  • Sunsook Hwang,*, Chanjin Lee, Kyungwoo Park, Sangwook Oh, Shin Jeon, Byeonggeun Kang, Yehyun Kim, Jaehak Oh, Sung Ho Jeon, Masanobu Satake, Ichiro Taniuchi, Ho Lee, and Rho Hyun Seong (2020) Twist2 promote CD8+ T-cell differentiation by repressing ThPOK expression. Cell Death and Differentiation. Nov; 27(11):3053-3064
  • Sangwook Oh*, Jaehak Oh*, Chanjin Lee*, Seungjoon Oh, Shin Jeon, Jinwook Choi, Sunsook Hwang, Youmin Lee, Ho Lee, and Rho Hyun Seong (2016) Expression of Twist2 is controlled by T-cell receptor signaling and determines the survival and death of thymocytes. Cell Death and Differentiation. Nov 1;23(11):1804-1814

기타

■ 주요연구주제

 

- T세포 및 CAR-T세포의 활성을 조절하는 신호전달 기전

- CAR-T세포의 민감성과 안전성을 조절하는 기전  

콘텐츠 담당자 : 바이오메디컬학과

  • 전화번호 :033-248-2110
  • e-Mail :de2110@hallym.ac.kr