한림대학교 HALLYM UNIVERSITY

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■ 주요연구주제

- 항암제 연구(틸로머레이즈 저해제, 폴리머레이즈 저해제)

- 초분자 화학(포르피린과 유도체들의 합성과 특성 연구)

- 천연물 화학(천연물과 그 유도체들의 합성 및 생리활성 연구)

- BODIPY계 형광체의 합성과 생체내 응용 연구

- 화학생물학 및 생유기화학(효소, 단백질 및 핵산의 구조와 활성관계)

■ 논문

- J. H. Yoon, W. R. Lee, J. T. Lee, J. H. Song, G. Lee*, K.S. Lim*, “Design and Synthesis of Novel Lanthanide MOFs by Unique In-situ Organic and Inorganic Reactions”, Bulletin of the Korean Chemical Society, 2022, 43(9), 1136-1140.

- J. Nganga, Y. J. Jung, W. O. Choi, H. Lee, J. T. Lee*, J. K. Lee*, “Dibromorhodamine?based photoredox catalysis under visible light for the colorimetric detection of Hg(II) ion”, Bulletin of the Korean Chemical Society, 2022, 43(7), 946-950.

- H.-Y. Kim, H. J. Lee, G. Zuo, S. H. Hwang, J. S. Park, J. S. Hong, K. H. Kim, S. S. Montero, D.-K. Yi, J. T. Lee, H.-W. Suh, S. S. Lim*, “Antinociceptive activity of the Caesalpinia eriostachys Benth. ethanolic extract, fractions, and isolated compounds in mice”, Food Sicence & Nutrition, 2022, 10(7), 2381-2389.

- K. Damodar, S. Shin, S. H. Jeon*, J. T. Lee*, “First synthesis of tabamides A?C and their derivatives: in vitro nitric oxide inhibitory activity”, Tetrahedron Letters, 2021, 85, 153482.

- K. Y. Nam, K. Damodar, Y. Lee, L. S. Park, J. G. Gim, J. P. Park, S. H. Jeon*, J. T. Lee*, “Design and Synthesis of π-Extended Resveratrol Analogues and In Vitro Antioxidant and Anti-Inflammatory Activity Evaluation”, Molecules, 2021, 26(3), 646.

- H. R. Woo, K. Damodar, Y. Lee, S.-S. Lim, S. H. Jeon*, J. T. Lee*, “Discovery of Epinastine-NSAID Hybrids as Potential Anti-inflammatory Agents: Synthesis and In Vitro Nitric Oxide Production Inhibitory Activity Study”, Journal of the Korean Chemical Society, 2020, 64(2), 79-83.

- J. M. Lee, K. Damodar, Y. Lee, H. R. Woo, H. W. Suh, S. H. Jeon,* J. T. Lee*, “Novel Hybrid Molecules of Epinastine and Mefenamic Acid for Bioactive Assessment as Potential Anti-inflammatory Agents”, Bulletin of the Korean Chemical Society, 2020, 41(4), 444-449.

- J. Heo, J. H. Oh, J. T. Lee, Q. He, J. Sessler, S. K. Kim*, “Phenanthroline-Strapped Calix[4]pyrroles: Anion Receptors Displaying Affinity Reversal as a Function of Solvent Polarity”, Organic Chemistry Frontiers, 2020, 7(3), 548-556.

- M. I. Sanchez†, L. E. de Vries, C. Lehmann, J. T. Lee†, K. K. Ang, C. Wilson, S. Chen, M. R. Arkin, M. Bogyo, E. Deu*, “Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening”, PLoS ONE, 2019, 14(12): e0226270.

- J. Yoon, Y. J. Jung, J. B. Yoon, K. Damodar, H. Kim, M. Shin, M. Seo, D. W. Cho, J. T. Lee*, J. K. Lee*, “The heavy-atom effect on xanthene dyes for photopolymerization by visible light”, Polymer Chemistry, 2019, 10(42), 5737-5742.

- J. M. Lee, K. Damodar, Y. Lee, J.-Y. Lee, S. H. Jeon,* J. T. Lee,* “Synthesis and Biological Assay of Hybrids between Epinastine and Salicylic acid as Promising Nitric Oxide Production Inhibitors”, Bulletin of the Korean Chemical Society, 2019, 40(8), 735-740.

- S. Park, J. T. Lee, J. Kim, “Photocatalytic oxidation of urea on TiO2 in water and urine: mechanism, product distribution, and effect of surface platinization”, Environmental Science and Pollution Research, 2019, 26(2), 1044-1053.

- Synthesis and Biological Evaluation of Hybrids of Epinastine and Salicylic acid as Potential Nitric Oxide Production Inhibitors [Bulletin of the Korean Chemical Society, SCI, 공동(교신), 2019]

- Photocatalytic oxidation of urea on TiO2 in water and urine: mechanism, product distribution, and effect of surface platinization [Environmental Science and Pollution Research, SCI, 공동(참여), 2019] 

- Synthesis and in vitro evaluation of homoisoflavonoids as potent inhibitors of nitric oxide production in RAW-264.7 cells [Bioorganic & Medicinal Chemistry Letters, SCI, 공동(교신), 2018]

- Substituents modification of meso-aryl BODIPYs for tuning photophysical properties [Tetrahedron, SCI, 공동(교신), 2018]

- Enantioselective synthesis and antioxidant activity of 3,4,5-substituted piperidine derivatives [Bioorganic & Medicinal Chemistry Letter, SCI, 공동(교신), 2016]

- Recent Advancements in Calix [4]pyrrole-Based Anion-Receptor Chemistry [EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, SCI, 공동(참여),2015]

- Syntheses of Resveratrol Analogues and Evaluation of Their Antioxidant Activity [BULLETIN OF THE KOREAN CHEMICAL SOCIETY, SCI, 공동(교신) ,2014]

- Displacement-based, chromogenic calix[4]pyrrole-indicator complex for selective sensing of pyrophosphate anion[Tetrahedron Letter, SCI, 공동(교신),2013]

■ 특허

- 레스베라트롤 유사 화합물을 포함하는 항산화 조성물, 출원번호: 10-2017-0165097 (2017.12.04) 등록번호: 10-1985005 (2019. 05. 27)

- 레스베라트롤 유사 화합물을 포함하는 항산화제 및 항염증제, 출원번호: 10-2016-0167903 (2016.12.09), 등록번호: 10-1854829 (2018.04.27)

- 레스베라트롤 유사화합물을 포함하는 항산화제, 출원번호: 10-2014-0042297 (2014.01.09), 등록번호: 10-1687295 (2016.12.12)

- 항산화 활성을 갖는 3,4,5-치환 광학 활성 피페리딘 화합물 및 그 합성방법, 출원번호: 10-2012-0140515 (2012.12.05), 등록번호: 10-1458094 (2014.10.29)

■ 학회활동

1. 대한화학회 종신회원

2. 미국화학회 정회원

■ 교외 연구비 수혜현황(연구책임자 기준)

- 폴리페놀계 유도체들의 pi컨쥬게이션 확장과 heteroatom치환이 생리활성에 미치는 영향 / 한국연구재단 / 2017.06.01~2020.05.30 / 90,000,000원/년

- 수용성 초분자고리 피롤화합물의 합성과 응용 / 한국연구재단 /  2012.05.01~2015.04.30 / 49,920,000원/년

- 리팜핀,아이나,스트렙토 마이신 내성균 신속검사 키트의 개발 및 제품화 / 한국산업기술진흥원 / 2011.12.01~2013.11.30 / 20,000,000원/년

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■ 논문

1. Won J-I, Shin JM, Park SY, Yoon JH, Jeong D-H. (2020) Global Analysis of the Human RNA Degradome Reveals Widespread Decapped and Endonucleolytic Cleaved Transcripts. Int. J. Mol. Sci. 21: 6452 

2. Park SY, Choi JH, Oh DH, Johnson JC, Dassanayake M, Jeong D-H, Oh MH. (2020) Genome-wide analysis of brassinosteroid responsive small RNAs in Arabidopsis thaliana. Genes Genomics. 42: 957-969. 

3. Won J-I, Lee JB, Lee HW, Shin JM, Yoon JH, Jeong D-H. (2019) WebPORD: a web-based pipeline of RNA degradome. Int, J. Data Mining and Bioinformatics. 22: 216-230

4. Franke KR, Schmidt SA, Park S, Jeong D-H, Accerbi M, Green PJ. (2018) Analysis of Brachypodium miRNA targets: evidence for diverse control during stress and conservation in bioenergy crops. BMC Genomics. 19: 547

5. Chung PJ, Jung H, Jeong D-H, Ha SH, Choi YD, Kim JK. (2016) Transcriptome profiling of drought responsive noncoding RNAs and their target genes in rice. BMC Genomics. 17: 56 

6. Jeong D-H (2016) Functional diversity of microRNA variants in plants J. Plant Biol. 59: 303-310

7. Kim C-Y, Vo KTX, Nguyen CD, Jeong D-H, Lee S-K, Kumar M, Kim S-R, Park S-H, Kim J-K, Jeon J-S. (2016) Functional analysis of a cold-responsive rice WRKY gene, OsWRKY71. Plant Biotechnology Reports. 10:13-23 

8. Schmidt SA,  Foley PL, Jeong D-H, Rymarquis LA, Doyle F, Tenenbaum SA, Belasco JG,, and Green PJ. (2015) Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells. Nucleic Acids Res. 43: 309-323

9. Jeong D-H, Schmidt SA, Rymarquis LA, Park S, Ganssmann M, German MA, Accerbi M, Zhai J, De Paoli E, Fahlgren N, Fox SE, Garvin DF, Mockler TC, Carrington JC, Meyers BC, and Green PJ. (2013) Parallel analysis of RNA ends enhances global investigation of miRNAs and target RNAs of Brachypodium distachyon. Genome Biology 14:R145

10. Jeong D-H, and Green PJ. (2013) The role of rice microRNAs in abiotic stress responses. J. Plant Biol. 56: 187-197 (review) 

11. Jeong D-H*, Thatcher SR*, Brown RSH, Zhai J, Park S, Rymarquis LA, Meyers BC, and Green PJ. (2013) Comprehensive investigation of microRNAs enhanced by analysis of sequence variants, expression patterns, ARGONAUTE loading and target cleavage. Plant Physiol. 162:1225-1245 (*co-first authors)

12. Jeong D-H, and Green PJ. (2012) Methods for validation of miRNA sequence variants and the cleavage of their targets. Methods 58:135-143  

13. Song X, Li P, Zhai J, Zhou M, Liu B, Ma L, Jeong D-H, Nakata M, Cao S, Liu C, Chu C, Wang X-J, Green PJ, Meyers BC, and Cao X.(2012) Role of DCL4 and DCL3b in rice phased small RNA biogenesis. Plant J. 69:462-474

14. Jeong D-H, Park S, Zhai J, Gurazada SGR, De Paoli E, Meyers BC, and Green PJ. (2011) Massive analysis of rice small RNAs: Mechanistic implication of regulated miRNAs and variants for differential target RNA cleavage. Plant Cell 23: 4185-4207

15. Zhai J, Jeong D-H, De Paoli E,Park S,Rosen BD, Li Y, González AJ,Yan Z, Kitto SL, Grusak MA, Jackson SA, Stacey G,  Cook DR, Green PJ, Sherrier DJ, Meyers BC. (2011) microRNAs as Master Regulators of the Plant NB-LRR Defense Gene Family via the Production of Phased, Trans-acting siRNAs. Genes and Development 25:1540

16. Young ND, Debellé F, Oldroyd G, Geurts R, Cannon SB, Mayer KFX, Gouzy J, Van de Peer Y, Schoof H, Udvardi MK, Cook DR, Meyers BC, Spannagl M, Cheung F, De Mita S, Proost S, Krishnakumar V, Gundlach H, Zhou S, Mudge J, Bharti AK, Benedito VA, Murray JD, Naoumkina MA, Rosen B, Silverstein KA, Tang H, Rombauts S, Zhao PX, Zhou P, Barbe V, Bardou P, Bechner M, Bellec A, Berger A, Bergès H, Bidwell S, Bisseling T, Choisne N, Couloux A, Denny R, Deshpande S, Doyle JJ, Dudez A-M, Farmer AD,  Fouteau S, Franken C,  Gibelin C, Gish J, González AJ, Green PJ, Hallab A, Hartog M, Hua A, Humphray S, Jeong D-H, Jing Y, Jöcker A, Kenton SM, Kim D-J, Kathrin Klee, Lai H, Lang C, Lin S, Macmil SL, Magdelenat G, Matthews L, McCorrison J, Monaghan EL, Mun J-H, Najar FZ, Nicholson C, Noirot C, Paule CR, Poulain J, Prion F, Qin B, Qu C, Retzel EF, Riddle C, Sallet E, Samain S, Samson N, Saurat O, Scarpelli C, Schiex T, Segurens B, Seigfried M,  Severin A, Sherrier DJ, Shi R, Sims S, Sinharoy S, Sterck L, Vasylenko I, Viollet A, Wang K, Wang B-B, Wang X, Warfsmann J, Weissenbach J, White DD, White JD, Wiley GB, Wincker P, Xing Y, Yang L, Yao Z, Ying F, Zhai J, Zhou L, Zuber A, Dénarié J, Dixon RA, May GD, Schwartz DC, Rogers J, Quétier F, Town CD, Roe BA. (2011) The Medicago Genome Provides Insight into the Evolution of Rhizobial Symbioses. Nature 480:520-524

17. Lee Y-S, Jeong D-H, Lee D-Y, Yi J, Ryu C-H, Kim SL, Jeong HJ, Choi SC, Jin P, Yang J, Choi L-H, Choi H, and An G (2010) OsCOL4 is a constitutive flowering repressor upstream of Ehd1 and downstream of OsphyB. Plant J. 63:1830.

18. Joshi T, Yan Z, Libault M, Jeong D-H, Park S, Green PJ, Sherrier Dj, Farmer A, May G, Meyers BC, Xu D, Stacey G (2010) Prediction of novel miRNAs and associated target genes in Glycine max. BMC Bioinformatics 11 (Suppl 1):S14. 

19. De Paoli E, Dorantes A, Zhai J, Accerbi M, Jeong D-H, Park S, Meyers BC, Jorgensen RA, Green PJ (2009). Distinct extremely abundant siRNAs associated with cosuppression in petunia. RNA 15:1965-1970.

20. Haas BJ, Kamoun S, Zody MC, Jiang RHY, HandsakerRE, Cano LM, Grabherr M, Kodira CD, Raffaele S, Torto-Alalibo T, Bozkurt TO, Ah-Fong AMV, Alvarado L, Anderson VL, Armstrong MR, Avrova A, Baxter L, Beynon J, Boevink PC, Bollmann SR, Bos JIB, Broad Institute Genome Sequencing Platform, Bulone V, Cai G, Cakir C, Carrington JC, Chawner M, Conti L, Costanzo S, Ewan R,Fahlgren N,Fischbach MA, Fugelstad J, Gilroy EM, Gnerre S, Green PJ, Grenville-Briggs LJ, Griffith J, Grünwald NJ, Horn K, Horner NR, Hu C-H, Huitema E, Jeong D-H, Jones AME, Jones JDJ, Jones RW, Karlsson EK, Kunjeti SG, Lamour K, Liu Z, Ma LJ, MacLean D, Marcus C, McDonald H, McWalters J, Meijer HJG, Morgan W, Morris PF, Munro CA, O'Neill K, Ospina-Giraldo M, Pinzón A, Pritchard L, Ramsahoye B, Ren Q, Restrepo S, Roy S, Sadanandom A, Savidor A, Schornack S, Schwartz DC, Schumann UD, Schwessinger B, Seyer L, Sharpe T, Silvar C, Song J, Studholme DJ, Sykes S, Thines M, van de Vondervoort PJI, Vipaporn P, Wawra S, Weide R, Win J, Young C, Zhou S, Fry W, Meyers BC, van West P, Ristaino J, Govers F, Birch PRJ, Whisson SC, Judelson HS, Nusbaum C (2009). Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature 461:393-398.

21. Moon S, Giglione C, Lee D-Y, An S, Jeong D-H, Meinnel T, An G (2008) Rice peptide deformylase PDF1B is crucial for development of chloroplasts. Plant and Cell Physiology 49: 1535-1546.

22. Nobuta K, Lu C, Shrivastava R, Pillay M, De Paoli E, Accerbi M, Arteaga-Vasquez M, Sidorenko L, Jeong D-H, Yen Y, Chandler V, Green PJ, Meyers BC (2008) A novel size distribution of endogenous siRNAs in maize: evidence from sequencing in the mop1-1 mutant. P.N.A.S. 105:14958-14963.

23. German MA, Pillay M, Jeong D-H, Hetawal A, Luo S, Janardhanan P, Kannan V, Rymarquis LA, Nobuta K, German R, De Paoli E, Lu C, Schroth G, Meyers BC, Green PJ (2008) Global identification of microRNA-target RNA pairs by parallel analysis of RNA ends. Nat. Biotechnol. 26:941-946.

24. Lee S, Jeong D-H, An G (2008) A possible working mechanism for rice SVP group MADS-box proteins as negative regulators of brassinosteroid responses. Plant signaling & behavior 3: 471-474.

25. Lu C, Jeong D-H, Kulkarni K, Pillay M, Nobuta K,  German R, Thatcher SR, Maher C,  Zhang L, Ware D, Liu B, Cao X, Meyers BC, Green PJ (2008) Genome-wide analysis for discovery of unique rice miRNAs reveals natural antisense miRNAs (nat-miRNAs). P.N.A.S. 105:4951-4956.

26. Jeong D-H, Lee S, Kim SL, Hwang I, An G, (2007) Regulation of brassinosteroid responses by phytochrome B in rice. Plant Cell Environ. 30: 590-599.

27. Jeong D-H*, An S*, Park S, Kang H-G, Park G-G, Kim S-R, Sim J, Kim Y-O, Kim M-K, Kim S-R, Kim J, Shin M, Jung M, An G. (2006) Generation of flanking sequence tag database for activation tagging lines in japonica rice, Plant J. 45:123-132. (*co-first authors)

28. Kim SJ, Jeong DH, An G, Kim S-R (2005) Characterization of a drought-responsive gene, OsTPS1, identified by the T-DNA gene-trap system in rice, J. Plant Biol. 48:371-379. 

29. Shin J-H, Jeong D-H, Park MC, An G. (2005) Characterization and transcriptional expression of the α-expansin gene family in rice, Mol. Cells, 20:210-218.

30. An G, Jeong D-H, Jung K-H, Lee S. (2005) Reverse genetic approaches for functional genomics of rice. Plant Mol. Biol. 59:111-123. (review) 

31. Lee S-C, Kim J-Y, Kim S-H, Kim S-J, Lee K, Han S-K, Choi H-S, Jeong D-H, An G, Kim S-R, (2004) Trapping and characterization of cold-responsive genes from T-DNA tagging lines in rice, Plant Science,166: 69-79.

32. Lee S, Kim J, Son J-S, Nam J, Jeong D-H, Lee K, Jang S, Yoo J, Lee J, Lee D-Y, Kang H-G, An G, (2003) Systematic reverse genetic screening of T-DNA tagged genes in rice for functional genomic analyses: MADS-box genes as a test case. Plant Cell Physiol, 44: 1403-1411.

33. An S, Park S, Jeong D-H, Lee D-Y, Kang H-G, Yu J-H, Hur J, Kim S-R, Kim Y-H, Lee M, Han S, Kim S-J, Yang J, Kim E, Wi SJ, Chung HS, Hong J-P, Choe V, Lee H-K, Choi J-H, Nam J, Kim S-R, Park P-B, Park KY, Kim WT, Choe S, Lee C-B, An G. (2003) Generation and analysis of end-sequence database for T-DNA tagging lines in rice. Plant Physiol 133: 2040-2047.

34. Sasaki A, Itoh H, Gomi K, Ueguchi-Tanaka M, Ishiyama K, Kobayashi M, Jeong D-H, An G, Kitano H, Ashikari M, Matsuoka M. (2003) Accumulation of phosphorylated repressor for gibberellin signaling in an F-box mutant. Science 299: 1896-1898.

35. Jeong D-H, An S, Kang H-G, Moon S, Han J-J, Park S, Lee H S, An K, An G. (2002) T-DNA insertional mutagenesis for activation tagging in rice. Plant Physiol. 130:1636-1644. 

36. Yang K, Jeong D-H, Jang S, An G. (2001) Molecular cloning and characterization of a rice PP2C, OsPP2C4. J. Plant Biol. 44: 1-6. 

37. Sung S-K, Yu G-H, Nam J, Jeong D-H, An G. (2000) Developmentally regulated expression of two MADS-box genes, MdMADS3 and MdMADS4, in the morphogenesis of flower buds and fruits in apple. Planta 210: 519-528. 

38. Jeon J-S, Lee S, Jung K-H, Jun S-H, Jeong D-H, Lee J, Kim C, Jang S, Lee S-Y, Yang K, Nam J-M, An K, Han M-J, Sung R-J, Choi H-S, Yu J-W, Choi J-H, Cho S-Y, Cha S-S, An G. (2000) T-DNA insertional mutagenesis for functional genomics in rice. Plant J. 22: 561-570. 

39. Kim C, Jeong D-H, An G. (2000) Molecular cloning and characterization of OsLRK1 encoding a putative receptor-like protein kinase from Oryza sativa. Plant Sci. 152: 17-26. 

40. Jeong D-H, Sung S-K, An G. (1999) Molecular cloning and characterization of CONSTANS-like cDNA clones of the Fuji apple. J. Plant Biol. 42: 23-31. 

41. Sung S-K, Jeong D-H, Nam J, Kim S-H, Kim S.-R, An G. (1998) Expressed sequence tags of fruits, peels, and carpels and analysis of mRNAs expression levels of the tagged cDNAs of fruits from the Fuji apple. Mol. Cells 8: 565-577.

■  특허

- 전종성, 이상규, 심수현, 고희종, 김백기, 정동훈, 박소영 (2021) 벼의 폐화수정 유도를 위한 MicroRNA172b 유전자 및 이의 돌연변이에 의한 폐화수정 벼의 제조방법. 국내특허출원번호 10-2021-0084572

- 전종성, 김치열, 키우 티 수안 보, 얀 콩 뉴엔, 정동훈, 김성룡, 김주곤, 이상규 (2016) OsWRKY71 유전자의 발현이 증진된 저온 내성 형질전환 식물체. 출원번호: 10-2016-0048355

- An G, Lee S, Jeong D-H, Yoo JH, Ryu C-H, Jeon J-S, Kim S-R, Kim Y-O, Kim J, An S, (2014) Regulator for flowering time, transgenic plant transformed with the same, and method for regulating flowering time. US Patent No. 8785724B2

- An G, Jeong D-H, Kang H-G, An S, An K, S-O Moon. The method for preparing transformed monocotyledon with T-DNA tagging vector comprising an enhancer element for activation tagging and a reporter gene trapping and the transformants prepared by this method. Republic of Korea, Patent No. 0464677 (2004.12.22). 

■ 주요 연구주제
- RNA Genomics: 차세대염기서열분석기술(Next Generation Sequencing technology)를이용하여 small RNA 및 mRNA와 같은 다양한 전사체(transcriptome)를 유전체 수준에서 연구함
- Crop Functional Genomics: 벼의 꽃발달 관여 유전자 및 환경스트레스 관련 유전자의 발굴과 형질전환식물체 개발을 통한 기능유전체 연구를 수행하고 있음
- Post-transcriptional Gene Regulation: microRNA를 포함한 small RNA가 전사후단계에서 유전자 발현을 조절하는 기작을 연구하며, RNA degradome 분석을 통한 RNA 분해기작을 주로 연구함.
- Epigenetics and Epitranscriptomics: DNA 및 RNA의 변형이 유전자 발현 및 mRNA 안정화에 미치는 영향을 연구함.

■ 학회활동
- 한국식물학회
- 한국유전학회

■ 수상
- 한국식물학회JPB 논문상(2016)

Decursinol angelate mitigates sepsis induced by methicillin-resistant Staphylococcus aureus Infection by modulating the inflammatory responses of macrophages (2021) Int J Mol Sci. 22:10950

CD11b deficiency exacerbates methicillin-resistant Staphylococcus aureus-induced sepsis by upregulating inflammatory responses of macrophages (2021) Immune Netw. 21:e13

mTORC1 as a cell-intrinsic rheostat that shapes development, preimmune repertoire, and function of B lymphocytes (2019) FASEB J.33:13202-13215

Metabolic influence on macrophage polarization and pathogenesis (2019) BMB Rep. 52:360-372

Decursinol angelate ameliorates dextran sodium sulfate-induced colitis by modulating type 17 helper T cell responses (2019) Biomol Ther. 27:466-473

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53 (2019) Oncogene. 38:1635-1650.

Critical role of mTORC2-Akt signaling in TGF-b1-induced myofibroblast differentiation of human pterygium fibroblasts (2019) Invest Ophthalmol Vis Sci. 60:82-92

Expression of Lrig1, a negative regulator of EGFR, is dynamically altered during different stages of gastric carcinogenesis (2018) Am J Pathol. 188:2912-2923

B cell-intrinsic mTORC1 promotes germinal center-defining transcription factor gene expression, somatic hypermutation, and memory B cell generation in humoral immunity (2018) J Immunol. 200:2627-2639

CD11b regulates antibody class switching via inducing AID (2017) Mol Immunol. 87:47-59

Rapamycin-resistant and torin-sensitive mTOR signaling promotes survival and proliferation of leukemic cells (2016) BMB Rep. 49:63-68

Regulation of endothelial cell proliferation and vascular assembly through distinct mTORC2 signaling pathways (2015) Mol Cell Biol. 35:1299-1313

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells (2014) J Exp Med. 211:2281-2295

Immune response and the tumor microenvironment: how they communicate to regulate gastric cancer (2014) Gut Liver. 8:1-9

Requirement for Rictor in homeostasis and function of mature B lymphoid cells (2013) Blood. 122:2369-2379

Cdc42 promotes host defenses against fatal infection (2013) Infect Immun. 81:2714-2723

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia (2012) J Exp Med. 209:713-728.

A “Tsc, Tsc” keeps the kids quie(scen)t and holds off ROS (2011) Nat Immunol. 12:811-812.

Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathways (2010) Immunity. 32:743-753.

■ 주요연구주제

- Dissecting the PI3K/PTEN/mTOR signaling network in immunity:

    Part 1) Antibody responses of B cells against pathogen infection

    Part 2) Functional polarization of macrophages in inflammatory diseases and cancer development

- Elucidating host-microbiota interactions in the gut homeostasis and inflammation:

    Part 1) Regulation of the monocyte-macrophage waterfall in the context of the gut mucosal host-microbiota interactions

    Part 2) Functional impact of microbial metabolites on immune responses in the gut homeostasis and colitis

- Study on the tumor immune microenvironment:

    Part 1) Identification of tumor-derived immunoediting factors

    Part 2) Functional impact of the putative immunoediting factor on shaping tumor microenvironment

■ 학회활동

• 생화학분자생물학회: 대의원
• 한국실험동물학회: 평의원, 총무간사
• 한국분자세포생물학회: 운영위원
• 대한면역학회: 회원
• American Association of Immunologist (AAI) 회원

Google Scholar

연구실 홈페이지

■ 연구분야
만성질환 관련 식생활 위험요인 분석
청년 식생활 개선을 위한 중재연구
푸드 리터러시 지표 개발과 측정 
푸드 리터러시 향상을 위한 중재연구 
혼합연구방법을 이용한 건강증진 프로그램 개발 
 
■ 논문 (최근 5년)

· Ko E, Jang E, Sim J, Jeong M, Park S. Evaluating the effectiveness of a food literacy pilot program for university students: using a mixed-methods research approach. Nutrition Research and Practice 2024 (In press) 

· Jang E, Ko E, Sim J, Jeong M, Park S. Mukbang media: correlations with the dietary behavior of children and adolescents in Korean. Nutrition Research and Practice 2024 (In press)

· Jung S, Lee Y, Kim K and Park S. Association of the dietary inflammatory index with sarcopenic obesity and frailty in older adults. BMC Geriatrics, 2024

· Sim J, Lim J, Lee H, Park S, Shin D. A 3-month nutrition and exercise program improved hallux strength among senior daycare center users in Korea: a cluster randomized controlled trial. Frontiers in Public Health, 2024

· Sim J, Lim J, Ko E, Jang E, Jeong M, Park S. Development of a frailty prevention program including nutrition and exercise interventions for older adults in senior daycare centers in South Korea: using a mixed methods research design. Nutrition Research and Practice 2024;18(3):372-386

· Jeong S, Jeong J-Y, Park S. Changes in food sufficiency among Korean adults in urban and rural areas during the COVID-19 pandemic: an analysis of the 7th and 8th Korea National Health and Nutrition Examination Survey. Epidemiology and Health, 45 2024

· Yoo H, Jo E, Lee H, Ko E, Jang E, Sim J, Park S. Level of happiness and its association with food literacy among Seoul citizens: results from Seoul Food Survey 2021. Nutrition Research and Practice 2024;18(1):119-131

· Jung S, Seo J, Kim JY, Park S. Associations of Ultra-Processed Food Intake with Body Fat and Skeletal Muscle Mass by Sociodemographic Factors, Diabetes & Metabolism Journal, 2024 

· Jung S, Kim J-Y, Park S. Eating patterns in Korean adults, 1998–2018: increased energy contribution of ultra‑processed foods in main meals and snacks. European Journal of Nutrition, 2024

· Jung S, Jang E, Lee H, Kim J-Y, Park S. Higher consumption of ultra-processed food is associated with cardiovascular risk in Korean adults: KNHANES 2016–2018. Frontiers in Nutrition, 2023

· Jeong S, Lee H, Jung S, Kim J-Y, Park S. Higher energy consumption in the evening is associated with increased odds of obesity and metabolic syndrome: findings from the 2016-2018 Korea National Health and Nutrition Examination Survey (7th KNHANES). Epidemiology and Health 45, 2023

· Yoo H, Jo E, Lee H, Ko E, Jang E, Sim J, Park S. Who has a high level of food literacy, and who does not?: a qualitative study of college students in South Korea. Nutrition Research and Practice 2023;17(6):1155-1169

· Yoo H, Jo E, Lee H, Ko E, Jang E, Sim J, Kim K, Park S.  The level of food literacy and its association with food intake and obesity status among Seoul citizens: results from Seoul Food Survey 2021. Nutrition Research and Practice 2023;17(5): 945-958 

· Lee S, Park S, Kim K. Food literacy and its relationship with food intake: a comparison between adults and older adults using 2021 Seoul Food Survey data. Epidemiology and Health 45, 2023

· Lee H, Park S. Regional differences in the associations of diet quality, obesity, and possible sarcopenia using the seventh Korea National Health and Nutrition Examination Survey (2016-2018). Epidemiology and Health 45, 2023

· Ko E, Jang E, Sim J, Jeong M, Park S. Development of a campus-based intervention program to strengthen food literacy among university students: A qualitative formative study, Korean J Community Nutr 28(6): 495~508, 2023

·  Cho YJ, Park S et al. The Gangwon Obesity and Metabolic Syndrome Study: Methods and Initial Baseline Data. Journal of Obesity and Metabolic Syndrome 2022; 31: 303-312

·  Jung S, Par S. Positive association of unhealthy plant-based diets with the incidence of abdominal obesity: Comparison of baseline, most recent, and cumulative average diets. Epidemiology and Health 44, 2022

·  Jo J, Yoo H, Kim K, Kim S, Kim CK, Lee H, Jeong J, Park S. Who has experienced better or worse health conditions since the outbreak of COVID-19?: Results from a representative cross-sectional survey in Seoul. Nutrition Research and Practice 2022;16:e50 

· Yoo H, Jo E, Lee H, Park S. Development of a food literacy assessment tool for healthy, joyful, and sustainable diet in South Korea. Nutrients 2022; 14, 1507

· Jung S, Park S, Kim JY. Comparison of dietary share of ultra-processed foods assessed with a FFQ against a 24-h dietary recall in adults: Results from KNHANES 2016. Public Health Nutrition 2022;25(5):1166-1175

· Jo E, Shim JE, Ryou HJ, Kim K, Song SJ, Kim HJ, Ahn JS, Kwon K, Lee HY, Park S. Using service design tools in community nutrition research: a case study in developing dietary guidelines for young adults. Korean Journal of Community Nutrition 2022;27(3):177-191 [Korean]

 · Park S, Jung S, Yoon H. The role of nutritional status in the relationship between diabetes and health-related quality of life. Nutrition Research and Practice 2022;16(4):505-516 

· Park S, Hwang JY, Shim JE, Kim K. Basic concepts and detailed dimensions of food security and related indicators for policy development and evaluation. Korean J Community Nutr 2021;26(6):429-440 [Korean]

· Yoo H L, Jo E, Kim K, Park S. Defining food literacy and its application to nutrition interventions: A scoping review. Korean J Community Nutr  2021; 26(2):77-92 [Korean]

· Park S, Kim H-J, Kim K. Do where the elderly live matter? Factors associated with diet quality among Korean elderly population living in urban versus rural areas. Nutrients 2020; 12, 1314

· Park S, Sung E. "You gotta have something to chew on" - Perceptions of stress-induced eating and weight gain among office workers in South Korea. Public Health Nutrition 2020; 24(3): 499-511

■ 저서 및 편역서  

· Gittelsohn J, Park S. “School and Community-Based Interventions,” in Pediatric Obesity: Etiology, Pathogenesis and Treatment (Freemark M, editor, 2nd Edition), 2018; Humana Press: New York
· 생활 속의 영양학, 라이프사이언스, 2021
· 노인간호학, 메디컬사이언스, 2022
· 지역사회영양학, 파워북, 2023

■ 논문

◦ Comparison of word production ability of young and middle-aged adults using word-chain tasks. Audiology and Speech Research (SCOPUS), 교신저자, in press
◦ Changes in pen pressure, letter size, and writing speed according to visual cues in patients with Parkinson's disease. Audiology and Speech Research (SCOPUS), 교신저자, in press
◦ Predictive Indicators of Kinematic Writing Ability in Patients with Parkinson’s Disease: Focusing on Cognition, Depression, and Motor Abilities. Communication Sciences & Disorders (SCOPUS), 교신저자, 2022
◦ Exploring Text Mining as a Vocabulary Evaluation Method: Focusing on Utterance Data from Children and Adolescents. Communication Sciences & Disorders (SCOPUS), 공동저자, 2022
◦ Honorific Speech Impairment: A Characteristic Sign of Frontotemporal Dementia. Cognitive & Behavioral Neurology (SCI), 교신저자, 2021  
◦ 청년층, 중장년층, 노년층의 대화 특성 비교: 화용 능력을 중심으로 (학진등재), 교신저자, 2021
◦ Comparison of Word Reading between Cognitively Normal Elderly and Elderly with Mild Cognitive Impairment according to Word Condition. Audiology and Speech Research (SCOPUS), 교신저자, 2021
◦ Comparison of Word-Writing Performance according to the Degree of Cognitive Decline: Focused on Patients with Subjective Memory Complaint, Mild Cognitive Impairment, and Alzheimer’s Disease. Audiology and Speech Research (SCOPUS), 교신저자, 2021
◦ Attitude of Korean Speech-Language Pathologists toward Usage of Language Sample Analysis and Computer-aided LSA. Communication Sciences & Disorders (SCOPUS), 공동저자, 2020
◦ The tip-of-the-tongue phenomenon in older adults with subjective memory complaints. Plos One (SCI), 교신저자, 2020
◦ A qualitative study on experiences and needs of language sample analysis by speech-language pathologists: Focused on children with language disorders. Communication Sciences & Disorders (SCOPUS), 공동저자, 2020
◦ A qualitative study on experiences and needs of language sample analysis by speech-language pathologists: Focused on patients with acquired neurogenic language disorders. Communication Sciences & Disorders (SCOPUS), 제1저자, 2020
◦ Characteristics of writing in Parkinson's disease: Focused on pen pressure, letter size, and writing speed. Communication Sciences & Disorders (SCOPUS), 교신저자, 2020
◦ Characteristics of conversation in patients with right hemisphere damage. Communication Sciences & Disorders (SCOPUS), 교신저자, 2019  
◦ Changes in naming and cognitive abilities as the effects of semantic feature analysis treatment in middle-aged and older adults. Communication Sciences & Disorders (SCOPUS), 교신저자, 2019 
◦ A web service for evaluating the level of speech in Korean. Applied Sciences (SCI), 공동저자, 2019  
◦ Subjective rating scale for discourse: evidence from the efficacy of subjective rating scale in amnestic mild cognitive impairments. Medicine (SCI), 교신저자, 2019 ◦ Lifespan development of syntactic ability from early childhood to old age. Communication Sciences & Disorders (SCOPUS), 제1저자, 2018
◦ Characteristics and underlying mechanisms of semantic clustering in Parkinson’s disease. Communication Sciences & Disorders (SCOPUS), 교신저자, 2018 
◦ Reading and writing characteristics of cerebral infarction patients with or without aphasia. Communication Sciences & Disorders (SCOPUS), 교신저자, 2018
◦ Development of conversational skills from late children to adolescent. Communication Sciences & Disorders (SCOPUS), 공동저자, 2018 
◦ Medial-vowel writing difficulty in Korean syllabic writing: a characteristic sign of Alzheimer’s disease. Journal of Clinical Neurology (SCI), 제1저자, 2018 
◦ Characteristics of conversation in frontotemporal dementia: comparison with dementia of the Alzheimer’s type. Communication Sciences & Disorders (SCOPUS), 교신저자, 2018 
◦ Comparison between self-reported and objective measures on speech characteristics in patients with Parkinson’s disease. Communication Sciences & Disorders (SCOPUS), 제1저자, 2018 
◦ Characteristics of word reading according to word condition in normal adults.  Communication Sciences & Disorders (SCOPUS), 교신저자, 2017 
◦ Lifespan development of word use from early childhood to old age. Communication Sciences & Disorders (SCOPUS), 공동저자, 2017 
◦ Characteristics of confrontation naming ability according to word frequency in patients with amnestic mild cognitive impairment: A preliminary study. Communication Sciences & Disorders (SCOPUS), 교신저자, 2017 
◦ 노년층의 글쓰기 특성 -이야기문법과 구문구조-. 재활복지 (학진등재), 교신저자, 2017 
도시와 농촌거주 노인의 인지기능 비교: 예비연구. 디지털융복합연구 (학진등재), 교신저자, 2017 
◦ Numerical Processing and Calculation Deficits in Alzheimer’s Disease. Communication Sciences & Disorders (SCOPUS), 공동저자, 2017 
◦ Word Lexicality- and Regularity-Dependent Alexia in Alzheimer’s Disease. Communication Sciences & Disorders (SCOPUS), 공동저자, 2017 
◦ Neuroanatomical Correlates of Hypophonia in Subcortical Vascular Cognitive Impairment. European Neurology (SCI), 제1저자, 2017
◦ 노년층과 청년층의 상위범주어 과제 수행력 비교. 재활복지 (학진등재), 교신저자, 2016 
◦ 정상 청년층과 노년층의 비유언어 이해 능력: 직유, 은유, 관용어, 속담을 중심으로. 한국노년학 (학진등재), 교신저자, 2016 
◦ 노년층의 문법판단 및 오류수정능력. 언어치료교육 (학진등재), 교신저자, 2016 
◦ Characteristics of the defining ability of the elderly in nouns, verbs, and adjectives. Communication Sciences & Disorders (SCOPUS), 교신저자, 2016 
◦ Micrographia in Parkinson's disease: Comparison between horizontal and vertical handwritings. Communication Sciences & Disorders (SCOPUS), 교신저자, 2016
◦ Category norms for Korean adults age 55 to 74. Communication Sciences & Disorders (SCOPUS), 교신저자, 2015
◦ 정상 노인의 절차 담화 특성. 한국노년학 (학진등재), 교신저자, 2015 
◦ The distinctive effect of providing syllables in letter fluency testing: Literate vs. illiterate elderly persons. Speech Communication (SCI), 교신저자, 2015
◦ 생성이름대기를 통한 정상 노인의 단어 찾기 책략 특성. 재활복지 (학진등재), 교신저자, 2015 
◦ 파킨슨병 환자의 교대운동속도 과제에서 관찰된 ‘말 뭉침’의 음향학적 특성. 말소리와 음성과학 (학진등재), 교신저자, 2015 
◦ Efficacy of language-appropriate cueing on micrographia in Korean patients with Parkinson's disease. Geriatrics & Gerontology International (SCI). 공동저자, 2015 
◦ Initial phase performance in a 30-s verbal fluency task as being reflective of aging effect. Geriatrics & Gerontology International (SCI). 공동저자, 2015 
◦ Effect of literacy level on cognitive and language tests in Korean illiterate older adults. Geriatrics & Gerontology International (SCI). 공동저자, 2014
◦ Response time measurements in the iOS app-based Token Test, the Brief Token Test in the elderly. Geriatrics & Gerontology International (SCI). 공동저자, 2014
◦ 후천성 말실행증 진단에 대한 인식 조사. 언어치료연구 (학진등재), 제1저자, 2014
◦ 정상 노화와 치아소실 유무에 따른 삼킴문제 및 삶의 질. 한국노년학. (학진등재), 교신저자, 2014
◦ 소리내어 생각하기(Think-aloud) 방법을 통한 청년층과 노년층의 추론특성 비교. 재활복지 (학진등재), 교신저자, 2014
◦ Size variability of handwriting in healthy Korean older adults. Geriatrics & Gerontology International (SCI). 제1저자, 2014
◦ 근거기반실무(Evidence-based practice)에 대한 언어재활사의 인식 및 실태 조사. 재활복지 (학진등재), 제1저자, 2014
◦ 쓰기서술에서 나타난 정상노인의 언어능력 특성. 언어치료연구 (학진등재), 교신저자, 2014
◦ 정상 노인의 연령에 따른 철자 산출 특성 말소리와 음성과학 (학진등재), 제1저자, 2014
◦ 삼킴장애 진단과 치료에 대한 언어치료전공자의 인식 및 현황. 말소리와 음성과학 (학진등재), 제1저자, 2013
◦ 언어치료 전공 학생들의 언어재활실습에 대한 만족도 및 인식. 언어치료연구 (학진등재), 제1저자, 2013 
◦ 음성위생교육 만족도에 대한 예비 연구. 말소리와 음성과학 (학진등재), 제1저자, 2013 
◦ 진성대 질환군에 따른 가성대 움직임의 비교. 언어치료연구 (학진등재), 공동저자, 2013
◦ Orthographic Knowledge of Hangul Syllable in Alzheimer’s Disease. Communication Sciences & Disorders (SCOPUS), 제1저자, 2013
◦ Dysgraphia in Korean patients with Alzheimer's disease as a manifestation of bilateral hemispheric dysfunction. Journal of Neurological Sciences (SCI), 제1저자, 2012
◦ Agraphia in Korean patients with early onset Alzheimer's disease. International Psychogeriatrics (SCI), 제1저자, 2011
◦ Language-Specific Dysgraphia in Korean Stroke Patients. Cognitive & Behavioral Neurology (SCI), 제1저자, 2010
◦ Is Phonological-Lexical Representation Preserved in Moderate Stage Alzheimer Disease? Evidence From the Efficacy of Korean Syllabic Cues. Alzheimer Disease & Associated Disorders (SCI), 제1저자, 2010

■ 저서

◦ 노화와 의사소통, (역서, 공동), 학지사 2020
◦ 언어재활현장실무 (저서, 공동), 학지사, 2019
◦ 말운동장애: 기질, 감별진단, 중재 (역서, 공동), 박학사, 2016
◦ 임상가를 위한 인지신경학, 신경심리학 (저서, 공동), 뇌미인, 2016
◦ 치매증례집 (저서, 공동), 뇌미인, 2016
◦ 노화와 의사소통장애 (역서, 공동), 학지사, 2015

학회활동

한국언어청각임상학회 상임이사, 학술위원
한국언어재활사협회 교육위원
한국음성학회 상임이사, 편집위원
한국노년학회 상임이사

Google Scholar

연구

◦ Jin, I. K., Choi, S. J., & Ku, M. (2021). Notched and Nonnotched Stimuli Are Equally Effective at the Mixing Point Level in Sound Therapy for Tinnitus Relief. JAAA.

◦ Jin, I. K., Choi, S. J., Yoo, J., Jeong, S., Heo, S., & Oh, H. (2021). Effects of tinnitus sound therapy determined using subjective measurements. JAAA.

◦ Choi, S. J., Ku, M., Lee, T., Sim, Y., Yoo, J., Shukor, N. F. A., ... & Jin, I. K. (2021). Purpose, Procedure, and Contents of Counseling according to Tinnitus Interventions. ASR.

◦ Jin, I. K., & Oh, S. H. (2021). Comparison of Domestic and Foreign Audiologist Education Status and Qualification System. ASR.

◦ Jinbae Shin, Sohee Heo, Ho-Ki Lee, Richard Tyler, and In-Ki Jin. (2019). Reliability and Validity of a Korean Version of the Tinnitus Primary Function Questionnaire. AJA.

◦ Jeeun Yoo, Hongyeop Oh, Seungyeop Jeong, and In-Ki Jin. (2019). Comparison of Speech Rate and Long-Term Average Speech Spectrum between Korean Clear Speech and Conversational Speech. JAO.

◦ Seungyeop Jeong, Sohee Heo, Hongyeop Oh, Jeeun Yoo, In-Ki Jin. (2019). Tinnitus Rehabilitation Effects Using Partial Masking with Nature Sounds. ASR.

◦ Seungyeop Jeong, Sohee Heo, Hongyeop Oh, Jeeun Yoo, In-Ki Jin. (2019). Methods and Application of Sound Therapy for Tinnitus Rehabilitation. ASR.

◦ Hongyeop Oh, Sohee Heo, In-Ki Jin. (2019). A Comparison of Band-Importance Function and Transfer Function Using Clear Speech and Conversational Speech. ASR.

◦ Kyungju Lee, Hongyeop Oh, Suyeon Shin, Sohee Heo, In-Ki Jin. (2018). Comparison of Dynamic Range of Clear Speech and Conversational Speech in Korean. ASR

◦ Sohee Heo, Hongyeop Oh, In-Ki Jin. (2018). Comparisons of the Korean Band-Importance and Absolute Transfer Functions according to Speakers’ Gender. ASR.

◦ Jangwon Lee, Kyungju Lee, Hongyeop Oh, Seungyeop Jeong, In-Ki Jin. (2018). Analytical Review of Tinnitus Questionnaires: Characteristics and Understanding. ASR.

◦ Seungyeop Jeong, Sohee Heo, Hongyeop Oh, In-Ki Jin. (2018). Effect of Tinnitus Rehabilitation for Elderly Patients through a Visiting Service. ASR.

◦ Kyungju Lee, In-Ki Jin. (2018). A Comparison of Acoustical Characteristics between International Speech Test Signal and Korean Speech Stimuli. CSD.

◦ In-Ki Jin, James M. Kates, and Kathryn H. Arehart. (2018). Author’s Rebuttal to Smits et al. (2017), “Comment on ‘Sensitivity of the Speech Intelligibility Index to the Assumed Dynamic Range’ by Jin et al. (2017)”. JSLHR.

◦ Dongchang Kim, Jinbae Shin, Kyungju Lee, In-Ki Jin. (2017). Rehabilitation options for subjective tinnitus. Audiology and Speech Research, 13(1), 1-8.

◦ In-Ki Jin, Kyoungwon Lee, Jinsook Kim, Dongwook Kim, Junil Sohn, Junghak Lee. (2017). Comparison of a Hearing Aid Fitting Formula Based on Korean Acoustic Characteristics and Existing Fitting Formulae. Audiology and Speech Research, 13(3), 216-221.

◦ In-Ki Jin, James M. Kates, & Kathryn H. Arehart. (2017). Sensitivity of the Speech Intelligibility Index to the Assumed Dynamic Range Journal of Speech Language and Hearing Research, 60, 1674-1680.

◦ KyungjuLee, & In-Ki Jin. (2016). A Study of Durations for Korean Vowels at Isolated Utterance Condition. Aduiology & Speech Research, 12(3), 150-156.

◦ In-Ki Jin, Junghak Lee, Kyoungwon Lee, Jinsook Kim, Dongwook Kim, Junil Sohn, & Kyungju lee. (2016). The Band-Importance Function for the Korean Standard Sentence Lists for Adults. Journal of Audiology & Otology, 20(2), 91-95.

◦ Kyungju Lee, & In-Ki Jin. (2016). A study of durations for Korean vowels at an isolated utterance condition. Audiology & Speech Research, 12, 150-156.

◦ In-Ki Jin, James M. Kates, & Kathryn H. Arehart. Does Language Matter when using a Graphical Method for Calculating the Speech Intelligibility Index? Journal of the American Academy of Audiology, 28(2), 119-126.

◦ In-Ki Jin, James M. Kates, Kyoungwon Lee, & Kathryn H. Arehart. (2015). Derivations of the band-importance function: A cross-procedure comparison. The Journal of the Acoustical Society of America, 138(2), 938-941.

◦ Gun-Gu Kim, In-Ki Jin. (2015). Measurements and Applications of the Speech Intelligibility Index (SII). Audiology and Speech Research, 11(3), 186-195.

◦ Kyeong-Yeon Park, & In-Ki Jin. (2015). The Dynamic Range for Korean Standard Sentence Material: A Gender Comparison in a Male and a Female Speakers. Journal of audiology & otology, 19(2), 97-100.

◦ In-Ki Jin, James M. Kates, and Kathryn H. Arehart. (2014). The Dynamic range for speech materials in Korean, English, and Mandarin: A cross-language comparison. Journal of Speech, Language, and Hearing Research.

◦ In-Ki Jin, James M. Kates, and Kathryn H. Arehart. (2012). The effect of noise envelope modulation on quality judgments of noisy speech. Journal of Acoustical Society of America, 132(4), 277-283.

◦ In-Ki Jin, & Jae-Hee Lee. (2010). Effects of Talker Variability on Speech Recognition of Normal-Hearing Listeners for Korean Speech Audiometry. Audiology Rehabilitation, 6, 19-24.

◦ In-Ki Jin, & Jae-Hee Lee. (2010). A Comparison of Long-Term Average Speech Spectrum (LTASS) among Korean Monosyllabic Words, Sentences, and English Sentences. Audiology Rehabilitation, 6, 164-172.

저서

◦ 보청기 실제 1판. (2019). 교우사. 책임저자

◦ 청각학 개론 2판. (2017). 학지사. 공저자

■연구비 수주

◦2020 ~ 2021 개인 맞춤형 이명소리치료 어플리케이션 개발 (과학기술일자리진흥원)

◦2018 ~ 2021 복합음을 활용한 이명 재활용 소리치료 음원 개발 (한국연구재단)

◦2015 ~ 2018 한국형 어음인지지수의 개발: 보청기적합효과의 예측 모델 (한국연구재단)

■ 대외활동

◦2021 ~ Present 강원정보문화진흥원 기술닥터
◦2021 ~ Present 사단법인 한국청각언어재활학회 총무이사
◦2021 ~ Present 한국청능사협회 부회장

◦2019 ~ Present 국립환경과학원 환경표준심의회 일반소음분과 전문위원

◦2019 ~ 2020 한국청능사협회 총무이사
◦2016 ~ 2020 국제표준화기구 ISO 보청기적합국제표준안개발 한국팀 위원
◦2016 ~ 2020 한국청각언어재활학회 교육위원회 부위원장

◦2019 ~ Present 한국청능사협회 총무이사

◦2016 ~ Present 국제표준화기구 ISO 보청기적합국제표준안개발 한국팀 위원

◦2016 ~ Present 한국청각언어재활학회 교육위원회 부위원장

◦2016 ~ 2018 청능사자격검정원 총무이사

◦2016 ~ 2017 AURIS medical 국제돌발성난청연구 한국지부 총괄자문위원

◦2016 ~ 2017 코이카 베트남 언어청각전문인력양성 및 역량강화 사업 청각분과 파견 강사

[저역서]

2018 수영지도자 길라잡이(ebook), (지식과 감성 – 공저)

2017 스포츠전공자를 위한 인체해부학 (한미의학-저서)

2015 유소년축구길라잡이 (도서출판 노력하는 사람들-저서)

2012 Maual of Structural Kinesiology (도서출판한미의학-역서)

2011 재활수중운동의 이해와 실제 (미래출판사-저서)

2010 라이프스타일 리모델링 (소화-저서)

2010 재활수중운동론 (예문사-저서)

2001 한국노년의 건강 (한림과학원-저서)

[주요연구실적]

2019. 9 정상시각유발전위를 이용한 동체시력의 평가. 한국사회체육학회

2019. 6 피트니스센터 이용자들의 운동처방환경 서비스와 참가정도가 이용만족 및 재이용의도에 미치는 영향, 한국엔터테인먼트산업학회지 제13권 제4호

2018. 4 대학생의 자기주도 운동참여와 건강관련체력 및 웰니스지수의 관계, 한국체육과학회지 제27권 제2호

2018. 1 대학생들의 자기 주도적 운동 적용을 위한 운동자각 및 건강관련체력에 대한 연구 한국엔터테인먼트산업학회논문지 제12권 제1호

2017.11 교양체육 페러다임 변화를 위한 대학생의 자기주도적 운동적용-한국엔터네인먼트산업학회지

2017.09 Health effects of nanomaterials with sportswear application/International Journal of Applied Engineering Research

2017.09 Characteristics & applications of nanomaterials on sportswear fabric/International Journal of Applied Engineering Research

2015.10 오르막 걷기 시 폴 사용이 비만 여성의 혈중 COMP농도, 근 손상 및 피로지표에 미치는 영향 – 한국체육과학회지

2014.12 신체활동이 대학생의 웰니스에 미치는 영향 – 한국생활환경학회지

2013.09 성인 남성의 하지 등속성 근력과 점프수행능력 간의 상관관계 – 생활환경학회지

2012.12 Effects of Acute Soccer Game in Serum levels of Neurotrophins and Nuerocognitive Functions in Male Adolescents – 한국생명과학회지

2012.06 정주대학(Residential College)스포츠여가 참여와 웰니스, 생활만족과의 관계 – 한국생명과학지

2011.12 Effects of exercise program on appetite-regulating hormones, inflammatory mediators, lipid profiles, and body composition in healthy men – JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS

2011.10 장소 환경이 걷기 운동시 생리, 심리적 반응요인 및 면역요인에 미치는 영향 – 한국생활환경학회

2010.10 수중운동이 여성노인의 건강관련 체력 및 대사증후군 위험요인에 미치는 효과 – 운동학 학술지

2010.04 유소년 태권도 선수들의 칼슘량, 신체구성, 등속성 근기능 간의 상관성 및 수련 정도별 재변인의 차이 – 대한무도학회지

2010.03 대학생의 신체활동 코칭에 필요한 선호경향 분석 – 코칭능력개발지

2010.02 축구동호인의 준비운동이 운동상해에 미치는 영향 – 한국운동재활학회지

2010.02 대학생의 기본인명구조술(BLS)지식수준에 관한 연구 – 한국운동재활학회지

2009.12 저항성 운동이 폐경기 전, 후 비만여성의 신체구성, 혈중지질 및 근력에 미치는 영향 – 코칭능력개발지

2009.12 노인의 생활체육참여자가 우울증 성생활 및 건강관련 체력에 미치는 영향- 한국생활환경학회지

2009.12 윈게이트 운동직후 세 가지 유형의 회복방법이 유도선수들의 혈중젖산농도와 중앙 주파수에 미치는 영향 – 대한무도확회지

2009.11 축구참여의 재미요인이 운동지속과 심리적 행복감에 미치는 영향 – 한국체육과학회지

2009.11 페러글라이딩 동호인의 참가정도가 운동지속 및 운동중독에 미치는 영향 – 한국체육과학회지

2009.07 춘천 국제레저경기대회의 관람객에 대한 서비스 품질과 이미지, 만족도, 애호도와의 관계 – 한국체육학회지

2004.12 유산소 및 저항성 훈련 프로그램이 비만 여대생의 체지방, 렙틴 및 인슐린 농도에 미치는 영향 – 한국코칭능력개발지

2004.12 태권도 선수들의 영양지식, 식습과, 음식기호도 및 영양섭취에 관한 연구 – 한국스포츠리서치

2004.12 태권도 훈련기간이 유소년 선수들의 등속성 근기능 변인에 미치는 효과 – 한국코칭능력개발지

2004.01 장기간 운동이 노인들의 심혈관계 기능변화에 미치는 효과 - 대한스포츠의학회지

microRNA와 autophagy

- 윤부줄기세포(limbal stem cells)에서 microRNA에 의한 줄기세포 특성 및 autophagy 조절기전 연구

- 각막상피세포(corneal epithelial cells)에서 microRNA에 의한 각막세포재생, 신생혈관형성, autophagy 조절기전 연구

- MicroRNA에 의한 암세포의 성장, 전이, 세포사멸 기전연구

■ 논문 (2010년 이후)

ㆍ Yun BD, Choi YJ, Son SW, Cipolla GA, Berti FCB, Malheiros D, Oh T-J, Kuh HJ, Choi SY, Park JK. Oncogenic Role of Exosomal Circular and Long Noncoding RNAs in Gastrointestinal Cancers. Int J Mol Med. 2022; 23(2):930.

 
ㆍ Jang SD, Song JY, Kim HA, Im CN, Khawar IA, Park JK, Kuh HJ. Anti-Cancer Activity Profiling of Chemotherapeutic Agents in 3D Co-Cultures of Pancreatic Tumor Spheroids with Cancer-Associated Fibroblasts and Macrophages. Cancers (Basel). 2021 Nov 26;13(23):5955.

 
ㆍ Yun BD, Son SW, Choi SY, Kuh HJ, Oh T-J, Park JK. Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha. Int J Mol Med. 2021; 22(18):9819.

 
ㆍ Khawar IA, Ghosh T, Park JK, Kuh HJ. Tumor spheroid-based microtumor models for preclinical evaluation of anticancer nanomedicines. J. Pharm. Investig. (2021).

 
ㆍ Son SW, Yun BD, Song MG, Lee JK, Choi SY, Kuh HJ, Park JK. The Hypoxia–Long Noncoding RNA Interaction in Solid Cancers. Int J Mol Med. 2021; 22(14):7261.

 
ㆍ Choi YJ, Kim DW, Shin MJ, Yeo HJ, Yeo EJ, Lee LR, Song Y, Kim D-S, Han KH, Park J, Lee KW, Park JK, Eum WS, Choi SY. PEP-1-GLRX1 Reduces Dopaminergic Neuronal Cell Loss by Modulating MAPK and Apoptosis Signaling in Parkinson’s Disease. Molecules. 2021; 26(11):3329.

 
ㆍ Berti FCB, Lobo-Alves SC, Oliveira-Toré CdF, Salviano-Silva A, de Oliveira KB, de Araújo-Souza PS, Park JK, Cipolla GA, Malheiros D. Competing Endogenous RNAs in Cervical Carcinogenesis: A New Layer of Complexity. Processes. 2021; 9(6):991.

 
ㆍ Son SW, Song MG, Yun BD, Park JK. Noncoding RNAs Associated with Therapeutic Resistance in Pancreatic Cancer. Biomedicines 2021, 9(3), 263.

 
ㆍ Cho SB, Eum WS, Shin MJ, Yeo HJ, Yeo EJ, Choi YJ, Kwon HJ, Cho SW, Park J, Han KH, Lee KW, Park JK, Kim DS, Kim DW, Choi SY. Tat‑aldose reductase prevents dopaminergic neuronal cell death by inhibiting oxidative stress and MAPK activation. Int J Mol Med. 2021 Feb;47(2):751-760.

 
ㆍ Yeo EJ, Eum WS, Yeo HJ, Choi YJ, Sohn EJ, Kwon HJ, Kim DW, Kim DS, Cho SW, Park J, Han KH, Lee KW, Park JK, Shin MJ, Choi SY. Protective Role of Transduced Tat-Thioredoxin1 (Trx1) against Oxidative Stress-Induced Neuronal Cell Death via ASK1-MAPK Signal Pathway. Biomol Ther (Seoul). 2021 Jan 13.

 
ㆍ Lee HY, Son SW, Moeng S, Choi SY, Park JK. The Role of Noncoding RNAs in the Regulation of Anoikis and Anchorage-Independent Growth in Cancer. Int J Mol Sci. 2021, 22, 627.

ㆍ Oh MS, Khawar IA, Lee DW, Park JK, Kuh HJ. Three-Dimensional Imaging for Multiplex Phenotypic Analysis of Pancreatic Microtumors Grown on a Minipillar Array Chip. Cancers (Basel). 2020 Dec 7;12(12):3662.
 

ㆍ Park JH, Kim DW, Shin MJ, Park J, Han KH, Lee KW, Park JK, Choi YJ, Yeo HJ, Yeo EJ, Sohn EJ, Kim HC, Shin EJ, Cho SW, Kim DS, Cho YJ, Eum WS, Choi SY. Tat-indoleamine 2,3-dioxygenase 1 elicits neuroprotective effects on ischemic injury. BMB Rep. 2020 Nov;53(11):582-587.
 

ㆍ Son SW, Lee HY, Moeng S, Kuh HJ, Choi SY, Park JK. Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals. Molecules. 2020 Oct 14;25(20):4701.

 
ㆍ Moeng S, Son SW, Lee JS, Lee HY, Kim TH, Choi SY, Kuh HJ, Park JK. Extracellular Vesicles (EVs) and Pancreatic Cancer: From the Role of EVs to the Interference with EV-Mediated Reciprocal Communication. Biomedicines. 2020 Aug 3;8(8):267.

ㆍ Kim SK, Jang SD, Kim H, Chung S, Park JK, Kuh HJ. Phenotypic Heterogeneity and Plasticity of Cancer Cell Migration in a Pancreatic Tumor Three-Dimensional Culture Model. Cancers (Basel). 2020 May 21;12(5):1305. Cancers (Basel). 2020 May 21;12(5):1305.

ㆍ Kim SJ, Shin MJ, Kim DW, Yeo HJ, Yeo EJ, Choi YJ, Sohn EJ, Han KH, Park J, Lee KW, Park JK, Cho YJ, Kim DS, Eum WS, Choi SY. Tat-Biliverdin Reductase A Exerts a Protective Role in Oxidative Stress-Induced Hippocampal Neuronal Cell Damage by Regulating the Apoptosis and MAPK Signaling. Int J Mol Sci. 2020 Apr 11;21(8):2672.
 

ㆍ Moeng S, Son SW, Seo HA, Lee JS, Kim CK, Kuh HJ, Park JK. Luteolin-regulated MicroRNA-301-3p Targets Caspase-8 and Modulates TRAIL Sensitivity in PANC-1 Cells. Anticancer Res. 2020 Feb;40(2):723-731.

 
ㆍ Youn GS, Park JK, Lee CY, Jang JH, Yun SH, Kwon HY, Choi SY, Park J. MicroRNA-22 negatively regulates LPS-induced inflammatory responses by targeting HDAC6 in macrophages. BMB Rep. 2020 Jan 21. pii: 4744.

ㆍ Kaplan N, Dong Y, Wang S, Yang W, Park JK, Wang J, Fiolek E, White BP, Chandel NS, Peng H, Lavker RM. FIH‐1 engages novel binding partners to positively influence epithelial proliferation via p63. FASEB J, 2020 Jan; 34: 525-539.

ㆍ Seo HA, Moeng S, Sim S, Kuh HJ, Choi SY, Park JK. MicroRNA-Based Combinatorial Cancer Therapy: Effects of MicroRNAs on the Efficacy of Anti-Cancer Therapies. Cells. 2019 Dec 20;9(1). pii: E29.

ㆍ Nam S, Khawar IA, Park JK, Chang S, Kuh HJ. Cellular context-dependent interaction between cancer and stellate cells in hetero-type multicellular spheroids of pancreatic tumor. Biochem Biophys Res Commun. 2019 Jul 12;515(1):183-189.

ㆍ Seo HA, Hwang CY, Moeng S, Park JK. An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells. J Vis Exp. 2019 May 21;(147)

ㆍ Moeng S, Seo HA, Hwang CY, Cipolla GA, Lee DJ, Kuh HJ, Park JK. MicroRNA-107 Targets IKBKG and Sensitizes A549 Cells to Parthenolide. Anticancer Res. 2018 Nov;38(11):6309-6316.

ㆍ Park JK, Seo JS, Lee SK, Chan KK, Kuh HJ. Combinatorial antitumor activity of oxaliplatin with epgenetic modifying agents, 5-Aza-CdR and FK228, in human gastric cancer cells. Biomol Ther (Seoul). 2018 Nov 1;26(6):591-598.

ㆍ Khawar IA, Park JK, Jung ES, Lee MA, Chang S, Kuh HJ, Three dimensional mixed-cell spheroids mimic stroma-mediated chemoresistance and invasive migration in hepatocellular carcinoma, Neoplasia 2018 2018 Jul 4;20(8):800-812.

ㆍ Park JK, Doseff A, Schmittgen TD. MicroRNAs targeting caspase-3 and -7 in panc-1 cells. Int J Mol Sci. 2018 Apr 16;19(4). pii: E1206 (co-corresponding).

ㆍ Cipolla GA, Park JK, Lavker RM, Petzl-Erler ML. Crosstalk between Signaling Pathways in Pemphigus: A Role for Endoplasmic Reticulum Stress in p38 Mitogen-Activated Protein Kinase Activation? Front Immunol. 2017 Sep 5; 8: 1022.

ㆍ Peng H, Park JK, Lavker RM. Eyeing Autophagy and Macropinocytosis in the Corneal/Limbal Epithelia. Autophagy. 2017 May 4;13(5):975-977. (co 1st author).

ㆍ Peng H, Park JK, Lavker RM. Autophagy and Macropinocytosis: Keeping an Eye on the Corneal/limbal Epithelia. Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):416-423. (co 1st author).

ㆍ Park JK, Peng H, Yang W, Katsnelson J, Volpert O, Lavker RM. microRNA-184 exhibits angiostatic properties via regulation of Akt and VEGF signaling pathways. FASEB J. 2017 Jan 1; 31(1):256-265.

ㆍ Park JK, Peng H, Katsnelson J, Yang W, Kaplan N, Dong Y, Rappoport JZ, He C, Lavker RM. microRNAs-103/107 coordinately regulate macropinocytosis and autophagy. J Cell Biol. 2016 Dec 5;215(5):667-685.

ㆍ Kim JH, Badawi M, Park JK, Jiang J, Mo X, Roberts LR, Schmittgen TD. Anti-invasion and anti-migration effects of miR-199a-3p in hepatocellular carcinoma are due in part to targeting CD151. Int J Oncol. 2016 Nov;49(5):2037-2045. 

ㆍ Cipolla GA, Park JK, de Oliveira LA, Lobo-Alves SC, de Almeida RC, Farias TD, de S Lemos D, Malheiros D, Lavker RM, Petzl-Erler ML. A 3'UTR polymorphism marks differential KLRG1 mRNA levels through disruption of a miR-584-5p binding site and associates with pemphigus foliaceus susceptibility. Biochim Biophys Acta. 2016 Oct;1859(10):1306-13. 

ㆍ Park JK, Yang W, Katsnelson J, Lavker RM, Peng H. microRNAs enhance keratinocyte proliferative capacity in a stem cell-enriched epithelium. PLoS One. 2015; 10(8): e0134853.

ㆍ Peng H, Park JK, Katsnelson J, Kaplan N, Yang W, Getsios S, Lavker RM. microRNA-103/107 family regulates multiple epithelial stem cell characteristics. Stem Cells. 2015; 33(5):1642-56. (co 1st author).

ㆍ Lee SH, Nam JK, Park JK, Lee JH, Min DS, Kuh HJ. Differential protein expression and novel biomarkers related to 5-FU resistance in a 3D colorectal adenocarcinoma model. Oncol Rep. 2014; 32(4):1427-34.

ㆍ Kim TW, Cui R, Jeon YJ, Lee JH, Lee JH, Sim HS, Park JK, Fadda P, Tili E, Nakanishi H, Huh MI, Kim SH, Cho JH, Sung BH, Peng Y, Lee TJ, Luo Z, Sun HL, Wei H, Alder H, Oh JS, Shim KS, Ko SB, Croce CM. Long-range interaction and correlation between MYC enhancer and oncogenic lncRNA CARLo-5. Proc Natl Acad Sci U S A. 2014; 18;111(11):4173-8.

ㆍ Elgamal OA, Park JK, Gusev Y, Azevedo-Pouly AC, Jiang J, Roopra A, Schmittgen TD. Tumor Suppressive Function of mir-205 in Breast Cancer Is Linked to HMGB3 Regulation. PLoS One. 2013; 2;8(10):e76402. (co 1st author).

ㆍ Park JK, Kogure T, Nuovo GJ, Jiang J, He L, Kim JH, Phelps MA, Papenfuss TL, Croce CM, Patel T, Schmittgen TD. miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Cancer Res. 2011; 71(24): 7608-16.

ㆍ Park JK, Henry JC, Jiang J, Esau C, Gusev Y, Lerner MR, Postier RG, Brackett DJ, Schmittgen TD. miR-132 and miR-212 are increased in pancreatic adenocarcinoma and target the retinoblastoma tumor suppressor. Biochem Biophys Res Commun. 2011; 406(4): 518-23.

ㆍ Henry JC, Park JK, Jiang J, Kim JH, Nagorney DM, Roberts LR, Banerjee S, Schmittgen TD. miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun. 2010; 403(1): 120-5. (co 1st author).

학회활동

2018 ~ 현재, Oncology Letters, Editorial Board Member  

2006 – 현재, 미국 암학회 (AACR)

2012 – 현재, 미국 안과 및 시과학회 (ARVO)

미국 고든 리서치 세미나 의장 (Cornea, Biology & Pathobiology of the Gordon Research Seminar, 2016년)